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An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation
(Elsevier Science BV, Amsterdam, 2007)
Quantitative correlations between in vivo and in vitro data (IVIVC) reduce the number of human in vivo studies, thus decreasing the overall time and expenses necessary for the development of optimal drug product formulation. ...
Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption
(Elsevier Science BV, Amsterdam, 2008)
Ibuprofen is a widely used NSAID which is often co-administered with antacids because of its gastro-irritant effects. Literature data suggest that antacid interactions may increase or decrease the drug's absorption rate ...
An Investigation into the Importance of "Very Rapid Dissolution" Criteria for Drug Bioequivalence Demonstration using Gastrointestinal Simulation Technology
(Springer, New York, 2009)
The Biopharmaceutics Classification System (BCS) is based on the mechanistic assumptions that the rate and extent of oral drug absorption are governed by drug solubility, intestinal permeability, and dissolution rate from ...