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Приказ резултата 11-20 од 26
Multiomics tools for improved atherosclerotic cardiovascular disease management
(Elsevier Ltd, 2023)
Multiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) ...
In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function
(Elsevier, 2023)
The purpose of this study was to examine the impact of low doses of lead (Pb) on levels of thyroid hormones (T3, T4, FT3, and FT4) and thyroid-related antibodies (anti-Tg and anti-TPO) in the rat model, as well as genes ...
Adrenoceptors as potential target for add-on immunomodulatory therapy in multiple sclerosis
(Elsevier Inc., 2023)
This review summarizes recent findings related to the role of the sympathetic nervous system (SNS) in pathogenesis of multiple sclerosis (MS) and its commonly used experimental model – experimental autoimmune encephalomyelitis ...
Results of the first survey of the EFLM Task Force Preparation of Labs for Emergencies (TF-PLE)
(De Gruyter Open Ltd, 2023)
The antidepressant drugs vortioxetine and duloxetine differentially and sex-dependently affect animal well-being, cognitive performance, cardiac redox status and histology in a model of osteoarthritis
(Elsevier Masson, 2023)
Osteoarthritis represents a leading cause of disability with limited treatment options. Furthermore, it is frequently accompanied by cardiovascular and cognitive disorders, which can be exacerbated by osteoarthritis or ...
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors
(Elsevier, 2023)
An X-ray structure of a CLICK chemistry-based BET PROTAC bound to BRD2(BD2) inspired synthesis of JQ1 derived heterocyclic amides. This effort led to the discovery of potent BET inhibitors displaying overall improved ...
New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
(Elsevier Inc, 2023)
The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per ...
Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans
(Elsevier Ltd, 2023)
Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response ...
Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status
(Elsevier B.V., 2024)
The understanding that humans are exposed to a low level of toxic metals and metalloids in their lifetime has resulted in a shift in scientific and regulatory perspectives from the traditional evaluation of single metal ...
Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A
(Elsevier B.V., 2023)
Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative ...