Приказ основних података о документу
HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients
dc.creator | Stefanović, Aleksandra | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Spasić, Slavica | |
dc.creator | Vekić, Jelena | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.date.accessioned | 2019-09-02T11:20:58Z | |
dc.date.available | 2019-09-02T11:20:58Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1367 | |
dc.description.abstract | Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | Diabetes mellitus type 2 | en |
dc.subject | Oxidative stress | en |
dc.subject | Paraoxonase | en |
dc.subject | HDL 2 particles | en |
dc.title | HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Векић, Јелена; Котур-Стевуљевић, Јелена; Јелић-Ивановић, Зорана; Стефановић, Aлександра; Спасић, Славица; Спасојевић-Калимановска, Весна; Зељковић, Aлександра; | |
dc.citation.volume | 43 | |
dc.citation.issue | 15 | |
dc.citation.spage | 1230 | |
dc.citation.epage | 1235 | |
dc.citation.other | 43(15): 1230-1235 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000282204400010 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2010.08.005 | |
dc.identifier.pmid | 20709049 | |
dc.identifier.scopus | 2-s2.0-77956719446 | |
dc.type.version | publishedVersion |