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Characterization of thymocyte phenotypic alterations induced by long-lasting beta-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosis
dc.creator | Leposavić, Gordana | |
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Radojević, Katarina | |
dc.creator | Kosec, Duško | |
dc.creator | Pešić, V. | |
dc.creator | Vidić-Danković, Biljana | |
dc.creator | Plećaš-Solarović, Bosiljka | |
dc.creator | Pilipović, Ivan | |
dc.date.accessioned | 2019-09-02T11:07:49Z | |
dc.date.available | 2019-09-02T11:07:49Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0300-8177 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/856 | |
dc.description.abstract | Adult male Wistar rats were subjected to propranolol (P, 0.40 mg/100 g/day) or saline (S) administration (controls) over 14 days. The expression of major differentiation molecules on thymocytes and Thy-1 (CD90) molecules, which are shown to adjust thymocyte sensitivity to TCR alpha beta signaling, was studied. In addition, the sensitivity of thymocytes to induction of apoptosis and concanavalin A (Con A) signaling was estimated. The thymocytes from P-treated (PT) rats exhibited an increased sensitivity to induction of apoptosis, as well as to Con A stimulation. Furthermore, P treatment produced changes in the distribution of thymocyte subsets suggesting that more cells passed positive selection and further differentiated into mature CD4+ or CD8+ single positive (SP) TCR alpha beta(high) cells. These changes may, at least partly, be related to the markedly increased density of Thy-1 surface expression on TCR alpha beta(low) thymocytes from these rats. The increased frequency of cells expressing the CD4+25+ phenotype, which has been shown to be characteristic for regulatory cells in the thymus, may also indicate alterations in thymocyte selection following P treatment. Inasmuch as positive and negative selections play an important role in continuously reshaping the T-cell repertoire and maintaining tolerance, the hereby presented study suggests that pharmacological manipulations with beta-AR signaling, or chemically evoked alterations in catecholamine release, may interfere with the regulation of thymocyte selection, and consequently with the immune response. | en |
dc.publisher | Springer, Dordrecht | |
dc.rights | restrictedAccess | |
dc.source | Molecular and Cellular Biochemistry | |
dc.subject | beta-adrenoceptor blockade | en |
dc.subject | CD90 expression | en |
dc.subject | Con A | en |
dc.subject | T-cell differentiation | en |
dc.subject | thymocyte apoptosis | en |
dc.subject | thymocyte proliferation | en |
dc.title | Characterization of thymocyte phenotypic alterations induced by long-lasting beta-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Пилиповић, Иван; Видић-Данковић, Биљана; Пешић, В.; Косец, Душко; Радојевић, Катарина; Лепосавић, Гордана; Aрсеновић-Ранин, Невена; Плећаш-Соларовић, Босиљка; | |
dc.citation.volume | 285 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 87 | |
dc.citation.epage | 99 | |
dc.citation.other | 285(1-2): 87-99 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000238521100009 | |
dc.identifier.doi | 10.1007/s11010-005-9059-5 | |
dc.identifier.pmid | 16477376 | |
dc.identifier.scopus | 2-s2.0-33646152757 | |
dc.type.version | publishedVersion |