TY  - JOUR
AU  - Ivanović, Nevena
AU  - Ilić, Tijana
AU  - Zrnić-Ćirić, Milica
AU  - Todorović, Vanja
AU  - Đuričić, Ivana
AU  - Dabetić, Nevena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4979
AB  - The disposal of waste generated in the agri-food industry is one of the greatest challenges
in achieving sustainable development. Although agri-food residues are a potential source of
bioactive compounds with proven health benefits, they are largely unused and disposed of as
organic waste. The recovery of bioactive compounds from agri-food waste to obtain products
with high biological value, such as functional foods and nutraceuticals, is an idea that stems from
the concept of bioeconomy and combines environmental issues with economically viable
production. Some of the main agri-food wastes in Serbia that have the potential to be recycled
into value-added products are apple, plum, grape, tomato, and beet pomace, and oilseed cakes.
Bioactive compounds isolated from these wastes include polyphenols, fibers, essential fatty acids,
minerals, various volatiles and pigments. This article focuses on the most common food wastes
and the potential reuse of these undervalued material to produce value-added products such as
functional foods, nutraceuticals or food additives.
AB  - Odlaganje otpada koji nastaje u prehrambenoj industriji jedan je od najvećih izazova u
postizanju održivog razvoja. Iako su nusproizvodi koji nastaju u prehrambenoj industriji
potencijalni izvor bioaktivnih jedinjenja sa dokazanim pozitivnim zdravstvenim efektima, oni se
uglavnom odlažu kao organski otpad. Iskorišćenje bioaktivnih jedinjenja iz ovih nusproizvoda u
cilju dobijanja proizvoda sa dodatom nutritivnom i biološkom vrednošću, kao što su funkcionalna
hrana i nutraceutici, ideja je koja proizilazi iz koncepta bioekonomije i kombinuje ekološki aspekt
sa ekonomski održivom proizvodnjom. Neki od glavnih nusproizvoda koji se generišu u Srbiji sa
potencijalom da se iskoriste u proizvodnji proizvoda sa dodatom vrednošću su trop jabuke, trop
šljive, komina grožđa, trop paradajza, uljane pogače i dr. Bioaktivna jedinjenja izolovana iz ovih
otpada uključuju polifenole, peptide, vlakna, esencijalne masne kiseline, minerale, različite
isparljive materije i pigmente. Ovaj članak se fokusira na najčešće otpade prehrambene industrije
i potencijalnu ponovnu upotrebu ovog još uvek neiskorišćenog otpadnog materijala za
proizvodnju proizvoda sa dodatom vrednošću kao što su funkcionalna hrana, nutraceutici ili
aditivi.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
T2  - Arhiv za farmaciju
T1  - Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals
T1  - Nusproizvodi agro-industrije kao izvor održivih sastojaka za proizvodnju funkcionalne hrane i nutraceutika
VL  - 73
IS  - 3
SP  - 190
EP  - 204
DO  - 10.5937/arhfarm73-44481
ER  - 

@article{
author = "Ivanović, Nevena and Ilić, Tijana and Zrnić-Ćirić, Milica and Todorović, Vanja and Đuričić, Ivana and Dabetić, Nevena",
year = "2023",
abstract = "The disposal of waste generated in the agri-food industry is one of the greatest challenges
in achieving sustainable development. Although agri-food residues are a potential source of
bioactive compounds with proven health benefits, they are largely unused and disposed of as
organic waste. The recovery of bioactive compounds from agri-food waste to obtain products
with high biological value, such as functional foods and nutraceuticals, is an idea that stems from
the concept of bioeconomy and combines environmental issues with economically viable
production. Some of the main agri-food wastes in Serbia that have the potential to be recycled
into value-added products are apple, plum, grape, tomato, and beet pomace, and oilseed cakes.
Bioactive compounds isolated from these wastes include polyphenols, fibers, essential fatty acids,
minerals, various volatiles and pigments. This article focuses on the most common food wastes
and the potential reuse of these undervalued material to produce value-added products such as
functional foods, nutraceuticals or food additives., Odlaganje otpada koji nastaje u prehrambenoj industriji jedan je od najvećih izazova u
postizanju održivog razvoja. Iako su nusproizvodi koji nastaju u prehrambenoj industriji
potencijalni izvor bioaktivnih jedinjenja sa dokazanim pozitivnim zdravstvenim efektima, oni se
uglavnom odlažu kao organski otpad. Iskorišćenje bioaktivnih jedinjenja iz ovih nusproizvoda u
cilju dobijanja proizvoda sa dodatom nutritivnom i biološkom vrednošću, kao što su funkcionalna
hrana i nutraceutici, ideja je koja proizilazi iz koncepta bioekonomije i kombinuje ekološki aspekt
sa ekonomski održivom proizvodnjom. Neki od glavnih nusproizvoda koji se generišu u Srbiji sa
potencijalom da se iskoriste u proizvodnji proizvoda sa dodatom vrednošću su trop jabuke, trop
šljive, komina grožđa, trop paradajza, uljane pogače i dr. Bioaktivna jedinjenja izolovana iz ovih
otpada uključuju polifenole, peptide, vlakna, esencijalne masne kiseline, minerale, različite
isparljive materije i pigmente. Ovaj članak se fokusira na najčešće otpade prehrambene industrije
i potencijalnu ponovnu upotrebu ovog još uvek neiskorišćenog otpadnog materijala za
proizvodnju proizvoda sa dodatom vrednošću kao što su funkcionalna hrana, nutraceutici ili
aditivi.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals, Nusproizvodi agro-industrije kao izvor održivih sastojaka za proizvodnju funkcionalne hrane i nutraceutika",
volume = "73",
number = "3",
pages = "190-204",
doi = "10.5937/arhfarm73-44481"
}

Ivanović, N., Ilić, T., Zrnić-Ćirić, M., Todorović, V., Đuričić, I.,& Dabetić, N.. (2023). Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 73(3), 190-204.
https://doi.org/10.5937/arhfarm73-44481

Ivanović N, Ilić T, Zrnić-Ćirić M, Todorović V, Đuričić I, Dabetić N. Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals. in Arhiv za farmaciju. 2023;73(3):190-204.
doi:10.5937/arhfarm73-44481 .

Ivanović, Nevena, Ilić, Tijana, Zrnić-Ćirić, Milica, Todorović, Vanja, Đuričić, Ivana, Dabetić, Nevena, "Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals" in Arhiv za farmaciju, 73, no. 3 (2023):190-204,
https://doi.org/10.5937/arhfarm73-44481 . .

