Vuleta, Gordana

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  • Vuleta, Gordana (68)
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Author's Bibliography

Film-forming materials in contemporary formulations of cosmetic products

Pantelić, Ivana; Savić, Snežana; Milić, Jela; Vuleta, Gordana

(Savez farmaceutskih udruženja Srbije, Beograd, 2018)

TY  - JOUR
AU  - Pantelić, Ivana
AU  - Savić, Snežana
AU  - Milić, Jela
AU  - Vuleta, Gordana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3097
AB  - Film-formers are cosmetic raw materials responsible for generating a film after their application. Recently, a certain expansion of these materials is noted, with numerous alleged functions and effects on skin or its appendages, making them a true example of multifunctional ingredients. CosIng database currently lists 965 ingredients with the recognized film-forming function. This paper offers a review of different types of film-formers as cosmetic raw materials, their properties and possible combinations in cosmetic products for skin, hair or nails. Although film-forming materials increasingly form part of contemporary cosmetic formulations, the paper mentions only the groups of cosmetic products that contain them in larger amounts, such as anti-age cosmetic products (lifting effect), sunscreens (water resistance and SPF/UVA-PF boosting), hair styling products and nail polishes. In line with the increase in their use, the Scientific Committee on Consumer Safety, operating within the European Commission, has announced recent development of scientific opinions on several cosmetic raw materials with film-forming properties.
AB  - Materijali/sastojci koji obrazuju film na mestu primene kozmetičkih proizvoda su poznati i pod nazivom film-formirajući materijali ili film-formeri. Poslednjih godina, primetno je povećanje broja ovih sirovina na tržištu, kojima se pripisuju različite uloge u kozmetičkim formulacijama, ali i kozmetički efekti na koži ili njenim adneksima, čineći ih dobrim primerom multifunkcionalnih sastojaka.CosIng baza podataka trenutno vodi čak 965 sastojaka sa ulogom 'film forming' sirovina. U radu je dat pregled film-formera različitog porekla, karakteristika i mogućnosti kombinovanja u kozmetičkim proizvodima za negu, zaštitu ili ulepšavanje kože, kose ili noktiju. Ove kozmetičke sirovine su sve češće deo savremenih kozmetičkih formulacija različite vrste i namene, ali su u radu obrađene one grupe kozmetičkih proizvoda koje ih sadrže u većoj koncentraciji, kao što su anti-age kozmetički proizvodi (lifting efekat), kozmetički proizvodi za zaštitu kože od sunca (vodootpornost i potenciranje SPF/UVA-PF faktora), za stilizovanje kose i dekorisanje noktiju. U skladu sa sve većom primenom, Naučni komitet za bezbednost korisnika pri Evropskoj komisiji najavio je skoro objavljivanje stručnih mišljenja o nekoliko kozmetičkih sastojaka iz ove grupe.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Film-forming materials in contemporary formulations of cosmetic products
T1  - Materijali koji obrazuju film u savremenim formulacijama kozmetičkih proizvoda
VL  - 68
IS  - 1
SP  - 46
EP  - 64
DO  - 10.5937/arhFarm1801046P
ER  - 
@article{
author = "Pantelić, Ivana and Savić, Snežana and Milić, Jela and Vuleta, Gordana",
year = "2018",
abstract = "Film-formers are cosmetic raw materials responsible for generating a film after their application. Recently, a certain expansion of these materials is noted, with numerous alleged functions and effects on skin or its appendages, making them a true example of multifunctional ingredients. CosIng database currently lists 965 ingredients with the recognized film-forming function. This paper offers a review of different types of film-formers as cosmetic raw materials, their properties and possible combinations in cosmetic products for skin, hair or nails. Although film-forming materials increasingly form part of contemporary cosmetic formulations, the paper mentions only the groups of cosmetic products that contain them in larger amounts, such as anti-age cosmetic products (lifting effect), sunscreens (water resistance and SPF/UVA-PF boosting), hair styling products and nail polishes. In line with the increase in their use, the Scientific Committee on Consumer Safety, operating within the European Commission, has announced recent development of scientific opinions on several cosmetic raw materials with film-forming properties., Materijali/sastojci koji obrazuju film na mestu primene kozmetičkih proizvoda su poznati i pod nazivom film-formirajući materijali ili film-formeri. Poslednjih godina, primetno je povećanje broja ovih sirovina na tržištu, kojima se pripisuju različite uloge u kozmetičkim formulacijama, ali i kozmetički efekti na koži ili njenim adneksima, čineći ih dobrim primerom multifunkcionalnih sastojaka.CosIng baza podataka trenutno vodi čak 965 sastojaka sa ulogom 'film forming' sirovina. U radu je dat pregled film-formera različitog porekla, karakteristika i mogućnosti kombinovanja u kozmetičkim proizvodima za negu, zaštitu ili ulepšavanje kože, kose ili noktiju. Ove kozmetičke sirovine su sve češće deo savremenih kozmetičkih formulacija različite vrste i namene, ali su u radu obrađene one grupe kozmetičkih proizvoda koje ih sadrže u većoj koncentraciji, kao što su anti-age kozmetički proizvodi (lifting efekat), kozmetički proizvodi za zaštitu kože od sunca (vodootpornost i potenciranje SPF/UVA-PF faktora), za stilizovanje kose i dekorisanje noktiju. U skladu sa sve većom primenom, Naučni komitet za bezbednost korisnika pri Evropskoj komisiji najavio je skoro objavljivanje stručnih mišljenja o nekoliko kozmetičkih sastojaka iz ove grupe.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Film-forming materials in contemporary formulations of cosmetic products, Materijali koji obrazuju film u savremenim formulacijama kozmetičkih proizvoda",
volume = "68",
number = "1",
pages = "46-64",
doi = "10.5937/arhFarm1801046P"
}
Pantelić, I., Savić, S., Milić, J.,& Vuleta, G.. (2018). Film-forming materials in contemporary formulations of cosmetic products. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(1), 46-64.
https://doi.org/10.5937/arhFarm1801046P
Pantelić I, Savić S, Milić J, Vuleta G. Film-forming materials in contemporary formulations of cosmetic products. in Arhiv za farmaciju. 2018;68(1):46-64.
doi:10.5937/arhFarm1801046P .
Pantelić, Ivana, Savić, Snežana, Milić, Jela, Vuleta, Gordana, "Film-forming materials in contemporary formulations of cosmetic products" in Arhiv za farmaciju, 68, no. 1 (2018):46-64,
https://doi.org/10.5937/arhFarm1801046P . .

Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin

Filipović, Mila; Lukić, Milica; Savić, Snežana; Vuleta, Gordana

(Savez farmaceutskih udruženja Srbije, Beograd, 2018)

TY  - JOUR
AU  - Filipović, Mila
AU  - Lukić, Milica
AU  - Savić, Snežana
AU  - Vuleta, Gordana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3100
AB  - In the cosmetic industry, a frequent anti-aging approach is the protection of cells responsible for the continuous skin renewal and the maintenance of its barrier function - epidermal stem cells, using the secondary metabolites and epigenetic factors of the plant stem cells. Alp rose stem cells (ARSC) extract in liposomes is used as a cosmetic active ingredient in the cosmetic products for the skin care and its protection. According to the manufacturer, this cosmetic active ingredient possess the ability to increase the vitality of epidermal stem cells, protects them against the negative external influences, affects the regeneration of epidermal cells, improves the skin barrier function and has certain anti-aging effects. However, in order for these effects to be observed in in vivo conditions and for ARSC epigenetic factors and secondary metabolites to reach their target places, liposomes in the cosmetic products should remain intact and unchanged. Therefore, according to the EU regulations on the cosmetic products (Regulations 1223/2009 and 655/2013), cosmetic products with plant (alp rose) stem cells can not be attributed to the effects of the containing cosmetic ingredients, and any claims about the each product efficacy has to be supported by the data obtained on the human volunteers.
AB  - U industriji kozmetičkih proizvoda, čest anti-aging pristup jeste zaštita ćelija odgovornih za kontinuirano obnavljanje kože i održavanje njene barijerne funkcije - epidermalnih matičnih ćelija, upotrebom sekundarnih metabolita i epigenetskih faktora biljnih matičnih ćelija. Kao kozmetički aktivna supstanca (KAS) u proizvodima za negu i zaštitu kože, koristi se i ekstrakt matičnih ćelija alpske ruže (MĆAR) inkapsuliran u liposome, za koji proizvođač navodi da povećava otpornost humanih matičnih ćelija kože, štiti ih od negativnih spoljašnjih uticaja, utiče na regeneraciju epidermalnih ćelija, popravlja barijernu funkciju kože i ima određene anti-aging efekte. Međutim, da bi pomenuti efekti bili ispoljeni i u in vivo uslovima, a epigenetski faktori i sekundarni metaboliti MĆAR stigli do ciljnih mesta njihovog delovanja, liposomi u kozmetičkom proizvodu treba da ostanu neoštećeni i neizmenjenih osobina. Stoga, shodno važećim propisima o kozmetičkim proizvodima u EU (Uredbe 1223/2009 i 655/2013), gotovim kozmetičkim proizvodima sa biljnim matičnim ćelijama (alpske ruže) se ne mogu pripisati kozmetički efekti sastojaka koje sadrže, već eventualne tvrdnje o efikasnosti svakog proizvoda treba potkrepiti dokumentacijom o proceni njegovih efekata na humanim dobrovoljcima.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin
T1  - Matične ćelije alpske ruže kao sastojci kozmetičkih kremova - očekivani i utvrđeni efekti kremova na koži
VL  - 68
IS  - 4
SP  - 874
EP  - 884
DO  - 10.5937/ArhFarm1804874F
ER  - 
@article{
author = "Filipović, Mila and Lukić, Milica and Savić, Snežana and Vuleta, Gordana",
year = "2018",
abstract = "In the cosmetic industry, a frequent anti-aging approach is the protection of cells responsible for the continuous skin renewal and the maintenance of its barrier function - epidermal stem cells, using the secondary metabolites and epigenetic factors of the plant stem cells. Alp rose stem cells (ARSC) extract in liposomes is used as a cosmetic active ingredient in the cosmetic products for the skin care and its protection. According to the manufacturer, this cosmetic active ingredient possess the ability to increase the vitality of epidermal stem cells, protects them against the negative external influences, affects the regeneration of epidermal cells, improves the skin barrier function and has certain anti-aging effects. However, in order for these effects to be observed in in vivo conditions and for ARSC epigenetic factors and secondary metabolites to reach their target places, liposomes in the cosmetic products should remain intact and unchanged. Therefore, according to the EU regulations on the cosmetic products (Regulations 1223/2009 and 655/2013), cosmetic products with plant (alp rose) stem cells can not be attributed to the effects of the containing cosmetic ingredients, and any claims about the each product efficacy has to be supported by the data obtained on the human volunteers., U industriji kozmetičkih proizvoda, čest anti-aging pristup jeste zaštita ćelija odgovornih za kontinuirano obnavljanje kože i održavanje njene barijerne funkcije - epidermalnih matičnih ćelija, upotrebom sekundarnih metabolita i epigenetskih faktora biljnih matičnih ćelija. Kao kozmetički aktivna supstanca (KAS) u proizvodima za negu i zaštitu kože, koristi se i ekstrakt matičnih ćelija alpske ruže (MĆAR) inkapsuliran u liposome, za koji proizvođač navodi da povećava otpornost humanih matičnih ćelija kože, štiti ih od negativnih spoljašnjih uticaja, utiče na regeneraciju epidermalnih ćelija, popravlja barijernu funkciju kože i ima određene anti-aging efekte. Međutim, da bi pomenuti efekti bili ispoljeni i u in vivo uslovima, a epigenetski faktori i sekundarni metaboliti MĆAR stigli do ciljnih mesta njihovog delovanja, liposomi u kozmetičkom proizvodu treba da ostanu neoštećeni i neizmenjenih osobina. Stoga, shodno važećim propisima o kozmetičkim proizvodima u EU (Uredbe 1223/2009 i 655/2013), gotovim kozmetičkim proizvodima sa biljnim matičnim ćelijama (alpske ruže) se ne mogu pripisati kozmetički efekti sastojaka koje sadrže, već eventualne tvrdnje o efikasnosti svakog proizvoda treba potkrepiti dokumentacijom o proceni njegovih efekata na humanim dobrovoljcima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin, Matične ćelije alpske ruže kao sastojci kozmetičkih kremova - očekivani i utvrđeni efekti kremova na koži",
volume = "68",
number = "4",
pages = "874-884",
doi = "10.5937/ArhFarm1804874F"
}
Filipović, M., Lukić, M., Savić, S.,& Vuleta, G.. (2018). Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(4), 874-884.
https://doi.org/10.5937/ArhFarm1804874F
Filipović M, Lukić M, Savić S, Vuleta G. Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin. in Arhiv za farmaciju. 2018;68(4):874-884.
doi:10.5937/ArhFarm1804874F .
Filipović, Mila, Lukić, Milica, Savić, Snežana, Vuleta, Gordana, "Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin" in Arhiv za farmaciju, 68, no. 4 (2018):874-884,
https://doi.org/10.5937/ArhFarm1804874F . .

Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance

Bubić-Pajić, Nataša; Todosijević, Marija N.; Vuleta, Gordana; Cekić, Nebojša; Dobričić, Vladimir; Vučen, Sonja; Čalija, Bojan; Lukić, Milica; Ilić, Tanja; Savić, Snežana

(Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb, 2017)

TY  - JOUR
AU  - Bubić-Pajić, Nataša
AU  - Todosijević, Marija N.
AU  - Vuleta, Gordana
AU  - Cekić, Nebojša
AU  - Dobričić, Vladimir
AU  - Vučen, Sonja
AU  - Čalija, Bojan
AU  - Lukić, Milica
AU  - Ilić, Tanja
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2837
AB  - Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.
PB  - Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb
T2  - Acta Pharmaceutica
T1  - Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance
VL  - 67
IS  - 4
SP  - 415
EP  - 439
DO  - 10.1515/acph-2017-0036
ER  - 
@article{
author = "Bubić-Pajić, Nataša and Todosijević, Marija N. and Vuleta, Gordana and Cekić, Nebojša and Dobričić, Vladimir and Vučen, Sonja and Čalija, Bojan and Lukić, Milica and Ilić, Tanja and Savić, Snežana",
year = "2017",
abstract = "Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.",
publisher = "Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb",
journal = "Acta Pharmaceutica",
title = "Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance",
volume = "67",
number = "4",
pages = "415-439",
doi = "10.1515/acph-2017-0036"
}
Bubić-Pajić, N., Todosijević, M. N., Vuleta, G., Cekić, N., Dobričić, V., Vučen, S., Čalija, B., Lukić, M., Ilić, T.,& Savić, S.. (2017). Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance. in Acta Pharmaceutica
Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb., 67(4), 415-439.
https://doi.org/10.1515/acph-2017-0036
Bubić-Pajić N, Todosijević MN, Vuleta G, Cekić N, Dobričić V, Vučen S, Čalija B, Lukić M, Ilić T, Savić S. Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance. in Acta Pharmaceutica. 2017;67(4):415-439.
doi:10.1515/acph-2017-0036 .
Bubić-Pajić, Nataša, Todosijević, Marija N., Vuleta, Gordana, Cekić, Nebojša, Dobričić, Vladimir, Vučen, Sonja, Čalija, Bojan, Lukić, Milica, Ilić, Tanja, Savić, Snežana, "Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance" in Acta Pharmaceutica, 67, no. 4 (2017):415-439,
https://doi.org/10.1515/acph-2017-0036 . .
10
8
10

Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design

Filipović, M.; Lukić, Milica; Đorđević, S.; Krstonosić, Veljko; Pantelić, Ivana; Vuleta, Gordana; Savić, Snežana

(Wiley, Hoboken, 2017)

TY  - JOUR
AU  - Filipović, M.
AU  - Lukić, Milica
AU  - Đorđević, S.
AU  - Krstonosić, Veljko
AU  - Pantelić, Ivana
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2839
AB  - OBJECTIVE: Consumers' demand for improved products' performance, alongside with the obligation of meeting the safety and efficacy goals, presents a key reason for the reformulation, as well as a challenging task for formulators. Any change of the formulation, whether it is wanted - in order to innovate the product (new actives and raw materials) or necessary - due to, for example legislative changes (restriction of ingredients), ingredients market unavailability, new manufacturing equipment, may have a number of consequences, desired or otherwise. The aim of the study was to evaluate the influence of multiple factors - variations of the composition, manufacturing conditions and their interactions, on emulsion textural and rheological characteristics, applying the general experimental factorial design and, subsequently, to establish the approach that could replace, to some extent, certain expensive and time-consuming tests (e.g. certain sensory analysis), often required, partly or completely, after the reformulation. METHODS: An experimental design strategy was utilized to reveal the influence of reformulation factors (addition of new actives, preparation method change) on textural and rheological properties of cosmetic emulsions, especially those linked to certain sensorial attributes, and droplet size. RESULTS: The general experimental factorial design revealed a significant direct effect of each factor, as well as their interaction effects, on certain characteristics of the system and provided some valuable information necessary for fine-tuning reformulation conditions. Upon addition of STEM-liposomes, consistency, index of viscosity, firmness and cohesiveness were decreased, as along with certain rheology parameters (elastic and viscous modulus), whereas maximal and minimal apparent viscosities and droplet size were increased. The presence of an emollient (squalene) affected all the investigated parameters in a concentration-dependent manner. Modification of the preparation method (using Ultra Turrax instead of a propeller stirrer) produced emulsions with higher firmness and maximal apparent viscosity, but led to a decrease in minimal apparent viscosity, hysteresis loop area, all monitored parameters of oscillatory rheology and droplet size. CONCLUSION: The study showed that the established approach which combines a general experimental design and instrumental, rheological and textural measurements could be appropriate, more objective, repeatable and time and money-saving step towards developing cosmetic emulsions with satisfying, improved or unchanged, consumer-acceptable performance during the reformulation.
PB  - Wiley, Hoboken
T2  - International Journal of Cosmetic Science
T1  - Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design
VL  - 39
IS  - 5
SP  - 486
EP  - 499
DO  - 10.1111/ics.12402
ER  - 
@article{
author = "Filipović, M. and Lukić, Milica and Đorđević, S. and Krstonosić, Veljko and Pantelić, Ivana and Vuleta, Gordana and Savić, Snežana",
year = "2017",
abstract = "OBJECTIVE: Consumers' demand for improved products' performance, alongside with the obligation of meeting the safety and efficacy goals, presents a key reason for the reformulation, as well as a challenging task for formulators. Any change of the formulation, whether it is wanted - in order to innovate the product (new actives and raw materials) or necessary - due to, for example legislative changes (restriction of ingredients), ingredients market unavailability, new manufacturing equipment, may have a number of consequences, desired or otherwise. The aim of the study was to evaluate the influence of multiple factors - variations of the composition, manufacturing conditions and their interactions, on emulsion textural and rheological characteristics, applying the general experimental factorial design and, subsequently, to establish the approach that could replace, to some extent, certain expensive and time-consuming tests (e.g. certain sensory analysis), often required, partly or completely, after the reformulation. METHODS: An experimental design strategy was utilized to reveal the influence of reformulation factors (addition of new actives, preparation method change) on textural and rheological properties of cosmetic emulsions, especially those linked to certain sensorial attributes, and droplet size. RESULTS: The general experimental factorial design revealed a significant direct effect of each factor, as well as their interaction effects, on certain characteristics of the system and provided some valuable information necessary for fine-tuning reformulation conditions. Upon addition of STEM-liposomes, consistency, index of viscosity, firmness and cohesiveness were decreased, as along with certain rheology parameters (elastic and viscous modulus), whereas maximal and minimal apparent viscosities and droplet size were increased. The presence of an emollient (squalene) affected all the investigated parameters in a concentration-dependent manner. Modification of the preparation method (using Ultra Turrax instead of a propeller stirrer) produced emulsions with higher firmness and maximal apparent viscosity, but led to a decrease in minimal apparent viscosity, hysteresis loop area, all monitored parameters of oscillatory rheology and droplet size. CONCLUSION: The study showed that the established approach which combines a general experimental design and instrumental, rheological and textural measurements could be appropriate, more objective, repeatable and time and money-saving step towards developing cosmetic emulsions with satisfying, improved or unchanged, consumer-acceptable performance during the reformulation.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Cosmetic Science",
title = "Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design",
volume = "39",
number = "5",
pages = "486-499",
doi = "10.1111/ics.12402"
}
Filipović, M., Lukić, M., Đorđević, S., Krstonosić, V., Pantelić, I., Vuleta, G.,& Savić, S.. (2017). Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design. in International Journal of Cosmetic Science
Wiley, Hoboken., 39(5), 486-499.
https://doi.org/10.1111/ics.12402
Filipović M, Lukić M, Đorđević S, Krstonosić V, Pantelić I, Vuleta G, Savić S. Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design. in International Journal of Cosmetic Science. 2017;39(5):486-499.
doi:10.1111/ics.12402 .
Filipović, M., Lukić, Milica, Đorđević, S., Krstonosić, Veljko, Pantelić, Ivana, Vuleta, Gordana, Savić, Snežana, "Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design" in International Journal of Cosmetic Science, 39, no. 5 (2017):486-499,
https://doi.org/10.1111/ics.12402 . .
12
6
11

