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A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation
dc.creator | Radulović, Dušanka | |
dc.creator | Karljiković-Rajić, Katarina | |
dc.creator | Lucić, BM | |
dc.creator | Vujić, Zorica | |
dc.date.accessioned | 2019-09-02T10:53:26Z | |
dc.date.available | 2019-09-02T10:53:26Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/295 | |
dc.description.abstract | The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.rights | restrictedAccess | |
dc.source | Journal of Pharmaceutical and Biomedical Analysis | |
dc.title | A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Радуловић, Душанка; Карљиковић-Рајић, Катарина; Вујић, Зорица; Луцић, БМ; | |
dc.citation.volume | 24 | |
dc.citation.issue | 5-6 | |
dc.citation.spage | 871 | |
dc.citation.epage | 876 | |
dc.citation.other | 24(5-6): 871-876 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000167764200015 | |
dc.identifier.doi | 10.1016/S0731-7085(00)00555-0 | |
dc.identifier.pmid | 11248480 | |
dc.identifier.scopus | 2-s2.0-0035091312 | |
dc.type.version | publishedVersion |