TY  - JOUR
AU  - Anđelković, Marija
AU  - Baralić, Ivana
AU  - Đorđević, Brižita
AU  - Kotur-Stevuljević, Jelena
AU  - Radivojević, Nenad
AU  - Dikić, Nenad
AU  - Radojević-Skodrić, Sanja
AU  - Stojković, Mirjana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2310
AB  - Background: The purpose of the present study was to report and discuss the hematological and biochemical behavior of elite soccer players, in order to get more insight in the physiological characteristics of these sportsmen and to provide trainers and sports doctors with useful indicators. Methods: Nineteen male soccer players volunteered to participate in this study. We followed the young elite soccer players during a competitive half season. Venous blood samples were collected between 9:00 and 10:00 a.m. after an overnight fast (10 h) at baseline, after 45 and 90 days and hematological and biochemical parameters were measured. Results: Hemoglobin and hematocrit levels were significantly reduced over the observational period (p lt 0.05), but erythrocyte count and iron levels remained unchanged. Bilirubin and ferritin levels significantly increased in response to regular soccer training (p lt 0.05). We observed a significant decrease in muscle enzyme plasma activity during the 90 days study period. ANOVA analysis revealed a significant increase in the leukocyte and neutrophil counts (p lt 0.05), in parallel with a significant decrease in the lymphocyte count (p lt 0.05) after the observational period of 90 days. Conclusions: Elite soccer players are characterized by significant changes in biochemical and hematological parameters over the half season, which are linked to training workload, as well as adaptation induced by the soccer training. Although the values of the measured parameters fell within the reference range, regular monitoring of the biochemical and hematological parameters is fundamental for the identification of a healthy status and related optimal performances by sport doctors and trainers and selection of a correct workload by trainers.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season
VL  - 34
IS  - 4
SP  - 460
EP  - 466
DO  - 10.2478/jomb-2014-0057
ER  - 

@article{
author = "Anđelković, Marija and Baralić, Ivana and Đorđević, Brižita and Kotur-Stevuljević, Jelena and Radivojević, Nenad and Dikić, Nenad and Radojević-Skodrić, Sanja and Stojković, Mirjana",
year = "2015",
abstract = "Background: The purpose of the present study was to report and discuss the hematological and biochemical behavior of elite soccer players, in order to get more insight in the physiological characteristics of these sportsmen and to provide trainers and sports doctors with useful indicators. Methods: Nineteen male soccer players volunteered to participate in this study. We followed the young elite soccer players during a competitive half season. Venous blood samples were collected between 9:00 and 10:00 a.m. after an overnight fast (10 h) at baseline, after 45 and 90 days and hematological and biochemical parameters were measured. Results: Hemoglobin and hematocrit levels were significantly reduced over the observational period (p lt 0.05), but erythrocyte count and iron levels remained unchanged. Bilirubin and ferritin levels significantly increased in response to regular soccer training (p lt 0.05). We observed a significant decrease in muscle enzyme plasma activity during the 90 days study period. ANOVA analysis revealed a significant increase in the leukocyte and neutrophil counts (p lt 0.05), in parallel with a significant decrease in the lymphocyte count (p lt 0.05) after the observational period of 90 days. Conclusions: Elite soccer players are characterized by significant changes in biochemical and hematological parameters over the half season, which are linked to training workload, as well as adaptation induced by the soccer training. Although the values of the measured parameters fell within the reference range, regular monitoring of the biochemical and hematological parameters is fundamental for the identification of a healthy status and related optimal performances by sport doctors and trainers and selection of a correct workload by trainers.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season",
volume = "34",
number = "4",
pages = "460-466",
doi = "10.2478/jomb-2014-0057"
}

Anđelković, M., Baralić, I., Đorđević, B., Kotur-Stevuljević, J., Radivojević, N., Dikić, N., Radojević-Skodrić, S.,& Stojković, M.. (2015). Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(4), 460-466.
https://doi.org/10.2478/jomb-2014-0057

Anđelković M, Baralić I, Đorđević B, Kotur-Stevuljević J, Radivojević N, Dikić N, Radojević-Skodrić S, Stojković M. Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season. in Journal of Medical Biochemistry. 2015;34(4):460-466.
doi:10.2478/jomb-2014-0057 .

Anđelković, Marija, Baralić, Ivana, Đorđević, Brižita, Kotur-Stevuljević, Jelena, Radivojević, Nenad, Dikić, Nenad, Radojević-Skodrić, Sanja, Stojković, Mirjana, "Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season" in Journal of Medical Biochemistry, 34, no. 4 (2015):460-466,
https://doi.org/10.2478/jomb-2014-0057 . .

