Приказ основних података о документу
Changes in thymopoiesis in myasthenia gravis
dc.creator | Kosec, Duško | |
dc.creator | Lavrnić, Dragana | |
dc.creator | Apostolski, Slobodan | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2019-09-02T11:01:50Z | |
dc.date.available | 2019-09-02T11:01:50Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0020-7454 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/627 | |
dc.description.abstract | This study was undertaken to investigate T-cell maturation ill hyperplastic thymi of patients suffering from myasthenia gravis (MG). For this purpose, the expression of the major differentiational molecules (CD4, CD8, and CD3/TCRalphass) and that of the regulator. v and activation molecules oil thymocytes from MG patients and control subjects were estimated by flow cytometric analysis. In the MG patients the increase in relative proportion of immature (CD4-8- TCRalphass-) and the most mature (CD4+8- TCRalphass(high) and CD4-8- TCRhigh encompassing immunoregulatory NKT) thymocytes followed by a decrease in that of CD4+8+CD3 /TCRalphass- cells was found. Furthermore, in these patients the relative proportion of CD4+HLA-DR+ and CD4+71+ cells was increased, whereas that of CD4+25+ cells was slightly, but significantly, decreased (reflecting, most likely, decreased contribution of T reg cells bearing this phenotype). Moreover. in MG thymi the percentage of CD45RA+ cells was reduced indicating changes in the selection processes. In keeping with this finding the reduced thymocyte apoptotic index and percentage of cells bearing apoptosing (CD4-8- TCRalphass(low)) phenotype were detected. In conclusion, the study demonstrates substantial changes in intrathymic differentiation of T cells in hyperplastic MG thymi and suggests alterations in selection events providing an increased escape of potentially? autoreactive T-cell clones, on one side, and all altered maturation and/or selection of immunoregulatory cells (NKT and CD4+8-25+ T reg cells) keeping these cell clones under control, on the other side. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Neuroscience | |
dc.subject | immunoregulatory cells | en |
dc.subject | myasthenia gravis | en |
dc.subject | T-cell maturation | en |
dc.title | Changes in thymopoiesis in myasthenia gravis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Косец, Душко; Aпостолски, С; Лаврнић, Д; Лепосавић, Гордана; | |
dc.citation.volume | 115 | |
dc.citation.issue | 2 | |
dc.citation.spage | 223 | |
dc.citation.epage | 243 | |
dc.citation.other | 115(2): 223-243 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000226305300006 | |
dc.identifier.doi | 10.1080/00207450590519472 | |
dc.identifier.pmid | 15764003 | |
dc.identifier.scopus | 2-s2.0-11244318428 | |
dc.type.version | publishedVersion |