dc.creator | Vucković, S | |
dc.creator | Tomić, M | |
dc.creator | Stepanović-Petrović, Radica | |
dc.creator | Ugrešić, Nenad | |
dc.creator | Prostran, Milica | |
dc.creator | Bošković, B | |
dc.date.accessioned | 2019-09-02T11:07:46Z | |
dc.date.available | 2019-09-02T11:07:46Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 1347-8613 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/853 | |
dc.description.abstract | This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors. | en |
dc.publisher | Japanese Pharmacological Soc, Kyoto | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Pharmacological Sciences | |
dc.subject | local carbamazepine | en |
dc.subject | inflammatory mechanical hyperalgesia | en |
dc.subject | adenosine A(1) receptor | en |
dc.title | Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine? | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Степановић-Петровић, Радица; Вуцковић, С; Угрешић, Ненад; Простран, Милица; Томић, М; Бошковић, Б; | |
dc.citation.volume | 100 | |
dc.citation.issue | 4 | |
dc.citation.spage | 310 | |
dc.citation.epage | 314 | |
dc.citation.other | 100(4): 310-314 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000237098300009 | |
dc.identifier.doi | 10.1254/jphs.SCE05003X | |
dc.identifier.pmid | 16575152 | |
dc.identifier.scopus | 2-s2.0-33645845731 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/2219/851.pdf | |
dc.type.version | publishedVersion | |