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Cytotoxicity and Antimicrobial Activity of the Essential Oil from Satureja montana subsp pisidica (Lamiceae)
dc.creator | Kundaković, Tatjana | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Kolundžija, Branka | |
dc.creator | Marković, Stevan | |
dc.creator | Šukilović, Branka | |
dc.creator | Milenković, Marina | |
dc.creator | Lakušić, Branislava | |
dc.date.accessioned | 2019-09-02T11:42:01Z | |
dc.date.available | 2019-09-02T11:42:01Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2217 | |
dc.description.abstract | The antimicrobial and cytotoxic activities of the essential oil of Satureja montana ssp. pisidica from two localities (mountains Korab and Galicica) were studied. Forty-nine components were identified in the each sample. Oxygenated monoterpene hydrocarbons were the major compounds: carvacrol, thymol, carvacrol methyl ether and beta-linalool. Both tested essential oils showed very high and similar antimicrobial activity. Minimal inhibitory concentrations ranged from 12.5 mu g/mL against S. epidermidis to 50 mu g/mL against P. aerugmosa and C. albicans. The cytotoxic effect of the essential oils was tested against MDA-MB-361, MDA-MB-453, HeLa, LS174 and MRCS cells. The essential oil from Korab demonstrated significantly better results than the oil from Galicica, particularly against HeLa and MDA-MB-453 cell lines, with IC50 values of 63.5 and 72.3 mu g/mL, while the oil from Galicica was the most active on the human epithelial cervical cancer HeLa cells (IC50 99.7 mu g/mL). | en |
dc.publisher | Sage Publications Inc, Thousand Oaks | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Natural Product Communications | |
dc.subject | Satureja montana ssp pisidica | en |
dc.subject | Essential oil | en |
dc.subject | Cytotoxicity | en |
dc.subject | Antimicrobial activity | en |
dc.subject | Carvacrol | en |
dc.title | Cytotoxicity and Antimicrobial Activity of the Essential Oil from Satureja montana subsp pisidica (Lamiceae) | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Колунджија, Бранка; Станојковић, Татјана; Миленковић, Марина; Кундаковић, Татјана; Марковић, Стеван; Сукиловић, Бранка; Лакушић, Бранислава; | |
dc.citation.volume | 9 | |
dc.citation.issue | 4 | |
dc.citation.spage | 569 | |
dc.citation.epage | 572 | |
dc.citation.other | 9(4): 569-572 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000335083500037 | |
dc.identifier.pmid | 24868886 | |
dc.identifier.scopus | 2-s2.0-84898802085 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/7334/Cytotoxicity_Antimicrobial_Activity_pub_2014.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_2217 | |
dc.type.version | publishedVersion |