An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers
Abstract
Drug release from hydrophilic matrix tablets can be strongly influenced by the proportion of matrix forming polymer and the dimensions and geometry of the tablets. A complete two-factor, three-level factorial design, followed by multiple regression analysis and response surface methodology, was applied to investigate the influence of polymer level and tablet size on drug release kinetics from hydrophilic matrix tablets prepared with Carbopol 971P and Carbopol 71G. Tablet diameter, radius-to-height ratio, tablet surface area, and surface-area-to-volume ratio were evaluated as independent variables in terms of their applicability to characterize tablet size and geometry. The results indicate that it may be possible to control the rate of drug release by modifying the proportion of carbomer in tablets and tablet dimensions. The practical benefit of these simulations is to optimize the geometry and dimensions of a controlled release device and reduce the number of experiments involved in t...he development of new controlled release dosage forms.
Keywords:
carbomer / dissolution / drug delivery / hydrophilic matrix tablet / paracetamol / sustained releaseSource:
Drug Delivery, 2004, 11, 1, 59-65Publisher:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1080/10717540490265379
ISSN: 1071-7544
PubMed: 15168793
WoS: 000220043600009
Scopus: 2-s2.0-19244378905
Collections
Institution/Community
PharmacyTY - JOUR AU - Parojčić, Jelena AU - Đurić, Zorica AU - Jovanović, M AU - Ibrić, Svetlana PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/499 AB - Drug release from hydrophilic matrix tablets can be strongly influenced by the proportion of matrix forming polymer and the dimensions and geometry of the tablets. A complete two-factor, three-level factorial design, followed by multiple regression analysis and response surface methodology, was applied to investigate the influence of polymer level and tablet size on drug release kinetics from hydrophilic matrix tablets prepared with Carbopol 971P and Carbopol 71G. Tablet diameter, radius-to-height ratio, tablet surface area, and surface-area-to-volume ratio were evaluated as independent variables in terms of their applicability to characterize tablet size and geometry. The results indicate that it may be possible to control the rate of drug release by modifying the proportion of carbomer in tablets and tablet dimensions. The practical benefit of these simulations is to optimize the geometry and dimensions of a controlled release device and reduce the number of experiments involved in the development of new controlled release dosage forms. PB - Taylor & Francis Ltd, Abingdon T2 - Drug Delivery T1 - An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers VL - 11 IS - 1 SP - 59 EP - 65 DO - 10.1080/10717540490265379 ER -
@article{ author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana", year = "2004", abstract = "Drug release from hydrophilic matrix tablets can be strongly influenced by the proportion of matrix forming polymer and the dimensions and geometry of the tablets. A complete two-factor, three-level factorial design, followed by multiple regression analysis and response surface methodology, was applied to investigate the influence of polymer level and tablet size on drug release kinetics from hydrophilic matrix tablets prepared with Carbopol 971P and Carbopol 71G. Tablet diameter, radius-to-height ratio, tablet surface area, and surface-area-to-volume ratio were evaluated as independent variables in terms of their applicability to characterize tablet size and geometry. The results indicate that it may be possible to control the rate of drug release by modifying the proportion of carbomer in tablets and tablet dimensions. The practical benefit of these simulations is to optimize the geometry and dimensions of a controlled release device and reduce the number of experiments involved in the development of new controlled release dosage forms.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Drug Delivery", title = "An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers", volume = "11", number = "1", pages = "59-65", doi = "10.1080/10717540490265379" }
Parojčić, J., Đurić, Z., Jovanović, M.,& Ibrić, S.. (2004). An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers. in Drug Delivery Taylor & Francis Ltd, Abingdon., 11(1), 59-65. https://doi.org/10.1080/10717540490265379
Parojčić J, Đurić Z, Jovanović M, Ibrić S. An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers. in Drug Delivery. 2004;11(1):59-65. doi:10.1080/10717540490265379 .
Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, "An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers" in Drug Delivery, 11, no. 1 (2004):59-65, https://doi.org/10.1080/10717540490265379 . .