Influence of some Stachys taxa on carrageenan-induced paw edema in rats
Апстракт
This work investigates the anti- inflammatory activity of methanol extracts of four endemic Stachys ( Labiatae) taxa from the Balkans: S. beckeana Dorfler & Hayek, S. anisochila Vis. et Pancic, S. plumosa Griseb., and S. alpina L. subsp. dinarica Murb. As a model of acute inflammation, carrageenan- induced paw edema in rats was used. Extracts, applied at doses of 50, 100, and 200 mg/ kg p. o., exhibited dose- dependent activity. S. beckeana and S. anisochila extracts were the most active ones ( ED50 154.52 and 162.24 mg/ kg, respectively), with the activity comparable with indomethacin at doses of 2 and 4 mg/ kg. S. plumosa extract has shown less- pronounced anti- inflammatory effect ( ED50 220.81 mg= kg). Extract of S. alpina subsp. dinarica had the lowest efficiency, attenuating inflammation less than 50%.
Кључне речи:
anti-inflammatory activity / dinarica / S. alpina subsp. / S. beckeana / S. plumosa / Stachys anisochilaИзвор:
Pharmaceutical Biology, 2007, 45, 7, 560-563Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-MESTD-MPN2006-2010-143012)
DOI: 10.1080/13880200701498937
ISSN: 1388-0209
WoS: 000249795100006
Scopus: 2-s2.0-34548361329
Институција/група
PharmacyTY - JOUR AU - Kukić, Jelena AU - Dobrić, Silva AU - Petrović, Silvana PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/991 AB - This work investigates the anti- inflammatory activity of methanol extracts of four endemic Stachys ( Labiatae) taxa from the Balkans: S. beckeana Dorfler & Hayek, S. anisochila Vis. et Pancic, S. plumosa Griseb., and S. alpina L. subsp. dinarica Murb. As a model of acute inflammation, carrageenan- induced paw edema in rats was used. Extracts, applied at doses of 50, 100, and 200 mg/ kg p. o., exhibited dose- dependent activity. S. beckeana and S. anisochila extracts were the most active ones ( ED50 154.52 and 162.24 mg/ kg, respectively), with the activity comparable with indomethacin at doses of 2 and 4 mg/ kg. S. plumosa extract has shown less- pronounced anti- inflammatory effect ( ED50 220.81 mg= kg). Extract of S. alpina subsp. dinarica had the lowest efficiency, attenuating inflammation less than 50%. PB - Taylor & Francis Ltd, Abingdon T2 - Pharmaceutical Biology T1 - Influence of some Stachys taxa on carrageenan-induced paw edema in rats VL - 45 IS - 7 SP - 560 EP - 563 DO - 10.1080/13880200701498937 ER -
@article{ author = "Kukić, Jelena and Dobrić, Silva and Petrović, Silvana", year = "2007", abstract = "This work investigates the anti- inflammatory activity of methanol extracts of four endemic Stachys ( Labiatae) taxa from the Balkans: S. beckeana Dorfler & Hayek, S. anisochila Vis. et Pancic, S. plumosa Griseb., and S. alpina L. subsp. dinarica Murb. As a model of acute inflammation, carrageenan- induced paw edema in rats was used. Extracts, applied at doses of 50, 100, and 200 mg/ kg p. o., exhibited dose- dependent activity. S. beckeana and S. anisochila extracts were the most active ones ( ED50 154.52 and 162.24 mg/ kg, respectively), with the activity comparable with indomethacin at doses of 2 and 4 mg/ kg. S. plumosa extract has shown less- pronounced anti- inflammatory effect ( ED50 220.81 mg= kg). Extract of S. alpina subsp. dinarica had the lowest efficiency, attenuating inflammation less than 50%.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Pharmaceutical Biology", title = "Influence of some Stachys taxa on carrageenan-induced paw edema in rats", volume = "45", number = "7", pages = "560-563", doi = "10.1080/13880200701498937" }
Kukić, J., Dobrić, S.,& Petrović, S.. (2007). Influence of some Stachys taxa on carrageenan-induced paw edema in rats. in Pharmaceutical Biology Taylor & Francis Ltd, Abingdon., 45(7), 560-563. https://doi.org/10.1080/13880200701498937
Kukić J, Dobrić S, Petrović S. Influence of some Stachys taxa on carrageenan-induced paw edema in rats. in Pharmaceutical Biology. 2007;45(7):560-563. doi:10.1080/13880200701498937 .
Kukić, Jelena, Dobrić, Silva, Petrović, Silvana, "Influence of some Stachys taxa on carrageenan-induced paw edema in rats" in Pharmaceutical Biology, 45, no. 7 (2007):560-563, https://doi.org/10.1080/13880200701498937 . .