Antibiotics in local therapy of eye infections: Current aspects of drug products formulation
Antibiotici u lokalnoj terapiji oboljenja oka - savremeni aspekti formulacije proizvoda
Апстракт
In local therapy of ocular infections (bacterial conjunctivitis, bacterial keratitis, endophthalmitis) commonly used antibiotics are those with bactericidal effect: penicillins, cephalosporins, aminoglycosides and fluoroquinolones. Tetracycline, erythromycin, chloramphenicol and sulfonamide are bacteriostatic drugs administrating in less severe infections. A proper selection of final dosage form is of paramount importance for achieving the satisfying therapeutic effect of these drugs. For the reason of simple application and acceptable price conventional pharmaceutical forms of antibiotics (eye drops and ointments) are the most available at the market The disadvantage of the conventional dosage forms is relatively poor drug bioavailability in the eye, which is out to enhance either by promoting drugs’ biopharmaceutical properties or by development of novel drug delivery systems.
U lokalnoj terapiji infekcija oka (bakterijski keratitis, bakterijski konjunktivitis i endoftalmitis) najčešće se koriste antibiotici sa baktericidnim delovanjem (kod jakih bakterijskih infekcija): penicilini, cefalosporini, aminoglikozidi i fluorohinoloni. Tetraciklin, eritromicin, hloramfenikol i sulfonamidi pokazuju bakteriostatsko delovanje i primenjuju se kod infekcija slabijeg inteziteta. Za postizanje zadovoljavajućeg terapijskog delovanja ovih aktivnih supstanci veoma je važan izbor i formulacija finalnog preparata. Konvencionalni farmaceutski oblici antibiotika (kapi i masti za oči) su najviše zastupljeni na tržištu zbog jednostavnosti primene i prihvatljive cene. Nedostatak ovih oblika je relativno loša raspoloživost lekovite supstance u oku, koja se nastoji poboljšati unapređenjem njihovih biofarmaceutskih osobina i razvojem novih "nosača" lekovite supstance (eng. new drug delivery systems).
Кључне речи:
antibiotic / eye / local therapy / conventional pharmaceutical forms / novel drug delivery systems / antibiotik / oko / lokalna terapija / konvencionalni farmaceutski oblici / novi nosači lekovaИзвор:
Arhiv za farmaciju, 2007, 57, 4-5, 248-265Издавач:
- Savez farmaceutskih udruženja Srbije, Beograd
Институција/група
PharmacyTY - JOUR AU - Milić, Jela AU - Savić, Snežana PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/926 AB - In local therapy of ocular infections (bacterial conjunctivitis, bacterial keratitis, endophthalmitis) commonly used antibiotics are those with bactericidal effect: penicillins, cephalosporins, aminoglycosides and fluoroquinolones. Tetracycline, erythromycin, chloramphenicol and sulfonamide are bacteriostatic drugs administrating in less severe infections. A proper selection of final dosage form is of paramount importance for achieving the satisfying therapeutic effect of these drugs. For the reason of simple application and acceptable price conventional pharmaceutical forms of antibiotics (eye drops and ointments) are the most available at the market The disadvantage of the conventional dosage forms is relatively poor drug bioavailability in the eye, which is out to enhance either by promoting drugs’ biopharmaceutical properties or by development of novel drug delivery systems. AB - U lokalnoj terapiji infekcija oka (bakterijski keratitis, bakterijski konjunktivitis i endoftalmitis) najčešće se koriste antibiotici sa baktericidnim delovanjem (kod jakih bakterijskih infekcija): penicilini, cefalosporini, aminoglikozidi i fluorohinoloni. Tetraciklin, eritromicin, hloramfenikol i sulfonamidi pokazuju bakteriostatsko delovanje i primenjuju se kod infekcija slabijeg inteziteta. Za postizanje zadovoljavajućeg terapijskog delovanja