Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes
Апстракт
Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies. and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA A receptors containing the α 1 and α 5 subunits, whereas the effects on procedural memory can be mainly mediated by the α 1 subunit. The pervading involvement of the α 1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA A receptors. On the other hand, the role of α 5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory g...ives promise of selective pharmacological coping with certain memory deficit states.
Кључне речи:
Acquisition / Explicit memory / Procedural memory / ReceptorИзвор:
Neural Plasticity, 2005, 12, 4, 289-298Издавач:
- Hindawi Limited
Институција/група
PharmacyTY - JOUR AU - Savić, Miroslav AU - Obradović, Dragan I. AU - Ugrešić, Nenad AU - Bokonjić, Dubravko PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/644 AB - Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies. and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA A receptors containing the α 1 and α 5 subunits, whereas the effects on procedural memory can be mainly mediated by the α 1 subunit. The pervading involvement of the α 1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA A receptors. On the other hand, the role of α 5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states. PB - Hindawi Limited T2 - Neural Plasticity T1 - Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes VL - 12 IS - 4 SP - 289 EP - 298 DO - 10.1155/NP.2005.289 ER -
@article{ author = "Savić, Miroslav and Obradović, Dragan I. and Ugrešić, Nenad and Bokonjić, Dubravko", year = "2005", abstract = "Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies. and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA A receptors containing the α 1 and α 5 subunits, whereas the effects on procedural memory can be mainly mediated by the α 1 subunit. The pervading involvement of the α 1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA A receptors. On the other hand, the role of α 5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states.", publisher = "Hindawi Limited", journal = "Neural Plasticity", title = "Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes", volume = "12", number = "4", pages = "289-298", doi = "10.1155/NP.2005.289" }
Savić, M., Obradović, D. I., Ugrešić, N.,& Bokonjić, D.. (2005). Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes. in Neural Plasticity Hindawi Limited., 12(4), 289-298. https://doi.org/10.1155/NP.2005.289
Savić M, Obradović DI, Ugrešić N, Bokonjić D. Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes. in Neural Plasticity. 2005;12(4):289-298. doi:10.1155/NP.2005.289 .
Savić, Miroslav, Obradović, Dragan I., Ugrešić, Nenad, Bokonjić, Dubravko, "Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes" in Neural Plasticity, 12, no. 4 (2005):289-298, https://doi.org/10.1155/NP.2005.289 . .