Vitamins in cosmetic products: Current opinions and practice

Vasiljević, Dragana; Radonjić, Nataša; Vuleta, Gordana

(Savez farmaceutskih udruženja Srbije, Beograd, 2017)

TY  - JOUR
AU  - Vasiljević, Dragana
AU  - Radonjić, Nataša
AU  - Vuleta, Gordana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2980
AB  - Vitamins A, E, C, B3 and provitamin B5 (panthenol), and their numerous derivatives are most widely used in cosmetic products. Cosmetic retinoids (retinol, retinaldehyde, and retinyl esters) have been used for years in cosmetic treatments of (photo)aged skin - brightened hyperpigmentation, reducing roughness of the skin and fine lines and wrinkles. Using the new vitamin A derivative, retinyl retinoate, is considered to overcome the problems associated with instability and undesirable effects of retinol. Hydroxypinacolone retinoate is a new anti-aging ingredient with the efficacy of retinol, but with significantly less irritant potential. Vitamin E (tocopherol) slows down the formation of wrinkles and alleviates the existing ones. Because of the pronounced instability, vitamin E is used in the form of esters, usually as tocopheryl acetate. The novelty on the market is a water-soluble derivative of vitamin E - sodium tocopheryl phosphate. Vitamin C also has positive effects on the skin. However, free vitamin C (ascorbic acid) is very unstable and easily loses its activity. Newer derivatives of vitamin C, which may be water-soluble, amphiphilic or liposoluble, have improved stability compared to the ascorbic acid. They are used in skin care and skin lightening products. Panthenol, which is a very good moisturizer, has been used in various cosmetic products for skin and hair for many years. Vitamin B3 (niacinamide) is commonly used in facial day creams, as skin conditioner. Vitamins in cosmetic products can be considered as safe cosmetic active ingredients, when used in appropriate chemical forms and in allowed concentrations.
AB  - U savremenim kozmetičkim proizvodima najviše se koriste vitamini A, E, C, B3 i provitamin B5 (pantenol), kao i njihovi brojni derivati. Kozmetički retinoidi (retinol, retinaldehid i retinil estri) se godinama koriste u kozmetičkom tretmanu znakova (foto)ostarele kože jer posvetljuju hiperpigmentacije, smanjuju grubost kože i fine linije i bore. Noviji derivati vitamina A, retinil retinoat i hidroksipinakolon retinoat su anti-age sastojci povećane stabilnosti i smanjenog iritacionog potencijala, u poređenju sa retinolom. Vitamin E (tokoferol), dovodi do usporavanja nastanka i prividnog smanjenja postojećih bora. Zbog izražene nestabilnosti, vitamin E se koristi u obliku estara, najčešće kao tokoferil acetat. Novina na tržištu je hidrosolubilni derivat vitamina E - natrijum tokoferil fosfat. Vitamin C (askorbinska kiselina) takođe ima pozitivne efekte na koži, ali je veoma nestabilan. Noviji derivati vitamina C, koji mogu biti hidrosolubilni, amfifilni ili liposolubilni su poboljšane stabilnosti u odnosu na askorbinsku kiselinu. Koriste se u proizvodima za negu i posvetljivanje kože. Pantenol je izuzetno dobar ovlaživač kože i kose. Vitamin B3 (niacinamid) se uobičajeno koristi u dnevnim kremovima za negu lica, kao kondicioner kože. Vitamini u kozmetičkim proizvodima se mogu smatrati bezbednim KAS, kada se koriste u odgovarajućim hemijskim oblicima i u odobrenim koncentracijama.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Vitamins in cosmetic products: Current opinions and practice
T1  - Vitamini u kozmetičkim proizvodima - savremeni stavovi i praksa
VL  - 67
IS  - 4
SP  - 248
EP  - 264
DO  - 10.5937/arhfarm1704248V
ER  - 
@article{
author = "Vasiljević, Dragana and Radonjić, Nataša and Vuleta, Gordana",
year = "2017",
abstract = "Vitamins A, E, C, B3 and provitamin B5 (panthenol), and their numerous derivatives are most widely used in cosmetic products. Cosmetic retinoids (retinol, retinaldehyde, and retinyl esters) have been used for years in cosmetic treatments of (photo)aged skin - brightened hyperpigmentation, reducing roughness of the skin and fine lines and wrinkles. Using the new vitamin A derivative, retinyl retinoate, is considered to overcome the problems associated with instability and undesirable effects of retinol. Hydroxypinacolone retinoate is a new anti-aging ingredient with the efficacy of retinol, but with significantly less irritant potential. Vitamin E (tocopherol) slows down the formation of wrinkles and alleviates the existing ones. Because of the pronounced instability, vitamin E is used in the form of esters, usually as tocopheryl acetate. The novelty on the market is a water-soluble derivative of vitamin E - sodium tocopheryl phosphate. Vitamin C also has positive effects on the skin. However, free vitamin C (ascorbic acid) is very unstable and easily loses its activity. Newer derivatives of vitamin C, which may be water-soluble, amphiphilic or liposoluble, have improved stability compared to the ascorbic acid. They are used in skin care and skin lightening products. Panthenol, which is a very good moisturizer, has been used in various cosmetic products for skin and hair for many years. Vitamin B3 (niacinamide) is commonly used in facial day creams, as skin conditioner. Vitamins in cosmetic products can be considered as safe cosmetic active ingredients, when used in appropriate chemical forms and in allowed concentrations., U savremenim kozmetičkim proizvodima najviše se koriste vitamini A, E, C, B3 i provitamin B5 (pantenol), kao i njihovi brojni derivati. Kozmetički retinoidi (retinol, retinaldehid i retinil estri) se godinama koriste u kozmetičkom tretmanu znakova (foto)ostarele kože jer posvetljuju hiperpigmentacije, smanjuju grubost kože i fine linije i bore. Noviji derivati vitamina A, retinil retinoat i hidroksipinakolon retinoat su anti-age sastojci povećane stabilnosti i smanjenog iritacionog potencijala, u poređenju sa retinolom. Vitamin E (tokoferol), dovodi do usporavanja nastanka i prividnog smanjenja postojećih bora. Zbog izražene nestabilnosti, vitamin E se koristi u obliku estara, najčešće kao tokoferil acetat. Novina na tržištu je hidrosolubilni derivat vitamina E - natrijum tokoferil fosfat. Vitamin C (askorbinska kiselina) takođe ima pozitivne efekte na koži, ali je veoma nestabilan. Noviji derivati vitamina C, koji mogu biti hidrosolubilni, amfifilni ili liposolubilni su poboljšane stabilnosti u odnosu na askorbinsku kiselinu. Koriste se u proizvodima za negu i posvetljivanje kože. Pantenol je izuzetno dobar ovlaživač kože i kose. Vitamin B3 (niacinamid) se uobičajeno koristi u dnevnim kremovima za negu lica, kao kondicioner kože. Vitamini u kozmetičkim proizvodima se mogu smatrati bezbednim KAS, kada se koriste u odgovarajućim hemijskim oblicima i u odobrenim koncentracijama.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Vitamins in cosmetic products: Current opinions and practice, Vitamini u kozmetičkim proizvodima - savremeni stavovi i praksa",
volume = "67",
number = "4",
pages = "248-264",
doi = "10.5937/arhfarm1704248V"
}
Vasiljević, D., Radonjić, N.,& Vuleta, G.. (2017). Vitamins in cosmetic products: Current opinions and practice. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(4), 248-264.
https://doi.org/10.5937/arhfarm1704248V
Vasiljević D, Radonjić N, Vuleta G. Vitamins in cosmetic products: Current opinions and practice. in Arhiv za farmaciju. 2017;67(4):248-264.
doi:10.5937/arhfarm1704248V .
Vasiljević, Dragana, Radonjić, Nataša, Vuleta, Gordana, "Vitamins in cosmetic products: Current opinions and practice" in Arhiv za farmaciju, 67, no. 4 (2017):248-264,
https://doi.org/10.5937/arhfarm1704248V . .

Effects of anti-age cosmetic products: Claims substantiation

Denić, Dragana; Lukić, Milica; Vuleta, Gordana; Savić, Snežana

(Savez farmaceutskih udruženja Srbije, Beograd, 2017)

TY  - JOUR
AU  - Denić, Dragana
AU  - Lukić, Milica
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3021
AB  - Cosmetic products, labelled and advertised as anti-age, are more precisely cosmetic products intended for the reduction of the visible signs of skin aging. Joint influence of internal and external factors contributes to the process of skin aging, so that dominant signs of aged skin, like hyperpigmentation, fine lines and wrinkles, loss of tone and elasticity of the skin become visible. Aging skin loses its radiance and gloss, while the skin colour becomes uneven. Regular use of appropriate cosmetic products (usually creams and serums) can be useful in the maintenance of youthful-looking skin. The efficacy of these products must be confirmed, and the manufacturers have a number of available techniques and methods for testing the surface of the skin and measuring its biophysical parameters. Users rely on claims when they make a decision on products' choice. Claims that stand out for cosmetic products, which are related to the properties, active ingredients or efficacy of the product, must be substantiated in accordance with the requirements of Cosmetic Regulation EU 1223/2009. Additional relevant regulation is the EU Regulation 655/2013 on cosmetic claims, alongside with corresponding guidelines.
AB  - Kozmetički proizvodi koji su obeleženi i reklamiraju se kao anti-age, čine vrstu kozmetičkih proizvoda namenjenih umanjenju pojave vidljivih znakova starenja kože. Pod uticajem udruženih unutrašnjih i spoljašnjih faktora koji doprinose procesu starenja kože, javljaju se dominantni znakovi poput hiperpigmentacija, finih linija i bora, gubitka tonusa i elastičnosti kože. Koža koja stari gubi blistavost, a ton i boja kože postaju neujednačeni. Redovnom upotrebom odgovarajućih kozmetičkih proizvoda (najčešće krema i seruma), mogu se postići značajni rezultati u očuvanju mladalačkog izgleda kože. Efikasnost ovih proizvoda mora biti potvrđena, a proizvođačima su dostupne brojne tehnike i metode za ispitivanje površine kože i merenje njenih biofizičkih parametara. Tvrdnje koje se ističu o kozmetičkom proizvodu, a u vezi su sa osobinama, aktivnim supstancama ili efikasnošću proizvoda, moraju se dokazati u skladu sa zahtevima Kozmetičke Uredbe EU 1223/2009, kako bi korisnici bili sigurni u proizvod koji su odabrali. U iznošenju tvrdnji o efektima, odnosno karakteristikama kozmetičkog proizvoda, dodatno se moraju poštovati zahtevi Uredbe EU 655/2013 o kozmetičkim tvrdnjama i odgovarajućih smernica/vodiča.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Effects of anti-age cosmetic products: Claims substantiation
T1  - Efekti anti-age kozmetičkih proizvoda - dokazivanje tvrdnji
VL  - 67
IS  - 3
SP  - 209
EP  - 219
DO  - 10.5937/arhfarm1703209D
ER  - 
@article{
author = "Denić, Dragana and Lukić, Milica and Vuleta, Gordana and Savić, Snežana",
year = "2017",
abstract = "Cosmetic products, labelled and advertised as anti-age, are more precisely cosmetic products intended for the reduction of the visible signs of skin aging. Joint influence of internal and external factors contributes to the process of skin aging, so that dominant signs of aged skin, like hyperpigmentation, fine lines and wrinkles, loss of tone and elasticity of the skin become visible. Aging skin loses its radiance and gloss, while the skin colour becomes uneven. Regular use of appropriate cosmetic products (usually creams and serums) can be useful in the maintenance of youthful-looking skin. The efficacy of these products must be confirmed, and the manufacturers have a number of available techniques and methods for testing the surface of the skin and measuring its biophysical parameters. Users rely on claims when they make a decision on products' choice. Claims that stand out for cosmetic products, which are related to the properties, active ingredients or efficacy of the product, must be substantiated in accordance with the requirements of Cosmetic Regulation EU 1223/2009. Additional relevant regulation is the EU Regulation 655/2013 on cosmetic claims, alongside with corresponding guidelines., Kozmetički proizvodi koji su obeleženi i reklamiraju se kao anti-age, čine vrstu kozmetičkih proizvoda namenjenih umanjenju pojave vidljivih znakova starenja kože. Pod uticajem udruženih unutrašnjih i spoljašnjih faktora koji doprinose procesu starenja kože, javljaju se dominantni znakovi poput hiperpigmentacija, finih linija i bora, gubitka tonusa i elastičnosti kože. Koža koja stari gubi blistavost, a ton i boja kože postaju neujednačeni. Redovnom upotrebom odgovarajućih kozmetičkih proizvoda (najčešće krema i seruma), mogu se postići značajni rezultati u očuvanju mladalačkog izgleda kože. Efikasnost ovih proizvoda mora biti potvrđena, a proizvođačima su dostupne brojne tehnike i metode za ispitivanje površine kože i merenje njenih biofizičkih parametara. Tvrdnje koje se ističu o kozmetičkom proizvodu, a u vezi su sa osobinama, aktivnim supstancama ili efikasnošću proizvoda, moraju se dokazati u skladu sa zahtevima Kozmetičke Uredbe EU 1223/2009, kako bi korisnici bili sigurni u proizvod koji su odabrali. U iznošenju tvrdnji o efektima, odnosno karakteristikama kozmetičkog proizvoda, dodatno se moraju poštovati zahtevi Uredbe EU 655/2013 o kozmetičkim tvrdnjama i odgovarajućih smernica/vodiča.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Effects of anti-age cosmetic products: Claims substantiation, Efekti anti-age kozmetičkih proizvoda - dokazivanje tvrdnji",
volume = "67",
number = "3",
pages = "209-219",
doi = "10.5937/arhfarm1703209D"
}
Denić, D., Lukić, M., Vuleta, G.,& Savić, S.. (2017). Effects of anti-age cosmetic products: Claims substantiation. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(3), 209-219.
https://doi.org/10.5937/arhfarm1703209D
Denić D, Lukić M, Vuleta G, Savić S. Effects of anti-age cosmetic products: Claims substantiation. in Arhiv za farmaciju. 2017;67(3):209-219.
doi:10.5937/arhfarm1703209D .
Denić, Dragana, Lukić, Milica, Vuleta, Gordana, Savić, Snežana, "Effects of anti-age cosmetic products: Claims substantiation" in Arhiv za farmaciju, 67, no. 3 (2017):209-219,
https://doi.org/10.5937/arhfarm1703209D . .
2
1

Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study

Đorđević, Sanela; Isailović, Tanja; Cekić, Nebojša; Vuleta, Gordana; Savić, Snežana

(Savez farmaceutskih udruženja Srbije, Beograd, 2016)

