TY  - JOUR
AU  - Agbaba, Danica
AU  - Novović, D
AU  - Karljiković-Rajić, Katarina
AU  - Marinković, Valentina
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/525
AB  - A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and N-methylpantoprazole, by HPTLC. The mobile phase chloroform-2-propanol-25% ammonia-acetonitrile, 10.8 + 1.2 + 0.3 + 4 (v/v), enables good resolution of large excesses of the drugs from the possible impurities. Regression coefficients (r > 0.998), recovery (90.7-120.0%), and detection limit (0.025-0.05%) were validated and found to be satisfactory. The methods is convenient for quantitative analysis and purity control of the compounds.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals
VL  - 17
IS  - 3
SP  - 169
EP  - 172
DO  - 10.1556/JPC.17.2004.3.2
ER  - 

@article{
author = "Agbaba, Danica and Novović, D and Karljiković-Rajić, Katarina and Marinković, Valentina",
year = "2004",
abstract = "A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and N-methylpantoprazole, by HPTLC. The mobile phase chloroform-2-propanol-25% ammonia-acetonitrile, 10.8 + 1.2 + 0.3 + 4 (v/v), enables good resolution of large excesses of the drugs from the possible impurities. Regression coefficients (r > 0.998), recovery (90.7-120.0%), and detection limit (0.025-0.05%) were validated and found to be satisfactory. The methods is convenient for quantitative analysis and purity control of the compounds.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals",
volume = "17",
number = "3",
pages = "169-172",
doi = "10.1556/JPC.17.2004.3.2"
}

Agbaba, D., Novović, D., Karljiković-Rajić, K.,& Marinković, V.. (2004). Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals. in Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 17(3), 169-172.
https://doi.org/10.1556/JPC.17.2004.3.2

Agbaba D, Novović D, Karljiković-Rajić K, Marinković V. Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals. in Journal of Planar Chromatography - Modern TLC. 2004;17(3):169-172.
doi:10.1556/JPC.17.2004.3.2 .

Agbaba, Danica, Novović, D, Karljiković-Rajić, Katarina, Marinković, Valentina, "Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals" in Journal of Planar Chromatography - Modern TLC, 17, no. 3 (2004):169-172,
https://doi.org/10.1556/JPC.17.2004.3.2 . .

TY  - JOUR
AU  - Karljiković-Rajić, Katarina
AU  - Novović, D
AU  - Marinković, Valentina
AU  - Agbaba, Danica
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/430
AB  - The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the first-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities
VL  - 32
IS  - 4-5
SP  - 1019
EP  - 1027
DO  - 10.1016/S0731-7085(03)00204-8
ER  - 

@article{
author = "Karljiković-Rajić, Katarina and Novović, D and Marinković, Valentina and Agbaba, Danica",
year = "2003",
abstract = "The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the first-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities",
volume = "32",
number = "4-5",
pages = "1019-1027",
doi = "10.1016/S0731-7085(03)00204-8"
}

Karljiković-Rajić, K., Novović, D., Marinković, V.,& Agbaba, D.. (2003). First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 32(4-5), 1019-1027.
https://doi.org/10.1016/S0731-7085(03)00204-8

Karljiković-Rajić K, Novović D, Marinković V, Agbaba D. First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):1019-1027.
doi:10.1016/S0731-7085(03)00204-8 .

Karljiković-Rajić, Katarina, Novović, D, Marinković, Valentina, Agbaba, Danica, "First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):1019-1027,
https://doi.org/10.1016/S0731-7085(03)00204-8 . .