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Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 ...
High-performance liquid chromatographic method for the determination of moclobemide and its two major metabolites in human plasma
(Elsevier Science BV, Amsterdam, 2007)
A selective, sensitive, and simple high-performance liquid chromatographic (HPLC) method was developed for the determination of moclobemide and its two major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma. Sample ...
Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically ...
Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity
(Elsevier Science BV, Amsterdam, 2004)
Tc-99m(V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylun ...
Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
(Elsevier Science BV, Amsterdam, 2004)
In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), ...
Isocratic RP-HPLC method for rutin determination in solid oral dosage forms
(Pergamon-Elsevier Science Ltd, Oxford, 2007)
A rapid and sensitive assay for quantitative determination of rutin in oral dosage forms based on isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed and validated. Using a C-18 reverse-phase ...
First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole ...
Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
A second order derivative spectrophotometric method for the determination of bifonazole in the presence of methyland propyl p-hydroxybenzoate as preservatives has been developed. The determination was performed in a 0.1 M ...
Photochemical degradation of solid-state nisoldipine monitored by HPLC
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times ...
Trace elements analysis of Echinacea purpurea - herbal medicinal
(Elsevier Science BV, Amsterdam, 2003)
Elemental composition of Echinacea purpurea (Asteracae), grown in Serbia under strongly controlled conditions, has been studied. To distinguish elemental patterns of different parts of the plant, the content of Zn, Fe, Cu, ...