TY  - CONF
AU  - Božić, Dragana
AU  - Ilić, Tijana
AU  - Marčetić, Mirjana
AU  - Samardžić, Stevan
AU  - Zdunić, Gordana
AU  - Vidović, Bojana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4616
AB  - In recent years, many preclinical studies have provided evidence that polyphenol compounds
and their metabolites exert prebiotic-like effects by selectively stimulating intestinal bacteria
growth and/or activity [1]. In this study, we investigated the chemical composition,
antioxidant capacity, and prebiotic potential of methanol extracts obtained from Prunus
spinosa L. (blackthorn) and Lycium ruthenicum Murray (black goji) fruits. Polyphenolic
profiles were characterized by using HPLC-DAD-ESI-MS and antioxidant capacity was
estimated with DPPH•, ABTS•+, and FRAP assays. The influence of plant extracts (0.312-5
mg/L) on the growth of three probiotic lactobacilli, probiotic yeast (Saccharomyces
boulardii), and two probiotic mixtures was examined. Studied plant extracts were
characterized by different phenolic compound patterns. Hydroxycinnamic acid derivatives,
quercetin glycosides and anthocyanins were detected in blackthorn extract, while black goji
extract was characterized by the presence of hydroxycinnamic acid derivatives and acylated
anthocyanins. The blackthorn fruit extract showed higher antiradical and reduction activity
than those obtained from black goji fruits. Both extracts have influenced the growth of all
tested probiotics in a concentration-dependent manner, especially of yeast, S. boulardii. The
black goji extract had more stimulatory effects, possibly due to higher anthocyanins content.
When the black goji extract was added to the growth medium at the concentration of 5
mg/mL, about 2-fold stimulation of the growth of S. boulardii was observed. In conclusion,
extracts of the black goji and blackthorn fruits promote the growth of probiotics in vitro.
Further studies are still needed to assess the prebiotic potential of these plant extracts.
PB  - University of Belgrade - Faculty of Agriculture
C3  - 1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts
T1  - In vitro assessment of the prebiotic potential of selected plant extracts
SP  - 54
EP  - 54
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4616
ER  - 

@conference{
author = "Božić, Dragana and Ilić, Tijana and Marčetić, Mirjana and Samardžić, Stevan and Zdunić, Gordana and Vidović, Bojana",
year = "2022",
abstract = "In recent years, many preclinical studies have provided evidence that polyphenol compounds
and their metabolites exert prebiotic-like effects by selectively stimulating intestinal bacteria
growth and/or activity [1]. In this study, we investigated the chemical composition,
antioxidant capacity, and prebiotic potential of methanol extracts obtained from Prunus
spinosa L. (blackthorn) and Lycium ruthenicum Murray (black goji) fruits. Polyphenolic
profiles were characterized by using HPLC-DAD-ESI-MS and antioxidant capacity was
estimated with DPPH•, ABTS•+, and FRAP assays. The influence of plant extracts (0.312-5
mg/L) on the growth of three probiotic lactobacilli, probiotic yeast (Saccharomyces
boulardii), and two probiotic mixtures was examined. Studied plant extracts were
characterized by different phenolic compound patterns. Hydroxycinnamic acid derivatives,
quercetin glycosides and anthocyanins were detected in blackthorn extract, while black goji
extract was characterized by the presence of hydroxycinnamic acid derivatives and acylated
anthocyanins. The blackthorn fruit extract showed higher antiradical and reduction activity
than those obtained from black goji fruits. Both extracts have influenced the growth of all
tested probiotics in a concentration-dependent manner, especially of yeast, S. boulardii. The
black goji extract had more stimulatory effects, possibly due to higher anthocyanins content.
When the black goji extract was added to the growth medium at the concentration of 5
mg/mL, about 2-fold stimulation of the growth of S. boulardii was observed. In conclusion,
extracts of the black goji and blackthorn fruits promote the growth of probiotics in vitro.
Further studies are still needed to assess the prebiotic potential of these plant extracts.",
publisher = "University of Belgrade - Faculty of Agriculture",
journal = "1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts",
title = "In vitro assessment of the prebiotic potential of selected plant extracts",
pages = "54-54",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4616"
}

Božić, D., Ilić, T., Marčetić, M., Samardžić, S., Zdunić, G.,& Vidović, B.. (2022). In vitro assessment of the prebiotic potential of selected plant extracts. in 1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts
University of Belgrade - Faculty of Agriculture., 54-54.
https://hdl.handle.net/21.15107/rcub_farfar_4616

Božić D, Ilić T, Marčetić M, Samardžić S, Zdunić G, Vidović B. In vitro assessment of the prebiotic potential of selected plant extracts. in 1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts. 2022;:54-54.
https://hdl.handle.net/21.15107/rcub_farfar_4616 .

Božić, Dragana, Ilić, Tijana, Marčetić, Mirjana, Samardžić, Stevan, Zdunić, Gordana, Vidović, Bojana, "In vitro assessment of the prebiotic potential of selected plant extracts" in 1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts (2022):54-54,
https://hdl.handle.net/21.15107/rcub_farfar_4616 .

TY  - CONF
AU  - Ilić, Tijana
AU  - Samardžić, Stevan
AU  - Zdunić, Gordana
AU  - Božić, Dragana
AU  - Marčetić, Mirjana
AU  - Vidović, Bojana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4617
AB  - Lycium ruthenicum Murray (Solanaceae), also known as black goji or black wolfberry, has
been used for centuries in traditional medicine and nutrition in Asian countries [1]. In recent
years, black goji berries have been gaining attention as one of the most valuable sources of
anthocyanins with many health-promoting effects [2]. Therefore, this study aimed to
investigate the phytochemical composition and in vitro biological properties of black goji
berry cultivated in southeastern Serbia. The total phenolics, flavonoids, anthocyanins, and
tannins content were determined spectrophotometrically. HPLC-DAD-ESI-MS analysis was
used to identify the phenolic compounds. Methanol extract from black goji berry was
screened for in vitro antioxidant (DPPH∙, ABTS∙+, FRAP, CUPRAC, and β-carotene bleaching
methods), antimicrobial, and hypoglycemic (α-amylase, α-glucosidase) potential.
Phytochemical screening of the extract confirmed the dominant presence of anthocyanins and
hydroxycinnamic acid derivatives, with petunidin 3-p-cumaroylrutinoside-5 glucoside as the
main phenolic compound [3]. The total phenolic content was 18.13 ± 0.15 mg gallic acid
equivalents/g freeze-dried sample. A high correlation is found between the total phenolic
content and the antioxidant activities using different in vitro antioxidant assays. The
antimicrobial activity of the black goji berry extract against eight laboratory control strains
was not pronounced (MIC > 2 mg/ml). The IC50 values were 6.55 ± 0.38 mg/mL and 7.37 ±
0.02 mg/ml for α-amylase, and α-glucosidase inhibition activity, respectively. Overall,
obtained results suggest that the black goji berry cultivated in Serbia should be considered a
valuable source of bioactive compounds for further use in the food, nutraceutical, and
cosmetic industries.
PB  - University of Belgrade - Faculty of Agriculture
C3  - 1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts
T1  - Screening of the phenolic composition and in vitro biological activities of the fruit of Lycium ruthenicum Murray
SP  - 44
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4617
ER  - 

