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A novel method for classification of wine based on organic acids
(Elsevier Sci Ltd, Oxford, 2019)
Bio-electronic tongue was linked to artificial intelligence processing unit and used for classification of wines based on carboxylic acids levels, which were indirectly related to malolactic fermentation. The system employed ...
The differential role of alpha(1)- and alpha(5)-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats
(Oxford Univ Press, Oxford, 2009)
The clinical use of benzodiazepines (BZs) is hampered by sedation and cognitive deterioration. Although genetic and pharmacological studies suggest that alpha(1)- and alpha(5)-containing GABA(A) receptors mediate and/or ...
Charged aerosol detector response modeling for fatty acids based on experimental settings and molecular features: a machine learning approach
(BioMed Central Ltd, 2021)
The charged aerosol detector (CAD) is the latest representative of aerosol-based detectors that generate a response independent of the analytes’ chemical structure. This study was aimed at accurately predicting the CAD ...
Investigation of chromatographic conditions for the separation of ofloxacin and its degradation products
(Elsevier Science BV, Amsterdam, 2006)
A sensitive, precise, and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous determination of fluoroquinolone antibacterial ofloxacin and its ...
α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials
(American Society for Pharmacology and Experimental Therapy, 2022)
GABAA receptors containing the α6 subunit are highly expressed in cerebellar granule cells and less abundantly in many other neuronal and peripheral tissues. Here, we for the first time summarize their importance for the ...
Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise
(W.B. Saunders, 2022)
Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of ...
Antiepileptic drugs as analgesics/adjuvants in inflammatory pain: current preclinical evidence
(Pergamon-Elsevier Science Ltd, Oxford, 2018)
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAID5, paracetamol and opioids) is limited by insufficient efficacy and/or side ...
Sexual dimorphism in Th17/Treg axis in lymph nodes draining inflamed joints in rats with collagen-induced arthritis
(Academic Press Inc Elsevier Science, San Diego, 2019)
Collagen type II-induced arthritis (CIA) in Dark Agouti rats, a model of rheumatoid arthritis (RA), reproduces sexual dimorphism in the incidence and severity of the human disease. Th17 cells are central in the ...
Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients
(Amer Psychiatric Publishing, Inc, Washington, 2018)
Objective: The antidepressant escitalopram is predominantly metabolized by the polymorphic CYP2C19 enzyme. The authors investigated the effect of CYP2C19 genotype on exposure and therapeutic failure of escitalopram in a ...
Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent
(Elsevier Sci Ltd, Oxford, 2018)
New composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. ...