TY  - JOUR
AU  - Đorđević, Sanela
AU  - Isailović, Tanja
AU  - Cekić, Nebojša
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2731
AB  - The aim of the present study was to develop parenteral nanoemulsions containing increasing content of oil phase (20, 30 and 40%, w/w of medium-chain triglycerides-soybean oil mixture at 4:1 ratio), stabilized by lecithin-polysorbate 80 mixture, and to assess their feasibility as carriers for poorly water-soluble psychopharmacological drugs. To this purpose, nanoemulsions loaded with diazepam as a model drug were prepared through high pressure homogenization and characterized regarding droplet size, polydispersity, surface charge, viscosity, pH value, and electrical conductivity. Furthermore, the in vitro release of diazepam from developed nanoemulsions was examined using reverse dialysis bag technique, and drug release kinetics was evaluated through several mathematical models. After preparation, all formulations revealed small mean droplet size (206 ± 7 nm), with narrow size distribution (0.116 ± 0.012) and zeta potential around -50 mV, complying with pharmacopoeial requirements (USP 39-NF 34), wherein there were no significant changes in monitored parameters after one year of storage at 25 ± 2°C. In vitro drug release study demonstrated that 40-50% of diazepam was released from actual nanoemulsions within 1 h, while the kinetic release process could be described by Korsmeyer-Peppas model. The results obtained suggest that formulated parenteral nanoemulsions might be promising carriers for rapid delivery of lipophilic, poorly water-soluble psychopharmacological drugs.
AB  - Cilj ovog istraživanja bio je da se razviju parenteralne nanoemulzije sa rastućom koncentracijom uljane faze (20, 30 i 40% smeše triglicerida srednje dužine lanca i sojinog ulja u odnosu 4:1), stabilizovane kombinacijom lecitina i polisorbata 80, i da se proceni njihova pogodnost kao nosača za slabo rastvorljive psihofarmakološke lekovite supstance. U tu svrhu, homogenizacijom pod visokim pritiskom izrađene su nanoemulzije sa diazepamom kao model lekovitom supstancom i okarakterisane u pogledu veličine kapi, indeksa polidisperznosti, površinskog naelektrisanja, viskoziteta, pH vrednosti i električne provodljivosti. Takođe, primenom reverzne tehnike sa dijaliznim vrećicama procenjena je brzina oslobađanja diazepama iz razvijenih nanoemulzija, uz karakterizaciju dobijenih profila oslobađanja primenom različitih matematičkih modela. Nakon izrade, sve formulacije imale su malu prosečnu veličinu kapi (206 ± 7 nm), sa uskom raspodelom veličina (0,116 ± 0,012) i zeta potencijalom oko -50 mV, što je u skladu sa farmakopejskim zahtevima (USP 39-NF 34) pri čemu se vrednosti navedenih parametara nisu značajno promenile nakon godinu dana čuvanja na 25 ± 2°C. In vitro ispitivanje brzine oslobađanja pokazalo je da se 40-50% diazepama oslobodi iz ispitivanih nanoemulzija tokom 1 h, pri čemu se kinetika oslobađanja može opisati Korsmeyer-Peppas modelom. Dobijeni rezultati ukazuju da formulisane parenteralne nanoemulzije predstavljaju obećavajuće nosače za brzu isporuku slabo rastvorljivih psihofarmakoloških lekovitih supstanci.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study
T1  - Parenteralne nanoemulzije diazepama - fizičkohemijska karakterizacija i in vitro ispitivanje brzine oslobađanja
VL  - 66
IS  - 1
SP  - 24
EP  - 41
DO  - 10.5937/arhfarm1601024D
ER  - 
@article{
author = "Đorđević, Sanela and Isailović, Tanja and Cekić, Nebojša and Vuleta, Gordana and Savić, Snežana",
year = "2016",
abstract = "The aim of the present study was to develop parenteral nanoemulsions containing increasing content of oil phase (20, 30 and 40%, w/w of medium-chain triglycerides-soybean oil mixture at 4:1 ratio), stabilized by lecithin-polysorbate 80 mixture, and to assess their feasibility as carriers for poorly water-soluble psychopharmacological drugs. To this purpose, nanoemulsions loaded with diazepam as a model drug were prepared through high pressure homogenization and characterized regarding droplet size, polydispersity, surface charge, viscosity, pH value, and electrical conductivity. Furthermore, the in vitro release of diazepam from developed nanoemulsions was examined using reverse dialysis bag technique, and drug release kinetics was evaluated through several mathematical models. After preparation, all formulations revealed small mean droplet size (206 ± 7 nm), with narrow size distribution (0.116 ± 0.012) and zeta potential around -50 mV, complying with pharmacopoeial requirements (USP 39-NF 34), wherein there were no significant changes in monitored parameters after one year of storage at 25 ± 2°C. In vitro drug release study demonstrated that 40-50% of diazepam was released from actual nanoemulsions within 1 h, while the kinetic release process could be described by Korsmeyer-Peppas model. The results obtained suggest that formulated parenteral nanoemulsions might be promising carriers for rapid delivery of lipophilic, poorly water-soluble psychopharmacological drugs., Cilj ovog istraživanja bio je da se razviju parenteralne nanoemulzije sa rastućom koncentracijom uljane faze (20, 30 i 40% smeše triglicerida srednje dužine lanca i sojinog ulja u odnosu 4:1), stabilizovane kombinacijom lecitina i polisorbata 80, i da se proceni njihova pogodnost kao nosača za slabo rastvorljive psihofarmakološke lekovite supstance. U tu svrhu, homogenizacijom pod visokim pritiskom izrađene su nanoemulzije sa diazepamom kao model lekovitom supstancom i okarakterisane u pogledu veličine kapi, indeksa polidisperznosti, površinskog naelektrisanja, viskoziteta, pH vrednosti i električne provodljivosti. Takođe, primenom reverzne tehnike sa dijaliznim vrećicama procenjena je brzina oslobađanja diazepama iz razvijenih nanoemulzija, uz karakterizaciju dobijenih profila oslobađanja primenom različitih matematičkih modela. Nakon izrade, sve formulacije imale su malu prosečnu veličinu kapi (206 ± 7 nm), sa uskom raspodelom veličina (0,116 ± 0,012) i zeta potencijalom oko -50 mV, što je u skladu sa farmakopejskim zahtevima (USP 39-NF 34) pri čemu se vrednosti navedenih parametara nisu značajno promenile nakon godinu dana čuvanja na 25 ± 2°C. In vitro ispitivanje brzine oslobađanja pokazalo je da se 40-50% diazepama oslobodi iz ispitivanih nanoemulzija tokom 1 h, pri čemu se kinetika oslobađanja može opisati Korsmeyer-Peppas modelom. Dobijeni rezultati ukazuju da formulisane parenteralne nanoemulzije predstavljaju obećavajuće nosače za brzu isporuku slabo rastvorljivih psihofarmakoloških lekovitih supstanci.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study, Parenteralne nanoemulzije diazepama - fizičkohemijska karakterizacija i in vitro ispitivanje brzine oslobađanja",
volume = "66",
number = "1",
pages = "24-41",
doi = "10.5937/arhfarm1601024D"
}
Đorđević, S., Isailović, T., Cekić, N., Vuleta, G.,& Savić, S.. (2016). Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 66(1), 24-41.
https://doi.org/10.5937/arhfarm1601024D
Đorđević S, Isailović T, Cekić N, Vuleta G, Savić S. Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study. in Arhiv za farmaciju. 2016;66(1):24-41.
doi:10.5937/arhfarm1601024D .
Đorđević, Sanela, Isailović, Tanja, Cekić, Nebojša, Vuleta, Gordana, Savić, Snežana, "Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study" in Arhiv za farmaciju, 66, no. 1 (2016):24-41,
https://doi.org/10.5937/arhfarm1601024D . .
3
4

Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?

Filipović, Mila; Gledović, Ana; Lukić, Milica; Tasić-Kostov, Marija; Isailović, Tanja; Pantelić, Ivana; Vuleta, Gordana; Savić, Snežana

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2016)

TY  - JOUR
AU  - Filipović, Mila
AU  - Gledović, Ana
AU  - Lukić, Milica
AU  - Tasić-Kostov, Marija
AU  - Isailović, Tanja
AU  - Pantelić, Ivana
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2628
AB  - Background/Aim. Since skin moisturization may be achieved by both actives and chosen carrier, plant stem cells, squalene and natural alkyl polyglucoside emulsifier may be potential components of contemporary cosmetic products. The aim of the study was in vivo evaluation of the skin irritation potential and the efficacy of Alpine Rose stem cells incorporated into liposomes and olive oil squalene as ingredients of moisturizing creams, with respect to the novel emulsifier used for creams' stabilization. Methods. With the employment of noninvasive skin biophysical measurements, skin hydration (EC), transepidermal water loss (TEWL), erythema index (EI) and viscoelasticity were measured on 76 healthy volunteers. In the first phase, skin irritation after a 24-hour occlusion and the long-term efficacy of creams (a 21-day study) on healthy skin were evaluated. Phase II of the study focused on the cream efficacy assessment after a 6-day treatment of sodium lauryl sulfate-irritated skin. Results. After a 24-hour occlusion, there were no significant changes in the EI for any tested sample. In the second phase of the study, the EI was not significantly altered for the cream containing squalene, while the application of all active samples resulted in a significant reduction of TEWL. In both phases of the study an EC increase was recorded, especially for the squalene-containing cream. Conclusion. Due to the lack of skin irritation and skin barrier impairment along with the marked hydration effect, it could be said that the investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams may be safely applied as ingredients for "tailor-made" cosmetic moisturizers intended for normal and dry skin care, whereas olive oil squalene could be used for the treatment of irritated or sensitive skin as well.
AB  - Uvod/Cilj. S obzirom na to da vlaženje kože može biti postignuto izborom kako aktivnih supstanci, tako i odgovarajućeg nosača, biljne matične ćelije, skvalen i prirodni alkil poliglukozidni emulgator mogu biti potencijalni sastojci savremenih kozmetičkih proizvoda. Cilj ovog rada bio je in vivo procena iritiranog potencijala i efikasnosti matičnih ćelija alpske ruže dodatih u liposome i skvalena maslinovog ulja, kao sastojaka vlažećih krema, imajući u vidu nov emulgator koji je korišćen za njihovu stabilizaciju. Metode. Upotrebom neinvazivnih metoda zasnovanih na biofizičkim merenjima na koži, kod 76 zdravih dobrovoljaca mereni su: hidratacija kože (EC), transepidermalni gubitak vlage (TEWL), eritema indeks (EI) i viskoelastičnost kože. U prvoj fazi studije vršena je procena iritacije kože nakon 24-h okluzije, kao i procena efikasnosti krema nakon primene na zdravoj koži dobrovoljaca u trajanju od 21 dana. Druga faza studije bila je bazirana na proceni efikasnosti krema nakon 6-dnevnog tretmana kože prethodno iritirane natrijum-lauril-sulfatom. Rezultati. Nakon 24-h okluzije nije bilo značajne promene vrednosti EI ni kod jednog ispitivanog krema. U drugoj fazi studije, krem sa skvalenom nije značajno uticao na promenu vrednosti EI, dok je primena svih aktivnih krema dovela do značajnog sniženja vrednosti TEWL. U obe faze studije zabeležen je porast EC, naročito nakon primene krema koji sadrži skvalen. Zaključak. Uzevši u obzir odsustvo nadraženosti kože i narušavanja kožne barijere, kao i porast hidratacije površinskog sloja kože, može se reći da se ispitivane aktivne supstance ubačene u kreme stabilizovane alkil-poliglukozidnim emulgatorom mogu bezbedno koristiti kao komponente tzv. "skrojenih" kozmetičkih ovlaživača namenjenih za negu zdrave i suve kože, dok se skvalen maslinovog ulja može koristiti i za negu iritirane i osetljive kože.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?
T1  - Matične ćelije alpske ruže, skvalen maslinovog ulja i prirodni alkil-poliglukozidni emulgator - da li su odgovarajući sastojci kremova za vlaženje - in vivo efikasnost na zdravoj i koži iritiranoj natrijum lauril sulfatom?
VL  - 73
IS  - 11
SP  - 991
EP  - 1002
DO  - 10.2298/VSP150116122F
ER  - 
@article{
author = "Filipović, Mila and Gledović, Ana and Lukić, Milica and Tasić-Kostov, Marija and Isailović, Tanja and Pantelić, Ivana and Vuleta, Gordana and Savić, Snežana",
year = "2016",
abstract = "Background/Aim. Since skin moisturization may be achieved by both actives and chosen carrier, plant stem cells, squalene and natural alkyl polyglucoside emulsifier may be potential components of contemporary cosmetic products. The aim of the study was in vivo evaluation of the skin irritation potential and the efficacy of Alpine Rose stem cells incorporated into liposomes and olive oil squalene as ingredients of moisturizing creams, with respect to the novel emulsifier used for creams' stabilization. Methods. With the employment of noninvasive skin biophysical measurements, skin hydration (EC), transepidermal water loss (TEWL), erythema index (EI) and viscoelasticity were measured on 76 healthy volunteers. In the first phase, skin irritation after a 24-hour occlusion and the long-term efficacy of creams (a 21-day study) on healthy skin were evaluated. Phase II of the study focused on the cream efficacy assessment after a 6-day treatment of sodium lauryl sulfate-irritated skin. Results. After a 24-hour occlusion, there were no significant changes in the EI for any tested sample. In the second phase of the study, the EI was not significantly altered for the cream containing squalene, while the application of all active samples resulted in a significant reduction of TEWL. In both phases of the study an EC increase was recorded, especially for the squalene-containing cream. Conclusion. Due to the lack of skin irritation and skin barrier impairment along with the marked hydration effect, it could be said that the investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams may be safely applied as ingredients for "tailor-made" cosmetic moisturizers intended for normal and dry skin care, whereas olive oil squalene could be used for the treatment of irritated or sensitive skin as well., Uvod/Cilj. S obzirom na to da vlaženje kože može biti postignuto izborom kako aktivnih supstanci, tako i odgovarajućeg nosača, biljne matične ćelije, skvalen i prirodni alkil poliglukozidni emulgator mogu biti potencijalni sastojci savremenih kozmetičkih proizvoda. Cilj ovog rada bio je in vivo procena iritiranog potencijala i efikasnosti matičnih ćelija alpske ruže dodatih u liposome i skvalena maslinovog ulja, kao sastojaka vlažećih krema, imajući u vidu nov emulgator koji je korišćen za njihovu stabilizaciju. Metode. Upotrebom neinvazivnih metoda zasnovanih na biofizičkim merenjima na koži, kod 76 zdravih dobrovoljaca mereni su: hidratacija kože (EC), transepidermalni gubitak vlage (TEWL), eritema indeks (EI) i viskoelastičnost kože. U prvoj fazi studije vršena je procena iritacije kože nakon 24-h okluzije, kao i procena efikasnosti krema nakon primene na zdravoj koži dobrovoljaca u trajanju od 21 dana. Druga faza studije bila je bazirana na proceni efikasnosti krema nakon 6-dnevnog tretmana kože prethodno iritirane natrijum-lauril-sulfatom. Rezultati. Nakon 24-h okluzije nije bilo značajne promene vrednosti EI ni kod jednog ispitivanog krema. U drugoj fazi studije, krem sa skvalenom nije značajno uticao na promenu vrednosti EI, dok je primena svih aktivnih krema dovela do značajnog sniženja vrednosti TEWL. U obe faze studije zabeležen je porast EC, naročito nakon primene krema koji sadrži skvalen. Zaključak. Uzevši u obzir odsustvo nadraženosti kože i narušavanja kožne barijere, kao i porast hidratacije površinskog sloja kože, može se reći da se ispitivane aktivne supstance ubačene u kreme stabilizovane alkil-poliglukozidnim emulgatorom mogu bezbedno koristiti kao komponente tzv. "skrojenih" kozmetičkih ovlaživača namenjenih za negu zdrave i suve kože, dok se skvalen maslinovog ulja može koristiti i za negu iritirane i osetljive kože.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?, Matične ćelije alpske ruže, skvalen maslinovog ulja i prirodni alkil-poliglukozidni emulgator - da li su odgovarajući sastojci kremova za vlaženje - in vivo efikasnost na zdravoj i koži iritiranoj natrijum lauril sulfatom?",
volume = "73",
number = "11",
pages = "991-1002",
doi = "10.2298/VSP150116122F"
}
Filipović, M., Gledović, A., Lukić, M., Tasić-Kostov, M., Isailović, T., Pantelić, I., Vuleta, G.,& Savić, S.. (2016). Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(11), 991-1002.
https://doi.org/10.2298/VSP150116122F
Filipović M, Gledović A, Lukić M, Tasić-Kostov M, Isailović T, Pantelić I, Vuleta G, Savić S. Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?. in Vojnosanitetski pregled. 2016;73(11):991-1002.
doi:10.2298/VSP150116122F .
Filipović, Mila, Gledović, Ana, Lukić, Milica, Tasić-Kostov, Marija, Isailović, Tanja, Pantelić, Ivana, Vuleta, Gordana, Savić, Snežana, "Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?" in Vojnosanitetski pregled, 73, no. 11 (2016):991-1002,
https://doi.org/10.2298/VSP150116122F . .
7
3
7

Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies

Filipović, Mila; Lukić, Milica; Krstonosić, Veljko; Đorđević, Sanela; Pantelić, Ivana; Gledović, Ana; Vuleta, Gordana; Savić, Snežana

(Carl Hanser Verlag, Munich, 2016)

TY  - JOUR
AU  - Filipović, Mila
AU  - Lukić, Milica
AU  - Krstonosić, Veljko
AU  - Đorđević, Sanela
AU  - Pantelić, Ivana
AU  - Gledović, Ana
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2527
AB  - During the formulation of liposome-containing products different problems can occur and the selection of a suitable carrier remains the greatest challenge. To estimate feasibility of a novel alkyl polyglucoside surfactant (hydroxystearyl alcohol and hydroxystearyl glucoside) as an emulsifier for cosmetics with liposome-encapsulated plant stem cells, we performed a two-phase study. In the first, the pre-formulation phase, the emulsifier's critical micelle concentration (CMC) and liposome-encapsulated active-emulsifier interactions were determined. The second phase was carried out to develop and characterize a cosmetic emulsion suitable to serve as a carrier for liposomes. The investigated emulsifier, with the obtained CMC value of 0.0085 wt.%, could be classified as liposome-friendly and can be used to develop stable and aesthetically acceptable cosmetics or even prospective pharmaceutical liposome-containing emulsions.
PB  - Carl Hanser Verlag, Munich
T2  - Tenside Surfactants Detergents
T1  - Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies
VL  - 53
IS  - 3
SP  - 214
EP  - 226
DO  - 10.3139/113.110426
ER  - 
@article{
author = "Filipović, Mila and Lukić, Milica and Krstonosić, Veljko and Đorđević, Sanela and Pantelić, Ivana and Gledović, Ana and Vuleta, Gordana and Savić, Snežana",
year = "2016",
abstract = "During the formulation of liposome-containing products different problems can occur and the selection of a suitable carrier remains the greatest challenge. To estimate feasibility of a novel alkyl polyglucoside surfactant (hydroxystearyl alcohol and hydroxystearyl glucoside) as an emulsifier for cosmetics with liposome-encapsulated plant stem cells, we performed a two-phase study. In the first, the pre-formulation phase, the emulsifier's critical micelle concentration (CMC) and liposome-encapsulated active-emulsifier interactions were determined. The second phase was carried out to develop and characterize a cosmetic emulsion suitable to serve as a carrier for liposomes. The investigated emulsifier, with the obtained CMC value of 0.0085 wt.%, could be classified as liposome-friendly and can be used to develop stable and aesthetically acceptable cosmetics or even prospective pharmaceutical liposome-containing emulsions.",
publisher = "Carl Hanser Verlag, Munich",
journal = "Tenside Surfactants Detergents",
title = "Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies",
volume = "53",
number = "3",
pages = "214-226",
doi = "10.3139/113.110426"
}
Filipović, M., Lukić, M., Krstonosić, V., Đorđević, S., Pantelić, I., Gledović, A., Vuleta, G.,& Savić, S.. (2016). Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies. in Tenside Surfactants Detergents
Carl Hanser Verlag, Munich., 53(3), 214-226.
https://doi.org/10.3139/113.110426
Filipović M, Lukić M, Krstonosić V, Đorđević S, Pantelić I, Gledović A, Vuleta G, Savić S. Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies. in Tenside Surfactants Detergents. 2016;53(3):214-226.
doi:10.3139/113.110426 .
Filipović, Mila, Lukić, Milica, Krstonosić, Veljko, Đorđević, Sanela, Pantelić, Ivana, Gledović, Ana, Vuleta, Gordana, Savić, Snežana, "Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies" in Tenside Surfactants Detergents, 53, no. 3 (2016):214-226,
https://doi.org/10.3139/113.110426 . .
6
3
7

Development and validation of an LC-MS/MS method for the determination of adapalene in pharmaceutical forms for skin application

Dobričić, Vladimir; Bubić-Pajić, Nataša; Marković, Bojan; Vladimirov, Sote; Savić, Snežana; Vuleta, Gordana

(Srpsko hemijsko društvo, Beograd, 2016)