@conference{
author = "Ilić, Tijana and Samardžić, Stevan and Zdunić, Gordana and Božić, Dragana and Marčetić, Mirjana and Vidović, Bojana",
year = "2022",
abstract = "Lycium ruthenicum Murray (Solanaceae), also known as black goji or black wolfberry, has
been used for centuries in traditional medicine and nutrition in Asian countries [1]. In recent
years, black goji berries have been gaining attention as one of the most valuable sources of
anthocyanins with many health-promoting effects [2]. Therefore, this study aimed to
investigate the phytochemical composition and in vitro biological properties of black goji
berry cultivated in southeastern Serbia. The total phenolics, flavonoids, anthocyanins, and
tannins content were determined spectrophotometrically. HPLC-DAD-ESI-MS analysis was
used to identify the phenolic compounds. Methanol extract from black goji berry was
screened for in vitro antioxidant (DPPH∙, ABTS∙+, FRAP, CUPRAC, and β-carotene bleaching
methods), antimicrobial, and hypoglycemic (α-amylase, α-glucosidase) potential.
Phytochemical screening of the extract confirmed the dominant presence of anthocyanins and
hydroxycinnamic acid derivatives, with petunidin 3-p-cumaroylrutinoside-5 glucoside as the
main phenolic compound [3]. The total phenolic content was 18.13 ± 0.15 mg gallic acid
equivalents/g freeze-dried sample. A high correlation is found between the total phenolic
content and the antioxidant activities using different in vitro antioxidant assays. The
antimicrobial activity of the black goji berry extract against eight laboratory control strains
was not pronounced (MIC > 2 mg/ml). The IC50 values were 6.55 ± 0.38 mg/mL and 7.37 ±
0.02 mg/ml for α-amylase, and α-glucosidase inhibition activity, respectively. Overall,
obtained results suggest that the black goji berry cultivated in Serbia should be considered a
valuable source of bioactive compounds for further use in the food, nutraceutical, and
cosmetic industries.",
publisher = "University of Belgrade - Faculty of Agriculture",
journal = "1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts",
title = "Screening of the phenolic composition and in vitro biological activities of the fruit of Lycium ruthenicum Murray",
pages = "44-44",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4617"
}

Ilić, T., Samardžić, S., Zdunić, G., Božić, D., Marčetić, M.,& Vidović, B.. (2022). Screening of the phenolic composition and in vitro biological activities of the fruit of Lycium ruthenicum Murray. in 1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts
University of Belgrade - Faculty of Agriculture., 44-44.
https://hdl.handle.net/21.15107/rcub_farfar_4617

Ilić T, Samardžić S, Zdunić G, Božić D, Marčetić M, Vidović B. Screening of the phenolic composition and in vitro biological activities of the fruit of Lycium ruthenicum Murray. in 1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts. 2022;:44-44.
https://hdl.handle.net/21.15107/rcub_farfar_4617 .

Ilić, Tijana, Samardžić, Stevan, Zdunić, Gordana, Božić, Dragana, Marčetić, Mirjana, Vidović, Bojana, "Screening of the phenolic composition and in vitro biological activities of the fruit of Lycium ruthenicum Murray" in 1st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) - Book of Abstracts (2022):44-44,
https://hdl.handle.net/21.15107/rcub_farfar_4617 .

TY  - CONF
AU  - Marčetić, Mirjana
AU  - Vidović, Bojana
AU  - Samardžić, Stevan
AU  - Ilić, Tijana
AU  - Božić, Dragana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4610
AB  - The blackthorn is widespread across temperate Europe and also occurs in the Near East and Africa. The fruit is traditionally used in the treatment of digestive, respiratory and kidney disorders. The aim of the study was to investigate composition and the antibacterial activity of methanol extract of blackthorn fruit, and potential prebiotic effect on selected probiotic microorganisms. The blackthorn fruit is a rich source of vitamin C (5.3 mg/100 g, determinated by titration) as well as Ca, Mg and P (106.7; 42.0 and 43.2 mg/100 g, respectively, determinated by ICP-OES). The total phenolic content was 1,235 mg gallic acid/100 g (FC method). Hydroxycinnamic acid derivatives (caffeoylquinic and feruloylquinic acids), flavonoids (glycosides of quercetin, methylquercetin and kaempferol) and anthocyanins (glycosides of cyanidin and peonidin) were tentatively identified by LC-DAD-ESI-MS. The antimicrobial activity on eight laboratory control strains of bacteria was not pronounced (MIC 1.25->5 mg/ml). On the other hand the extract (0.3-5.0 mg/ml) exhibited significant prebiotic effect on investigated probiotic strains of Lactobacillus spp., Saccharomyces boulardii and their mixtures. The stimulation of growth was in the range 4.0-52.8% in concentration dependent manner. In conclusion, significant prebiotic activity of blackthorn fruit confers new insight in blackthorn health benefits.
PB  - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
PB  - Institute for Nature Conservation of Serbia, Belgrade
C3  - 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
T1  - Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae
SP  - 167
EP  - 167
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4610
ER  - 

@conference{
author = "Marčetić, Mirjana and Vidović, Bojana and Samardžić, Stevan and Ilić, Tijana and Božić, Dragana",
year = "2022",
abstract = "The blackthorn is widespread across temperate Europe and also occurs in the Near East and Africa. The fruit is traditionally used in the treatment of digestive, respiratory and kidney disorders. The aim of the study was to investigate composition and the antibacterial activity of methanol extract of blackthorn fruit, and potential prebiotic effect on selected probiotic microorganisms. The blackthorn fruit is a rich source of vitamin C (5.3 mg/100 g, determinated by titration) as well as Ca, Mg and P (106.7; 42.0 and 43.2 mg/100 g, respectively, determinated by ICP-OES). The total phenolic content was 1,235 mg gallic acid/100 g (FC method). Hydroxycinnamic acid derivatives (caffeoylquinic and feruloylquinic acids), flavonoids (glycosides of quercetin, methylquercetin and kaempferol) and anthocyanins (glycosides of cyanidin and peonidin) were tentatively identified by LC-DAD-ESI-MS. The antimicrobial activity on eight laboratory control strains of bacteria was not pronounced (MIC 1.25->5 mg/ml). On the other hand the extract (0.3-5.0 mg/ml) exhibited significant prebiotic effect on investigated probiotic strains of Lactobacillus spp., Saccharomyces boulardii and their mixtures. The stimulation of growth was in the range 4.0-52.8% in concentration dependent manner. In conclusion, significant prebiotic activity of blackthorn fruit confers new insight in blackthorn health benefits.",
publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia, Belgrade",
journal = "14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts",
title = "Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae",
pages = "167-167",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4610"
}

Marčetić, M., Vidović, B., Samardžić, S., Ilić, T.,& Božić, D.. (2022). Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 167-167.
https://hdl.handle.net/21.15107/rcub_farfar_4610

Marčetić M, Vidović B, Samardžić S, Ilić T, Božić D. Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts. 2022;:167-167.
https://hdl.handle.net/21.15107/rcub_farfar_4610 .

