TY  - JOUR
AU  - Lalić-Ćosić, Sanja
AU  - Dopsaj, Violeta
AU  - Kovač, Mirjana
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Mobarrez, Fariborz
AU  - Antović, Aleksandra
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3997
AB  - Background: Pre-eclampsia (P-EC) is associated with systemic inflammation, endothelial dysfunction and hypercoagulability. The role of extracellular vesicles (EVs) in coagulation disturbances affecting the development and severity of P-EC remains elusive. We aimed to evaluate the concentration of EVs expressing phosphatidylserine (PS) and specific markers in relation to the thrombin and fibrin formation as well as fibrin clot properties, in pregnant women with P-EC in comparison to healthy pregnant women of similar gestational age. Methods: Blood samples of 30 pregnant women diagnosed with P-EC were collected on the morning following admission to hospital and after delivery (mean duration 5 days). The concentration of the PS-exposing EVs (PS+ EVs) from platelets (CD42a+, endothelial cells (CD62E+), and PS+ EVs expressing tissue factor (TF) and vascular cell adhesion molecule 1 (VCAM-1) were measured by flow cytometry. Further phenotyping of EVs also included expression of PlGF. Markers of maternal haemostasis were correlated with EVs concentration in plasma. Results: Preeclamptic pregnancy was associated with significantly higher plasma levels of PS+ CD42a+ EVs and PS+ VCAM-1+ EVs in comparison with normotensive pregnancy. P-EC patients after delivery had markedly elevated concentration of PS+ CD42a+ EVs, CD62E+ EVs, TF+ EVs, and VCAM-1+ EVs compared to those before delivery. Inverse correlation was observed between EVs concentrations (PS+, PS+ TF+, and PlGF+) and parameters of overall haemostatic potential (OHP) and fibrin formation, while PS+ VCAM-1+ EVs directly correlated with FVIII activity in plasma. Conclusion: Increased levels of PS+ EVs subpopulations in P-EC and their association with global haemostatic parameters, as well as with fibrin clot properties may suggest EVs involvement in intravascular fibrin deposition leading to subsequent microcirculation disorders.
PB  - Frontiers Media S.A.
T2  - Frontiers in Medicine
T1  - Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients
VL  - 8
DO  - 10.3389/fmed.2021.761453
ER  - 

@article{
author = "Lalić-Ćosić, Sanja and Dopsaj, Violeta and Kovač, Mirjana and Mandić-Marković, Vesna and Miković, Željko and Mobarrez, Fariborz and Antović, Aleksandra",
year = "2021",
abstract = "Background: Pre-eclampsia (P-EC) is associated with systemic inflammation, endothelial dysfunction and hypercoagulability. The role of extracellular vesicles (EVs) in coagulation disturbances affecting the development and severity of P-EC remains elusive. We aimed to evaluate the concentration of EVs expressing phosphatidylserine (PS) and specific markers in relation to the thrombin and fibrin formation as well as fibrin clot properties, in pregnant women with P-EC in comparison to healthy pregnant women of similar gestational age. Methods: Blood samples of 30 pregnant women diagnosed with P-EC were collected on the morning following admission to hospital and after delivery (mean duration 5 days). The concentration of the PS-exposing EVs (PS+ EVs) from platelets (CD42a+, endothelial cells (CD62E+), and PS+ EVs expressing tissue factor (TF) and vascular cell adhesion molecule 1 (VCAM-1) were measured by flow cytometry. Further phenotyping of EVs also included expression of PlGF. Markers of maternal haemostasis were correlated with EVs concentration in plasma. Results: Preeclamptic pregnancy was associated with significantly higher plasma levels of PS+ CD42a+ EVs and PS+ VCAM-1+ EVs in comparison with normotensive pregnancy. P-EC patients after delivery had markedly elevated concentration of PS+ CD42a+ EVs, CD62E+ EVs, TF+ EVs, and VCAM-1+ EVs compared to those before delivery. Inverse correlation was observed between EVs concentrations (PS+, PS+ TF+, and PlGF+) and parameters of overall haemostatic potential (OHP) and fibrin formation, while PS+ VCAM-1+ EVs directly correlated with FVIII activity in plasma. Conclusion: Increased levels of PS+ EVs subpopulations in P-EC and their association with global haemostatic parameters, as well as with fibrin clot properties may suggest EVs involvement in intravascular fibrin deposition leading to subsequent microcirculation disorders.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Medicine",
title = "Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients",
volume = "8",
doi = "10.3389/fmed.2021.761453"
}

Lalić-Ćosić, S., Dopsaj, V., Kovač, M., Mandić-Marković, V., Miković, Ž., Mobarrez, F.,& Antović, A.. (2021). Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. in Frontiers in Medicine
Frontiers Media S.A.., 8.
https://doi.org/10.3389/fmed.2021.761453

Lalić-Ćosić S, Dopsaj V, Kovač M, Mandić-Marković V, Miković Ž, Mobarrez F, Antović A. Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. in Frontiers in Medicine. 2021;8.
doi:10.3389/fmed.2021.761453 .

