Are antidepressants effective in quality of life improvement among children and adolescents? A systematic review
Samo za registrovane korisnike
2014
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
There is some evidence indicating that psychotropic medications might lead to health-related quality of life (QOL) improvements among children and adolescents with psychiatric disorders. The aim of this systematic review is to assess evidence regarding whether antidepressant treatment improves QOL among children and adolescents with depressive or anxiety disorders. A comprehensive search resulted in 5 clinical trials to be included in this review: 4 trials with major depressive disorder (MDD) and 1 trial with social anxiety disorder (SAD). In one MDD trial, fluoxetine combined with cognitive behavior therapy (CBT) significantly improved QOL compared to fluoxetine or CBT alone (effect sizes were 0.53 and 0.69, respectively). In 2 combined trials, sertraline alone significantly improved QOL among adolescents with MDD (effect size was 0.29), but not among children with MDD. Essentially, it was observed that antidepressants in these trials had minor positive effects on QOL improvement, whi...ch were lower than their potential to improve depressive symptoms. Although fluoxetine with CBT or sertraline monotherapy were shown to have some potential to improve QOL, this systematic review found inconclusive evidence that antidepressant treatments improve QOL among children and adolescents with depressive or anxiety disorders. More research is required, considering that QOL is currently under-evaluated in clinical trials with antidepressants among children and adolescents and available trials have limited methodological quality when reporting QOL data.
Ključne reči:
Anxiety disorders / clinical trial / depression / efficacy / quality of lifeIzvor:
CNS Spectrums, 2014, 19, 2, 134-141Izdavač:
- Cambridge University Press
DOI: 10.1017/S1092852913000576
ISSN: 1092-8529
PubMed: 24029410
WoS: 000337748000006
Scopus: 2-s2.0-84901711943
Institucija/grupa
PharmacyTY - JOUR AU - Stevanović, Dejan AU - Tadić, Ivana AU - Knez, Rajna PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2203 AB - There is some evidence indicating that psychotropic medications might lead to health-related quality of life (QOL) improvements among children and adolescents with psychiatric disorders. The aim of this systematic review is to assess evidence regarding whether antidepressant treatment improves QOL among children and adolescents with depressive or anxiety disorders. A comprehensive search resulted in 5 clinical trials to be included in this review: 4 trials with major depressive disorder (MDD) and 1 trial with social anxiety disorder (SAD). In one MDD trial, fluoxetine combined with cognitive behavior therapy (CBT) significantly improved QOL compared to fluoxetine or CBT alone (effect sizes were 0.53 and 0.69, respectively). In 2 combined trials, sertraline alone significantly improved QOL among adolescents with MDD (effect size was 0.29), but not among children with MDD. Essentially, it was observed that antidepressants in these trials had minor positive effects on QOL improvement, which were lower than their potential to improve depressive symptoms. Although fluoxetine with CBT or sertraline monotherapy were shown to have some potential to improve QOL, this systematic review found inconclusive evidence that antidepressant treatments improve QOL among children and adolescents with depressive or anxiety disorders. More research is required, considering that QOL is currently under-evaluated in clinical trials with antidepressants among children and adolescents and available trials have limited methodological quality when reporting QOL data. PB - Cambridge University Press T2 - CNS Spectrums T1 - Are antidepressants effective in quality of life improvement among children and adolescents? A systematic review VL - 19 IS - 2 SP - 134 EP - 141 DO - 10.1017/S1092852913000576 ER -
@article{ author = "Stevanović, Dejan and Tadić, Ivana and Knez, Rajna", year = "2014", abstract = "There is some evidence indicating that psychotropic medications might lead to health-related quality of life (QOL) improvements among children and adolescents with psychiatric disorders. The aim of this systematic review is to assess evidence regarding whether antidepressant treatment improves QOL among children and adolescents with depressive or anxiety disorders. A comprehensive search resulted in 5 clinical trials to be included in this review: 4 trials with major depressive disorder (MDD) and 1 trial with social anxiety disorder (SAD). In one MDD trial, fluoxetine combined with cognitive behavior therapy (CBT) significantly improved QOL compared to fluoxetine or CBT alone (effect sizes were 0.53 and 0.69, respectively). In 2 combined trials, sertraline alone significantly improved QOL among adolescents with MDD (effect size was 0.29), but not among children with MDD. Essentially, it was observed that antidepressants in these trials had minor positive effects on QOL improvement, which were lower than their potential to improve depressive symptoms. Although fluoxetine with CBT or sertraline monotherapy were shown to have some potential to improve QOL, this systematic review found inconclusive evidence that antidepressant treatments improve QOL among children and adolescents with depressive or anxiety disorders. More research is required, considering that QOL is currently under-evaluated in clinical trials with antidepressants among children and adolescents and available trials have limited methodological quality when reporting QOL data.", publisher = "Cambridge University Press", journal = "CNS Spectrums", title = "Are antidepressants effective in quality of life improvement among children and adolescents? A systematic review", volume = "19", number = "2", pages = "134-141", doi = "10.1017/S1092852913000576" }
Stevanović, D., Tadić, I.,& Knez, R.. (2014). Are antidepressants effective in quality of life improvement among children and adolescents? A systematic review. in CNS Spectrums Cambridge University Press., 19(2), 134-141. https://doi.org/10.1017/S1092852913000576
Stevanović D, Tadić I, Knez R. Are antidepressants effective in quality of life improvement among children and adolescents? A systematic review. in CNS Spectrums. 2014;19(2):134-141. doi:10.1017/S1092852913000576 .
Stevanović, Dejan, Tadić, Ivana, Knez, Rajna, "Are antidepressants effective in quality of life improvement among children and adolescents? A systematic review" in CNS Spectrums, 19, no. 2 (2014):134-141, https://doi.org/10.1017/S1092852913000576 . .