Marčetić, Mirjana, Vidović, Bojana, Samardžić, Stevan, Ilić, Tijana, Božić, Dragana, "Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae" in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts (2022):167-167,
https://hdl.handle.net/21.15107/rcub_farfar_4610 .

TY  - CONF
AU  - Ilić, Tijana
AU  - Kodranov, Igor
AU  - Kolašinac, Stefan
AU  - Ivanović, Nevena
AU  - Vidović, Bojana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4589
AB  - Fruits of Lycium barbarum L. (Solanaceae), known as wolfberries or goji berries, have
been long used in traditional medicine and nutrition in Asian countries. However, in recent
years, they have become popular in Europe, including Serbia. However, there are limited
data on the chemical composition of goji berries cultivated in our country. This study aimed
to estimate and perform a comparative analysis of the mineral content of goji berries from
six locations in Serbia. After microwave digestion, macro- (K, Na, P, S, Mg, Ca) and
microelement (Fe, Zn, Cu, Cr, Mn, Mo) contents in analyzed samples were determined by the
optical emission spectrometry with induced coupled plasma (ICP-OES). As expected, mineral
concentrations varied significantly among goji berry samples from different locations (p <
0.05). In general, the decreasing orders of minerals in goji berries were: K > P > S > Na > Mg >
Ca > Zn > Fe > Cu > Mn > Cr > Mo. According to the Recommended Daily Allowance (RDA)
values, dried goji berries (30 g) provide a rich source of Cr and Cu, while their contribution
to the daily intake of other minerals was below 15% RDA.
AB  - Plodovi Lycium barbarum L. (Solanaceae), poznatiji kao vučje bobice ili godži, imaju
dugu istoriju upotrebe u tradicionalnoj medicini i ishrani stanovnika azijskih zemalja, a
poslednjih godina su sve popularniji u Evropi, uključujući i Srbiju. Međutim, nema mnogo
podataka o hemijskom sastavu plodova godži gajenih u našoj zemlji. Cilj ovog rada je bio da
se izvrši komparativna analiza mineralnog sastava plodova godži prikupljenih sa šest
različitih lokacija u Srbiji. Nakon prethodne mikrotalasne digestije, sadržaj makro- (K, Na, P,
S, Mg, Ca) i mikroelemenata (Fe, Zn, Cu, Cr, Mn, Mo) u ispitivanim uzorcima suvih plodova
godži, određen je primenom optičke emisione spektrometrije sa indukovano spregnutom
plazmom (ICP-OES). Kao što je i očekivano, dobijeni rezultati ukazuju na statistički značajne
razlike u sadržaju mineralnih materija u plodovima godži prikupljenih sa različitih lokacija
(p < 0,05). Generalno, mineralne materije su zastupljene po sledećem opadajućem redosledu
koncentracija: K > P > S > Na > Mg > Ca > Zn > Fe > Cu > Mn > Cr > Mo. Utvrđeni sadržaj
makro- i mikroelemenata u jednoj porciji (30 g suvih plodova godži), u odnosu na nutritivne
referentne vrednosti (NRV), ukazuje da su plodovi godži bogat izvor Cr i Cu, dok je doprinos
jedne porcije plodova godži dnevnom unosu ostalih mineralnih materija ispod 15% NRV.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Analysis of mineral contents of fruits of Lycium barbarum L. (Solanaceae) cultivated in Serbia
T1  - Analiza sadržaja mineralnih materija u plodovima Lycium barbarum L. (Solanaceae) gajenim u Srbiji
VL  - 72
IS  - 4 suplement
SP  - S507
EP  - S508
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4589
ER  - 

@conference{
author = "Ilić, Tijana and Kodranov, Igor and Kolašinac, Stefan and Ivanović, Nevena and Vidović, Bojana",
year = "2022",
abstract = "Fruits of Lycium barbarum L. (Solanaceae), known as wolfberries or goji berries, have
been long used in traditional medicine and nutrition in Asian countries. However, in recent
years, they have become popular in Europe, including Serbia. However, there are limited
data on the chemical composition of goji berries cultivated in our country. This study aimed
to estimate and perform a comparative analysis of the mineral content of goji berries from
six locations in Serbia. After microwave digestion, macro- (K, Na, P, S, Mg, Ca) and
microelement (Fe, Zn, Cu, Cr, Mn, Mo) contents in analyzed samples were determined by the
optical emission spectrometry with induced coupled plasma (ICP-OES). As expected, mineral
concentrations varied significantly among goji berry samples from different locations (p <
0.05). In general, the decreasing orders of minerals in goji berries were: K > P > S > Na > Mg >
Ca > Zn > Fe > Cu > Mn > Cr > Mo. According to the Recommended Daily Allowance (RDA)
values, dried goji berries (30 g) provide a rich source of Cr and Cu, while their contribution
to the daily intake of other minerals was below 15% RDA., Plodovi Lycium barbarum L. (Solanaceae), poznatiji kao vučje bobice ili godži, imaju
dugu istoriju upotrebe u tradicionalnoj medicini i ishrani stanovnika azijskih zemalja, a
poslednjih godina su sve popularniji u Evropi, uključujući i Srbiju. Međutim, nema mnogo
podataka o hemijskom sastavu plodova godži gajenih u našoj zemlji. Cilj ovog rada je bio da
se izvrši komparativna analiza mineralnog sastava plodova godži prikupljenih sa šest
različitih lokacija u Srbiji. Nakon prethodne mikrotalasne digestije, sadržaj makro- (K, Na, P,
S, Mg, Ca) i mikroelemenata (Fe, Zn, Cu, Cr, Mn, Mo) u ispitivanim uzorcima suvih plodova
godži, određen je primenom optičke emisione spektrometrije sa indukovano spregnutom
plazmom (ICP-OES). Kao što je i očekivano, dobijeni rezultati ukazuju na statistički značajne
razlike u sadržaju mineralnih materija u plodovima godži prikupljenih sa različitih lokacija
(p < 0,05). Generalno, mineralne materije su zastupljene po sledećem opadajućem redosledu
koncentracija: K > P > S > Na > Mg > Ca > Zn > Fe > Cu > Mn > Cr > Mo. Utvrđeni sadržaj
makro- i mikroelemenata u jednoj porciji (30 g suvih plodova godži), u odnosu na nutritivne
referentne vrednosti (NRV), ukazuje da su plodovi godži bogat izvor Cr i Cu, dok je doprinos
jedne porcije plodova godži dnevnom unosu ostalih mineralnih materija ispod 15% NRV.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Analysis of mineral contents of fruits of Lycium barbarum L. (Solanaceae) cultivated in Serbia, Analiza sadržaja mineralnih materija u plodovima Lycium barbarum L. (Solanaceae) gajenim u Srbiji",
volume = "72",
number = "4 suplement",
pages = "S507-S508",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4589"
}

Ilić, T., Kodranov, I., Kolašinac, S., Ivanović, N.,& Vidović, B.. (2022). Analysis of mineral contents of fruits of Lycium barbarum L. (Solanaceae) cultivated in Serbia. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S507-S508.
https://hdl.handle.net/21.15107/rcub_farfar_4589

Ilić T, Kodranov I, Kolašinac S, Ivanović N, Vidović B. Analysis of mineral contents of fruits of Lycium barbarum L. (Solanaceae) cultivated in Serbia. in Arhiv za farmaciju. 2022;72(4 suplement):S507-S508.
https://hdl.handle.net/21.15107/rcub_farfar_4589 .