Lalić-Ćosić, Sanja, Dopsaj, Violeta, Kovač, Mirjana, Mandić-Marković, Vesna, Miković, Željko, Mobarrez, Fariborz, Antović, Aleksandra, "Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients" in Frontiers in Medicine, 8 (2021),
https://doi.org/10.3389/fmed.2021.761453 . .

TY  - JOUR
AU  - Ardalić, Daniela
AU  - Stefanović, Aleksandra
AU  - Banjac, Gorica
AU  - Cabunac, Petar
AU  - Miljković, Milica
AU  - Mandić-Marković, Vesna
AU  - Stanimirović, Srđan
AU  - Damnjanović Pažin, Barbara
AU  - Spasić, Slavíca
AU  - Spasojević-Kalimanovska, Vesna
AU  - Karadžov-Orlić, Nataša
AU  - Miković, Željko
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3626
AB  - Objectives: The goal of this study was to investigate metabolic changes in lipids and oxidative stress parameters in the first trimester of pregnancy with the more specific aim of estimating the significance and strength of researched parameters in the prediction of preeclampsia. Design and Methods. The study included 87 high-risk pregnant (HRG) female subjects, 14 with developed preeclampsia (PEC) and 43 healthy pregnant female subjects matched for gestational age (CG). Thiobarbituric acid-reactive substances (TBARS) concentration, lipid hydroperoxides (LOOH), pro-oxidant antioxidant balance (PAB) and total oxidative status (TOS) were measured as oxidative stress markers, while total antioxidant capacity (TAC) was measured as an antioxidative defense parameter. The Atherogenic Index of Plasma (AIP) was calculated as the base 10 logarithm of the ratio of the plasma concentration of triglycerides (TG) to the plasma concentration of highdensity lipoprotein cholesterol (HDL-C), with each concentration expressed in mmol/L. Results: The results have shown that lipid indices, especially AIP, were significantly higher in the first trimester of HRG (p < 0.001) and PEC (p < 0.001). Oxidative stress parameters were significantlly higher, while TAC was significantly lower in HRG vs. CG [0.7 ± 0.15 vs 1.1 ± 0.16; (p < 0.001)] and in PEC [0.6 ± 0.12 vs 1.1 ± 0.16; (p < 0.001)] vs. CG. Also, in the HRG, results have shown an independent association of AIP with the preeclampsia development (p < 0.05), while placental growth factor did not show the expected level of significance (p = 0.648). Analysis of the Receiver Operating Characteristics (ROC) curves indicated that certain parameters included in the research model have very good diagnostic accuracy for preeclampsia (AUC = 0.856). Conclusions: AIP is associated with high-risk pregnancies. Furthermore, our results firmly underscored AIP as a potential marker for preeclampsia prediction.
PB  - Elsevier
T2  - Clinical Biochemistry
T1  - Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction
VL  - 81
SP  - 34
EP  - 40
DO  - 10.1016/j.clinbiochem.2020.05.003
ER  - 

@article{
author = "Ardalić, Daniela and Stefanović, Aleksandra and Banjac, Gorica and Cabunac, Petar and Miljković, Milica and Mandić-Marković, Vesna and Stanimirović, Srđan and Damnjanović Pažin, Barbara and Spasić, Slavíca and Spasojević-Kalimanovska, Vesna and Karadžov-Orlić, Nataša and Miković, Željko",
year = "2020",
abstract = "Objectives: The goal of this study was to investigate metabolic changes in lipids and oxidative stress parameters in the first trimester of pregnancy with the more specific aim of estimating the significance and strength of researched parameters in the prediction of preeclampsia. Design and Methods. The study included 87 high-risk pregnant (HRG) female subjects, 14 with developed preeclampsia (PEC) and 43 healthy pregnant female subjects matched for gestational age (CG). Thiobarbituric acid-reactive substances (TBARS) concentration, lipid hydroperoxides (LOOH), pro-oxidant antioxidant balance (PAB) and total oxidative status (TOS) were measured as oxidative stress markers, while total antioxidant capacity (TAC) was measured as an antioxidative defense parameter. The Atherogenic Index of Plasma (AIP) was calculated as the base 10 logarithm of the ratio of the plasma concentration of triglycerides (TG) to the plasma concentration of highdensity lipoprotein cholesterol (HDL-C), with each concentration expressed in mmol/L. Results: The results have shown that lipid indices, especially AIP, were significantly higher in the first trimester of HRG (p < 0.001) and PEC (p < 0.001). Oxidative stress parameters were significantlly higher, while TAC was significantly lower in HRG vs. CG [0.7 ± 0.15 vs 1.1 ± 0.16; (p < 0.001)] and in PEC [0.6 ± 0.12 vs 1.1 ± 0.16; (p < 0.001)] vs. CG. Also, in the HRG, results have shown an independent association of AIP with the preeclampsia development (p < 0.05), while placental growth factor did not show the expected level of significance (p = 0.648). Analysis of the Receiver Operating Characteristics (ROC) curves indicated that certain parameters included in the research model have very good diagnostic accuracy for preeclampsia (AUC = 0.856). Conclusions: AIP is associated with high-risk pregnancies. Furthermore, our results firmly underscored AIP as a potential marker for preeclampsia prediction.",
publisher = "Elsevier",
journal = "Clinical Biochemistry",
title = "Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction",
volume = "81",
pages = "34-40",
doi = "10.1016/j.clinbiochem.2020.05.003"
}

