TY  - JOUR
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Grahovac, Lazar
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5516
AB  - Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.
PB  - MDPI
T2  - Antioxidants
T1  - Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies
VL  - 13
IS  - 2
DO  - 10.3390/antiox13020147
ER  - 

@article{
author = "Baralić, Katarina and Živanović, Jovana and Marić, Đurđica and Božić, Dragica and Grahovac, Lazar and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies",
volume = "13",
number = "2",
doi = "10.3390/antiox13020147"
}

Baralić, K., Živanović, J., Marić, Đ., Božić, D., Grahovac, L., Antonijević-Miljaković, E., Ćurčić, M., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants
MDPI., 13(2).
https://doi.org/10.3390/antiox13020147

Baralić K, Živanović J, Marić Đ, Božić D, Grahovac L, Antonijević-Miljaković E, Ćurčić M, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants. 2024;13(2).
doi:10.3390/antiox13020147 .

Baralić, Katarina, Živanović, Jovana, Marić, Đurđica, Božić, Dragica, Grahovac, Lazar, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies" in Antioxidants, 13, no. 2 (2024),
https://doi.org/10.3390/antiox13020147 . .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Manić, Luka
AU  - Grahovac, Lazar
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5513
AB  - In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ...
AB  - In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode
T1  - Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method
SP  - 154
EP  - 156
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5513
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živanović, Jovana and Živančević, Katarina and Marić, Đurđica and Vukelić, Dragana and Manić, Luka and Grahovac, Lazar and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ..., In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode, Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method",
pages = "154-156",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5513"
}

Božić, D., Baralić, K., Živanović, J., Živančević, K., Marić, Đ., Vukelić, D., Manić, L., Grahovac, L., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513

Božić D, Baralić K, Živanović J, Živančević K, Marić Đ, Vukelić D, Manić L, Grahovac L, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

Božić, Dragica, Baralić, Katarina, Živanović, Jovana, Živančević, Katarina, Marić, Đurđica, Vukelić, Dragana, Manić, Luka, Grahovac, Lazar, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):154-156,
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

TY  - CONF
AU  - Bonderović, Vera
AU  - Manić, Luka
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Stojilković, Nikola
AU  - Jorgovanović, Dragica
AU  - Grahovac, Lazar
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5510
AB  - Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ...
AB  - In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama
T1  - Informed mom, healthy baby - How to live safely with chemicals
SP  - 117
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5510
ER  - 

@conference{
author = "Bonderović, Vera and Manić, Luka and Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Stojilković, Nikola and Jorgovanović, Dragica and Grahovac, Lazar and Anđelković, Milena and Repić, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ..., In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama, Informed mom, healthy baby - How to live safely with chemicals",
pages = "117-118",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5510"
}

Bonderović, V., Manić, L., Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Stojilković, N., Jorgovanović, D., Grahovac, L., Anđelković, M., Repić, A., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2023). Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510

Bonderović V, Manić L, Živančević K, Baralić K, Vukelić D, Marić Đ, Stojilković N, Jorgovanović D, Grahovac L, Anđelković M, Repić A, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B, Buha-Đorđević A. Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

Bonderović, Vera, Manić, Luka, Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Stojilković, Nikola, Jorgovanović, Dragica, Grahovac, Lazar, Anđelković, Milena, Repić, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):117-118,
https://hdl.handle.net/21.15107/rcub_farfar_5510 .