TY  - JOUR
AU  - Dobričić, Vladimir
AU  - Bubić-Pajić, Nataša
AU  - Marković, Bojan
AU  - Vladimirov, Sote
AU  - Savić, Snežana
AU  - Vuleta, Gordana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2627
AB  - The development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of adapalene in pharmaceutical forms for skin application were presented in this study. The MS/MS analysis of adapalene was performed by use of three mobile phases, consisted of acetonitrile and a) 0.1 % formic acid, b) 0.1 % trifluoroacetic acid and c) 20 mM ammonium acetate. The strongest signals of parent ion and dominant product ion were obtained in negative mode by use of the mobile phase c). The validation of this method was performed according to the ICH guidelines. Small variations of selected chromatographic parameters (concentration of ammonium acetate, mobile phase composition, column temperature and flow rate) did not affect significantly the qualitative and quantitative system responses, which proved the method's robustness. The method is specific for the determination of adapalene. The linearity was proved in the concentration range of 6.7-700.0 ng mL(-1) (r = 0.9990), with limits of detection and quantification of 2.0 and 6.7 ng mL(-1), respectively. The accuracy was confirmed by calculated recoveries (98.4-101.5 %). The precision was tested at three levels: injection repeatability, analysis repeatability and intermediate precision. The calculated relative standard deviations were less than 1, 2 and 3 %, respectively.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Development and validation of an LC-MS/MS method for the determination of adapalene in pharmaceutical forms for skin application
VL  - 81
IS  - 10
SP  - 1171
EP  - 1181
DO  - 10.2298/JSC160215066D
ER  - 
@article{
author = "Dobričić, Vladimir and Bubić-Pajić, Nataša and Marković, Bojan and Vladimirov, Sote and Savić, Snežana and Vuleta, Gordana",
year = "2016",
abstract = "The development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of adapalene in pharmaceutical forms for skin application were presented in this study. The MS/MS analysis of adapalene was performed by use of three mobile phases, consisted of acetonitrile and a) 0.1 % formic acid, b) 0.1 % trifluoroacetic acid and c) 20 mM ammonium acetate. The strongest signals of parent ion and dominant product ion were obtained in negative mode by use of the mobile phase c). The validation of this method was performed according to the ICH guidelines. Small variations of selected chromatographic parameters (concentration of ammonium acetate, mobile phase composition, column temperature and flow rate) did not affect significantly the qualitative and quantitative system responses, which proved the method's robustness. The method is specific for the determination of adapalene. The linearity was proved in the concentration range of 6.7-700.0 ng mL(-1) (r = 0.9990), with limits of detection and quantification of 2.0 and 6.7 ng mL(-1), respectively. The accuracy was confirmed by calculated recoveries (98.4-101.5 %). The precision was tested at three levels: injection repeatability, analysis repeatability and intermediate precision. The calculated relative standard deviations were less than 1, 2 and 3 %, respectively.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Development and validation of an LC-MS/MS method for the determination of adapalene in pharmaceutical forms for skin application",
volume = "81",
number = "10",
pages = "1171-1181",
doi = "10.2298/JSC160215066D"
}
Dobričić, V., Bubić-Pajić, N., Marković, B., Vladimirov, S., Savić, S.,& Vuleta, G.. (2016). Development and validation of an LC-MS/MS method for the determination of adapalene in pharmaceutical forms for skin application. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 81(10), 1171-1181.
https://doi.org/10.2298/JSC160215066D
Dobričić V, Bubić-Pajić N, Marković B, Vladimirov S, Savić S, Vuleta G. Development and validation of an LC-MS/MS method for the determination of adapalene in pharmaceutical forms for skin application. in Journal of the Serbian Chemical Society. 2016;81(10):1171-1181.
doi:10.2298/JSC160215066D .
Dobričić, Vladimir, Bubić-Pajić, Nataša, Marković, Bojan, Vladimirov, Sote, Savić, Snežana, Vuleta, Gordana, "Development and validation of an LC-MS/MS method for the determination of adapalene in pharmaceutical forms for skin application" in Journal of the Serbian Chemical Society, 81, no. 10 (2016):1171-1181,
https://doi.org/10.2298/JSC160215066D . .
5
2
4

Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs

Pantelić, Ivana; Milić, Jela; Vuleta, Gordana; Dragičević, Nina; Savić, Snežana

(Springer Berlin Heidelberg, 2015)

TY  - CHAP
AU  - Pantelić, Ivana
AU  - Milić, Jela
AU  - Vuleta, Gordana
AU  - Dragičević, Nina
AU  - Savić, Snežana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2506
AB  - Due to the unceasing progress in design of novel emulsifiers, powerful influence of the ongoing ‘green’ trends in cosmetic industry, but also global environmental concerns, there is an increasing demand in development and application of natural-origin, biodegradable and skin-friendly emulsifiers. The present work aims to provide a deeper insight into the group of alkyl polyglucoside emulsifiers and their prospective impact on drug percutaneous permeation. Complexity of the observed lamellar liquid crystal and lamellar gel phases, which represent the basic mechanism of physical stabilisation by the alkyl polyglucosides, entails a comprehensive physicochemical evaluation of any alkyl polyglucoside-based prospective vehicle, prior to assessing its impact on skin absorption. Research conducted so far has suggested several possible mechanisms of alkyl polyglucoside-mediated percutaneous penetration enhancement, which are carefully elaborated throughout the chapter: (1) the observed similarity between the aforementioned complex structures which dominate alkyl polyglucoside-stabilised systems and the inherent stratum corneum lipid ordering could enhance penetration due to the optimal balance between their order and fluidity, (2) the observed complex colloidal structure may lead to diverse modes of water distribution within these systems, providing sustained skin hydration and hence improved skin permeability, and/or (3) the impact on a drug’s thermodynamic activity, easily tailored by the addition of various co-solvents/potential penetration enhancers.
PB  - Springer Berlin Heidelberg
T2  - Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the
T1  - Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs
SP  - 231
EP  - 250
DO  - 10.1007/978-3-662-47039-8_14
ER  - 
@inbook{
author = "Pantelić, Ivana and Milić, Jela and Vuleta, Gordana and Dragičević, Nina and Savić, Snežana",
year = "2015",
abstract = "Due to the unceasing progress in design of novel emulsifiers, powerful influence of the ongoing ‘green’ trends in cosmetic industry, but also global environmental concerns, there is an increasing demand in development and application of natural-origin, biodegradable and skin-friendly emulsifiers. The present work aims to provide a deeper insight into the group of alkyl polyglucoside emulsifiers and their prospective impact on drug percutaneous permeation. Complexity of the observed lamellar liquid crystal and lamellar gel phases, which represent the basic mechanism of physical stabilisation by the alkyl polyglucosides, entails a comprehensive physicochemical evaluation of any alkyl polyglucoside-based prospective vehicle, prior to assessing its impact on skin absorption. Research conducted so far has suggested several possible mechanisms of alkyl polyglucoside-mediated percutaneous penetration enhancement, which are carefully elaborated throughout the chapter: (1) the observed similarity between the aforementioned complex structures which dominate alkyl polyglucoside-stabilised systems and the inherent stratum corneum lipid ordering could enhance penetration due to the optimal balance between their order and fluidity, (2) the observed complex colloidal structure may lead to diverse modes of water distribution within these systems, providing sustained skin hydration and hence improved skin permeability, and/or (3) the impact on a drug’s thermodynamic activity, easily tailored by the addition of various co-solvents/potential penetration enhancers.",
publisher = "Springer Berlin Heidelberg",
journal = "Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the",
booktitle = "Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs",
pages = "231-250",
doi = "10.1007/978-3-662-47039-8_14"
}
Pantelić, I., Milić, J., Vuleta, G., Dragičević, N.,& Savić, S.. (2015). Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs. in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the
Springer Berlin Heidelberg., 231-250.
https://doi.org/10.1007/978-3-662-47039-8_14
Pantelić I, Milić J, Vuleta G, Dragičević N, Savić S. Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs. in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the. 2015;:231-250.
doi:10.1007/978-3-662-47039-8_14 .
Pantelić, Ivana, Milić, Jela, Vuleta, Gordana, Dragičević, Nina, Savić, Snežana, "Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs" in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the (2015):231-250,
https://doi.org/10.1007/978-3-662-47039-8_14 . .
3
2

Cosmetic ingredients from the sea in skin care products

Emeti, Ana; Vasiljević, Dragana; Primorac, Marija; Vuleta, Gordana

(Savez farmaceutskih udruženja Srbije, Beograd, 2015)

TY  - JOUR
AU  - Emeti, Ana
AU  - Vasiljević, Dragana
AU  - Primorac, Marija
AU  - Vuleta, Gordana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2500
AB  - Sea water, salt and mud have been used for centuries in beautification treatments, but their active ingredients have become a recent challenge in formulating new cosmetic products. Cosmetic ingredients which originate from the sea, are mostly obtained from algae, microalgae, marine sponges, corals and microorganisms. Exopolysaccharides (EPS) are new cosmetic ingredients produced by marine micro-organisms. They are used to protect skin from harmful external influences, give it softness and minimize fine lines. Pseudopterosins, present in the extracts of corals, are used to soothe the skin, while marine sponges are one of the major alternative to animal-derived collagen. Algae have been the most researched group, with the greatest potential among different sources of marine ingredients. Carrageenan, agar, and alginates from algae act as humectants, thickeners and gelling agents. The active ingredients of algae extracts (polysaccharides, proteins, vitamins, minerals) could hydrate, minimize fine lines, protect the skin from UV radiation, decrease redness and cellulite.
AB  - Morska voda, so i mulj koriste se od davnina u tretmanima za ulepšavanje, ali se njihovi aktivni sastojci tek od nedavno koriste za izradu kozmetičkih proizvoda. Kozmetičke sirovine poreklom iz mora najviše se dobijaju iz algi i mikroalgi, mikroorganizama, sunđera i korala. Egzopolisaharidi su novije kozmetičke sirovine koje proizvode morski mikroorganizmi. Navodi se da oni štite kožu od štetnih spoljašnjih uticaja, daju joj mekoću i smanjuju fine linije. Ekstrakti mikroalgi deluju antioksidantno i podstiču sintezu kolagena tipa I. Ekstrakt korala sa pseudopterozinima se koristi za umirivanje kože, dok su morski sunđeri jedan od najvećih alternativnih izvora za dobijanje kolagena. Od svih sirovina poreklom iz mora, alge su najviše istražene i imaju najveći potencijal. Iz algi se dobijaju karagen, agar i alginati, koji se koriste kao humektansi, ugušćivači i gelirajuća sredstva. Aktivni sastojci ekstrakata algi (polisaharidi, proteini, vitamini, minerali) hidriraju kožu, smanjuju fine linije, štite kožu od UV zraka, smanjuju crvenilo kože, a koriste se i u kozmetičkim proizvodima za smanjenje celulita.
AB  - Although some widespread, native cow parsnips (Heracleum L. spp., Apiaceae) had broad medicinal and culinary applications throughout history, the knowledge about their volatile constituents is insufficient. This work investigates the composition and bioactivities of H. sphondylium L. (HSPH), H. sibiricum L. (HSIB) and H. montanum Schleich. ex Gaudin (HMON) essential oils. The composition was tested by GC and GC-MS. (Z)-β-Ocimene was the most abundant in HSPH (28.9%) and HMON (20.4%) root oils, while in HSIB root oil, β-pinene (26.2%), methyl eugenol (22.3%) and elemicin (25.6%) prevailed. Leaf and flower oils were dominated by various sesquiterpenes (germacrene D, β-sesquiphellandrene, (E)-β-farnesene and/or (E)-caryophyllene) and/or phenylpropanoids (apiole, methyl eugenol, elemicin and/or (Z)-isoelemicin). Octyl acetate (57.5-67.1%) was the main constituent of all fruit oils. The antimicrobial activity was screened by a microdilution method against eight bacteria and eight fungi. The strongest antimicrobial effect, in several cases better than the activity of antibiotics, was shown by HSPH (MICs = 0.12-3.30 mg mL-1) and HMON (MICs = 0.10-1.30 mg mL-1) flower oils against bacteria, and HSIB fruit oil against fungi (MICs = 0.15-0.40 mg mL-1). The MTT test revealed that the oils were not or weakly cytotoxic against human malignant HeLa, LS174 and/or A549 cells (except HSPH root oil; IC50 = 5.72-24.31 μg mL-1) and that tested oils were not toxic against human normal MRC-5 cells (at 200.00 μg mL-1). Significant activity observed against microorganisms that are the common cause of foodborne diseases, food contamination and/or hospital-acquired infections justifies certain traditional uses of the investigated plants and represents a good basis for further research of these Heracleum oils.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Cosmetic ingredients from the sea in skin care products
T1  - Kozmetičke sirovine poreklom iz mora u proizvodima za negu kože
VL  - 65
IS  - 5
SP  - 316
EP  - 325
DO  - 10.5937/arhfarm1505316E
ER  - 
@article{
author = "Emeti, Ana and Vasiljević, Dragana and Primorac, Marija and Vuleta, Gordana",
year = "2015",
abstract = "Sea water, salt and mud have been used for centuries in beautification treatments, but their active ingredients have become a recent challenge in formulating new cosmetic products. Cosmetic ingredients which originate from the sea, are mostly obtained from algae, microalgae, marine sponges, corals and microorganisms. Exopolysaccharides (EPS) are new cosmetic ingredients produced by marine micro-organisms. They are used to protect skin from harmful external influences, give it softness and minimize fine lines. Pseudopterosins, present in the extracts of corals, are used to soothe the skin, while marine sponges are one of the major alternative to animal-derived collagen. Algae have been the most researched group, with the greatest potential among different sources of marine ingredients. Carrageenan, agar, and alginates from algae act as humectants, thickeners and gelling agents. The active ingredients of algae extracts (polysaccharides, proteins, vitamins, minerals) could hydrate, minimize fine lines, protect the skin from UV radiation, decrease redness and cellulite., Morska voda, so i mulj koriste se od davnina u tretmanima za ulepšavanje, ali se njihovi aktivni sastojci tek od nedavno koriste za izradu kozmetičkih proizvoda. Kozmetičke sirovine poreklom iz mora najviše se dobijaju iz algi i mikroalgi, mikroorganizama, sunđera i korala. Egzopolisaharidi su novije kozmetičke sirovine koje proizvode morski mikroorganizmi. Navodi se da oni štite kožu od štetnih spoljašnjih uticaja, daju joj mekoću i smanjuju fine linije. Ekstrakti mikroalgi deluju antioksidantno i podstiču sintezu kolagena tipa I. Ekstrakt korala sa pseudopterozinima se koristi za umirivanje kože, dok su morski sunđeri jedan od najvećih alternativnih izvora za dobijanje kolagena. Od svih sirovina poreklom iz mora, alge su najviše istražene i imaju najveći potencijal. Iz algi se dobijaju karagen, agar i alginati, koji se koriste kao humektansi, ugušćivači i gelirajuća sredstva. Aktivni sastojci ekstrakata algi (polisaharidi, proteini, vitamini, minerali) hidriraju kožu, smanjuju fine linije, štite kožu od UV zraka, smanjuju crvenilo kože, a koriste se i u kozmetičkim proizvodima za smanjenje celulita., Although some widespread, native cow parsnips (Heracleum L. spp., Apiaceae) had broad medicinal and culinary applications throughout history, the knowledge about their volatile constituents is insufficient. This work investigates the composition and bioactivities of H. sphondylium L. (HSPH), H. sibiricum L. (HSIB) and H. montanum Schleich. ex Gaudin (HMON) essential oils. The composition was tested by GC and GC-MS. (Z)-β-Ocimene was the most abundant in HSPH (28.9%) and HMON (20.4%) root oils, while in HSIB root oil, β-pinene (26.2%), methyl eugenol (22.3%) and elemicin (25.6%) prevailed. Leaf and flower oils were dominated by various sesquiterpenes (germacrene D, β-sesquiphellandrene, (E)-β-farnesene and/or (E)-caryophyllene) and/or phenylpropanoids (apiole, methyl eugenol, elemicin and/or (Z)-isoelemicin). Octyl acetate (57.5-67.1%) was the main constituent of all fruit oils. The antimicrobial activity was screened by a microdilution method against eight bacteria and eight fungi. The strongest antimicrobial effect, in several cases better than the activity of antibiotics, was shown by HSPH (MICs = 0.12-3.30 mg mL-1) and HMON (MICs = 0.10-1.30 mg mL-1) flower oils against bacteria, and HSIB fruit oil against fungi (MICs = 0.15-0.40 mg mL-1). The MTT test revealed that the oils were not or weakly cytotoxic against human malignant HeLa, LS174 and/or A549 cells (except HSPH root oil; IC50 = 5.72-24.31 μg mL-1) and that tested oils were not toxic against human normal MRC-5 cells (at 200.00 μg mL-1). Significant activity observed against microorganisms that are the common cause of foodborne diseases, food contamination and/or hospital-acquired infections justifies certain traditional uses of the investigated plants and represents a good basis for further research of these Heracleum oils.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Cosmetic ingredients from the sea in skin care products, Kozmetičke sirovine poreklom iz mora u proizvodima za negu kože",
volume = "65",
number = "5",
pages = "316-325",
doi = "10.5937/arhfarm1505316E"
}
Emeti, A., Vasiljević, D., Primorac, M.,& Vuleta, G.. (2015). Cosmetic ingredients from the sea in skin care products. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 65(5), 316-325.
https://doi.org/10.5937/arhfarm1505316E
Emeti A, Vasiljević D, Primorac M, Vuleta G. Cosmetic ingredients from the sea in skin care products. in Arhiv za farmaciju. 2015;65(5):316-325.
doi:10.5937/arhfarm1505316E .
Emeti, Ana, Vasiljević, Dragana, Primorac, Marija, Vuleta, Gordana, "Cosmetic ingredients from the sea in skin care products" in Arhiv za farmaciju, 65, no. 5 (2015):316-325,
https://doi.org/10.5937/arhfarm1505316E . .

Towards Alkyl Polyglucoside-stabilized formulations: Influence of some common excipients

Pantelić, Ivana; Lukić, Milica; Vuleta, Gordana; Savić, Snežana

(Elsevier Inc., 2014)

TY  - CHAP
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2253
AB  - When formulating topical drugs, research and development departments usually create preparations containing only essential components, while the cosmetic industry formulates more complex vehicles. This chapter reviews Alkyl Polyglucoside-related studies on the formulation of topical preparations. Some APG surfactants form liquid crystalline phases, and other excipients may become components of these mesophases, affecting self-assembly processes prior to liquid crystalline phase formation. Co-stabilization of APG-based systems with lipophilic and hydrophilic stabilizers has been attempted. Some novel APG co-surfactants have also been introduced. Oils of different polarity have been investigated, either as the single component of the oil phase or in complex mixtures. Finally, since many entities intended for topical application are poorly water-soluble, suitable co-solvents, preferably also acting as penetration enhancers, are discussed in detail.
PB  - Elsevier Inc.
T2  - Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems
T1  - Towards Alkyl Polyglucoside-stabilized formulations: Influence of some common excipients
SP  - 53
EP  - 72
DO  - 10.1533/9781908818775.53
ER  - 
@inbook{
author = "Pantelić, Ivana and Lukić, Milica and Vuleta, Gordana and Savić, Snežana",
year = "2014",
abstract = "When formulating topical drugs, research and development departments usually create preparations containing only essential components, while the cosmetic industry formulates more complex vehicles. This chapter reviews Alkyl Polyglucoside-related studies on the formulation of topical preparations. Some APG surfactants form liquid crystalline phases, and other excipients may become components of these mesophases, affecting self-assembly processes prior to liquid crystalline phase formation. Co-stabilization of APG-based systems with lipophilic and hydrophilic stabilizers has been attempted. Some novel APG co-surfactants have also been introduced. Oils of different polarity have been investigated, either as the single component of the oil phase or in complex mixtures. Finally, since many entities intended for topical application are poorly water-soluble, suitable co-solvents, preferably also acting as penetration enhancers, are discussed in detail.",
publisher = "Elsevier Inc.",
journal = "Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems",
booktitle = "Towards Alkyl Polyglucoside-stabilized formulations: Influence of some common excipients",
pages = "53-72",
doi = "10.1533/9781908818775.53"
}
Pantelić, I., Lukić, M., Vuleta, G.,& Savić, S.. (2014). Towards Alkyl Polyglucoside-stabilized formulations: Influence of some common excipients. in Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems
Elsevier Inc.., 53-72.
https://doi.org/10.1533/9781908818775.53
Pantelić I, Lukić M, Vuleta G, Savić S. Towards Alkyl Polyglucoside-stabilized formulations: Influence of some common excipients. in Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems. 2014;:53-72.
doi:10.1533/9781908818775.53 .
Pantelić, Ivana, Lukić, Milica, Vuleta, Gordana, Savić, Snežana, "Towards Alkyl Polyglucoside-stabilized formulations: Influence of some common excipients" in Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems (2014):53-72,
https://doi.org/10.1533/9781908818775.53 . .
5
5

Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods

Pantelić, Ivana; Lukić, Milica; Marković, Bojan; Daniels, Rolf; Vesić, Sonja; Vuleta, Gordana; Savić, Snežana