Ardalić, D., Stefanović, A., Banjac, G., Cabunac, P., Miljković, M., Mandić-Marković, V., Stanimirović, S., Damnjanović Pažin, B., Spasić, S., Spasojević-Kalimanovska, V., Karadžov-Orlić, N.,& Miković, Ž.. (2020). Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction. in Clinical Biochemistry
Elsevier., 81, 34-40.
https://doi.org/10.1016/j.clinbiochem.2020.05.003

Ardalić D, Stefanović A, Banjac G, Cabunac P, Miljković M, Mandić-Marković V, Stanimirović S, Damnjanović Pažin B, Spasić S, Spasojević-Kalimanovska V, Karadžov-Orlić N, Miković Ž. Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction. in Clinical Biochemistry. 2020;81:34-40.
doi:10.1016/j.clinbiochem.2020.05.003 .

Ardalić, Daniela, Stefanović, Aleksandra, Banjac, Gorica, Cabunac, Petar, Miljković, Milica, Mandić-Marković, Vesna, Stanimirović, Srđan, Damnjanović Pažin, Barbara, Spasić, Slavíca, Spasojević-Kalimanovska, Vesna, Karadžov-Orlić, Nataša, Miković, Željko, "Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction" in Clinical Biochemistry, 81 (2020):34-40,
https://doi.org/10.1016/j.clinbiochem.2020.05.003 . .

TY  - JOUR
AU  - Lalić-Ćosić, Sanja
AU  - Dopsaj, Violeta
AU  - Kovač, Mirjana
AU  - Pruner, Iva
AU  - Littmann, Karin
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Antović, Aleksandra
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3609
AB  - Introduction: Haemostatic balance shifted towards hypercoagulability in normal pregnancy is even more pronounced in pre-eclampsia (P-EC). The aim of this study was to analyse haemostatic disturbances and fibrin clot properties in women with pre-eclampsia and to investigate their association with maternal and foetal outcomes. Methods: Forty-six pregnant women diagnosed with pre-eclampsia were included in the study, with blood sampling done on the morning following admission to hospital, as well as after delivery (mean duration 4.8 days). Two global haemostatic assays—endogenous thrombin potential (ETP) and assay of overall haemostatic potential (OHP)—were employed, including fibrin clot turbidity measurements and scanning electron microscopy (SEM) of representative samples. Results: Three thrombin generation parameters (ETP, t_lag and peak height) and OHP were significantly increased in pre-eclampsia compared with controls, whereas overall fibrinolytic potential (OFP—determined as a parameter of the OHP assay) had significantly lower values. Clot lysis time was significantly prolonged in patients with pre-eclampsia. In the pre-eclamptic group after delivery, we observed a significant elevation in the peak height and a reduction in the time to peak and OFP compared with values before delivery. Pre-eclamptic patients with renal complications had significantly higher values for ETP, peak height and D-dimer. Turbidity measurements and SEM revealed dense fibrin structure in patients with pre-eclampsia. Conclusion: Patients with pre-eclampsia have enhanced coagulation and impaired fibrinolysis before, and even after, delivery. In particular, the presence of multi-organ dysfunction, such as renal dysfunction, may be associated with increased thrombin generation in pre-eclampsia.
PB  - Wiley-Blackwell
T2  - International Journal of Laboratory Hematology
T1  - Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia
VL  - 42
IS  - 3
SP  - 322
EP  - 330
DO  - 10.1111/ijlh.13183
ER  - 

