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Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous
(Belgrade : Serbian Chemical Society, 2020)
Two new complexes with the general formula [Cu2(L)tpmc](ClO4)3·nH2O (tpmc = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane, L = N-methylglycine, n = 3; L = N,N- -dimethylglycine, ...
Current computer-aided drug design methodologies in discovery of novel drug candidates for neuropsychiatric and inflammatory diseases / Metode kompjuterski potpomognutog dizajniranja lekova u istraživanju novih potencijalnih terapeutika za neuropsihijatrijske i inflamatorne bolesti
(Beograd : Savez farmaceutskih udruženja Srbije, 2021)
Drug discovery and development is a very challenging, expensive and time-consuming
process. Impressive technological advances in computer sciences and molecular biology have
made it possible to use computer-aided drug ...
Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products
(MDPI AG, 2021)
Acidic pH of the skin surface has been recognized as a regulating factor for the maintenance of the stratum corneum homeostasis and barrier permeability. The most important functions of acidic pH seem to be related to the ...
Shotgun metagenomics reveals differences in antibiotic resistance genes among bacterial communities in Western Balkans glacial lakes sediments
(NLM (Medline), 2020)
Long-term overuse of antibiotics has driven the propagation and spreading of antibiotic resistance genes (ARGs) such as efflux pumps in the environment, which can be transferred to clinically relevant pathogens. This study ...
Cholesterol homeostasis is dysregulated in women with preeclampsia
(Medycyna Praktyczna Cholerzyn, 2021)
Introduction The link between preeclampsia and dyslipidemia has been established. Even though lipid profile parameters have been intensively investigated in the pathology of preeclampsia, their accurate molecular mechanisms ...
Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site
(Springer, 2020)
bstract: Concomitant use of two or more drugs in therapy is becoming a more frequent phenomenon and clinically relevant drug–drug interactions at the level of binding to human serum albumin (HSA) are more often. The influence ...
Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease
(Elsevier Ltd, 2020)
Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various ...
Comparative efficacy evaluation of different penetration enhancement strategies for dermal delivery of poorly soluble drugs – A case with sertaconazole nitrate
(Elsevier B.V., 2021)
The aim of this study was to compare the efficacy of different approaches for enhancement of dermal availability of the highly lipophilic antifungal model drug – sertaconazole nitrate (SN). For this purpose, a physical ...
Flow and tableting behaviors of some egyptian kaolin powders as potential pharmaceutical excipients
(MDPI, 2020)
The present work aimed at assessing the pharmaceutical tableting properties of some Egyptian kaolin samples belong to the Abu Zenima kaolin deposits (estimated at 120 million tons). Four representative samples were selected ...
Experimental design in HPLC separation of pharmaceuticals / Primena eksperimentalnog dizajna za razdvajanje lekova HPLC metodom
(Beograd : Savez farmaceutskih udruženja Srbije, 2021)
Design of Experiments (DoE) is an indispensable tool in contemporary drug analysis as it
simultaneously balances a number of chromatographic parameters to ensure optimal separation
in High Pressure Liquid Chromatography ...