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Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature
(MDPI, 2020)
Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed ...
Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots
(Elsevier B.V., 2020)
Perennial plant Gentiana lutea L. is used worldwide for the preparation of pharmaceutical and food products. Health benefits of G. lutea roots are associated with the presence of major bitter-tasting secoiridoid gentiopicroside ...
EFFECT of colored noise on the generation of seismic fault MOVEMENT: Analogy with spring-block model DYNAMICS
(Elsevier, 2020)
In present paper authors examined the effect of colored noise on the onset of seismic fault motion. For this purpose, they analyze the dynamics of spring-block model, with 10 all-to all coupled blocks. This spring-block ...
Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies
(Pergamon-Elsevier Science Ltd, Oxford, 2019)
Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to ...
In vitro - in vivo - in silico approach in the development of inhaled drug products: Nanocrystal-based formulations with budesonide as a model drug
(Elsevier B.V., 2021)
This study aims to understand the absorption patterns of three different kinds of inhaled formulations via in silico modeling using budesonide (BUD) as a model drug. The formulations investigated in this study are: (i) ...
International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans
(Amer Soc Pharmacology Experimental Therapeutics, Bethesda, 2018)
GABAA receptors are themajor inhibitory transmitter receptors in the brain. They are ligand-gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive steroids, anesthetics, and convulsants. ...
Are GABA(A) receptors containing alpha 5 Subunits contributing to the sedative properties of benzodiazepine site agonists?
(Nature Publishing Group, London, 2008)
Classical benzodiazepines (BZs) exert anxiolytic, sedative, hypnotic, muscle relaxant, anticonvulsive, and amnesic effects through potentiation of neurotransmission at GABA(A) receptors containing alpha(1), alpha(2), ...
Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics
(Elsevier B.V., 2020)
This study investigated the combined influence of pH adjusting agent type (hydrochloric, acetic or lactic acid) and initial pH value (3.6, 4.6, and 5.6) on formation of biocompatible chitosan/xanthan polyelectrolyte complexes ...
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
(Springer Heidelberg, Heidelberg, 2018)
Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our ...
A novel method for classification of wine based on organic acids
(Elsevier Sci Ltd, Oxford, 2019)
Bio-electronic tongue was linked to artificial intelligence processing unit and used for classification of wines based on carboxylic acids levels, which were indirectly related to malolactic fermentation. The system employed ...