@article{
author = "Lalić-Ćosić, Sanja and Dopsaj, Violeta and Kovač, Mirjana and Pruner, Iva and Littmann, Karin and Mandić-Marković, Vesna and Miković, Željko and Antović, Aleksandra",
year = "2020",
abstract = "Introduction: Haemostatic balance shifted towards hypercoagulability in normal pregnancy is even more pronounced in pre-eclampsia (P-EC). The aim of this study was to analyse haemostatic disturbances and fibrin clot properties in women with pre-eclampsia and to investigate their association with maternal and foetal outcomes. Methods: Forty-six pregnant women diagnosed with pre-eclampsia were included in the study, with blood sampling done on the morning following admission to hospital, as well as after delivery (mean duration 4.8 days). Two global haemostatic assays—endogenous thrombin potential (ETP) and assay of overall haemostatic potential (OHP)—were employed, including fibrin clot turbidity measurements and scanning electron microscopy (SEM) of representative samples. Results: Three thrombin generation parameters (ETP, t_lag and peak height) and OHP were significantly increased in pre-eclampsia compared with controls, whereas overall fibrinolytic potential (OFP—determined as a parameter of the OHP assay) had significantly lower values. Clot lysis time was significantly prolonged in patients with pre-eclampsia. In the pre-eclamptic group after delivery, we observed a significant elevation in the peak height and a reduction in the time to peak and OFP compared with values before delivery. Pre-eclamptic patients with renal complications had significantly higher values for ETP, peak height and D-dimer. Turbidity measurements and SEM revealed dense fibrin structure in patients with pre-eclampsia. Conclusion: Patients with pre-eclampsia have enhanced coagulation and impaired fibrinolysis before, and even after, delivery. In particular, the presence of multi-organ dysfunction, such as renal dysfunction, may be associated with increased thrombin generation in pre-eclampsia.",
publisher = "Wiley-Blackwell",
journal = "International Journal of Laboratory Hematology",
title = "Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia",
volume = "42",
number = "3",
pages = "322-330",
doi = "10.1111/ijlh.13183"
}

Lalić-Ćosić, S., Dopsaj, V., Kovač, M., Pruner, I., Littmann, K., Mandić-Marković, V., Miković, Ž.,& Antović, A.. (2020). Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia. in International Journal of Laboratory Hematology
Wiley-Blackwell., 42(3), 322-330.
https://doi.org/10.1111/ijlh.13183

Lalić-Ćosić S, Dopsaj V, Kovač M, Pruner I, Littmann K, Mandić-Marković V, Miković Ž, Antović A. Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia. in International Journal of Laboratory Hematology. 2020;42(3):322-330.
doi:10.1111/ijlh.13183 .

Lalić-Ćosić, Sanja, Dopsaj, Violeta, Kovač, Mirjana, Pruner, Iva, Littmann, Karin, Mandić-Marković, Vesna, Miković, Željko, Antović, Aleksandra, "Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia" in International Journal of Laboratory Hematology, 42, no. 3 (2020):322-330,
https://doi.org/10.1111/ijlh.13183 . .

TY  - JOUR
AU  - Ardalić, Daniela
AU  - Stefanović, Aleksandra
AU  - Spasić, Slavica
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2699
AB  - Specifically altered lipid profile and physiological hyperlipidemia during pregnancy are considered essential for the normal course of pregnancy and fetal development. This specific alteration of the lipid profile raises the questions about potential proaterogenic effect of these altered lipid parameters during pregnancy and its influence on the development of cardiovascular disease in women later in life. Research topic was also the association of altered lipid profile during pregnancy with the development of complications in pregnancy, especially gestational diabetes, hypertension and preeclampsia. Through the mediation of cholesterol ester transfer protein (CETP), the activity of which grows in mid-gestation, there are exchanges of the triglycerides between VLDL and LDL or HDL particle, which leads to increased accumulation of triglycerides in these particles, causes them to become smaller and denser with much greater atherogenic potential. These changes in lipid profile point out that a large number of pregnancies increase risk of development of cardiovascular diseases later in life. In order to optimize the predictive capacity of the lipid profile during pregnancy, it is recommended to determine the indexes of lipid.
AB  - Specifično izmenjen lipidni profil i fiziološka hiperlipidemija tokom trudnoće smatraju se esencijalnim za normalan ishod trudnoće i razvoj fetusa, a upravo ova specifičnost promena parametara lipidnog profila otvara pitanja njihove potencijalne proaterogenosti tokom trudnoće i uticaja na rizik za razvoj kardiovaskularne bolesti u kasnijem životu žene. Takođe se ispituje i povezanost izmenjenog lipidnog profila tokom trudnoće sa razvojem komplikacija u trudnoći, pre svega sa razvojem gestacijskog dijabetesa, hipertenzije i preeklampsije. Posredovanjem holesterol estar transportnog proteina (CETP), čija aktivnost raste sredinom trudnoće, dolazi do izmene triglicerida i holesterola između lipoproteinskih čestica vrlo niske gustine (VLDL) i lipoproteinskih čestica male gustine (LDL) ili lipoproteinskih čestica velike gustine (HDL), tako da dolazi do povećanog nakupljanja triglicerida u LDL i HDL česticama, pri čemu one postaju manje i gušće, i kao takve imaju veći proaterogeni potencijal, što sve ukazuje i na proaterogeni potencijal trudnoće, posebno ukoliko se ona ponavlja više puta tokom života. Da bi se optimizirao prediktivni kapacitet lipidnog profila tokom trudnoće preporučuje se određivanje lipidnih indeksa.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Lipid status in phyisiological non-complicated pregnancy
T1  - Lipidni status fiziološke nekomplikovane trudnoće
VL  - 66
IS  - 5
SP  - 191
EP  - 206
DO  - 10.5937/arhfarm1605191A
ER  - 

