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The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia
(John Wiley and Sons Inc, 2023)
Aims: CYP2C19 transgenic mouse expresses the human CYP2C19 gene in the liver and developing brain, and it exhibits altered neurodevelopment associated with impairments in emotionality and locomotion. Because the validation ...
Integration of epigenetic regulatory mechanisms in heart failure
(Springer Science and Business Media Deutschland GmbH, 2023)
The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with ...
Multiomics tools for improved atherosclerotic cardiovascular disease management
(Elsevier Ltd, 2023)
Multiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) ...
Three kinds of W-potentials in nonlinear biophysics of microtubules
(Elsevier, 2023)
In the present article we investigate the nonlinear dynamics of microtubules, the basic components of the eukaryotic cytoskeleton, relying on the known general model. We introduce the W-potential energy, describing a crucial ...
Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells
(Elsevier, 2023)
Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained ...
Goat milk proteins enriched with Agaricus blazei Murrill ss. Heinem extracts: Electrophoretic, FTIR, DLS and microstructure characterization
(Elsevier Ltd, 2023)
This study aimed to characterize mixtures of goat milk proteins and Agaricus blazei Murrill (ABM) extracts (aqueous, AE and polysaccharides, PE). The mixtures showed stable particles with ζ-potential more negative than ...
In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function
(Elsevier, 2023)
The purpose of this study was to examine the impact of low doses of lead (Pb) on levels of thyroid hormones (T3, T4, FT3, and FT4) and thyroid-related antibodies (anti-Tg and anti-TPO) in the rat model, as well as genes ...
New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
(Elsevier Inc, 2023)
The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per ...
Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A
(Elsevier B.V., 2023)
Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative ...
Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different
(Elsevier B.V., 2023)
The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats ...