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Results of the first survey of the EFLM Task Force Preparation of Labs for Emergencies (TF-PLE)
(De Gruyter Open Ltd, 2023)
Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different
(Elsevier B.V., 2023)
The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats ...
Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells
(Elsevier, 2023)
Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained ...
Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans
(Elsevier Ltd, 2023)
Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response ...
Three kinds of W-potentials in nonlinear biophysics of microtubules
(Elsevier, 2023)
In the present article we investigate the nonlinear dynamics of microtubules, the basic components of the eukaryotic cytoskeleton, relying on the known general model. We introduce the W-potential energy, describing a crucial ...
The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia
(John Wiley and Sons Inc, 2023)
Aims: CYP2C19 transgenic mouse expresses the human CYP2C19 gene in the liver and developing brain, and it exhibits altered neurodevelopment associated with impairments in emotionality and locomotion. Because the validation ...
Integration of epigenetic regulatory mechanisms in heart failure
(Springer Science and Business Media Deutschland GmbH, 2023)
The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with ...
Multiomics tools for improved atherosclerotic cardiovascular disease management
(Elsevier Ltd, 2023)
Multiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) ...
Digital transformation towards the clinical laboratory of the future. Perspectives for the next decade
(De Gruyter Open Ltd, 2023)
The transformation of clinical laboratories towards digitalization requires processes that improve digital maturity. This requires establishing connectivity, end-to-end workflow, and advanced analytical technologies and ...
New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
(Elsevier Inc, 2023)
The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per ...