Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands
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2007
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Metapodaci
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The retention constant (110) is determined for 11 selected adrenergic and imidazoline receptor ligands by reverse-phase-thin layer chromatography. It is established that the retention behavior of investigated compounds mostly depends on geometrical, electrostatic, and hydrogen bonding properties. Good correlations among hydrophobic parameters R-m(0) versus log P for all eleven tested compounds are obtained. The satisfactory correlations are found between R-m(0) versus apparent partition coefficient octanol-buffer pH 7.4 (log P-1) or apparent partition coefficient in four liposome systems (log K-M(1)) and hypotensive activity (pC(25)) for five imidazolines. The results confirm the suitability of this parameter in quantitative structure-property and structure-activity relationships studies of these drugs.
Izvor:
Journal of Chromatographic Science, 2007, 45, 3, 140-145Izdavač:
- Oxford Univ Press Inc, Cary
Finansiranje / projekti:
- Sinteza, kvantitativni odnosi između strukture/osobina i aktivnosti, fizičko-hemijska karakterizacija i analiza farmakološki aktivnih supstanci (RS-MESTD-MPN2006-2010-142071)
DOI: 10.1093/chromsci/45.3.140
ISSN: 0021-9665
PubMed: 17462128
WoS: 000244876700005
Scopus: 2-s2.0-33947142405
Institucija/grupa
PharmacyTY - JOUR AU - Erić, Slavica AU - Pavlović, A. AU - Popović, Gordana AU - Agbaba, Danica PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/952 AB - The retention constant (110) is determined for 11 selected adrenergic and imidazoline receptor ligands by reverse-phase-thin layer chromatography. It is established that the retention behavior of investigated compounds mostly depends on geometrical, electrostatic, and hydrogen bonding properties. Good correlations among hydrophobic parameters R-m(0) versus log P for all eleven tested compounds are obtained. The satisfactory correlations are found between R-m(0) versus apparent partition coefficient octanol-buffer pH 7.4 (log P-1) or apparent partition coefficient in four liposome systems (log K-M(1)) and hypotensive activity (pC(25)) for five imidazolines. The results confirm the suitability of this parameter in quantitative structure-property and structure-activity relationships studies of these drugs. PB - Oxford Univ Press Inc, Cary T2 - Journal of Chromatographic Science T1 - Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands VL - 45 IS - 3 SP - 140 EP - 145 DO - 10.1093/chromsci/45.3.140 ER -
@article{ author = "Erić, Slavica and Pavlović, A. and Popović, Gordana and Agbaba, Danica", year = "2007", abstract = "The retention constant (110) is determined for 11 selected adrenergic and imidazoline receptor ligands by reverse-phase-thin layer chromatography. It is established that the retention behavior of investigated compounds mostly depends on geometrical, electrostatic, and hydrogen bonding properties. Good correlations among hydrophobic parameters R-m(0) versus log P for all eleven tested compounds are obtained. The satisfactory correlations are found between R-m(0) versus apparent partition coefficient octanol-buffer pH 7.4 (log P-1) or apparent partition coefficient in four liposome systems (log K-M(1)) and hypotensive activity (pC(25)) for five imidazolines. The results confirm the suitability of this parameter in quantitative structure-property and structure-activity relationships studies of these drugs.", publisher = "Oxford Univ Press Inc, Cary", journal = "Journal of Chromatographic Science", title = "Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands", volume = "45", number = "3", pages = "140-145", doi = "10.1093/chromsci/45.3.140" }
Erić, S., Pavlović, A., Popović, G.,& Agbaba, D.. (2007). Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands. in Journal of Chromatographic Science Oxford Univ Press Inc, Cary., 45(3), 140-145. https://doi.org/10.1093/chromsci/45.3.140
Erić S, Pavlović A, Popović G, Agbaba D. Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands. in Journal of Chromatographic Science. 2007;45(3):140-145. doi:10.1093/chromsci/45.3.140 .
Erić, Slavica, Pavlović, A., Popović, Gordana, Agbaba, Danica, "Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands" in Journal of Chromatographic Science, 45, no. 3 (2007):140-145, https://doi.org/10.1093/chromsci/45.3.140 . .