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Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate
(Elsevier, 2019)
Three-dimensional (3D) printing enables the production of different objects adjusted for the specific application, which has particular importance of providing personalized therapy, whereby the challenge is to apply ...
Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): Effects on size, physical stability and particle matrix structure
(Elsevier Science BV, Amsterdam, 2011)
The two polyhydroxy surfactants polyglycerol 6-distearate (Plurol (R) Stearique WL1009 - (PS)) and caprylyl/capryl glucoside (Plantacare (R) 810 - (PL)) are a class of PEG-free stabilizers, made from renewable resources. ...
The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems
(Elsevier Science BV, Amsterdam, 2008)
The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol ...
Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration
(Elsevier Science BV, Amsterdam, 2009)
Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper ...
Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling
(Elsevier Science BV, Amsterdam, 2018)
The aim of this study is to develop nanosuspension of carvedilol (CRV) by wet media milling. Concentration of polymeric stabilizer (hydroxypropyl cellulose-HPC-SL), milling speed and size of milling beads were identified ...
Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application
(Elsevier Science BV, Amsterdam, 2018)
The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for ...
Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release
(Elsevier Science BV, Amsterdam, 2012)
The purpose of this study was to investigate solid self-microemulsifying drug delivery system (SSMEDDS), as potential delivery system for poorly water soluble drug carbamazepine (CBZ). Self-microemulsifying drug delivery ...
Tablet disintegration and drug dissolution in viscous media: Paracetamol IR tablets
(Elsevier Science BV, Amsterdam, 2008)
An investigation into the influence of viscous media on tablet disintegration and drug dissolution was performed with the aim to simulate the potential formulation-specific food effect for a selected highly soluble model ...
The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides
(Elsevier Science BV, Amsterdam, 2008)
In the present study the effect of type and concentration of a cosurfactant and oil on the ability of nonionic surfactant PEG-8 caprylic/capric glycerides (Labrasol (R)) to solubilize both oil and water phases was evaluated. ...
Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation
(Elsevier Science BV, Amsterdam, 2006)
An emerging class of natural surfactants, named alkylpolyglucosides, which can form both, the thermotropic and the lyotropic, liquid crystalline phases, were focused. The aim of the study was to integrate some physicochemical ...