Ilić, Tijana, Kodranov, Igor, Kolašinac, Stefan, Ivanović, Nevena, Vidović, Bojana, "Analysis of mineral contents of fruits of Lycium barbarum L. (Solanaceae) cultivated in Serbia" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S507-S508,
https://hdl.handle.net/21.15107/rcub_farfar_4589 .

TY  - JOUR
AU  - Marčetić, Mirjana
AU  - Samardžić, Stevan
AU  - Ilić, Tijana
AU  - Božić, Dragana
AU  - Vidović, Bojana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4311
AB  - Blackthorn (Prunus spinosa L.) fruit is bluish-black wild fruit traditionally used in nutrition and medicine. It is recently gaining attention as a functional food and an underutilized source of bioactive compounds for application in the food and pharmaceutical industry. This study aimed to assess the health-promoting potential of blackthorn fruits from Serbia by examining their chemical composition and in vitro biological activities. Phytochemical analysis of the blackthorn fruit extracts was performed using LC-DAD-ESI-MS. The total phenolic (TPC), total flavonoid (TFC), total anthocyanin (TAC) content, antioxidant capacity, and enzyme inhibitory activities were determined spectrophotometrically. The antimicrobial and prebiotic properties were tested using the broth microdilution method. Twenty-seven phenolics belonging to the classes of hydroxybenzoic and hydroxycinnamic acids derivatives, flavonoids, and anthocyanins were identified, with caffeoylquinic acid as the most abundant compound. Blackthorn extracts were characterized by notable TPCs, TFCs, and TACs, and free radical scavenging and reducing ability. The enzyme inhibitory effects (IC50 = 0.43–2.16 mg/mL) were observed towards α-amylase, α-glucosidase, acetylcholinesterase, and tyrosinase. Blackthorn fruit extracts in a concentration-dependent manner (0.3–5 mg/mL) stimulated the growth of several probiotic microorganisms and their mixtures, especially the yeast Saccharomyces boulardii. Obtained results support further evaluation of the functional food potential of blackthorn fruit.
PB  - MDPI
T2  - Foods
T1  - Phenolic Composition, Antioxidant, Anti-Enzymatic, Antimicrobial and Prebiotic Properties of Prunus spinosa L. Fruits
VL  - 11
IS  - 20
DO  - 10.3390/foods11203289
ER  - 

@article{
author = "Marčetić, Mirjana and Samardžić, Stevan and Ilić, Tijana and Božić, Dragana and Vidović, Bojana",
year = "2022",
abstract = "Blackthorn (Prunus spinosa L.) fruit is bluish-black wild fruit traditionally used in nutrition and medicine. It is recently gaining attention as a functional food and an underutilized source of bioactive compounds for application in the food and pharmaceutical industry. This study aimed to assess the health-promoting potential of blackthorn fruits from Serbia by examining their chemical composition and in vitro biological activities. Phytochemical analysis of the blackthorn fruit extracts was performed using LC-DAD-ESI-MS. The total phenolic (TPC), total flavonoid (TFC), total anthocyanin (TAC) content, antioxidant capacity, and enzyme inhibitory activities were determined spectrophotometrically. The antimicrobial and prebiotic properties were tested using the broth microdilution method. Twenty-seven phenolics belonging to the classes of hydroxybenzoic and hydroxycinnamic acids derivatives, flavonoids, and anthocyanins were identified, with caffeoylquinic acid as the most abundant compound. Blackthorn extracts were characterized by notable TPCs, TFCs, and TACs, and free radical scavenging and reducing ability. The enzyme inhibitory effects (IC50 = 0.43–2.16 mg/mL) were observed towards α-amylase, α-glucosidase, acetylcholinesterase, and tyrosinase. Blackthorn fruit extracts in a concentration-dependent manner (0.3–5 mg/mL) stimulated the growth of several probiotic microorganisms and their mixtures, especially the yeast Saccharomyces boulardii. Obtained results support further evaluation of the functional food potential of blackthorn fruit.",
publisher = "MDPI",
journal = "Foods",
title = "Phenolic Composition, Antioxidant, Anti-Enzymatic, Antimicrobial and Prebiotic Properties of Prunus spinosa L. Fruits",
volume = "11",
number = "20",
doi = "10.3390/foods11203289"
}

Marčetić, M., Samardžić, S., Ilić, T., Božić, D.,& Vidović, B.. (2022). Phenolic Composition, Antioxidant, Anti-Enzymatic, Antimicrobial and Prebiotic Properties of Prunus spinosa L. Fruits. in Foods
MDPI., 11(20).
https://doi.org/10.3390/foods11203289

Marčetić M, Samardžić S, Ilić T, Božić D, Vidović B. Phenolic Composition, Antioxidant, Anti-Enzymatic, Antimicrobial and Prebiotic Properties of Prunus spinosa L. Fruits. in Foods. 2022;11(20).
doi:10.3390/foods11203289 .

Marčetić, Mirjana, Samardžić, Stevan, Ilić, Tijana, Božić, Dragana, Vidović, Bojana, "Phenolic Composition, Antioxidant, Anti-Enzymatic, Antimicrobial and Prebiotic Properties of Prunus spinosa L. Fruits" in Foods, 11, no. 20 (2022),
https://doi.org/10.3390/foods11203289 . .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Milinčić, Danijel
AU  - Marčetić, Mirjana
AU  - Đuriš, Jelena
AU  - Ilić, Tijana
AU  - Kostić, Aleksandar
AU  - Pešić, Mirjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4053
AB  - Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due to wide-range bioactive compounds with health-promoting properties. In addition, they are gaining increased research attention as a source of functional ingredients with potential industrial applications. This review focuses on the antioxidant properties of goji berries, scientific evidence on their health effects based on human interventional studies, safety concerns, goji berry processing technologies, and applications of goji berry-based ingredients in developing functional food products.
PB  - MDPI
T2  - Antioxidants
T1  - Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review
VL  - 11
IS  - 2
DO  - 10.3390/antiox11020248
ER  - 