(Taylor & Francis Ltd, Abingdon, 2014)

TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Marković, Bojan
AU  - Daniels, Rolf
AU  - Vesić, Sonja
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2177
AB  - Context: Alkyl polyglucoside surfactants (APG) remain prominent natural origin stabilizers offering a prospect of combining satisfactory stability with mild dermatological properties and complete biodegradability. Objective: With the purpose of adjusting the dose to a patient's needs, dilution of commercial corticosteroid formulations is a practice which may modify efficacy uncontrolledly. The rational of the study was to investigate whether a simple change in ready-to-use bases (co-solvent addition) could address these needs in a more predictive manner. Methods: Hydrocortisone (HC) delivery from such emulsion systems was comparatively assessed employing two in vivo methods: the established human skin blanching assay versus skin stripping technique. Results: HC permeation data obtained after three dose durations showed better overall performance of the APG-stabilized bases relative to reference ones. Although the solubility study showed that all the assessed active samples retained equal thermodynamic activity, diverse HC permeation/penetration implies the importance of the applied base's colloidal structure and/or changes endured. Isopropyl alcohol (IPA) addition offered faster drug penetration enhancement, while glycerol as a moisturizing agent influenced HC penetration through the increase in skin hydration. Conclusion: Although the performed in vivo methods cannot be considered alternative, skin stripping technique proved to be a cost-efficient mode of percutaneous penetration assessment, providing additional information on vehicle-skin interactions.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Pharmaceutical Development and Technology
T1  - Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods
VL  - 19
IS  - 1
SP  - 55
EP  - 64
DO  - 10.3109/10837450.2012.751407
ER  - 
@article{
author = "Pantelić, Ivana and Lukić, Milica and Marković, Bojan and Daniels, Rolf and Vesić, Sonja and Vuleta, Gordana and Savić, Snežana",
year = "2014",
abstract = "Context: Alkyl polyglucoside surfactants (APG) remain prominent natural origin stabilizers offering a prospect of combining satisfactory stability with mild dermatological properties and complete biodegradability. Objective: With the purpose of adjusting the dose to a patient's needs, dilution of commercial corticosteroid formulations is a practice which may modify efficacy uncontrolledly. The rational of the study was to investigate whether a simple change in ready-to-use bases (co-solvent addition) could address these needs in a more predictive manner. Methods: Hydrocortisone (HC) delivery from such emulsion systems was comparatively assessed employing two in vivo methods: the established human skin blanching assay versus skin stripping technique. Results: HC permeation data obtained after three dose durations showed better overall performance of the APG-stabilized bases relative to reference ones. Although the solubility study showed that all the assessed active samples retained equal thermodynamic activity, diverse HC permeation/penetration implies the importance of the applied base's colloidal structure and/or changes endured. Isopropyl alcohol (IPA) addition offered faster drug penetration enhancement, while glycerol as a moisturizing agent influenced HC penetration through the increase in skin hydration. Conclusion: Although the performed in vivo methods cannot be considered alternative, skin stripping technique proved to be a cost-efficient mode of percutaneous penetration assessment, providing additional information on vehicle-skin interactions.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Pharmaceutical Development and Technology",
title = "Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods",
volume = "19",
number = "1",
pages = "55-64",
doi = "10.3109/10837450.2012.751407"
}
Pantelić, I., Lukić, M., Marković, B., Daniels, R., Vesić, S., Vuleta, G.,& Savić, S.. (2014). Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods. in Pharmaceutical Development and Technology
Taylor & Francis Ltd, Abingdon., 19(1), 55-64.
https://doi.org/10.3109/10837450.2012.751407
Pantelić I, Lukić M, Marković B, Daniels R, Vesić S, Vuleta G, Savić S. Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods. in Pharmaceutical Development and Technology. 2014;19(1):55-64.
doi:10.3109/10837450.2012.751407 .
Pantelić, Ivana, Lukić, Milica, Marković, Bojan, Daniels, Rolf, Vesić, Sonja, Vuleta, Gordana, Savić, Snežana, "Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods" in Pharmaceutical Development and Technology, 19, no. 1 (2014):55-64,
https://doi.org/10.3109/10837450.2012.751407 . .
1
6
5
6

Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation

Kovačević, Anđelka; Mueller, Rainer H.; Savić, Snežana; Vuleta, Gordana; Keck, Cornelia M.

(Elsevier Science BV, Amsterdam, 2014)

TY  - JOUR
AU  - Kovačević, Anđelka
AU  - Mueller, Rainer H.
AU  - Savić, Snežana
AU  - Vuleta, Gordana
AU  - Keck, Cornelia M.
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2189
AB  - Polyhydroxy surfactants are nonionic ethylene oxide free stabilizers known for their complimentary dermatological properties and favorable environmental profile. The aim of this study was to develop solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants varying in the chemical structure and to investigate the influence of the surfactants on the characteristics of the particles. Particles were produced by hot high pressure homogenization and the physico-chemical properties, e.g. contact angle, particle size, size distribution, zeta potential and crystallinity were determined. Results showed that the chemical structure of the surfactants influences the contact angle, particle size and crystallinity. Furthermore, the low surfactants concentration used (1% (w/w)) allowed the formation of the particles with a mean size below 200 nm, polydispersity index lower than 0.1 and sufficient physical stability for at least 6 months. As postulated by the zeta potential analysis stabilization ability of the surfactants was attributed to the superposition of electrostatic and steric effect which complement each other. All SLN formulations consisted of the same lipid matrix, but were found to possess different crystallinity indices. These differences are obviously created by the differences in the chemical structure of the surfactants. Therefore, the polyhydroxy surfactants investigated in this study can be judged to be novel suitable stabilizers for the formulation of well-skin tolerable SLN. The use of specific chemical structures of the surfactants can be used for the production of "tailor-made" SLN in the future.
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces A: Physicochemical and Engineering Aspects
T1  - Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation
VL  - 444
SP  - 15
EP  - 25
DO  - 10.1016/j.colsurfa.2013.12.023
ER  - 
@article{
author = "Kovačević, Anđelka and Mueller, Rainer H. and Savić, Snežana and Vuleta, Gordana and Keck, Cornelia M.",
year = "2014",
abstract = "Polyhydroxy surfactants are nonionic ethylene oxide free stabilizers known for their complimentary dermatological properties and favorable environmental profile. The aim of this study was to develop solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants varying in the chemical structure and to investigate the influence of the surfactants on the characteristics of the particles. Particles were produced by hot high pressure homogenization and the physico-chemical properties, e.g. contact angle, particle size, size distribution, zeta potential and crystallinity were determined. Results showed that the chemical structure of the surfactants influences the contact angle, particle size and crystallinity. Furthermore, the low surfactants concentration used (1% (w/w)) allowed the formation of the particles with a mean size below 200 nm, polydispersity index lower than 0.1 and sufficient physical stability for at least 6 months. As postulated by the zeta potential analysis stabilization ability of the surfactants was attributed to the superposition of electrostatic and steric effect which complement each other. All SLN formulations consisted of the same lipid matrix, but were found to possess different crystallinity indices. These differences are obviously created by the differences in the chemical structure of the surfactants. Therefore, the polyhydroxy surfactants investigated in this study can be judged to be novel suitable stabilizers for the formulation of well-skin tolerable SLN. The use of specific chemical structures of the surfactants can be used for the production of "tailor-made" SLN in the future.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
title = "Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation",
volume = "444",
pages = "15-25",
doi = "10.1016/j.colsurfa.2013.12.023"
}
Kovačević, A., Mueller, R. H., Savić, S., Vuleta, G.,& Keck, C. M.. (2014). Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation. in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Elsevier Science BV, Amsterdam., 444, 15-25.
https://doi.org/10.1016/j.colsurfa.2013.12.023
Kovačević A, Mueller RH, Savić S, Vuleta G, Keck CM. Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation. in Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2014;444:15-25.
doi:10.1016/j.colsurfa.2013.12.023 .
Kovačević, Anđelka, Mueller, Rainer H., Savić, Snežana, Vuleta, Gordana, Keck, Cornelia M., "Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation" in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 444 (2014):15-25,
https://doi.org/10.1016/j.colsurfa.2013.12.023 . .
97
66
96

Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants

Keck, Cornelia M.; Kovacević, Anđelka; Mueller, Rainer H.; Savić, Snežana; Vuleta, Gordana; Milić, Jela

(Elsevier Science BV, Amsterdam, 2014)

TY  - JOUR
AU  - Keck, Cornelia M.
AU  - Kovacević, Anđelka
AU  - Mueller, Rainer H.
AU  - Savić, Snežana
AU  - Vuleta, Gordana
AU  - Milić, Jela
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2078
AB  - Alkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility. Thus they seem to be excellent stabilizers for lipid nanoparticles for dermal application. To investigate this, different APGs were selected to evaluate their influence on the formation and characteristics of solid lipid nanoparticles (SLN). Contact angle analysis of the aqueous solutions/dispersions of the APGs on cetyl palmitate films revealed good wettability for all APG surfactants. Cetyl palmitate based SLN were prepared by hot high pressure homogenization and subjected to particle size, charge and inner structure analysis. 1% of each APG was sufficient to obtain SLN with a mean size between 150 nm and 175 nm and a narrow size distribution. The zeta potential in water was similar to -50 mV; the values in the original medium were distinctly lower, but still sufficient high to provide good physical stability. Physical stability at different temperatures (5 degrees C, 25 degrees C and 40 degrees C) was confirmed by a constant particle size over an observation period of 90 days in all dispersions. In comparison to SLN stabilized with classical surfactants, e.g., Polysorbate, APG stabilized SLN possess a smaller size, improved physical stability and contain less surfactant. Therefore, the use of APGs for the stabilization of lipid nanoparticles is superior in comparison to classical stabilizers. Further, the results indicate that the length of the alkyl chain of the APG influences the diminution efficacy, the final particle size and the crystallinity of the particles. APGs with short alkyl chain led to a faster reduction in size during high pressure homogenization, to a smaller particle size of the SLN and to a lower recrystallization index, i.e., to a lower crystallinity of the SLN. The crystallinity of the SLN increased with an increase in the alkyl chain length of APGs. Therefore, by using the tested APGs differing in the alkyl chain length, not only small sized and physically stable but also SLN with different sizes and crystallinity can be obtained. An optimized selection of these stabilizers might therefore enable the production of lipid nanoparticles with "tailor-made" properties.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants
VL  - 474
IS  - 1-2
SP  - 33
EP  - 41
DO  - 10.1016/j.ijpharm.2014.08.008
ER  - 
@article{
author = "Keck, Cornelia M. and Kovacević, Anđelka and Mueller, Rainer H. and Savić, Snežana and Vuleta, Gordana and Milić, Jela",
year = "2014",
abstract = "Alkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility. Thus they seem to be excellent stabilizers for lipid nanoparticles for dermal application. To investigate this, different APGs were selected to evaluate their influence on the formation and characteristics of solid lipid nanoparticles (SLN). Contact angle analysis of the aqueous solutions/dispersions of the APGs on cetyl palmitate films revealed good wettability for all APG surfactants. Cetyl palmitate based SLN were prepared by hot high pressure homogenization and subjected to particle size, charge and inner structure analysis. 1% of each APG was sufficient to obtain SLN with a mean size between 150 nm and 175 nm and a narrow size distribution. The zeta potential in water was similar to -50 mV; the values in the original medium were distinctly lower, but still sufficient high to provide good physical stability. Physical stability at different temperatures (5 degrees C, 25 degrees C and 40 degrees C) was confirmed by a constant particle size over an observation period of 90 days in all dispersions. In comparison to SLN stabilized with classical surfactants, e.g., Polysorbate, APG stabilized SLN possess a smaller size, improved physical stability and contain less surfactant. Therefore, the use of APGs for the stabilization of lipid nanoparticles is superior in comparison to classical stabilizers. Further, the results indicate that the length of the alkyl chain of the APG influences the diminution efficacy, the final particle size and the crystallinity of the particles. APGs with short alkyl chain led to a faster reduction in size during high pressure homogenization, to a smaller particle size of the SLN and to a lower recrystallization index, i.e., to a lower crystallinity of the SLN. The crystallinity of the SLN increased with an increase in the alkyl chain length of APGs. Therefore, by using the tested APGs differing in the alkyl chain length, not only small sized and physically stable but also SLN with different sizes and crystallinity can be obtained. An optimized selection of these stabilizers might therefore enable the production of lipid nanoparticles with "tailor-made" properties.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants",
volume = "474",
number = "1-2",
pages = "33-41",
doi = "10.1016/j.ijpharm.2014.08.008"
}
Keck, C. M., Kovacević, A., Mueller, R. H., Savić, S., Vuleta, G.,& Milić, J.. (2014). Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 474(1-2), 33-41.
https://doi.org/10.1016/j.ijpharm.2014.08.008
Keck CM, Kovacević A, Mueller RH, Savić S, Vuleta G, Milić J. Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants. in International Journal of Pharmaceutics. 2014;474(1-2):33-41.
doi:10.1016/j.ijpharm.2014.08.008 .
Keck, Cornelia M., Kovacević, Anđelka, Mueller, Rainer H., Savić, Snežana, Vuleta, Gordana, Milić, Jela, "Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants" in International Journal of Pharmaceutics, 474, no. 1-2 (2014):33-41,
https://doi.org/10.1016/j.ijpharm.2014.08.008 . .
57
42
57

Labelling of stock preparations and extemporaneous drugs: National and international legislation and practices

Vuleta, Gordana; Dabović, Marija; Đekić, Ljiljana

(Savez farmaceutskih udruženja Srbije, Beograd, 2014)

TY  - JOUR
AU  - Vuleta, Gordana
AU  - Dabović, Marija
AU  - Đekić, Ljiljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2269
AB  - The pharmaceutical industry has provided drug production of uniform quality, safety and efficacy, and the same is necessary for the preparation of stock preparations and extemporaneous drugs. Therefore, this type of pharmaceutical activity follow relevant legislation and harmonize by applying the relevant standards. In Serbia, production and trade of stock preparations and extemporaneous drugs takes place in accordance with the Zakon o zdravstvenoj zaštiti (Sl. glas. RS 107/2005, 72/2009, 88/2010, 99/2010, and 57/2011), Zakon o lekovima i medicinskim sredstvima Republike Srbije (Sl. glas. RS 30/20120, and 107/2012) and the rulebooks adopted in accordance with these regulations. Labelling of stock preparations in Serbia is regulated by two sets of the rulebooks, but there are no regulations for the labeling of extemporaneous drugs. In the US, labeling of extemporaneous drugs is regulated through Pharmacopoeia, state/federal laws, guides to good practice in the development of extemporaneous drugs. This field is regulated similarly in the EU - through legislation, Pharmacopoeia Supplements, corresponding guidelines and Resolution CMResAP EU (2011)1. Drug labelling is essential for patient safety. Drug signature enables his identification and indicates the way of his administration by the patient. Proper labelling of extemporaneous drugs is especially important for the acceptance of the drug by the patient and can have a significant impact on its safe use and adherence.
AB  - Izrada galenskih i magistralnih lekova, kao jednog vida farmaceutske delatnosti, delimično je regulisana zakonskim/podzakonskim propisima i odgovarajućim standardima. U Republici Srbiji izrada i promet galenskih lekova odvija se u skladu sa Zakonom o zdravstvenoj zaštiti (Sl. glas. RS 107/2005, 72/2009, 88/2010, 99/2010 i 57/2011), Zakonom o lekovima i medicinskim sredstvima Republike Srbije (Sl. glas. RS 30/20120 i 107/2012) i pravilnicima koji su usvojeni u skladu sa ovim propisima, dok se pitanje izrade magistralnih lekova tek spominje samo u nekim članovima zakona. Obeležavanje galenskih lekova u Srbiji je regulisano odgovarajućim pravilnicima, što nije slučaj sa obeležavanjem magistralnih lekova. U SAD je obeležavanje magistralnih lekova definisano u određenim poglavljima/monografijama USP, državnih/saveznih zakona, vodiča za dobru praksu u izradi magistralnih lekova, a na sličan način je regulisano i u zemljama EU - zakonskim propisima, dodacima farmakopeja, odgovarajućim vodičima, kao i Rezolucijom CM/ResAP(2011)1. Obeležavanje lekova je suštinsko za bezbednost pacijenta. Signatura na leku omogućava njegovu identifikaciju i ukazuje pacijentu na koji način da taj lek koristi i koliki je njegov rok upotrebe. Pravilno obeležavanje magistralnih lekova je naročito važno za prihvatanje preparata od strane pacijenta i može imati značajan uticaj na njihovu bezbednu primenu i adherencu. Predlog za obeležavanje magistralnih lekova treba da potekne iz Farmaceutske komore Srbije i bude upućen Republičkoj stručnoj komisiji za farmaciju koja bi ga razmotrila i prosledila Ministarstvu zdravlja Republike Srbije.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Labelling of stock preparations and extemporaneous drugs: National and international legislation and practices
T1  - Obeležavanje galenskih i magistralnih lekova - nacionalni i međunarodni propisi i praksa
VL  - 64
IS  - 5
SP  - 403
EP  - 420
DO  - 10.5937/arhfarm1405403V
ER  - 
@article{
author = "Vuleta, Gordana and Dabović, Marija and Đekić, Ljiljana",
year = "2014",
abstract = "The pharmaceutical industry has provided drug production of uniform quality, safety and efficacy, and the same is necessary for the preparation of stock preparations and extemporaneous drugs. Therefore, this type of pharmaceutical activity follow relevant legislation and harmonize by applying the relevant standards. In Serbia, production and trade of stock preparations and extemporaneous drugs takes place in accordance with the Zakon o zdravstvenoj zaštiti (Sl. glas. RS 107/2005, 72/2009, 88/2010, 99/2010, and 57/2011), Zakon o lekovima i medicinskim sredstvima Republike Srbije (Sl. glas. RS 30/20120, and 107/2012) and the rulebooks adopted in accordance with these regulations. Labelling of stock preparations in Serbia is regulated by two sets of the rulebooks, but there are no regulations for the labeling of extemporaneous drugs. In the US, labeling of extemporaneous drugs is regulated through Pharmacopoeia, state/federal laws, guides to good practice in the development of extemporaneous drugs. This field is regulated similarly in the EU - through legislation, Pharmacopoeia Supplements, corresponding guidelines and Resolution CMResAP EU (2011)1. Drug labelling is essential for patient safety. Drug signature enables his identification and indicates the way of his administration by the patient. Proper labelling of extemporaneous drugs is especially important for the acceptance of the drug by the patient and can have a significant impact on its safe use and adherence., Izrada galenskih i magistralnih lekova, kao jednog vida farmaceutske delatnosti, delimično je regulisana zakonskim/podzakonskim propisima i odgovarajućim standardima. U Republici Srbiji izrada i promet galenskih lekova odvija se u skladu sa Zakonom o zdravstvenoj zaštiti (Sl. glas. RS 107/2005, 72/2009, 88/2010, 99/2010 i 57/2011), Zakonom o lekovima i medicinskim sredstvima Republike Srbije (Sl. glas. RS 30/20120 i 107/2012) i pravilnicima koji su usvojeni u skladu sa ovim propisima, dok se pitanje izrade magistralnih lekova tek spominje samo u nekim članovima zakona. Obeležavanje galenskih lekova u Srbiji je regulisano odgovarajućim pravilnicima, što nije slučaj sa obeležavanjem magistralnih lekova. U SAD je obeležavanje magistralnih lekova definisano u određenim poglavljima/monografijama USP, državnih/saveznih zakona, vodiča za dobru praksu u izradi magistralnih lekova, a na sličan način je regulisano i u zemljama EU - zakonskim propisima, dodacima farmakopeja, odgovarajućim vodičima, kao i Rezolucijom CM/ResAP(2011)1. Obeležavanje lekova je suštinsko za bezbednost pacijenta. Signatura na leku omogućava njegovu identifikaciju i ukazuje pacijentu na koji način da taj lek koristi i koliki je njegov rok upotrebe. Pravilno obeležavanje magistralnih lekova je naročito važno za prihvatanje preparata od strane pacijenta i može imati značajan uticaj na njihovu bezbednu primenu i adherencu. Predlog za obeležavanje magistralnih lekova treba da potekne iz Farmaceutske komore Srbije i bude upućen Republičkoj stručnoj komisiji za farmaciju koja bi ga razmotrila i prosledila Ministarstvu zdravlja Republike Srbije.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Labelling of stock preparations and extemporaneous drugs: National and international legislation and practices, Obeležavanje galenskih i magistralnih lekova - nacionalni i međunarodni propisi i praksa",
volume = "64",
number = "5",
pages = "403-420",
doi = "10.5937/arhfarm1405403V"
}
Vuleta, G., Dabović, M.,& Đekić, L.. (2014). Labelling of stock preparations and extemporaneous drugs: National and international legislation and practices. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 64(5), 403-420.
https://doi.org/10.5937/arhfarm1405403V
Vuleta G, Dabović M, Đekić L. Labelling of stock preparations and extemporaneous drugs: National and international legislation and practices. in Arhiv za farmaciju. 2014;64(5):403-420.
doi:10.5937/arhfarm1405403V .
Vuleta, Gordana, Dabović, Marija, Đekić, Ljiljana, "Labelling of stock preparations and extemporaneous drugs: National and international legislation and practices" in Arhiv za farmaciju, 64, no. 5 (2014):403-420,
https://doi.org/10.5937/arhfarm1405403V . .
1

