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Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease
dc.creator | Džoljić, Eleonora | |
dc.creator | Sarić-Matutinović, Marija | |
dc.creator | Stojković, Oliver | |
dc.creator | Veličković, Jelena | |
dc.creator | Milinković, Neda | |
dc.creator | Kostić, Vladimir | |
dc.creator | Ignjatović, Svetlana | |
dc.date.accessioned | 2023-10-31T14:01:23Z | |
dc.date.available | 2023-10-31T14:01:23Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0306-4522 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/5179 | |
dc.description.abstract | Background: Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson's disease (PD). We aimed to clarify the relationship between hypovitaminosis D and the predisposition for PD and its clinical presentation. An additional aim was to examine the specific gene polymorphisms associated with vitamin D level. Material and methods: Total level of 25(OH)-vitamin D (25(OH)D) was measured in the serum of parkinsonian patients (n = 113) and controls (n = 82) using a commercial immunoassay. Genetic analyses were performed using Taqman assays on Real Time PCR amplification system. Results: Higher frequency of vitamin D deficiency (<50 nmol/L) was observed in PD patients, compared to controls (40.7% and 23.2%, respectively, P = 0.010). It was also a positive predictive marker of PD (OR, 2.27; 95% CI, 1.206–4.298; P < 0.011). Significantly higher UPDRS (35.85 ± 1.35 and 32.09 ± 0.99, respectively, P = 0.023) and HY scores (2(1.5–2.5) and 1.5(1.0–2.0), respectively, P = 0.005) were present in patients with 25(OH)D level < 50 nmol/L compared to patients with 25(OH)D level ≥ 50 nmol/L. Despite some trends observed, differences in allelic and genotypic distribution between controls and patients, as well as between subgroups, did not reach the level of significance (P > 0.05). Conclusions: Findings of this study confirm the hypothesis of a significant relationship between hypovitaminosis D and PD. We demonstrated higher prevalence of vitamin D deficiency in PD patients, as well as its predictive potential for the onset and progression of PD. | |
dc.publisher | Elsevier Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.rights | restrictedAccess | |
dc.source | Neuroscience | |
dc.subject | Parkinson's disease | |
dc.subject | 25(OH)-vitamin D | |
dc.subject | vitamin D | |
dc.subject | vitamin D deficiency | |
dc.title | Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease | |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.volume | 533 | |
dc.citation.spage | 53 | |
dc.citation.epage | 62 | |
dc.citation.rank | M22~ | |
dc.identifier.doi | 10.1016/j.neuroscience.2023.10.004 | |
dc.identifier.pmid | 37832907 | |
dc.identifier.scopus | 2-s2.0-85174537476 | |
dc.type.version | publishedVersion |