@article{
author = "Vidović, Bojana and Milinčić, Danijel and Marčetić, Mirjana and Đuriš, Jelena and Ilić, Tijana and Kostić, Aleksandar and Pešić, Mirjana",
year = "2022",
abstract = "Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due to wide-range bioactive compounds with health-promoting properties. In addition, they are gaining increased research attention as a source of functional ingredients with potential industrial applications. This review focuses on the antioxidant properties of goji berries, scientific evidence on their health effects based on human interventional studies, safety concerns, goji berry processing technologies, and applications of goji berry-based ingredients in developing functional food products.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review",
volume = "11",
number = "2",
doi = "10.3390/antiox11020248"
}

Vidović, B., Milinčić, D., Marčetić, M., Đuriš, J., Ilić, T., Kostić, A.,& Pešić, M.. (2022). Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review. in Antioxidants
MDPI., 11(2).
https://doi.org/10.3390/antiox11020248

Vidović B, Milinčić D, Marčetić M, Đuriš J, Ilić T, Kostić A, Pešić M. Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review. in Antioxidants. 2022;11(2).
doi:10.3390/antiox11020248 .

Vidović, Bojana, Milinčić, Danijel, Marčetić, Mirjana, Đuriš, Jelena, Ilić, Tijana, Kostić, Aleksandar, Pešić, Mirjana, "Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review" in Antioxidants, 11, no. 2 (2022),
https://doi.org/10.3390/antiox11020248 . .

TY  - CONF
AU  - Obuljen, Marija
AU  - Ivanović, Nevena
AU  - Zeković, Milica
AU  - Ilić, Tijana
AU  - Dodevska, Margarita
AU  - Okuka, Nina
AU  - Kukić-Marković, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5100
AB  - Aim: This study aimed to assess parents’ level of knowledge, to analyze the attitudes and dietary habits of parents regarding use od dietary supplements among their children aged 1 to 12. Methods: Research was conducted in April 2021, and designed as a cross-sectional study. Data was collected via an online self-reported questionnaire, from 209 parents of both sexes, with various educational levels. Results: Among respondents, 44% have declared the use of dietary supplements among their children.
PB  - Serbian Nutrition Society
C3  - 14th International Congress on Nutrition, Belgrade, Serbia, 8-10. November 2021., Book of abstracts
T1  - Knowledge, Attitudes and ditary practices of parents regarding dietary supplementation use among their children
SP  - 135
EP  - 136
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5100
ER  - 

@conference{
author = "Obuljen, Marija and Ivanović, Nevena and Zeković, Milica and Ilić, Tijana and Dodevska, Margarita and Okuka, Nina and Kukić-Marković, Jelena",
year = "2021",
abstract = "Aim: This study aimed to assess parents’ level of knowledge, to analyze the attitudes and dietary habits of parents regarding use od dietary supplements among their children aged 1 to 12. Methods: Research was conducted in April 2021, and designed as a cross-sectional study. Data was collected via an online self-reported questionnaire, from 209 parents of both sexes, with various educational levels. Results: Among respondents, 44% have declared the use of dietary supplements among their children.",
publisher = "Serbian Nutrition Society",
journal = "14th International Congress on Nutrition, Belgrade, Serbia, 8-10. November 2021., Book of abstracts",
title = "Knowledge, Attitudes and ditary practices of parents regarding dietary supplementation use among their children",
pages = "135-136",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5100"
}

Obuljen, M., Ivanović, N., Zeković, M., Ilić, T., Dodevska, M., Okuka, N.,& Kukić-Marković, J.. (2021). Knowledge, Attitudes and ditary practices of parents regarding dietary supplementation use among their children. in 14th International Congress on Nutrition, Belgrade, Serbia, 8-10. November 2021., Book of abstracts
Serbian Nutrition Society., 135-136.
https://hdl.handle.net/21.15107/rcub_farfar_5100

Obuljen M, Ivanović N, Zeković M, Ilić T, Dodevska M, Okuka N, Kukić-Marković J. Knowledge, Attitudes and ditary practices of parents regarding dietary supplementation use among their children. in 14th International Congress on Nutrition, Belgrade, Serbia, 8-10. November 2021., Book of abstracts. 2021;:135-136.
https://hdl.handle.net/21.15107/rcub_farfar_5100 .

Obuljen, Marija, Ivanović, Nevena, Zeković, Milica, Ilić, Tijana, Dodevska, Margarita, Okuka, Nina, Kukić-Marković, Jelena, "Knowledge, Attitudes and ditary practices of parents regarding dietary supplementation use among their children" in 14th International Congress on Nutrition, Belgrade, Serbia, 8-10. November 2021., Book of abstracts (2021):135-136,
https://hdl.handle.net/21.15107/rcub_farfar_5100 .

TY  - CONF
AU  - Ilić, Tijana
AU  - Krgović, Nemanja
AU  - Marčetić, Mirjana
AU  - Vidović, Bojana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5096
AB  - Due to the presence of many nutrients and bioactive compounds, fruits of Lycium species (Fructus Lycii, goji berries) are recognized as a “superfood,” which regular consumption might exert many beneficial health effects. Therefore, in addition to China and other Asian countries, the cultivation of Lycium species has become widespread throughout Europe. This study investigated the total phenolics (TPC), total flavonoids (TFC) and polysaccharides content, as well as biological properties of goji berry (Lycium barbarum L.) cultivated in the Belgrade region, Serbia. The HPLC method was used for the identification of individual phenolic compounds (rutin, quercetin-diglucuronide, chlorogenic acid and caffeic acid). Antioxidant properties of goji berry extracts with different solvent were evaluated for radical scavenging (DPPH, ABTS), reducing power (CUPRAC, FRAP), and β-carotene/linoleic acid bleaching inhibition capacity. Additionally, goji berry extracts were screened for their anti-diabetic (α-amylase, α-glucosidase), anti-tyrosinase, and anti-acetylcholinesterase activities. Methanol was identified as the most effective solvent for the extraction, resulting in the highest contents of TPC (3.76 mg GAE/g dry weight), TFC (0.65 mg CE/g dry weight), as well as superior antioxidant activity evaluated by all assays. Also, the methanol extract of goji berry inhibited all tested enzymes in concentration-dependent manners. The highest enzyme inhibitory activity was shown for tyrosinase (IC50 of 1.4 mg ± 0.01 mg/mL). The IC50 values were 4.66 ± 0.25 mg/mL, 10.68 ± 0.07 mg/mL, 7.07 ± 0.1 mg/mL for α-amylase, α-glucosidase and acetylcholinesterase inhibition activity, respectively. Overall, obtained results suggest that goji berry cultivated in Serbia is a valuable source of bioactive compounds that can be use in the food, nutraceutical, and cosmetic industries.
PB  - University of Belgrade
C3  - UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts
T1  - Phytochemical composition and in vitro biological activities of goji berry cultivated in Serbia
SP  - 110
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5096
ER  - 

