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Discovery of membrane permeability, pharmacokinetics properties and mechanism of action for analogs of ethylenediamine-n,n′-di-2-(3-cyclohexyl)propionic acid and 1,3-propandiamine-n,n′-di-2-(3-cyclohexyl)propionic acid with antiproliferative activity using In Vitro and In Silico Methods
(Springer Verlag, 2020)
In previously in vitro studies on different cell lines and in vivo on melanoma and 4T1 murine breast cancer and metastasis it was shown antiproliferative activity for ester derivatives of (S,S)-ethylenediamine-N,N′-di-2- ...
Inhaler technique training of community pharmacists and common errors
(European Respiratory Society, 2020)
Introduction: Pharmacists have a significant role in improving patient inhaler technique (HK. Reddel, et al. Eur Respir J 2008;32: 812; Alismail A, et al. Respir Care 2016;61:593). Hence, it is crucial for pharmacists to ...
Impact of defatting process on antioxidant potential of grape seeds
(University of Belgrade, Belgrade, Serbia, 2020)
Grape seeds contain a wide range of phenolic compounds responsible for its health promoting
effects. Interest for grape seed utilization has increased significantly along with a growing
recognition that present biologically ...
Estimation of gastrointestinal absorption of a series of dual DNA Gyrase and Topoisomerase IV inhibitors using Pampa technique
(MuTaLig COST ACTION CA15135, 2020)
In this study, estimation of gastrointestinal absorption of thirteen selected dual DNA gyrase and topoisomerase IV
inhibitors was carried out using PAMPA test. Diffusion through artificial membrane, consisting of egg ...
Design of novel thiourea derivatives of naproxen with potential antitumor activity
(COST Action 17104 (STRATAGEM), 2020)
In the search for potent biologically active molecules, thiourea and other structure-related derivatives such as
thiosemicarbazones have attracted great attention. In the past two decades, thiourea derivatives have been ...
Application of computational methods for antipsychotic drug design and optimization
(10th International Conference on Biotechnology and Bioengineering (ICBB2020). Dec. 16-18, 2020. Virtual conference, 2020)
Combined ligand-based and structure-based approaches in rational drug design of novel 5-HT2A receptor antagonists
(European Research Network on Signal Transduction (ERNEST) CA18133, 2020)
Serotonin 5-HT2A receptors (5-HT2AR) are highly expressed in human prefrontal cortex, essential for
learning and cognition [1]. Consequently, antagonists of these receptors are effective in treatment of
various ...
In silico rational druga design and modelling studies of novel 5-HT2A receptor antagonsts
(EFMC-ISMC & EFMC-YMCS, 2020)
Exploring the chemical space of sirt2 inhibitors through biomolecular simulations
(EFMC-ISMC & EFMC-YMCS, 2020)
Multitargeting epi-epi drugs for multidrug reistance
(COST Action 17104 (STRATAGEM), 2020)
Epigenetic therapy is now a clinical reality with eight approved drugs that target
DNA methyltransferases, histone deacetylases (HDACs) and lysine
methyltransferases. A further recent development is the concept of ...