@article{
author = "Ardalić, Daniela and Stefanović, Aleksandra and Spasić, Slavica and Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2016",
abstract = "Specifically altered lipid profile and physiological hyperlipidemia during pregnancy are considered essential for the normal course of pregnancy and fetal development. This specific alteration of the lipid profile raises the questions about potential proaterogenic effect of these altered lipid parameters during pregnancy and its influence on the development of cardiovascular disease in women later in life. Research topic was also the association of altered lipid profile during pregnancy with the development of complications in pregnancy, especially gestational diabetes, hypertension and preeclampsia. Through the mediation of cholesterol ester transfer protein (CETP), the activity of which grows in mid-gestation, there are exchanges of the triglycerides between VLDL and LDL or HDL particle, which leads to increased accumulation of triglycerides in these particles, causes them to become smaller and denser with much greater atherogenic potential. These changes in lipid profile point out that a large number of pregnancies increase risk of development of cardiovascular diseases later in life. In order to optimize the predictive capacity of the lipid profile during pregnancy, it is recommended to determine the indexes of lipid., Specifično izmenjen lipidni profil i fiziološka hiperlipidemija tokom trudnoće smatraju se esencijalnim za normalan ishod trudnoće i razvoj fetusa, a upravo ova specifičnost promena parametara lipidnog profila otvara pitanja njihove potencijalne proaterogenosti tokom trudnoće i uticaja na rizik za razvoj kardiovaskularne bolesti u kasnijem životu žene. Takođe se ispituje i povezanost izmenjenog lipidnog profila tokom trudnoće sa razvojem komplikacija u trudnoći, pre svega sa razvojem gestacijskog dijabetesa, hipertenzije i preeklampsije. Posredovanjem holesterol estar transportnog proteina (CETP), čija aktivnost raste sredinom trudnoće, dolazi do izmene triglicerida i holesterola između lipoproteinskih čestica vrlo niske gustine (VLDL) i lipoproteinskih čestica male gustine (LDL) ili lipoproteinskih čestica velike gustine (HDL), tako da dolazi do povećanog nakupljanja triglicerida u LDL i HDL česticama, pri čemu one postaju manje i gušće, i kao takve imaju veći proaterogeni potencijal, što sve ukazuje i na proaterogeni potencijal trudnoće, posebno ukoliko se ona ponavlja više puta tokom života. Da bi se optimizirao prediktivni kapacitet lipidnog profila tokom trudnoće preporučuje se određivanje lipidnih indeksa.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Lipid status in phyisiological non-complicated pregnancy, Lipidni status fiziološke nekomplikovane trudnoće",
volume = "66",
number = "5",
pages = "191-206",
doi = "10.5937/arhfarm1605191A"
}

Ardalić, D., Stefanović, A., Spasić, S., Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2016). Lipid status in phyisiological non-complicated pregnancy. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 66(5), 191-206.
https://doi.org/10.5937/arhfarm1605191A

Ardalić D, Stefanović A, Spasić S, Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Mandić-Marković V, Miković Ž, Cerović N. Lipid status in phyisiological non-complicated pregnancy. in Arhiv za farmaciju. 2016;66(5):191-206.
doi:10.5937/arhfarm1605191A .

Ardalić, Daniela, Stefanović, Aleksandra, Spasić, Slavica, Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "Lipid status in phyisiological non-complicated pregnancy" in Arhiv za farmaciju, 66, no. 5 (2016):191-206,
https://doi.org/10.5937/arhfarm1605191A . .

TY  - JOUR
AU  - Ardalić, Daniela
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Vujović, Ana
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2143
AB  - Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and Miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods. Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured through the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results. TBARS concetration was significantly higher (p  lt  0.05) and PON1 activity was significantly lower (p  lt  0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions. Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women.
PB  - Wroclaw Medical Univ, Wroclaw
T2  - Advances in Clinical and Experimental Medicine
T1  - The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy
VL  - 23
IS  - 4
SP  - 575
EP  - 583
DO  - 10.17219/acem/37226
ER  - 

@article{
author = "Ardalić, Daniela and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Vujović, Ana and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2014",
abstract = "Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and Miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods. Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured through the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results. TBARS concetration was significantly higher (p  lt  0.05) and PON1 activity was significantly lower (p  lt  0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions. Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women.",
publisher = "Wroclaw Medical Univ, Wroclaw",
journal = "Advances in Clinical and Experimental Medicine",
title = "The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy",
volume = "23",
number = "4",
pages = "575-583",
doi = "10.17219/acem/37226"
}

Ardalić, D., Stefanović, A., Kotur-Stevuljević, J., Vujović, A., Spasić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2014). The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy. in Advances in Clinical and Experimental Medicine
Wroclaw Medical Univ, Wroclaw., 23(4), 575-583.
https://doi.org/10.17219/acem/37226

Ardalić D, Stefanović A, Kotur-Stevuljević J, Vujović A, Spasić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Mandić-Marković V, Miković Ž, Cerović N. The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy. in Advances in Clinical and Experimental Medicine. 2014;23(4):575-583.
doi:10.17219/acem/37226 .