@conference{
author = "Ilić, Tijana and Krgović, Nemanja and Marčetić, Mirjana and Vidović, Bojana",
year = "2021",
abstract = "Due to the presence of many nutrients and bioactive compounds, fruits of Lycium species (Fructus Lycii, goji berries) are recognized as a “superfood,” which regular consumption might exert many beneficial health effects. Therefore, in addition to China and other Asian countries, the cultivation of Lycium species has become widespread throughout Europe. This study investigated the total phenolics (TPC), total flavonoids (TFC) and polysaccharides content, as well as biological properties of goji berry (Lycium barbarum L.) cultivated in the Belgrade region, Serbia. The HPLC method was used for the identification of individual phenolic compounds (rutin, quercetin-diglucuronide, chlorogenic acid and caffeic acid). Antioxidant properties of goji berry extracts with different solvent were evaluated for radical scavenging (DPPH, ABTS), reducing power (CUPRAC, FRAP), and β-carotene/linoleic acid bleaching inhibition capacity. Additionally, goji berry extracts were screened for their anti-diabetic (α-amylase, α-glucosidase), anti-tyrosinase, and anti-acetylcholinesterase activities. Methanol was identified as the most effective solvent for the extraction, resulting in the highest contents of TPC (3.76 mg GAE/g dry weight), TFC (0.65 mg CE/g dry weight), as well as superior antioxidant activity evaluated by all assays. Also, the methanol extract of goji berry inhibited all tested enzymes in concentration-dependent manners. The highest enzyme inhibitory activity was shown for tyrosinase (IC50 of 1.4 mg ± 0.01 mg/mL). The IC50 values were 4.66 ± 0.25 mg/mL, 10.68 ± 0.07 mg/mL, 7.07 ± 0.1 mg/mL for α-amylase, α-glucosidase and acetylcholinesterase inhibition activity, respectively. Overall, obtained results suggest that goji berry cultivated in Serbia is a valuable source of bioactive compounds that can be use in the food, nutraceutical, and cosmetic industries.",
publisher = "University of Belgrade",
journal = "UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts",
title = "Phytochemical composition and in vitro biological activities of goji berry cultivated in Serbia",
pages = "110-110",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5096"
}

Ilić, T., Krgović, N., Marčetić, M.,& Vidović, B.. (2021). Phytochemical composition and in vitro biological activities of goji berry cultivated in Serbia. in UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts
University of Belgrade., 110-110.
https://hdl.handle.net/21.15107/rcub_farfar_5096

Ilić T, Krgović N, Marčetić M, Vidović B. Phytochemical composition and in vitro biological activities of goji berry cultivated in Serbia. in UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts. 2021;:110-110.
https://hdl.handle.net/21.15107/rcub_farfar_5096 .

Ilić, Tijana, Krgović, Nemanja, Marčetić, Mirjana, Vidović, Bojana, "Phytochemical composition and in vitro biological activities of goji berry cultivated in Serbia" in UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts (2021):110-110,
https://hdl.handle.net/21.15107/rcub_farfar_5096 .

TY  - CONF
AU  - Marčetić, Mirjana
AU  - Samardžić, Stevan
AU  - Ilić, Tijana
AU  - Božić, Dragana
AU  - Vidović, Bojana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5097
AB  - The blackthorn, Prunus spinosa L. (Rosaceae) is a continental shrub widespread in Europe. The fruit is used in traditional medicine in the treatment of respiratory disorders, as well as diuretic, spasmolytic and anti-inflammatory agent. The aim of this study was to investigate the phenolic profile and in vitro biological activities: antioxidant, anti-diabetic, anti-tyrosinase, and anti-acetylcholinesterase. Furthermore the effect of blackthorn fruit extract on probiotic microorganisms was also studied. The blackthorn fruits were collected from two localities in Serbia and extracted with water, methanol and ethanol (50% V/V) at room temperature. The total phenolic contents was analysed by the Folin-Ciocalteu assay and was the highest in methanol extracts (321.36±9.13 and 217.04±17.99 mg GAE/100 g). On the contrary ethanol extracts contained the highest total flavonoids content (67.88±1.05 and 39.70±3.19 mg CE/100 g). Hydroxycinnamic acid derivatives (caffeoylquinic acid, caffeoyl hexoside) and quercetin glycosides (rutin, quercetin pentosyl-hexoside, isoquercitrin, quercetin pentoside) were detected in methanol extracts of both samples by LC-MS. Blackthorn ethanol extracts showed pronounced ferric reducing activity in FRAP test (2.80±0.07 and 1.89±0.01 mmol Trolox /100 g) and highest ability to neutralise ABTS radical (41.02±0.77 and 45.84±1.01 mmol Trolox /100 g). On the other hand methanol extract of both samples exerted significant DPPH radical scavenging activity (3.38±0.1 and 2.61±0.17 mmol Trolox/100 g) and highest activity in β-carotene/linoleic acid bleaching test (20.89±2.28 and 21.16±2.43%). Methanol extract of both samples inhibited the enzimes: α-amylase (IC50 2.05±0.05 and 1.26±0.04 mg/ml) α-glucosidase (IC50 0.63±0.02 and 0.43±0.06 mg/ml), tyrosinase (IC50 1.0±0.07 and 0.57±0.02 mg/ml), and acetylcholinesterase (IC50 0.56±0.28 and 2.16±0.56 mg/ml). In addition the methanol extracts of both samples markedly stimulated the growth of investigated probiotic microorganisms.
The blackthorn fruit represents a rich source of biologically active compounds and although it is almost forgotten it should be used again in human nutrition to maintain health.
PB  - University of Belgrade
C3  - UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts
T1  - Phenolic profile and in vitro biological activities of blackthorn fruit (Prunus spinosa L.)
SP  - 85
EP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5097
ER  - 