Properties and use of plant stem cells in cosmetic products

Prhal, Jelena; Milić, Jela; Krajišnik, Danina; Vuleta, Gordana

(Savez farmaceutskih udruženja Srbije, Beograd, 2014)

TY  - JOUR
AU  - Prhal, Jelena
AU  - Milić, Jela
AU  - Krajišnik, Danina
AU  - Vuleta, Gordana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2275
AB  - Stem cells are undifferentiated cells present in numerous tissues. Homeostasis and regeneration of those tissues depend on stem cell activity. Skin is the biggest organ of human body that is undergoing constant cellular turnover enabled by the activity of its own stem cells. In epidermis they are located in the bulge region of hair follicle, sebaceous glands and interfollicular epidermis. They also appear in dermis. Their activity is regulated by intrinsic programmes, niche stimuli and environmental factors. Aging of skin stem cells is associated with loss of proper signalling and accumulation of stress induced changes in cells. Cosmetic active ingredients claiming to protect skin stem cells have following effects: to neutralise negative effects of UV rays, to neutralise free radicals, to provide optimal conditions for skin and hair renewal. Plant stem cell extracts are innovative approach for obtaining natural active ingredients in controlled conditions, in ecological and sustainable manner, with possibility of inducing synthesis of desired secondary metabolites. Differences that exist between human and plant stem cells, and their regulatory substances, are defining their application in cosmetics. Their effects on skin are antioxidant, soothing, protection of skin stem cells and skin cells from UV ray induced damages or stimulation of synthesis of extracellular proteins.
AB  - Matične ćelije predstavljaju nediferencirane ćelije, koje se nalaze u većini tkiva, od kojih zavisi obnavljanje i regeneracija odgovarajućih tkiva. Koža je najveći organ ljudskog organizma i nalazi se u procesu stalnog obnavljanja koji zavisi od matičnih ćelija. Matične ćelije su u epidermisu smeštene u bazalnoj lamini u bulbusu dlake, lojnoj žlezdi i interfolikularnom epidermisu, dok u dermisu postoje dermalne matične ćelije. Njihovu aktivnost regulišu unutrašnji faktori/programi, signali iz mikrosredine i spoljašnji uticaji. Starenjem dolazi do promena njihove aktivnosti koje su posledica slabljenja lokalnih mehanizama regulacije i izloženosti stresu. Kozmetički aktivne supstance za koje se navodi da ostvaruju pozitivan efekat na matične ćelije kože često neutrališu negativne uticaje kao što su UV zračenje, stvaranje slobodnih radikala ili podržavaju optimalne uslove za obnavljanje kože i kose. Ekstrakti biljnih matičnih ćelija predstavljaju inovativni pristup za dobijanje prirodnih kozmetički aktivnih supstanci u kontrolisanim uslovima, uz mogućnost stimulacije sinteze željenih sekundarnih metabolita, na ekološki i održivi način. Razlike između humanih i biljnih matičnih ćelija, kao i faktora koji regulišu njihovu aktivnost određuju delovanje ovih ekstrakata. Ono se ogleda u 'smirivanju' kože, antioksidantnom dejstvu, zaštiti matičnih ćelija i ćelija kože od štetnih efekata UV zračenja ili stimulaciji sinteze proteina ekstracelularnog matriksa.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Properties and use of plant stem cells in cosmetic products
T1  - Karakteristike i primena biljnih matičnih ćelija u kozmetičkim proizvodima
VL  - 64
IS  - 1
SP  - 26
EP  - 37
DO  - 10.5937/arhfarm1401026P
ER  - 
@article{
author = "Prhal, Jelena and Milić, Jela and Krajišnik, Danina and Vuleta, Gordana",
year = "2014",
abstract = "Stem cells are undifferentiated cells present in numerous tissues. Homeostasis and regeneration of those tissues depend on stem cell activity. Skin is the biggest organ of human body that is undergoing constant cellular turnover enabled by the activity of its own stem cells. In epidermis they are located in the bulge region of hair follicle, sebaceous glands and interfollicular epidermis. They also appear in dermis. Their activity is regulated by intrinsic programmes, niche stimuli and environmental factors. Aging of skin stem cells is associated with loss of proper signalling and accumulation of stress induced changes in cells. Cosmetic active ingredients claiming to protect skin stem cells have following effects: to neutralise negative effects of UV rays, to neutralise free radicals, to provide optimal conditions for skin and hair renewal. Plant stem cell extracts are innovative approach for obtaining natural active ingredients in controlled conditions, in ecological and sustainable manner, with possibility of inducing synthesis of desired secondary metabolites. Differences that exist between human and plant stem cells, and their regulatory substances, are defining their application in cosmetics. Their effects on skin are antioxidant, soothing, protection of skin stem cells and skin cells from UV ray induced damages or stimulation of synthesis of extracellular proteins., Matične ćelije predstavljaju nediferencirane ćelije, koje se nalaze u većini tkiva, od kojih zavisi obnavljanje i regeneracija odgovarajućih tkiva. Koža je najveći organ ljudskog organizma i nalazi se u procesu stalnog obnavljanja koji zavisi od matičnih ćelija. Matične ćelije su u epidermisu smeštene u bazalnoj lamini u bulbusu dlake, lojnoj žlezdi i interfolikularnom epidermisu, dok u dermisu postoje dermalne matične ćelije. Njihovu aktivnost regulišu unutrašnji faktori/programi, signali iz mikrosredine i spoljašnji uticaji. Starenjem dolazi do promena njihove aktivnosti koje su posledica slabljenja lokalnih mehanizama regulacije i izloženosti stresu. Kozmetički aktivne supstance za koje se navodi da ostvaruju pozitivan efekat na matične ćelije kože često neutrališu negativne uticaje kao što su UV zračenje, stvaranje slobodnih radikala ili podržavaju optimalne uslove za obnavljanje kože i kose. Ekstrakti biljnih matičnih ćelija predstavljaju inovativni pristup za dobijanje prirodnih kozmetički aktivnih supstanci u kontrolisanim uslovima, uz mogućnost stimulacije sinteze željenih sekundarnih metabolita, na ekološki i održivi način. Razlike između humanih i biljnih matičnih ćelija, kao i faktora koji regulišu njihovu aktivnost određuju delovanje ovih ekstrakata. Ono se ogleda u 'smirivanju' kože, antioksidantnom dejstvu, zaštiti matičnih ćelija i ćelija kože od štetnih efekata UV zračenja ili stimulaciji sinteze proteina ekstracelularnog matriksa.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Properties and use of plant stem cells in cosmetic products, Karakteristike i primena biljnih matičnih ćelija u kozmetičkim proizvodima",
volume = "64",
number = "1",
pages = "26-37",
doi = "10.5937/arhfarm1401026P"
}
Prhal, J., Milić, J., Krajišnik, D.,& Vuleta, G.. (2014). Properties and use of plant stem cells in cosmetic products. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 64(1), 26-37.
https://doi.org/10.5937/arhfarm1401026P
Prhal J, Milić J, Krajišnik D, Vuleta G. Properties and use of plant stem cells in cosmetic products. in Arhiv za farmaciju. 2014;64(1):26-37.
doi:10.5937/arhfarm1401026P .
Prhal, Jelena, Milić, Jela, Krajišnik, Danina, Vuleta, Gordana, "Properties and use of plant stem cells in cosmetic products" in Arhiv za farmaciju, 64, no. 1 (2014):26-37,
https://doi.org/10.5937/arhfarm1401026P . .
2
2

Microneedles: Physical enhancers for (trans)dermal drug delivery

Vučen, Sonja; Bubić-Pajić, Nataša; Savić, Snežana; Vuleta, Gordana

(Savez farmaceutskih udruženja Srbije, Beograd, 2014)

TY  - JOUR
AU  - Vučen, Sonja
AU  - Bubić-Pajić, Nataša
AU  - Savić, Snežana
AU  - Vuleta, Gordana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2273
AB  - The efficiency of(trans)dermal drug delivery has been severely reduced by the inability of most drugs to penetrate the skin at therapeutically useful rates. Recently, the use of micron-scale needles has been shown to increase skin permeability and significantly improve (trans)dermal drug delivery, particularly for macromolecules. Using the tools of the microelectronics industry and different materials, microneedles of various sizes and shapes have been fabricated. Due to their micron size (less than 300 μm in diameter and 50-900 μm in length), these needles do not reach the nerve endings in the dermis, providing a painless application, which is considered as their main advantage over hypodermic needles. Pathways created using microneedles are orders of magnitude bigger than molecular dimensions and, therefore, should readily permit transport of macromolecules, as well as possibly supramolecular complexes and microparticles Recently, in vivo studies have demonstrated a successful delivery of oligonucleotides, insulin, and many other drugs using a microneedles, as well as induction of the immune response from protein and DNA vaccines. Numerous studies conducted in this research field have led to launching the first microneedle-based (trans)dermal drug delivery systems on the market.
AB  - Efikasnost terapijskih sistema za (trans)dermalnu isporuku lijekova je u znatnoj mjeri umanjena zbog otežanog prolaska lijekova u/kroz kožu. Nedavno je pokazano da je upotrebom igala mikronskih veličina moguće povećati permeabilnost kože i znatno poboljšati (trans)dermalnu isporuku, naročito u slučaju makromolekula. Primjenom dostignuća mikroelektronske industrije, od različitih materijala su proizvedene mikroigle različitih veličina i oblika. S obzirom na svoje mikronske veličine (prečnika obično oko 1 μm i dužine 50-900 μm), ovakve igle ne dopiru do nervnih završetaka u dermisu, čime obezbjeđuju bezbolnu primjenu, što se smatra njihovom osnovnom prednošću u odnosu na potkožne igle. Nastale pore u koži su nekoliko puta veće od dimenzija molekula, te je omogućen transport makromolekula, kao i supramolekularnih kompleksa i nano/mikročestica. Dosadašnje in vivo studije su pokazale uspješnu (trans)dermalnu isporuku oligonukleotida, insulina i drugih lijekova primjenom mikroigala, kao i indukciju imunskog odgovora proteinskim i DNK vakcinama. Brojni radovi sprovedeni u ovoj oblasti istraživanja doveli su i do pojave na tržištu prvih sistema za (trans)dermalnu isporuku lijekova zasnovanih na tehnologiji mikroigala.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Microneedles: Physical enhancers for (trans)dermal drug delivery
T1  - Mikroigle - fizički pojačivači (trans)dermalne isporuke lijekova
VL  - 64
IS  - 4
SP  - 295
EP  - 321
DO  - 10.5937/arhfarm1404295V
ER  - 
@article{
author = "Vučen, Sonja and Bubić-Pajić, Nataša and Savić, Snežana and Vuleta, Gordana",
year = "2014",
abstract = "The efficiency of(trans)dermal drug delivery has been severely reduced by the inability of most drugs to penetrate the skin at therapeutically useful rates. Recently, the use of micron-scale needles has been shown to increase skin permeability and significantly improve (trans)dermal drug delivery, particularly for macromolecules. Using the tools of the microelectronics industry and different materials, microneedles of various sizes and shapes have been fabricated. Due to their micron size (less than 300 μm in diameter and 50-900 μm in length), these needles do not reach the nerve endings in the dermis, providing a painless application, which is considered as their main advantage over hypodermic needles. Pathways created using microneedles are orders of magnitude bigger than molecular dimensions and, therefore, should readily permit transport of macromolecules, as well as possibly supramolecular complexes and microparticles Recently, in vivo studies have demonstrated a successful delivery of oligonucleotides, insulin, and many other drugs using a microneedles, as well as induction of the immune response from protein and DNA vaccines. Numerous studies conducted in this research field have led to launching the first microneedle-based (trans)dermal drug delivery systems on the market., Efikasnost terapijskih sistema za (trans)dermalnu isporuku lijekova je u znatnoj mjeri umanjena zbog otežanog prolaska lijekova u/kroz kožu. Nedavno je pokazano da je upotrebom igala mikronskih veličina moguće povećati permeabilnost kože i znatno poboljšati (trans)dermalnu isporuku, naročito u slučaju makromolekula. Primjenom dostignuća mikroelektronske industrije, od različitih materijala su proizvedene mikroigle različitih veličina i oblika. S obzirom na svoje mikronske veličine (prečnika obično oko 1 μm i dužine 50-900 μm), ovakve igle ne dopiru do nervnih završetaka u dermisu, čime obezbjeđuju bezbolnu primjenu, što se smatra njihovom osnovnom prednošću u odnosu na potkožne igle. Nastale pore u koži su nekoliko puta veće od dimenzija molekula, te je omogućen transport makromolekula, kao i supramolekularnih kompleksa i nano/mikročestica. Dosadašnje in vivo studije su pokazale uspješnu (trans)dermalnu isporuku oligonukleotida, insulina i drugih lijekova primjenom mikroigala, kao i indukciju imunskog odgovora proteinskim i DNK vakcinama. Brojni radovi sprovedeni u ovoj oblasti istraživanja doveli su i do pojave na tržištu prvih sistema za (trans)dermalnu isporuku lijekova zasnovanih na tehnologiji mikroigala.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Microneedles: Physical enhancers for (trans)dermal drug delivery, Mikroigle - fizički pojačivači (trans)dermalne isporuke lijekova",
volume = "64",
number = "4",
pages = "295-321",
doi = "10.5937/arhfarm1404295V"
}
Vučen, S., Bubić-Pajić, N., Savić, S.,& Vuleta, G.. (2014). Microneedles: Physical enhancers for (trans)dermal drug delivery. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 64(4), 295-321.
https://doi.org/10.5937/arhfarm1404295V
Vučen S, Bubić-Pajić N, Savić S, Vuleta G. Microneedles: Physical enhancers for (trans)dermal drug delivery. in Arhiv za farmaciju. 2014;64(4):295-321.
doi:10.5937/arhfarm1404295V .
Vučen, Sonja, Bubić-Pajić, Nataša, Savić, Snežana, Vuleta, Gordana, "Microneedles: Physical enhancers for (trans)dermal drug delivery" in Arhiv za farmaciju, 64, no. 4 (2014):295-321,
https://doi.org/10.5937/arhfarm1404295V . .
1
2

Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability

Đorđević, Sanela; Cekić, Nebojša; Isailović, Tanja; Milić, Jela; Vuleta, Gordana; Lazić, Miodrag; Savić, Snežana

(Savez hemijskih inženjera, Beograd, 2013)