TY  - JOUR
AU  - Žarković, Miloš
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Ćirić, Jasmina
AU  - Beleslin, Biljana
AU  - Savić, Slavica
AU  - Stojković, Mirjana
AU  - Bulat, Petar
AU  - Trbojević, Bozo
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1026
AB  - Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.
PB  - Bioscientifica Ltd, Bristol
T2  - European Journal of Endocrinology
T1  - Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans
VL  - 159
IS  - 5
SP  - 649
EP  - 652
DO  - 10.1530/EJE-08-0544
ER  - 

@article{
author = "Žarković, Miloš and Ignjatović, Svetlana and Dajak, Marijana and Ćirić, Jasmina and Beleslin, Biljana and Savić, Slavica and Stojković, Mirjana and Bulat, Petar and Trbojević, Bozo",
year = "2008",
abstract = "Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.",
publisher = "Bioscientifica Ltd, Bristol",
journal = "European Journal of Endocrinology",
title = "Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans",
volume = "159",
number = "5",
pages = "649-652",
doi = "10.1530/EJE-08-0544"
}

Žarković, M., Ignjatović, S., Dajak, M., Ćirić, J., Beleslin, B., Savić, S., Stojković, M., Bulat, P.,& Trbojević, B.. (2008). Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. in European Journal of Endocrinology
Bioscientifica Ltd, Bristol., 159(5), 649-652.
https://doi.org/10.1530/EJE-08-0544

Žarković M, Ignjatović S, Dajak M, Ćirić J, Beleslin B, Savić S, Stojković M, Bulat P, Trbojević B. Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. in European Journal of Endocrinology. 2008;159(5):649-652.
doi:10.1530/EJE-08-0544 .

Žarković, Miloš, Ignjatović, Svetlana, Dajak, Marijana, Ćirić, Jasmina, Beleslin, Biljana, Savić, Slavica, Stojković, Mirjana, Bulat, Petar, Trbojević, Bozo, "Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans" in European Journal of Endocrinology, 159, no. 5 (2008):649-652,
https://doi.org/10.1530/EJE-08-0544 . .

TY  - JOUR
AU  - Timotijević-Marković, Ivana
AU  - Pokrajac, Milena
AU  - Miljković, Branislava
AU  - Stojković, Mirjana
AU  - Veličković, Ružica
PY  - 1992
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/92
AB  - The application of tryciclic antidepressants amitriptyline in the therapy of depression is followed by some side effects both those muscarinic and antihistaminic and alpha-adrenergic effects. The manifested degree of side effects directly correlates with the dosage and concentration in plasma, so that maximal effects are manifested when drug concentration in patient's plasma is maximal. When amitriptyline is used in the therapy an effective drug dosage enabling the maximal therapeutic effect and minimal side effects should be determined. By this the maximal outcome of the therapy is made possible.
PB  - Institut za mentalno zdravlje, Beograd
T2  - Psihijatrija danas
T1  - The clinical pharmacological correlation between amitriptyline dosage and side effects
T1  - Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata
VL  - 24
IS  - 3-4
SP  - 231
EP  - 249
UR  - https://hdl.handle.net/21.15107/rcub_farfar_92
ER  - 

@article{
author = "Timotijević-Marković, Ivana and Pokrajac, Milena and Miljković, Branislava and Stojković, Mirjana and Veličković, Ružica",
year = "1992",
abstract = "The application of tryciclic antidepressants amitriptyline in the therapy of depression is followed by some side effects both those muscarinic and antihistaminic and alpha-adrenergic effects. The manifested degree of side effects directly correlates with the dosage and concentration in plasma, so that maximal effects are manifested when drug concentration in patient's plasma is maximal. When amitriptyline is used in the therapy an effective drug dosage enabling the maximal therapeutic effect and minimal side effects should be determined. By this the maximal outcome of the therapy is made possible.",
publisher = "Institut za mentalno zdravlje, Beograd",
journal = "Psihijatrija danas",
title = "The clinical pharmacological correlation between amitriptyline dosage and side effects, Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata",
volume = "24",
number = "3-4",
pages = "231-249",
url = "https://hdl.handle.net/21.15107/rcub_farfar_92"
}

Timotijević-Marković, I., Pokrajac, M., Miljković, B., Stojković, M.,& Veličković, R.. (1992). The clinical pharmacological correlation between amitriptyline dosage and side effects. in Psihijatrija danas
Institut za mentalno zdravlje, Beograd., 24(3-4), 231-249.
https://hdl.handle.net/21.15107/rcub_farfar_92

Timotijević-Marković I, Pokrajac M, Miljković B, Stojković M, Veličković R. The clinical pharmacological correlation between amitriptyline dosage and side effects. in Psihijatrija danas. 1992;24(3-4):231-249.
https://hdl.handle.net/21.15107/rcub_farfar_92 .

Timotijević-Marković, Ivana, Pokrajac, Milena, Miljković, Branislava, Stojković, Mirjana, Veličković, Ružica, "The clinical pharmacological correlation between amitriptyline dosage and side effects" in Psihijatrija danas, 24, no. 3-4 (1992):231-249,
https://hdl.handle.net/21.15107/rcub_farfar_92 .