Determination of nisoldipine and its impurities in pharmaceuticals
Abstract
A method has been established for separation of nisoldipine and impurities, for example reactants, products of side-reactions, and photodegradation products, by HPTLC on LiChrospher Si 60 F-254s plates with detection at 280 nm. The mobile phase, cyclohexane-ethyl acetate-toluene, 7.5:7.5:10 (v/v), enables acceptable resolution of nisoldipine, in large excess, and possible impurities. Regression coefficients (r greater than or equal to 0.997), recovery (98-108%), and determination limit (0.02-0.2%) were validated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of nisoldipine in its raw material and dosage forms.
Keywords:
thin-layer chromatography / nisoldipine and impurities / pharmaceutical preparationsSource:
Chromatographia, 2004, 60, 3-4, 223-227Publisher:
- Springer Heidelberg, Heidelberg
DOI: 10.1365/s10337-004-0335-4
ISSN: 0009-5893
WoS: 000224100700014
Scopus: 2-s2.0-4344560347
Collections
Institution/Community
PharmacyTY - JOUR AU - Agbaba, Danica AU - Vučićević, Katarina AU - Marinković, Valentina PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/546 AB - A method has been established for separation of nisoldipine and impurities, for example reactants, products of side-reactions, and photodegradation products, by HPTLC on LiChrospher Si 60 F-254s plates with detection at 280 nm. The mobile phase, cyclohexane-ethyl acetate-toluene, 7.5:7.5:10 (v/v), enables acceptable resolution of nisoldipine, in large excess, and possible impurities. Regression coefficients (r greater than or equal to 0.997), recovery (98-108%), and determination limit (0.02-0.2%) were validated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of nisoldipine in its raw material and dosage forms. PB - Springer Heidelberg, Heidelberg T2 - Chromatographia T1 - Determination of nisoldipine and its impurities in pharmaceuticals VL - 60 IS - 3-4 SP - 223 EP - 227 DO - 10.1365/s10337-004-0335-4 ER -
@article{ author = "Agbaba, Danica and Vučićević, Katarina and Marinković, Valentina", year = "2004", abstract = "A method has been established for separation of nisoldipine and impurities, for example reactants, products of side-reactions, and photodegradation products, by HPTLC on LiChrospher Si 60 F-254s plates with detection at 280 nm. The mobile phase, cyclohexane-ethyl acetate-toluene, 7.5:7.5:10 (v/v), enables acceptable resolution of nisoldipine, in large excess, and possible impurities. Regression coefficients (r greater than or equal to 0.997), recovery (98-108%), and determination limit (0.02-0.2%) were validated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of nisoldipine in its raw material and dosage forms.", publisher = "Springer Heidelberg, Heidelberg", journal = "Chromatographia", title = "Determination of nisoldipine and its impurities in pharmaceuticals", volume = "60", number = "3-4", pages = "223-227", doi = "10.1365/s10337-004-0335-4" }
Agbaba, D., Vučićević, K.,& Marinković, V.. (2004). Determination of nisoldipine and its impurities in pharmaceuticals. in Chromatographia Springer Heidelberg, Heidelberg., 60(3-4), 223-227. https://doi.org/10.1365/s10337-004-0335-4
Agbaba D, Vučićević K, Marinković V. Determination of nisoldipine and its impurities in pharmaceuticals. in Chromatographia. 2004;60(3-4):223-227. doi:10.1365/s10337-004-0335-4 .
Agbaba, Danica, Vučićević, Katarina, Marinković, Valentina, "Determination of nisoldipine and its impurities in pharmaceuticals" in Chromatographia, 60, no. 3-4 (2004):223-227, https://doi.org/10.1365/s10337-004-0335-4 . .