ovih aktivnih supstanci veoma je važan izbor i formulacija finalnog preparata. Konvencionalni farmaceutski oblici antibiotika (kapi i masti za oči) su najviše zastupljeni na tržištu zbog jednostavnosti primene i prihvatljive cene. Nedostatak ovih oblika je relativno loša raspoloživost lekovite supstance u oku, koja se nastoji poboljšati unapređenjem njihovih biofarmaceutskih osobina i razvojem novih "nosača" lekovite supstance (eng. new drug delivery systems). PB - Savez farmaceutskih udruženja Srbije, Beograd T2 - Arhiv za farmaciju T1 - Antibiotics in local therapy of eye infections: Current aspects of drug products formulation T1 - Antibiotici u lokalnoj terapiji oboljenja oka - savremeni aspekti formulacije proizvoda VL - 57 IS - 4-5 SP - 248 EP - 265 UR - https://hdl.handle.net/21.15107/rcub_farfar_926 ER -
@article{ author = "Milić, Jela and Savić, Snežana", year = "2007", abstract = "In local therapy of ocular infections (bacterial conjunctivitis, bacterial keratitis, endophthalmitis) commonly used antibiotics are those with bactericidal effect: penicillins, cephalosporins, aminoglycosides and fluoroquinolones. Tetracycline, erythromycin, chloramphenicol and sulfonamide are bacteriostatic drugs administrating in less severe infections. A proper selection of final dosage form is of paramount importance for achieving the satisfying therapeutic effect of these drugs. For the reason of simple application and acceptable price conventional pharmaceutical forms of antibiotics (eye drops and ointments) are the most available at the market The disadvantage of the conventional dosage forms is relatively poor drug bioavailability in the eye, which is out to enhance either by promoting drugs’ biopharmaceutical properties or by development of novel drug delivery systems., U lokalnoj terapiji infekcija oka (bakterijski keratitis, bakterijski konjunktivitis i endoftalmitis) najčešće se koriste antibiotici sa baktericidnim delovanjem (kod jakih bakterijskih infekcija): penicilini, cefalosporini, aminoglikozidi i fluorohinoloni. Tetraciklin, eritromicin, hloramfenikol i sulfonamidi pokazuju bakteriostatsko delovanje i primenjuju se kod infekcija slabijeg inteziteta. Za postizanje zadovoljavajućeg terapijskog delovanja ovih aktivnih supstanci veoma je važan izbor i formulacija finalnog preparata. Konvencionalni farmaceutski oblici antibiotika (kapi i masti za oči) su najviše zastupljeni na tržištu zbog jednostavnosti primene i prihvatljive cene. Nedostatak ovih oblika je relativno loša raspoloživost lekovite supstance u oku, koja se nastoji poboljšati unapređenjem njihovih biofarmaceutskih osobina i razvojem novih "nosača" lekovite supstance (eng. new drug delivery systems).", publisher = "Savez farmaceutskih udruženja Srbije, Beograd", journal = "Arhiv za farmaciju", title = "Antibiotics in local therapy of eye infections: Current aspects of drug products formulation, Antibiotici u lokalnoj terapiji oboljenja oka - savremeni aspekti formulacije proizvoda", volume = "57", number = "4-5", pages = "248-265", url = "https://hdl.handle.net/21.15107/rcub_farfar_926" }
Milić, J.,& Savić, S.. (2007). Antibiotics in local therapy of eye infections: Current aspects of drug products formulation. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije, Beograd., 57(4-5), 248-265. https://hdl.handle.net/21.15107/rcub_farfar_926
Milić J, Savić S. Antibiotics in local therapy of eye infections: Current aspects of drug products formulation. in Arhiv za farmaciju. 2007;57(4-5):248-265. https://hdl.handle.net/21.15107/rcub_farfar_926 .
Milić, Jela, Savić, Snežana, "Antibiotics in local therapy of eye infections: Current aspects of drug products formulation" in Arhiv za farmaciju, 57, no. 4-5 (2007):248-265, https://hdl.handle.net/21.15107/rcub_farfar_926 .