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Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C
dc.creator | Klisić, Aleksandra | |
dc.creator | Kavarić, Nebojša | |
dc.creator | Soldatović, Ivan | |
dc.creator | Ninić, Ana | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.date.accessioned | 2019-09-02T12:10:05Z | |
dc.date.available | 2019-09-02T12:10:05Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2567-9430 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3306 | |
dc.description.abstract | Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women. | en |
dc.publisher | Walter de Gruyter Gmbh, Berlin | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Laboratory Medicine | |
dc.subject | cystatin C | en |
dc.subject | metabolic syndrome | en |
dc.subject | postmenopausal | en |
dc.subject | retinol-binding protein 4 | en |
dc.title | Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Котур-Стевуљевић, Јелена; Солдатовић, Иван; Каварић, Небојша; Нинић, Aна; Клисић, Aлександра; | |
dc.citation.volume | 43 | |
dc.citation.issue | 1 | |
dc.citation.spage | 29 | |
dc.citation.epage | 34 | |
dc.citation.other | 43(1): 29-34 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000460105600005 | |
dc.identifier.doi | 10.1515/labmed-2018-0325 | |
dc.identifier.scopus | 2-s2.0-85062660682 | |
dc.type.version | publishedVersion |