Ardalić, Daniela, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Vujović, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy" in Advances in Clinical and Experimental Medicine, 23, no. 4 (2014):575-583,
https://doi.org/10.17219/acem/37226 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasić, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Gojković, Tamara
AU  - Ardalić, Daniela
AU  - Mandić-Marković, Vesna
AU  - Cerović, Nikola
AU  - Miković, Željko
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1918
AB  - Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL subclasses distributions before delivery with parameters of newborn size. Blood samples were collected from 41 healthy pregnant women throughout entire pregnancy, before delivery and 7 weeks postpartum. LDL and HDL subclasses were determined by gradient gel electrophoresis, while other biochemical parameters were measured by standard laboratory methods. During gestation LDL size significantly decreased (P  lt  0.001), due to reduction in relative proportion of LDL I (P  lt  0.01) and increase of LDL II (P  lt  0.001) and IIIA (P  lt  0.05) subclasses. In the same time, HDL size and proportions of HDL 2a particles significantly decreased (P  lt  0.001), with concomitant increase of HDL 3b and 3c subclasses (P  lt  0.05). Observed alterations were associated with changes in serum triglyceride levels. Rearrangement in LDL subclasses distribution during gestation was transient, while postpartum HDL subclasses distribution remained shifted toward smaller particles. Higher proportion of LDL IVB in maternal plasma before delivery was an independent predictor of smaller birth weights and lengths, while higher proportions of LDL IVB and HDL 2a subclasses were independent determinants of newborns' smaller head circumferences. Routine gestational and prenatal care in otherwise normal pregnancy could be complemented with evaluation of LDL and HDL particles distribution in order to ensure an adequate size of the newborn.
PB  - Springer/Plenum Publishers, New York
T2  - Maternal and Child Health Journal
T1  - Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference
VL  - 17
IS  - 3
SP  - 556
EP  - 565
DO  - 10.1007/s10995-012-1031-x
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasić, Slavica and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Gojković, Tamara and Ardalić, Daniela and Mandić-Marković, Vesna and Cerović, Nikola and Miković, Željko",
year = "2013",
abstract = "Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL subclasses distributions before delivery with parameters of newborn size. Blood samples were collected from 41 healthy pregnant women throughout entire pregnancy, before delivery and 7 weeks postpartum. LDL and HDL subclasses were determined by gradient gel electrophoresis, while other biochemical parameters were measured by standard laboratory methods. During gestation LDL size significantly decreased (P  lt  0.001), due to reduction in relative proportion of LDL I (P  lt  0.01) and increase of LDL II (P  lt  0.001) and IIIA (P  lt  0.05) subclasses. In the same time, HDL size and proportions of HDL 2a particles significantly decreased (P  lt  0.001), with concomitant increase of HDL 3b and 3c subclasses (P  lt  0.05). Observed alterations were associated with changes in serum triglyceride levels. Rearrangement in LDL subclasses distribution during gestation was transient, while postpartum HDL subclasses distribution remained shifted toward smaller particles. Higher proportion of LDL IVB in maternal plasma before delivery was an independent predictor of smaller birth weights and lengths, while higher proportions of LDL IVB and HDL 2a subclasses were independent determinants of newborns' smaller head circumferences. Routine gestational and prenatal care in otherwise normal pregnancy could be complemented with evaluation of LDL and HDL particles distribution in order to ensure an adequate size of the newborn.",
publisher = "Springer/Plenum Publishers, New York",
journal = "Maternal and Child Health Journal",
title = "Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference",
volume = "17",
number = "3",
pages = "556-565",
doi = "10.1007/s10995-012-1031-x"
}

Zeljković, A., Vekić, J., Spasić, S., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Gojković, T., Ardalić, D., Mandić-Marković, V., Cerović, N.,& Miković, Ž.. (2013). Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference. in Maternal and Child Health Journal
Springer/Plenum Publishers, New York., 17(3), 556-565.
https://doi.org/10.1007/s10995-012-1031-x

Zeljković A, Vekić J, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Gojković T, Ardalić D, Mandić-Marković V, Cerović N, Miković Ž. Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference. in Maternal and Child Health Journal. 2013;17(3):556-565.
doi:10.1007/s10995-012-1031-x .

