Plasma C1 inhibitor in malignant diseases: Functional activity versus concentration
Samo za registrovane korisnike
1991
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Plasma C1 inhibitor (C1-INH) was determined in 64 patients with different malignant diseases and in 58 healthy persons. Cl-INH antigen concentration was measured by radial immunodiffusion (RID), whereas its functional activity was assayed with chromogenic substrate. Within-run and day-to-day precision of both methods were good, with CVs ranging from 3.6 to 5.4%. Plasma C1-INH antigen concentrations were significantly higher in the patients than in healthy controls (P=4.0 x 10-3), as were their C1-INH functional activities (P=3.5 x 10-3). C1-INH activities obtained in the patient plasma samples were in correlation with their antigen concentrations (r = 0.914), showing that C1-INH synthesized in malignant disease was functional. However, the specific activity of the C1-INH (functional activity/antigen concentration ratio) was significantly lower in the patient group as compared with the controls (P=2.1 x 10-6), indicating partial inactivation of plasma C1-INH in malignant diseases. The C...1-INH specific activity in patients was inversely proportional to its antigen concentration.
Ključne reči:
Chromogenic substrate / Complement / Radial immunodiffusionIzvor:
Annals of Clinical Biochemistry, 1991, 28, 6, 595-598Institucija/grupa
PharmacyTY - JOUR AU - Starcević, D AU - Jelić-Ivanović, Zorana AU - Kalimanovska, Vesna PY - 1991 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/88 AB - Plasma C1 inhibitor (C1-INH) was determined in 64 patients with different malignant diseases and in 58 healthy persons. Cl-INH antigen concentration was measured by radial immunodiffusion (RID), whereas its functional activity was assayed with chromogenic substrate. Within-run and day-to-day precision of both methods were good, with CVs ranging from 3.6 to 5.4%. Plasma C1-INH antigen concentrations were significantly higher in the patients than in healthy controls (P=4.0 x 10-3), as were their C1-INH functional activities (P=3.5 x 10-3). C1-INH activities obtained in the patient plasma samples were in correlation with their antigen concentrations (r = 0.914), showing that C1-INH synthesized in malignant disease was functional. However, the specific activity of the C1-INH (functional activity/antigen concentration ratio) was significantly lower in the patient group as compared with the controls (P=2.1 x 10-6), indicating partial inactivation of plasma C1-INH in malignant diseases. The C1-INH specific activity in patients was inversely proportional to its antigen concentration. T2 - Annals of Clinical Biochemistry T1 - Plasma C1 inhibitor in malignant diseases: Functional activity versus concentration VL - 28 IS - 6 SP - 595 EP - 598 DO - 10.1177/000456329102800609 ER -
@article{ author = "Starcević, D and Jelić-Ivanović, Zorana and Kalimanovska, Vesna", year = "1991", abstract = "Plasma C1 inhibitor (C1-INH) was determined in 64 patients with different malignant diseases and in 58 healthy persons. Cl-INH antigen concentration was measured by radial immunodiffusion (RID), whereas its functional activity was assayed with chromogenic substrate. Within-run and day-to-day precision of both methods were good, with CVs ranging from 3.6 to 5.4%. Plasma C1-INH antigen concentrations were significantly higher in the patients than in healthy controls (P=4.0 x 10-3), as were their C1-INH functional activities (P=3.5 x 10-3). C1-INH activities obtained in the patient plasma samples were in correlation with their antigen concentrations (r = 0.914), showing that C1-INH synthesized in malignant disease was functional. However, the specific activity of the C1-INH (functional activity/antigen concentration ratio) was significantly lower in the patient group as compared with the controls (P=2.1 x 10-6), indicating partial inactivation of plasma C1-INH in malignant diseases. The C1-INH specific activity in patients was inversely proportional to its antigen concentration.", journal = "Annals of Clinical Biochemistry", title = "Plasma C1 inhibitor in malignant diseases: Functional activity versus concentration", volume = "28", number = "6", pages = "595-598", doi = "10.1177/000456329102800609" }
Starcević, D., Jelić-Ivanović, Z.,& Kalimanovska, V.. (1991). Plasma C1 inhibitor in malignant diseases: Functional activity versus concentration. in Annals of Clinical Biochemistry, 28(6), 595-598. https://doi.org/10.1177/000456329102800609
Starcević D, Jelić-Ivanović Z, Kalimanovska V. Plasma C1 inhibitor in malignant diseases: Functional activity versus concentration. in Annals of Clinical Biochemistry. 1991;28(6):595-598. doi:10.1177/000456329102800609 .
Starcević, D, Jelić-Ivanović, Zorana, Kalimanovska, Vesna, "Plasma C1 inhibitor in malignant diseases: Functional activity versus concentration" in Annals of Clinical Biochemistry, 28, no. 6 (1991):595-598, https://doi.org/10.1177/000456329102800609 . .