Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats
Samo za registrovane korisnike
2023
Autori
Vukelić, DraganaBuha-Đorđević, Aleksandra
Anđelković, Milena
Repić, Aleksandra
Baralić, Katarina
Ćurčić, Marijana
Đukić-Ćosić, Danijela
Boričić, Novica
Antonijević, Biljana
Bulat, Zorica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The objectives of the study were to simulate low-level Pb exposure scenario in an animal model and to examine reproductive adverse effects. Based on obtained data, we have performed Benchmark dose (BMD)-response modelling. Male Wistar rats were randomized in seven groups (n = 6): one control and six treated with: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight, daily for 28 days by oral gavage. The rats were sacrificed and the blood and testes were used for further analysis of testosterone levels in serum, testicular essential metal levels and histological analysis. The Pb treatment led to a dose-dependent decrease of serum testosterone levels with a negative trend (BMDI 0.17–6.13 mg Pb/kg). Increase of Zn (dose-dependent, BMDI 0.004–19.7 mg Pb/kg) and Cu and a decrease of Mn testicular levels were also detected with unscathed histology of the testes. The presented results might be used in further evaluation of the point of departure in human health risk assessment for Pb.
Ključne reči:
Essential metals / BMD / Dose-response / Low BLL / TestosteroneIzvor:
Toxicology Letters, 2023, 375, 69-76Izdavač:
- Elsevier Ireland Ltd
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200161 (Univerzitet u Beogradu, Farmaceutski fakultet) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/j.toxlet.2023.01.001
ISSN: 0378-4274
PubMed: 36610527
WoS: 000973858900001
Scopus: 2-s2.0-85146091361
Institucija/grupa
PharmacyTY - JOUR AU - Vukelić, Dragana AU - Buha-Đorđević, Aleksandra AU - Anđelković, Milena AU - Repić, Aleksandra AU - Baralić, Katarina AU - Ćurčić, Marijana AU - Đukić-Ćosić, Danijela AU - Boričić, Novica AU - Antonijević, Biljana AU - Bulat, Zorica PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4385 AB - The objectives of the study were to simulate low-level Pb exposure scenario in an animal model and to examine reproductive adverse effects. Based on obtained data, we have performed Benchmark dose (BMD)-response modelling. Male Wistar rats were randomized in seven groups (n = 6): one control and six treated with: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight, daily for 28 days by oral gavage. The rats were sacrificed and the blood and testes were used for further analysis of testosterone levels in serum, testicular essential metal levels and histological analysis. The Pb treatment led to a dose-dependent decrease of serum testosterone levels with a negative trend (BMDI 0.17–6.13 mg Pb/kg). Increase of Zn (dose-dependent, BMDI 0.004–19.7 mg Pb/kg) and Cu and a decrease of Mn testicular levels were also detected with unscathed histology of the testes. The presented results might be used in further evaluation of the point of departure in human health risk assessment for Pb. PB - Elsevier Ireland Ltd T2 - Toxicology Letters T1 - Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats VL - 375 SP - 69 EP - 76 DO - 10.1016/j.toxlet.2023.01.001 ER -
@article{ author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Repić, Aleksandra and Baralić, Katarina and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Boričić, Novica and Antonijević, Biljana and Bulat, Zorica", year = "2023", abstract = "The objectives of the study were to simulate low-level Pb exposure scenario in an animal model and to examine reproductive adverse effects. Based on obtained data, we have performed Benchmark dose (BMD)-response modelling. Male Wistar rats were randomized in seven groups (n = 6): one control and six treated with: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight, daily for 28 days by oral gavage. The rats were sacrificed and the blood and testes were used for further analysis of testosterone levels in serum, testicular essential metal levels and histological analysis. The Pb treatment led to a dose-dependent decrease of serum testosterone levels with a negative trend (BMDI 0.17–6.13 mg Pb/kg). Increase of Zn (dose-dependent, BMDI 0.004–19.7 mg Pb/kg) and Cu and a decrease of Mn testicular levels were also detected with unscathed histology of the testes. The presented results might be used in further evaluation of the point of departure in human health risk assessment for Pb.", publisher = "Elsevier Ireland Ltd", journal = "Toxicology Letters", title = "Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats", volume = "375", pages = "69-76", doi = "10.1016/j.toxlet.2023.01.001" }
Vukelić, D., Buha-Đorđević, A., Anđelković, M., Repić, A., Baralić, K., Ćurčić, M., Đukić-Ćosić, D., Boričić, N., Antonijević, B.,& Bulat, Z.. (2023). Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats. in Toxicology Letters Elsevier Ireland Ltd., 375, 69-76. https://doi.org/10.1016/j.toxlet.2023.01.001
Vukelić D, Buha-Đorđević A, Anđelković M, Repić A, Baralić K, Ćurčić M, Đukić-Ćosić D, Boričić N, Antonijević B, Bulat Z. Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats. in Toxicology Letters. 2023;375:69-76. doi:10.1016/j.toxlet.2023.01.001 .
Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Repić, Aleksandra, Baralić, Katarina, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Boričić, Novica, Antonijević, Biljana, Bulat, Zorica, "Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats" in Toxicology Letters, 375 (2023):69-76, https://doi.org/10.1016/j.toxlet.2023.01.001 . .