Zeljković, Aleksandra, Vekić, Jelena, Spasić, Slavica, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Gojković, Tamara, Ardalić, Daniela, Mandić-Marković, Vesna, Cerović, Nikola, Miković, Željko, "Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference" in Maternal and Child Health Journal, 17, no. 3 (2013):556-565,
https://doi.org/10.1007/s10995-012-1031-x . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Ardalić, Daniela
AU  - Kotur-Stevuljević, Jelena
AU  - Vujović, Ana
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1694
AB  - The purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon) activity method. As a parameter of oxidative stress status we measured the redox balance. Paraoxonase-1 activity significantly decreased at gestational week 32. In addition, the lipid profile was more atherogenic. Redox balance was significantly increased across gestational weeks. There were independent direct associations between maternal smoking habits before pregnancy, glucose concentrations and redox balance with PON1 activity in the third trimester. This study shows that pregnancy is followed by a decrease in PON1 activity and increased risk for development of cardiovascular diseases. We conclude that changes in paraoxonase-1 status during pregnancy are associated with maternal oxidative stress status and smoking habits.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Research in Microbiology
T1  - Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy
VL  - 33
IS  - 1
SP  - 20
EP  - 26
DO  - 10.1016/j.reprotox.2011.10.009
ER  - 

@article{
author = "Stefanović, Aleksandra and Ardalić, Daniela and Kotur-Stevuljević, Jelena and Vujović, Ana and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2012",
abstract = "The purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon) activity method. As a parameter of oxidative stress status we measured the redox balance. Paraoxonase-1 activity significantly decreased at gestational week 32. In addition, the lipid profile was more atherogenic. Redox balance was significantly increased across gestational weeks. There were independent direct associations between maternal smoking habits before pregnancy, glucose concentrations and redox balance with PON1 activity in the third trimester. This study shows that pregnancy is followed by a decrease in PON1 activity and increased risk for development of cardiovascular diseases. We conclude that changes in paraoxonase-1 status during pregnancy are associated with maternal oxidative stress status and smoking habits.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Research in Microbiology",
title = "Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy",
volume = "33",
number = "1",
pages = "20-26",
doi = "10.1016/j.reprotox.2011.10.009"
}

Stefanović, A., Ardalić, D., Kotur-Stevuljević, J., Vujović, A., Spasić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2012). Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy. in Research in Microbiology
Pergamon-Elsevier Science Ltd, Oxford., 33(1), 20-26.
https://doi.org/10.1016/j.reprotox.2011.10.009

Stefanović A, Ardalić D, Kotur-Stevuljević J, Vujović A, Spasić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Mandić-Marković V, Miković Ž, Cerović N. Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy. in Research in Microbiology. 2012;33(1):20-26.
doi:10.1016/j.reprotox.2011.10.009 .

Stefanović, Aleksandra, Ardalić, Daniela, Kotur-Stevuljević, Jelena, Vujović, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy" in Research in Microbiology, 33, no. 1 (2012):20-26,
https://doi.org/10.1016/j.reprotox.2011.10.009 . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Vujović, Ana
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Martinović, Jelena
AU  - Ardalić, Daniela
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1635
AB  - Background: Pregnancy is a stressful condition linked with altered lipid profile, increased oxidative stress and increased inflammation processes. The purpose of the present study was to determine the associations between those alterations with increased weight gain during pregnancy. Methods: The atherogenic index of plasma (AIP) and oxidative stress status parameters were determinated in 50 healthy and 172 pregnant women with non-complicated pregnancy. Pregnant women were divided in four groups according to body mass index (BMI) values (BMI quartiles). Results: Oxidative stress parameters were significantly lower in the control group compared with all the pregnant women quartiles. Unexpectedly, differences in oxidative stress parameters between BMI quartiles groups were not significant. The antioxidant defence parameters remained quite similar in the different BMI quartiles. Weight gain and paraoxonase-1 (PON1) activities were independently associated with increased AIP while weight gain and triglyceride concentration were found to be significant predictors of PON1 activities. Conclusions: The results of our current study indicate the association of maternal weight gain during pregnancy and altered lipid profile, elevated oxidative stress and changed antioxidative capacity of PON1. Taken together all these facts indicate possible increased risk of cardiovascular disease (CVD) development in later life if the weight gain during pregnancy is excessive.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy
VL  - 50
IS  - 11
SP  - 2019
EP  - 2025
DO  - 10.1515/cclm-2012-0117
ER  - 

@article{
author = "Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Vujović, Ana and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Martinović, Jelena and Ardalić, Daniela and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2012",
abstract = "Background: Pregnancy is a stressful condition linked with altered lipid profile, increased oxidative stress and increased inflammation processes. The purpose of the present study was to determine the associations between those alterations with increased weight gain during pregnancy. Methods: The atherogenic index of plasma (AIP) and oxidative stress status parameters were determinated in 50 healthy and 172 pregnant women with non-complicated pregnancy. Pregnant women were divided in four groups according to body mass index (BMI) values (BMI quartiles). Results: Oxidative stress parameters were significantly lower in the control group compared with all the pregnant women quartiles. Unexpectedly, differences in oxidative stress parameters between BMI quartiles groups were not significant. The antioxidant defence parameters remained quite similar in the different BMI quartiles. Weight gain and paraoxonase-1 (PON1) activities were independently associated with increased AIP while weight gain and triglyceride concentration were found to be significant predictors of PON1 activities. Conclusions: The results of our current study indicate the association of maternal weight gain during pregnancy and altered lipid profile, elevated oxidative stress and changed antioxidative capacity of PON1. Taken together all these facts indicate possible increased risk of cardiovascular disease (CVD) development in later life if the weight gain during pregnancy is excessive.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy",
volume = "50",
number = "11",
pages = "2019-2025",
doi = "10.1515/cclm-2012-0117"
}