TY  - JOUR
AU  - Đorđević, Sanela
AU  - Cekić, Nebojša
AU  - Isailović, Tanja
AU  - Milić, Jela
AU  - Vuleta, Gordana
AU  - Lazić, Miodrag
AU  - Savić, Snežana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2064
AB  - The aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80-based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemulsions were prepared by high pressure homogenization, using 20, 30 and 40 mass% medium chain triglyceride as oil phase, and 4, 6 and 8 mass% lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as emulsifiers. The effects of emulsifier type, emulsifier concentration and oil content were investigated with respect to changes in particle size, particle size distribution, surface charge and physical stability. The influence of production parameters (number of homogenization cycles, type of homogenization process, homogenization pressure) on particle size was also investigated. Analysis was performed by photon correlation spectroscopy, laser diffraction, zeta potential, pH and electrical conductivity measurements. All the produced formulations revealed a small droplet size ranging from 147 to 228 nm and a very narrow size distribution (polydispersity index range 0.072-0.124). Zeta potentials were found to be about -20 and -50 mV for nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl glucoside, respectively. The results obtained from the stability studies (6 months at 25 °C and 1 month at 40 °C) indicated that nanoemulsion stability was influenced by their composition. The results also suggested the most appropriate production parameters: 9 homogenization cycles, homogenization pressure of 500 bar and discontinuous process of homogenization.
AB  - Cilj ovog istraživanja bio je da se homogenizacijom pod visokim pritiskom izrade nanoemulzije stabilizovane alkil poliglukozidnim (APG) emulgatorom i da se njihove karakteristike i fizička stabilnost uporede sa nanoemulzijama stabilizovanim standardnom kombinacijom lecitina (L) i polisorbata 80 (P80). U istraživanju je praćen uticaj parametara formulacije, i to vrste i koncentracije emulgatora (smeša L/P80 vs. APG, u koncentraciji od 4, 6 i 8%) i koncentracije uljane faze (20, 30 i 40% trigliceridi srednje dužine lanca) na veličinu i raspodelu veličina kapi, zeta potencijal (ζ) i fizičku stabilnost nanoemulzija. Takođe je praćen uticaj procesnih parametara (postupak, pritisak i broj ciklusa homogenizacije) na veličinu kapi i indeks polidisperznosti (PdI), u cilju identifikovanja optimalnih uslova za izradu nanoemulzija. Dobijeni rezultati pokazuju da postoji uticaj sastava formulacije na karakteristike (L/P80 nanoemulzije: veličina kapi 147-156 nm, ζ oko -20 mV; APG nanoemulzije: veličina kapi 165-228 nm, ζ oko -50 mV) i fizičku stabilnost ispitivanih nanoemulzija, i da se diskontinualnim postupkom homogenizacije (9 ciklusa, 500 bar) mogu dobiti nanoemulzije optimalnih svojstava (veličina kapi, PdI).
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability
T1  - Nanoemulzije dobijene variranjem tipa emulgatora i udela masne faze - uticaj formulacije i procesnih parametara na karakteristike i fizičku stabilnost
VL  - 67
IS  - 5
SP  - 795
EP  - 809
DO  - 10.2298/HEMIND120905005D
ER  - 
@article{
author = "Đorđević, Sanela and Cekić, Nebojša and Isailović, Tanja and Milić, Jela and Vuleta, Gordana and Lazić, Miodrag and Savić, Snežana",
year = "2013",
abstract = "The aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80-based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemulsions were prepared by high pressure homogenization, using 20, 30 and 40 mass% medium chain triglyceride as oil phase, and 4, 6 and 8 mass% lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as emulsifiers. The effects of emulsifier type, emulsifier concentration and oil content were investigated with respect to changes in particle size, particle size distribution, surface charge and physical stability. The influence of production parameters (number of homogenization cycles, type of homogenization process, homogenization pressure) on particle size was also investigated. Analysis was performed by photon correlation spectroscopy, laser diffraction, zeta potential, pH and electrical conductivity measurements. All the produced formulations revealed a small droplet size ranging from 147 to 228 nm and a very narrow size distribution (polydispersity index range 0.072-0.124). Zeta potentials were found to be about -20 and -50 mV for nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl glucoside, respectively. The results obtained from the stability studies (6 months at 25 °C and 1 month at 40 °C) indicated that nanoemulsion stability was influenced by their composition. The results also suggested the most appropriate production parameters: 9 homogenization cycles, homogenization pressure of 500 bar and discontinuous process of homogenization., Cilj ovog istraživanja bio je da se homogenizacijom pod visokim pritiskom izrade nanoemulzije stabilizovane alkil poliglukozidnim (APG) emulgatorom i da se njihove karakteristike i fizička stabilnost uporede sa nanoemulzijama stabilizovanim standardnom kombinacijom lecitina (L) i polisorbata 80 (P80). U istraživanju je praćen uticaj parametara formulacije, i to vrste i koncentracije emulgatora (smeša L/P80 vs. APG, u koncentraciji od 4, 6 i 8%) i koncentracije uljane faze (20, 30 i 40% trigliceridi srednje dužine lanca) na veličinu i raspodelu veličina kapi, zeta potencijal (ζ) i fizičku stabilnost nanoemulzija. Takođe je praćen uticaj procesnih parametara (postupak, pritisak i broj ciklusa homogenizacije) na veličinu kapi i indeks polidisperznosti (PdI), u cilju identifikovanja optimalnih uslova za izradu nanoemulzija. Dobijeni rezultati pokazuju da postoji uticaj sastava formulacije na karakteristike (L/P80 nanoemulzije: veličina kapi 147-156 nm, ζ oko -20 mV; APG nanoemulzije: veličina kapi 165-228 nm, ζ oko -50 mV) i fizičku stabilnost ispitivanih nanoemulzija, i da se diskontinualnim postupkom homogenizacije (9 ciklusa, 500 bar) mogu dobiti nanoemulzije optimalnih svojstava (veličina kapi, PdI).",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability, Nanoemulzije dobijene variranjem tipa emulgatora i udela masne faze - uticaj formulacije i procesnih parametara na karakteristike i fizičku stabilnost",
volume = "67",
number = "5",
pages = "795-809",
doi = "10.2298/HEMIND120905005D"
}
Đorđević, S., Cekić, N., Isailović, T., Milić, J., Vuleta, G., Lazić, M.,& Savić, S.. (2013). Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 67(5), 795-809.
https://doi.org/10.2298/HEMIND120905005D
Đorđević S, Cekić N, Isailović T, Milić J, Vuleta G, Lazić M, Savić S. Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability. in Hemijska industrija. 2013;67(5):795-809.
doi:10.2298/HEMIND120905005D .
Đorđević, Sanela, Cekić, Nebojša, Isailović, Tanja, Milić, Jela, Vuleta, Gordana, Lazić, Miodrag, Savić, Snežana, "Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability" in Hemijska industrija, 67, no. 5 (2013):795-809,
https://doi.org/10.2298/HEMIND120905005D . .
1
1
2

Extemporaneous drugs and stock preparations: Legislation aspects and standards

Đekić, Ljiljana; Čalija, Bojan; Vuleta, Gordana

(Savez farmaceutskih udruženja Srbije, Beograd, 2013)

TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Čalija, Bojan
AU  - Vuleta, Gordana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2050
AB  - Nowadays, registered drugs available on market do not always meet the needs of individual patients. This emphasizes importance of pharmaceutical skills and knowledge required for drug compounding. The need for compounded drugs has been driven by: limited choice of doses and dosage forms of registered drugs available on market (especially for pediatric patients), shortage of the orphan drugs, and requirements for combinations of two or more active pharmaceutical ingredients in the same dosage form. Furthermore, the problem of sudden drug shortages can be solved by drug compounding which is of great importance for every health care system. Current opinion of pharmaceutical practitioners concerning drug compounding is defined by documents such as: Ph. Eur 7.7 monograph Pharmaceutical Preparations (04/2013:2619), EU resolution CM/ResAP (2011)1, USP34/NF29 monographs 795 and 797, and Good Pharmacy Practice (part Good Compounding Practice).
AB  - U današnje vreme dostupni registrovani lekovi ne zadovoljavaju uvek potrebe pojedinačnih bolesnika, čime se ističe značaj znanja i veština farmaceuta prilikom izrade različitih magistralnih i galenskih lekova. Potreba za izradom magistralnih i galenskih lekova nastaje kao rezultat ograničenog izbora doza/jačina lekovitih supstanci u registrovanim lekovima ili nepostojanja odgovarajućih farmaceutskih oblika (posebno za decu), ali i nepostojanja odgovarajućih kombinacija dve ili više lekovitih supstanci u istom obliku, ili lekova za retke bolesti. Za zdravstveni sistem svake zemlje je od velikog značaja da se izradom magistralnih ili galenskih preparata, kao zamenom za određene registrovane lekove, reši problem nestašica, kada je to moguće ili obezbede potrebni lekovi za bolesnike, koji se iz različitih razloga ne mogu proizvoditi u farmaceutskoj industriji. Stav farmaceutske struke o izradi magistralnih preparata pre svega je definisan dokumentima kao što su: monografija Farmaceutskih preparata (04/2013:2619) u sedmom dodatku Evropske farmakopeje (Ph. Eur. 7.7), Rezolucija Saveta Evrope CM/ResAP (2011)1, monografije 795 i 797 u Američkoj farmakopeji (USP34/NF29) i u Dobroj apotekarskoj praksi (DAP) (Farmaceutska komora Srbije, 2013), deo Dobra praksa u izradi lekova.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Extemporaneous drugs and stock preparations: Legislation aspects and standards
T1  - Izrada magistralnih i galenskih lekova - propisi i standardi
VL  - 63
IS  - 5
SP  - 443
EP  - 469
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2050
ER  - 
@article{
author = "Đekić, Ljiljana and Čalija, Bojan and Vuleta, Gordana",
year = "2013",
abstract = "Nowadays, registered drugs available on market do not always meet the needs of individual patients. This emphasizes importance of pharmaceutical skills and knowledge required for drug compounding. The need for compounded drugs has been driven by: limited choice of doses and dosage forms of registered drugs available on market (especially for pediatric patients), shortage of the orphan drugs, and requirements for combinations of two or more active pharmaceutical ingredients in the same dosage form. Furthermore, the problem of sudden drug shortages can be solved by drug compounding which is of great importance for every health care system. Current opinion of pharmaceutical practitioners concerning drug compounding is defined by documents such as: Ph. Eur 7.7 monograph Pharmaceutical Preparations (04/2013:2619), EU resolution CM/ResAP (2011)1, USP34/NF29 monographs 795 and 797, and Good Pharmacy Practice (part Good Compounding Practice)., U današnje vreme dostupni registrovani lekovi ne zadovoljavaju uvek potrebe pojedinačnih bolesnika, čime se ističe značaj znanja i veština farmaceuta prilikom izrade različitih magistralnih i galenskih lekova. Potreba za izradom magistralnih i galenskih lekova nastaje kao rezultat ograničenog izbora doza/jačina lekovitih supstanci u registrovanim lekovima ili nepostojanja odgovarajućih farmaceutskih oblika (posebno za decu), ali i nepostojanja odgovarajućih kombinacija dve ili više lekovitih supstanci u istom obliku, ili lekova za retke bolesti. Za zdravstveni sistem svake zemlje je od velikog značaja da se izradom magistralnih ili galenskih preparata, kao zamenom za određene registrovane lekove, reši problem nestašica, kada je to moguće ili obezbede potrebni lekovi za bolesnike, koji se iz različitih razloga ne mogu proizvoditi u farmaceutskoj industriji. Stav farmaceutske struke o izradi magistralnih preparata pre svega je definisan dokumentima kao što su: monografija Farmaceutskih preparata (04/2013:2619) u sedmom dodatku Evropske farmakopeje (Ph. Eur. 7.7), Rezolucija Saveta Evrope CM/ResAP (2011)1, monografije 795 i 797 u Američkoj farmakopeji (USP34/NF29) i u Dobroj apotekarskoj praksi (DAP) (Farmaceutska komora Srbije, 2013), deo Dobra praksa u izradi lekova.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Extemporaneous drugs and stock preparations: Legislation aspects and standards, Izrada magistralnih i galenskih lekova - propisi i standardi",
volume = "63",
number = "5",
pages = "443-469",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2050"
}
Đekić, L., Čalija, B.,& Vuleta, G.. (2013). Extemporaneous drugs and stock preparations: Legislation aspects and standards. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(5), 443-469.
https://hdl.handle.net/21.15107/rcub_farfar_2050
Đekić L, Čalija B, Vuleta G. Extemporaneous drugs and stock preparations: Legislation aspects and standards. in Arhiv za farmaciju. 2013;63(5):443-469.
https://hdl.handle.net/21.15107/rcub_farfar_2050 .
Đekić, Ljiljana, Čalija, Bojan, Vuleta, Gordana, "Extemporaneous drugs and stock preparations: Legislation aspects and standards" in Arhiv za farmaciju, 63, no. 5 (2013):443-469,
https://hdl.handle.net/21.15107/rcub_farfar_2050 .
2

Cosmetovigilance: Establishing the system for monitoring of adverse effects to cosmetic products

Mirković, Ivana; Vuleta, Gordana; Savić, Snežana

(Savez farmaceutskih udruženja Srbije, Beograd, 2013)

TY  - JOUR
AU  - Mirković, Ivana
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2040
AB  - Both production and consumption of personal hygiene products and cosmetics have been increasing in popularity with an ever growing number of consumers, which is where cosmetovigilance is becoming more relevant through a set of its own activities, aiming at the detection, assessment, identification, and prevention of adverse effects potentially occurring as a result of the application of cosmetic products. The Regulation (EC) 1223/2009 on cosmetic products stipulates not only the conditions necessary for placing a cosmetic product on the market, but also includes the necessary documentation of the safety of cosmetic products to consumers in order to avoid potential adverse effects. This Regulation sets the basic terms of the cosmetovigilance system, which shall enter into force on the 11th of July 2013, which will further ensure the safety and quality level of both new and existing cosmetics on the market. Furthermore, for the continued implementation of cosmetovigilance, it is essential to promote the application of an adverse effects questionnaire that is in accordance with regulation as being a prerequisite for the implementation of future major steps, such as: warning system within the EU and withdrawal from the market.
AB  - Potreba i svest ljudi za unapređenjem fizičkog izgleda je iz godine u godinu, prema raznim vrstama istraživanja i sprovođenja postmarketinških ispitivanja, u stalnom porastu. Shodno tome i proizvodnja, upotreba i potrošnja kako sredstava za ličnu higijenu, tako i samih kozmetičkih proizvoda postaje sve popularnija kod ogromnog broja potrošača. Uredba (EU) 1223/2009 o kozmetičkim proizvodima, usvojena 30. novembra 2009. godine, propisala je neophodne uslove za stavljanje kozmetičkog proizvoda na tržište koji između ostalog obuhvataju i neophodne dokaze o bezbednosti kozmetičkog proizvoda (svih njegovih sastojaka) za potrošače, pri primeni pod normalnim i predvidivim uslovima korišćenja. Uprkos neosporno visokom procentu bezbednosti i podnošljivosti kozmetičkih proizvoda, neželjeni efekti su ipak prisutni i najčešće su blage ili srednje blage jačine i uglavnom se manifestuju na koži. Kozmetovigilanca predstavlja skup definisanih aktivnosti koje imaju za cilj otkrivanje, procenu, razumevanje, evidenciju i preveniranje neželjenih događaja koji se potencijalno mogu javiti kao posledica primene kozmetičkih proizvoda. Uredba (EU) 1223/2009 o kozmetičkim proizvodima, koja je zvanično i u potpunosti stupila na snagu 11. jula 2013, zahteva od svih proizvođača imenovanje odgovorne osobe koja će kontinuirano pratiti i evidentirati sprovođenje kozmetovigilance za njihove proizvode koji se nalaze na tržištu. U ovom radu će biti predstavljeni podaci preuzeti iz sprovedenih studija koje su imale za cilj procenu pojave neželjenih dejstava pri primeni kozmetičkih proizvoda, spovođenje različitih modela njihovog otkrivanja, praćenja i preveniranja, kao i uspostavljanje standardnog sistema kozmetovigilance.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Cosmetovigilance: Establishing the system for monitoring of adverse effects to cosmetic products
T1  - Kozmetovigilanca - uspostavljanje sistema praćenja neželjenih efekata kozmetičkih preparata
VL  - 63
IS  - 4
SP  - 375
EP  - 386
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2040
ER  - 
@article{
author = "Mirković, Ivana and Vuleta, Gordana and Savić, Snežana",
year = "2013",
abstract = "Both production and consumption of personal hygiene products and cosmetics have been increasing in popularity with an ever growing number of consumers, which is where cosmetovigilance is becoming more relevant through a set of its own activities, aiming at the detection, assessment, identification, and prevention of adverse effects potentially occurring as a result of the application of cosmetic products. The Regulation (EC) 1223/2009 on cosmetic products stipulates not only the conditions necessary for placing a cosmetic product on the market, but also includes the necessary documentation of the safety of cosmetic products to consumers in order to avoid potential adverse effects. This Regulation sets the basic terms of the cosmetovigilance system, which shall enter into force on the 11th of July 2013, which will further ensure the safety and quality level of both new and existing cosmetics on the market. Furthermore, for the continued implementation of cosmetovigilance, it is essential to promote the application of an adverse effects questionnaire that is in accordance with regulation as being a prerequisite for the implementation of future major steps, such as: warning system within the EU and withdrawal from the market., Potreba i svest ljudi za unapređenjem fizičkog izgleda je iz godine u godinu, prema raznim vrstama istraživanja i sprovođenja postmarketinških ispitivanja, u stalnom porastu. Shodno tome i proizvodnja, upotreba i potrošnja kako sredstava za ličnu higijenu, tako i samih kozmetičkih proizvoda postaje sve popularnija kod ogromnog broja potrošača. Uredba (EU) 1223/2009 o kozmetičkim proizvodima, usvojena 30. novembra 2009. godine, propisala je neophodne uslove za stavljanje kozmetičkog proizvoda na tržište koji između ostalog obuhvataju i neophodne dokaze o bezbednosti kozmetičkog proizvoda (svih njegovih sastojaka) za potrošače, pri primeni pod normalnim i predvidivim uslovima korišćenja. Uprkos neosporno visokom procentu bezbednosti i podnošljivosti kozmetičkih proizvoda, neželjeni efekti su ipak prisutni i najčešće su blage ili srednje blage jačine i uglavnom se manifestuju na koži. Kozmetovigilanca predstavlja skup definisanih aktivnosti koje imaju za cilj otkrivanje, procenu, razumevanje, evidenciju i preveniranje neželjenih događaja koji se potencijalno mogu javiti kao posledica primene kozmetičkih proizvoda. Uredba (EU) 1223/2009 o kozmetičkim proizvodima, koja je zvanično i u potpunosti stupila na snagu 11. jula 2013, zahteva od svih proizvođača imenovanje odgovorne osobe koja će kontinuirano pratiti i evidentirati sprovođenje kozmetovigilance za njihove proizvode koji se nalaze na tržištu. U ovom radu će biti predstavljeni podaci preuzeti iz sprovedenih studija koje su imale za cilj procenu pojave neželjenih dejstava pri primeni kozmetičkih proizvoda, spovođenje različitih modela njihovog otkrivanja, praćenja i preveniranja, kao i uspostavljanje standardnog sistema kozmetovigilance.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Cosmetovigilance: Establishing the system for monitoring of adverse effects to cosmetic products, Kozmetovigilanca - uspostavljanje sistema praćenja neželjenih efekata kozmetičkih preparata",
volume = "63",
number = "4",
pages = "375-386",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2040"
}
Mirković, I., Vuleta, G.,& Savić, S.. (2013). Cosmetovigilance: Establishing the system for monitoring of adverse effects to cosmetic products. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(4), 375-386.
https://hdl.handle.net/21.15107/rcub_farfar_2040
Mirković I, Vuleta G, Savić S. Cosmetovigilance: Establishing the system for monitoring of adverse effects to cosmetic products. in Arhiv za farmaciju. 2013;63(4):375-386.
https://hdl.handle.net/21.15107/rcub_farfar_2040 .
Mirković, Ivana, Vuleta, Gordana, Savić, Snežana, "Cosmetovigilance: Establishing the system for monitoring of adverse effects to cosmetic products" in Arhiv za farmaciju, 63, no. 4 (2013):375-386,
https://hdl.handle.net/21.15107/rcub_farfar_2040 .
2

Magistral and galenic drugs in dermatology: Past or present

Vuleta, Gordana; Pantelić, Ivana; Savić, Snežana

(Savez farmaceutskih udruženja Srbije, Beograd, 2013)