Stefanović, A., Kotur-Stevuljević, J., Vujović, A., Spasić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Martinović, J., Ardalić, D., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2012). Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 50(11), 2019-2025.
https://doi.org/10.1515/cclm-2012-0117

Stefanović A, Kotur-Stevuljević J, Vujović A, Spasić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Martinović J, Ardalić D, Mandić-Marković V, Miković Ž, Cerović N. Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy. in Clinical Chemistry and Laboratory Medicine. 2012;50(11):2019-2025.
doi:10.1515/cclm-2012-0117 .

Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Vujović, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Martinović, Jelena, Ardalić, Daniela, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy" in Clinical Chemistry and Laboratory Medicine, 50, no. 11 (2012):2019-2025,
https://doi.org/10.1515/cclm-2012-0117 . .

TY  - CONF
AU  - Franković, I.
AU  - Spasić, S.
AU  - Kotur-Stevuljević, Jelena
AU  - Ardalić, Daniela
AU  - Osap, J.
AU  - Skelić, I.
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1532
PB  - Walter de Gruyter & Co, Berlin
C3  - Clinical Chemistry and Laboratory Medicine
T1  - Pregnancy levels of iron, total iron-binding capacity, transferin and ferritin
VL  - 49
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1532
ER  - 

@conference{
author = "Franković, I. and Spasić, S. and Kotur-Stevuljević, Jelena and Ardalić, Daniela and Osap, J. and Skelić, I. and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2011",
publisher = "Walter de Gruyter & Co, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Pregnancy levels of iron, total iron-binding capacity, transferin and ferritin",
volume = "49",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1532"
}

Franković, I., Spasić, S., Kotur-Stevuljević, J., Ardalić, D., Osap, J., Skelić, I., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2011). Pregnancy levels of iron, total iron-binding capacity, transferin and ferritin. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter & Co, Berlin., 49.
https://hdl.handle.net/21.15107/rcub_farfar_1532

Franković I, Spasić S, Kotur-Stevuljević J, Ardalić D, Osap J, Skelić I, Mandić-Marković V, Miković Ž, Cerović N. Pregnancy levels of iron, total iron-binding capacity, transferin and ferritin. in Clinical Chemistry and Laboratory Medicine. 2011;49.
https://hdl.handle.net/21.15107/rcub_farfar_1532 .

Franković, I., Spasić, S., Kotur-Stevuljević, Jelena, Ardalić, Daniela, Osap, J., Skelić, I., Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "Pregnancy levels of iron, total iron-binding capacity, transferin and ferritin" in Clinical Chemistry and Laboratory Medicine, 49 (2011),
https://hdl.handle.net/21.15107/rcub_farfar_1532 .

TY  - CONF
AU  - Corović, S.
AU  - Spasić, S.
AU  - Ardalić, Daniela
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1519
PB  - Walter de Gruyter & Co, Berlin
C3  - Clinical Chemistry and Laboratory Medicine
T1  - Serum high sensitive c-reactive protein level in normal pregnancy and his association with body mass index
VL  - 49
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1519
ER  - 

@conference{
author = "Corović, S. and Spasić, S. and Ardalić, Daniela and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2011",
publisher = "Walter de Gruyter & Co, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Serum high sensitive c-reactive protein level in normal pregnancy and his association with body mass index",
volume = "49",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1519"
}

Corović, S., Spasić, S., Ardalić, D., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2011). Serum high sensitive c-reactive protein level in normal pregnancy and his association with body mass index. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter & Co, Berlin., 49.
https://hdl.handle.net/21.15107/rcub_farfar_1519

Corović S, Spasić S, Ardalić D, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Mandić-Marković V, Miković Ž, Cerović N. Serum high sensitive c-reactive protein level in normal pregnancy and his association with body mass index. in Clinical Chemistry and Laboratory Medicine. 2011;49.
https://hdl.handle.net/21.15107/rcub_farfar_1519 .

Corović, S., Spasić, S., Ardalić, Daniela, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "Serum high sensitive c-reactive protein level in normal pregnancy and his association with body mass index" in Clinical Chemistry and Laboratory Medicine, 49 (2011),
https://hdl.handle.net/21.15107/rcub_farfar_1519 .