TY  - JOUR
AU  - Vuleta, Gordana
AU  - Pantelić, Ivana
AU  - Savić, Snežana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2004
AB  - Since the majority of registered drugs are available in single dose/strength and dosage form, the importance of drug compounding, especially in respect to treatment of various dermatological conditions, is being re-evaluated. Although the practice of extemporaneous drug preparation has been improved during the years, countries with otherwise highly developed pharmaceutical industry have become aware that providing individualized therapy is sometimes inevitable. Hence, throughout the world, a number of documents aiming to regulate this practice are being implemented. One of the recently adopted documents in EU is the Resolution CM/ResAP(2011)1 on quality and safety assurance requirements for medicinal products prepared in pharmacies for the special needs of patients. The importance of magistral and galenic drugs preparation is especially notable in case of conditions such as eczema, which are accompanied with dry skin and itching sensation. By preparing a magistral drug for the specific patient, a sufficient amount of the drug can be provided (approx. requirement of 250 g per week), in a suitable, emollient base. Thus, the potentially dangerous practice of diluting registered drugs, especially common for corticosteroids, may be avoided. Along with such a drug, a pharmacist may also prepare the base itself, and advise the patient to apply it between two corticosteroid treatments.
AB  - Činjenica da je većina registrovanih lekova dostupna u jednoj dozi/jačini i farmaceutskom obliku, dovela je do redefinisanja značaja izrade magistralnih i galenskih lekova, posebno za potrebe terapije dermatoloških oboljenja. Iako su znanja i veštine farmaceuta vezane za izradu magistralnih lekova unapređivane tokom godina, i zemlje sa razvijenom farmaceutskom industrijom postaju svesne značaja koncepta individualizacije terapije i rade na pripremi odgovarajućih dokumenata. Jedan od novijih dokumenata donet u EU sa ciljem uređenja ovog dela farmaceutske prakse je Resolution CM/ResAP(2011)1 on quality and safety assurance requirements for medicinal products prepared in pharmacies for the special needs of patients. Značaj izrade magistralnih lekova naročito je izražen u slučaju dermatoloških oboljenja poput ekcema različite etiologije, praćenih suvom kožom i svrabom. Izradom leka za pojedinačnog pacijenta, obezbeđuje se dovoljna količina leka (potreba od oko 250 g preparata nedeljno) u pogodnoj, emolijentnoj podlozi. Na ovaj način može se izbeći potencijalno opasna praksa razblaživanja registrovanih lekova za lokalnu terapiju kod dece, naročito česta kod primene kortikosteroidnih kremova. Uz lek, farmaceut može izdati i samu (praznu) podlogu/bazu, koja na koži bolesnika treba da ostvari emolijentno dejstvo, čija je primena naročito značajna između dva tretmana kortikosteroidnim preparatima.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Magistral and galenic drugs in dermatology: Past or present
T1  - Magistralni i galenski lekovi u dermatologiji - prošlost ili sadašnjost
VL  - 63
IS  - 2
SP  - 129
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2004
ER  - 
@article{
author = "Vuleta, Gordana and Pantelić, Ivana and Savić, Snežana",
year = "2013",
abstract = "Since the majority of registered drugs are available in single dose/strength and dosage form, the importance of drug compounding, especially in respect to treatment of various dermatological conditions, is being re-evaluated. Although the practice of extemporaneous drug preparation has been improved during the years, countries with otherwise highly developed pharmaceutical industry have become aware that providing individualized therapy is sometimes inevitable. Hence, throughout the world, a number of documents aiming to regulate this practice are being implemented. One of the recently adopted documents in EU is the Resolution CM/ResAP(2011)1 on quality and safety assurance requirements for medicinal products prepared in pharmacies for the special needs of patients. The importance of magistral and galenic drugs preparation is especially notable in case of conditions such as eczema, which are accompanied with dry skin and itching sensation. By preparing a magistral drug for the specific patient, a sufficient amount of the drug can be provided (approx. requirement of 250 g per week), in a suitable, emollient base. Thus, the potentially dangerous practice of diluting registered drugs, especially common for corticosteroids, may be avoided. Along with such a drug, a pharmacist may also prepare the base itself, and advise the patient to apply it between two corticosteroid treatments., Činjenica da je većina registrovanih lekova dostupna u jednoj dozi/jačini i farmaceutskom obliku, dovela je do redefinisanja značaja izrade magistralnih i galenskih lekova, posebno za potrebe terapije dermatoloških oboljenja. Iako su znanja i veštine farmaceuta vezane za izradu magistralnih lekova unapređivane tokom godina, i zemlje sa razvijenom farmaceutskom industrijom postaju svesne značaja koncepta individualizacije terapije i rade na pripremi odgovarajućih dokumenata. Jedan od novijih dokumenata donet u EU sa ciljem uređenja ovog dela farmaceutske prakse je Resolution CM/ResAP(2011)1 on quality and safety assurance requirements for medicinal products prepared in pharmacies for the special needs of patients. Značaj izrade magistralnih lekova naročito je izražen u slučaju dermatoloških oboljenja poput ekcema različite etiologije, praćenih suvom kožom i svrabom. Izradom leka za pojedinačnog pacijenta, obezbeđuje se dovoljna količina leka (potreba od oko 250 g preparata nedeljno) u pogodnoj, emolijentnoj podlozi. Na ovaj način može se izbeći potencijalno opasna praksa razblaživanja registrovanih lekova za lokalnu terapiju kod dece, naročito česta kod primene kortikosteroidnih kremova. Uz lek, farmaceut može izdati i samu (praznu) podlogu/bazu, koja na koži bolesnika treba da ostvari emolijentno dejstvo, čija je primena naročito značajna između dva tretmana kortikosteroidnim preparatima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Magistral and galenic drugs in dermatology: Past or present, Magistralni i galenski lekovi u dermatologiji - prošlost ili sadašnjost",
volume = "63",
number = "2",
pages = "129-146",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2004"
}
Vuleta, G., Pantelić, I.,& Savić, S.. (2013). Magistral and galenic drugs in dermatology: Past or present. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(2), 129-146.
https://hdl.handle.net/21.15107/rcub_farfar_2004
Vuleta G, Pantelić I, Savić S. Magistral and galenic drugs in dermatology: Past or present. in Arhiv za farmaciju. 2013;63(2):129-146.
https://hdl.handle.net/21.15107/rcub_farfar_2004 .
Vuleta, Gordana, Pantelić, Ivana, Savić, Snežana, "Magistral and galenic drugs in dermatology: Past or present" in Arhiv za farmaciju, 63, no. 2 (2013):129-146,
https://hdl.handle.net/21.15107/rcub_farfar_2004 .
4

Effects of dermocosmetic/cosmetic products for skin lightening: What is real to expect?

Tatljak-Nikolić, Snežana; Savić, Snežana; Vuleta, Gordana; Milić, Jela

(Savez farmaceutskih udruženja Srbije, Beograd, 2013)

TY  - JOUR
AU  - Tatljak-Nikolić, Snežana
AU  - Savić, Snežana
AU  - Vuleta, Gordana
AU  - Milić, Jela
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2026
AB  - Hyperpigmentation is the disorder of skin color, hair color, nails and mucous membranes resulting from the increased amount of melanin in these areas, and it is characterized as dark areas, often seeming unacceptable. The origin of the occurrence of hyperpigmentation are various external and internal factors, such as the harmful effects of sunlight, various postinflammations that occur after injury, chemical peels or laser therapy, and the influence of certain drugs or chemicals, and ageing, as well. Nowadays, even complexion without spots and freckles, translucent and velvety is something everybody tends to and almost half of the planet considers fair complexion to be the ideal of beauty. In African and Asian countries, there is a huge growth of market for whitening skin products. In Europe, whitening skin products are mostly used for special treatments such as evening out of skin tone, removal of stains and spots, or in the case of increased pigmentation, especially in the open areas of skin. The formulated skin whitening product of a high quality, stable and efficient is a big challenge for cosmetologists. There is a large number of active substances (CAS), which lead to the reduction in pigmentation by different mechanisms, but there’s a huge difference between them in visible effects they produce, even after long term use. The paper presents recent information on the mechanism of action and effects of whitening skin products that contain retinoids, hydroquinone, kojic acid, niacinamide, glycolic acid, Licorice extract, resorcinol or undecilenoil phenylalanine.
AB  - Hiperpigmentacije predstavljaju poremećaje boje kože, kose, sluzokože i noktiju koji nastaju usled povećane količine melanina u ovim oblastima, a karakterišu se kao tamna područja, često neprihvatljivog izgleda. Poreklo nastanka hiperpigmentacija su različiti spoljašnji i unutrašnji faktori, kao što su štetno delovanje sunčevih zraka, razne postinflamacije koje nastaju nakon povreda, hemijskog pilinga ili terapije laserom, kao i uticaj nekih lekova ili hemijskih sredstava, ali i starenja kože. Danas se teži ujednačenom tenu, bez pega i fleka, prozračnom i baršunastom, a skoro polovina planete smatra belu put idealom lepote. U afričkim i azijskim zemljama postoji ogroman rast tržišta proizvoda za izbeljivanje/posvetljivanje kože. U Evropi, preparati za izbeljivanje/posvetljivanje kože se uglavnom traže kao specijalni tretmani za izjednačavanje tena, uklanjanje fleka i pega ili u slučaju pojačane pigmentacije, posebno na otvorenim delovima kože. Formulisani proizvod za posvetljivanje/izbeljivanje kože koji je kvalitetan, stabilan i efikasan je veliki izazov za kozmetologe. Na raspolaganju je veliki broj kozmetički aktivnih supstanci (KAS), koje različitim mehanizmima dovode do smanjenja pigmentacija; ali je i velika razlika među njima u vidljivim efektima koje ostvaruju, čak i posle dugotrajne primene. U radu su izneti noviji podaci o mehanizmu delovanja i efektima posvetljivanja kože proizvoda koji sadrže retinoide, hidrohinon, kojic kiselinu, niacinamid, glikolnu kiselinu, ekstrat glicirize, rezorcinol ili undecilenoil fenilalanin.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Effects of dermocosmetic/cosmetic products for skin lightening: What is real to expect?
T1  - Efekti dermokozmetičkih/kozmetičkih preparata za posvetljivanje kože - šta je realno očekivati?
VL  - 63
IS  - 1
SP  - 20
EP  - 39
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2026
ER  - 
@article{
author = "Tatljak-Nikolić, Snežana and Savić, Snežana and Vuleta, Gordana and Milić, Jela",
year = "2013",
abstract = "Hyperpigmentation is the disorder of skin color, hair color, nails and mucous membranes resulting from the increased amount of melanin in these areas, and it is characterized as dark areas, often seeming unacceptable. The origin of the occurrence of hyperpigmentation are various external and internal factors, such as the harmful effects of sunlight, various postinflammations that occur after injury, chemical peels or laser therapy, and the influence of certain drugs or chemicals, and ageing, as well. Nowadays, even complexion without spots and freckles, translucent and velvety is something everybody tends to and almost half of the planet considers fair complexion to be the ideal of beauty. In African and Asian countries, there is a huge growth of market for whitening skin products. In Europe, whitening skin products are mostly used for special treatments such as evening out of skin tone, removal of stains and spots, or in the case of increased pigmentation, especially in the open areas of skin. The formulated skin whitening product of a high quality, stable and efficient is a big challenge for cosmetologists. There is a large number of active substances (CAS), which lead to the reduction in pigmentation by different mechanisms, but there’s a huge difference between them in visible effects they produce, even after long term use. The paper presents recent information on the mechanism of action and effects of whitening skin products that contain retinoids, hydroquinone, kojic acid, niacinamide, glycolic acid, Licorice extract, resorcinol or undecilenoil phenylalanine., Hiperpigmentacije predstavljaju poremećaje boje kože, kose, sluzokože i noktiju koji nastaju usled povećane količine melanina u ovim oblastima, a karakterišu se kao tamna područja, često neprihvatljivog izgleda. Poreklo nastanka hiperpigmentacija su različiti spoljašnji i unutrašnji faktori, kao što su štetno delovanje sunčevih zraka, razne postinflamacije koje nastaju nakon povreda, hemijskog pilinga ili terapije laserom, kao i uticaj nekih lekova ili hemijskih sredstava, ali i starenja kože. Danas se teži ujednačenom tenu, bez pega i fleka, prozračnom i baršunastom, a skoro polovina planete smatra belu put idealom lepote. U afričkim i azijskim zemljama postoji ogroman rast tržišta proizvoda za izbeljivanje/posvetljivanje kože. U Evropi, preparati za izbeljivanje/posvetljivanje kože se uglavnom traže kao specijalni tretmani za izjednačavanje tena, uklanjanje fleka i pega ili u slučaju pojačane pigmentacije, posebno na otvorenim delovima kože. Formulisani proizvod za posvetljivanje/izbeljivanje kože koji je kvalitetan, stabilan i efikasan je veliki izazov za kozmetologe. Na raspolaganju je veliki broj kozmetički aktivnih supstanci (KAS), koje različitim mehanizmima dovode do smanjenja pigmentacija; ali je i velika razlika među njima u vidljivim efektima koje ostvaruju, čak i posle dugotrajne primene. U radu su izneti noviji podaci o mehanizmu delovanja i efektima posvetljivanja kože proizvoda koji sadrže retinoide, hidrohinon, kojic kiselinu, niacinamid, glikolnu kiselinu, ekstrat glicirize, rezorcinol ili undecilenoil fenilalanin.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Effects of dermocosmetic/cosmetic products for skin lightening: What is real to expect?, Efekti dermokozmetičkih/kozmetičkih preparata za posvetljivanje kože - šta je realno očekivati?",
volume = "63",
number = "1",
pages = "20-39",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2026"
}
Tatljak-Nikolić, S., Savić, S., Vuleta, G.,& Milić, J.. (2013). Effects of dermocosmetic/cosmetic products for skin lightening: What is real to expect?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(1), 20-39.
https://hdl.handle.net/21.15107/rcub_farfar_2026
Tatljak-Nikolić S, Savić S, Vuleta G, Milić J. Effects of dermocosmetic/cosmetic products for skin lightening: What is real to expect?. in Arhiv za farmaciju. 2013;63(1):20-39.
https://hdl.handle.net/21.15107/rcub_farfar_2026 .
Tatljak-Nikolić, Snežana, Savić, Snežana, Vuleta, Gordana, Milić, Jela, "Effects of dermocosmetic/cosmetic products for skin lightening: What is real to expect?" in Arhiv za farmaciju, 63, no. 1 (2013):20-39,
https://hdl.handle.net/21.15107/rcub_farfar_2026 .
1

Dry skin as a condition and a symptom: The role of dermocosmetic preparations

Savić, Snežana; Lukić, Milica; Vuleta, Gordana

(Savez farmaceutskih udruženja Srbije, Beograd, 2013)

TY  - JOUR
AU  - Savić, Snežana
AU  - Lukić, Milica
AU  - Vuleta, Gordana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2008
AB  - Water is absolutely essential for the normal functioning of the skin and especially its outer layer, the stratum corneum (SC). Loss of water from the skin must be carefully regulated, a function dependent on the complex nature of the SC. The retention of water in the SC is dependent on two major components: 1) the presence of natural hygroscopic agents within the corneocytes (collectively referred to as natural moisturizing factor) and 2) the SC intercellular lipids (physiological lipids) orderly arranged to form a barrier to transepidermal water loss (TEWL). The water content of the SC is necessary for proper SC maturation and skin desquamation. In that sense, the use of dermocosmetic products for skin hydration of an optimal composition has the great meaning. The ingredients of these formulations reach their effect by the different manners. The oclusives cover the SC and reduce the TEWL; humectants attract the water from the atmosphere and lower epidermal layers and hydrate the skin, and emollients make it softer and smoother. Combining these three effects dermocosmetic products for skin moisturization realize their effect and use in the treatment of healthy skin with dryness signs, but also for diseased skin with the skin dryness as dominant symptom. To suggest an adequate product for determined skin type, the pharmacist has to know specific categories of ingredients in dermocosmetic products for skin hydration as well as their composition dependent effect.
AB  - Voda je nesumnjivo esencijalna za normalno funkcionisanje kože, posebno njenog spoljašnjeg sloja, stratum corneum-a (SC). Gubitak vode iz kože mora biti pažljivo regulisan, i funkcionalno je zavisan od kompleksne prirode SC. Zadržavanje vode u SC zavisi od dva glavna faktora: 1) prisustva prirodnih higroskopnih agenasa unutar korneocita označenih kao prirodni vlažeći faktor i 2) intercelularnih lipda SC (fiziološki lipidi) koji su strukturno organizovani da formiraju barijeru za pasivnu difuziju vode iz kože (transepidermalni gubitak vode (TEWL)). Odgovarajući sadržaj vode u SC važan je za njegovo odgovarajuće sazrevanje i deskvamaciju kože. U tom smislu primena dermokozmetičkih proizvoda za vlaženje kože određenog, dobro izbalansiranog sastava ima veliki značaj. Sastojci ovih formulacija svoj efekat postižu na različite načine. Okluzivi pokrivaju SC i smanjuju TEWL; humektansi privlače vodu iz atmosfere i nižih vijabilnih slojeva epidermisa i vlaže kožu, a emolijensi je omekšavaju i čine glatkijom. Kombinacijom ova tri efekta dermokozmetički proizvodi za vlaženje kože ostvaruju svoj efekat i koriste se u tretmanu zdrave kože sa znacima suvoće, ali i obolele kože kod koje je suvoća jedan od dominantnih simptoma. Kako bi predložio odgovarajući proizvod za određeni tip kože, farmaceut mora poznavati posebne kategorije sastojaka u dermokozmetičkim proizvodima za vlaženje kože i kako ovi proizvodi deluju, zavisno od sastava.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Dry skin as a condition and a symptom: The role of dermocosmetic preparations
T1  - Suva koža kao stanje i simptom - uloga dermokozmetičkih preparata
VL  - 63
IS  - 2
SP  - 158
EP  - 173
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2008
ER  - 
@article{
author = "Savić, Snežana and Lukić, Milica and Vuleta, Gordana",
year = "2013",
abstract = "Water is absolutely essential for the normal functioning of the skin and especially its outer layer, the stratum corneum (SC). Loss of water from the skin must be carefully regulated, a function dependent on the complex nature of the SC. The retention of water in the SC is dependent on two major components: 1) the presence of natural hygroscopic agents within the corneocytes (collectively referred to as natural moisturizing factor) and 2) the SC intercellular lipids (physiological lipids) orderly arranged to form a barrier to transepidermal water loss (TEWL). The water content of the SC is necessary for proper SC maturation and skin desquamation. In that sense, the use of dermocosmetic products for skin hydration of an optimal composition has the great meaning. The ingredients of these formulations reach their effect by the different manners. The oclusives cover the SC and reduce the TEWL; humectants attract the water from the atmosphere and lower epidermal layers and hydrate the skin, and emollients make it softer and smoother. Combining these three effects dermocosmetic products for skin moisturization realize their effect and use in the treatment of healthy skin with dryness signs, but also for diseased skin with the skin dryness as dominant symptom. To suggest an adequate product for determined skin type, the pharmacist has to know specific categories of ingredients in dermocosmetic products for skin hydration as well as their composition dependent effect., Voda je nesumnjivo esencijalna za normalno funkcionisanje kože, posebno njenog spoljašnjeg sloja, stratum corneum-a (SC). Gubitak vode iz kože mora biti pažljivo regulisan, i funkcionalno je zavisan od kompleksne prirode SC. Zadržavanje vode u SC zavisi od dva glavna faktora: 1) prisustva prirodnih higroskopnih agenasa unutar korneocita označenih kao prirodni vlažeći faktor i 2) intercelularnih lipda SC (fiziološki lipidi) koji su strukturno organizovani da formiraju barijeru za pasivnu difuziju vode iz kože (transepidermalni gubitak vode (TEWL)). Odgovarajući sadržaj vode u SC važan je za njegovo odgovarajuće sazrevanje i deskvamaciju kože. U tom smislu primena dermokozmetičkih proizvoda za vlaženje kože određenog, dobro izbalansiranog sastava ima veliki značaj. Sastojci ovih formulacija svoj efekat postižu na različite načine. Okluzivi pokrivaju SC i smanjuju TEWL; humektansi privlače vodu iz atmosfere i nižih vijabilnih slojeva epidermisa i vlaže kožu, a emolijensi je omekšavaju i čine glatkijom. Kombinacijom ova tri efekta dermokozmetički proizvodi za vlaženje kože ostvaruju svoj efekat i koriste se u tretmanu zdrave kože sa znacima suvoće, ali i obolele kože kod koje je suvoća jedan od dominantnih simptoma. Kako bi predložio odgovarajući proizvod za određeni tip kože, farmaceut mora poznavati posebne kategorije sastojaka u dermokozmetičkim proizvodima za vlaženje kože i kako ovi proizvodi deluju, zavisno od sastava.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Dry skin as a condition and a symptom: The role of dermocosmetic preparations, Suva koža kao stanje i simptom - uloga dermokozmetičkih preparata",
volume = "63",
number = "2",
pages = "158-173",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2008"
}
Savić, S., Lukić, M.,& Vuleta, G.. (2013). Dry skin as a condition and a symptom: The role of dermocosmetic preparations. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(2), 158-173.
https://hdl.handle.net/21.15107/rcub_farfar_2008
Savić S, Lukić M, Vuleta G. Dry skin as a condition and a symptom: The role of dermocosmetic preparations. in Arhiv za farmaciju. 2013;63(2):158-173.
https://hdl.handle.net/21.15107/rcub_farfar_2008 .
Savić, Snežana, Lukić, Milica, Vuleta, Gordana, "Dry skin as a condition and a symptom: The role of dermocosmetic preparations" in Arhiv za farmaciju, 63, no. 2 (2013):158-173,
https://hdl.handle.net/21.15107/rcub_farfar_2008 .