@conference{
author = "Marčetić, Mirjana and Samardžić, Stevan and Ilić, Tijana and Božić, Dragana and Vidović, Bojana",
year = "2021",
abstract = "The blackthorn, Prunus spinosa L. (Rosaceae) is a continental shrub widespread in Europe. The fruit is used in traditional medicine in the treatment of respiratory disorders, as well as diuretic, spasmolytic and anti-inflammatory agent. The aim of this study was to investigate the phenolic profile and in vitro biological activities: antioxidant, anti-diabetic, anti-tyrosinase, and anti-acetylcholinesterase. Furthermore the effect of blackthorn fruit extract on probiotic microorganisms was also studied. The blackthorn fruits were collected from two localities in Serbia and extracted with water, methanol and ethanol (50% V/V) at room temperature. The total phenolic contents was analysed by the Folin-Ciocalteu assay and was the highest in methanol extracts (321.36±9.13 and 217.04±17.99 mg GAE/100 g). On the contrary ethanol extracts contained the highest total flavonoids content (67.88±1.05 and 39.70±3.19 mg CE/100 g). Hydroxycinnamic acid derivatives (caffeoylquinic acid, caffeoyl hexoside) and quercetin glycosides (rutin, quercetin pentosyl-hexoside, isoquercitrin, quercetin pentoside) were detected in methanol extracts of both samples by LC-MS. Blackthorn ethanol extracts showed pronounced ferric reducing activity in FRAP test (2.80±0.07 and 1.89±0.01 mmol Trolox /100 g) and highest ability to neutralise ABTS radical (41.02±0.77 and 45.84±1.01 mmol Trolox /100 g). On the other hand methanol extract of both samples exerted significant DPPH radical scavenging activity (3.38±0.1 and 2.61±0.17 mmol Trolox/100 g) and highest activity in β-carotene/linoleic acid bleaching test (20.89±2.28 and 21.16±2.43%). Methanol extract of both samples inhibited the enzimes: α-amylase (IC50 2.05±0.05 and 1.26±0.04 mg/ml) α-glucosidase (IC50 0.63±0.02 and 0.43±0.06 mg/ml), tyrosinase (IC50 1.0±0.07 and 0.57±0.02 mg/ml), and acetylcholinesterase (IC50 0.56±0.28 and 2.16±0.56 mg/ml). In addition the methanol extracts of both samples markedly stimulated the growth of investigated probiotic microorganisms.
The blackthorn fruit represents a rich source of biologically active compounds and although it is almost forgotten it should be used again in human nutrition to maintain health.",
publisher = "University of Belgrade",
journal = "UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts",
title = "Phenolic profile and in vitro biological activities of blackthorn fruit (Prunus spinosa L.)",
pages = "85-85",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5097"
}

Marčetić, M., Samardžić, S., Ilić, T., Božić, D.,& Vidović, B.. (2021). Phenolic profile and in vitro biological activities of blackthorn fruit (Prunus spinosa L.). in UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts
University of Belgrade., 85-85.
https://hdl.handle.net/21.15107/rcub_farfar_5097

Marčetić M, Samardžić S, Ilić T, Božić D, Vidović B. Phenolic profile and in vitro biological activities of blackthorn fruit (Prunus spinosa L.). in UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts. 2021;:85-85.
https://hdl.handle.net/21.15107/rcub_farfar_5097 .

Marčetić, Mirjana, Samardžić, Stevan, Ilić, Tijana, Božić, Dragana, Vidović, Bojana, "Phenolic profile and in vitro biological activities of blackthorn fruit (Prunus spinosa L.)" in UNIFOOD conference, Belgrade, September 24-25, 2021, Book of Abstracts (2021):85-85,
https://hdl.handle.net/21.15107/rcub_farfar_5097 .

TY  - CONF
AU  - Ilić, Tijana
AU  - Vidović, Bojana
AU  - Kotur-Stevuljević, Jelena
AU  - Ostanek, Barbara
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5518
AB  - Telomeres are DNA-protein structures located at the ends of eukaryotic chromosomes. Since
their shortening is a natural process, which repeats with each cell division, telomere lengths
have been proposed as a biomarker of aging. Also, there is evidence that telomere shortening
and dysfunction can be accelerated by oxidative-stress and unhealthy lifestyle factors,
including physical inactivity and inadequate nutrition, Thus, we aimed to evaluate the
association of redox status and selected lifestyle factors with telomere length. The study
included 94 apparently healthy adults, both genders with average age 46±12 years. Before
anthropometric measurements and venous blood sampling, participants were asked to complete
a lifestyle questionnaire. Serum antioxidant defense markers (total sulfhydryl groups,
paraoxonase activity and total antioxidant status) and prooxidants and products of its activity
(malondialdehyde, superoxide anion and total oxidant status) were determined. The
Prooxidative score, Antioxidative score and Oxy score were calculated from measured redox
status markers by using z-score statistics. Telomere length was determined by qPCR method
using genomic DNA from peripheral blood leukocytes. A positive relation was found among
telomere length and a moderate level of physical activity, intake of fruits and vegetables,
especially for females. Increasing abdominal fat, alcohol and fried food intake, as well the Oxy
score (difference between Proxidative and Antioxidative scores) were inversely associated with
telomere length. Overall, these results support the impact of healthy lifestyle on healthy aging
and redox control in the term of prevention of major age-related diseases.
PB  - University of Belgrade, Belgrade, Serbia
C3  - Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
T1  - Association of redox status and lifestyle factors with telomere length in healthy subjects
SP  - 38
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5518
ER  - 

@conference{
author = "Ilić, Tijana and Vidović, Bojana and Kotur-Stevuljević, Jelena and Ostanek, Barbara",
year = "2020",
abstract = "Telomeres are DNA-protein structures located at the ends of eukaryotic chromosomes. Since
their shortening is a natural process, which repeats with each cell division, telomere lengths
have been proposed as a biomarker of aging. Also, there is evidence that telomere shortening
and dysfunction can be accelerated by oxidative-stress and unhealthy lifestyle factors,
including physical inactivity and inadequate nutrition, Thus, we aimed to evaluate the
association of redox status and selected lifestyle factors with telomere length. The study
included 94 apparently healthy adults, both genders with average age 46±12 years. Before
anthropometric measurements and venous blood sampling, participants were asked to complete
a lifestyle questionnaire. Serum antioxidant defense markers (total sulfhydryl groups,
paraoxonase activity and total antioxidant status) and prooxidants and products of its activity
(malondialdehyde, superoxide anion and total oxidant status) were determined. The
Prooxidative score, Antioxidative score and Oxy score were calculated from measured redox
status markers by using z-score statistics. Telomere length was determined by qPCR method
using genomic DNA from peripheral blood leukocytes. A positive relation was found among
telomere length and a moderate level of physical activity, intake of fruits and vegetables,
especially for females. Increasing abdominal fat, alcohol and fried food intake, as well the Oxy
score (difference between Proxidative and Antioxidative scores) were inversely associated with
telomere length. Overall, these results support the impact of healthy lifestyle on healthy aging
and redox control in the term of prevention of major age-related diseases.",
publisher = "University of Belgrade, Belgrade, Serbia",
journal = "Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade",
title = "Association of redox status and lifestyle factors with telomere length in healthy subjects",
pages = "38-38",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5518"
}

Ilić, T., Vidović, B., Kotur-Stevuljević, J.,& Ostanek, B.. (2020). Association of redox status and lifestyle factors with telomere length in healthy subjects. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
University of Belgrade, Belgrade, Serbia., 38-38.
https://hdl.handle.net/21.15107/rcub_farfar_5518

Ilić T, Vidović B, Kotur-Stevuljević J, Ostanek B. Association of redox status and lifestyle factors with telomere length in healthy subjects. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade. 2020;:38-38.
https://hdl.handle.net/21.15107/rcub_farfar_5518 .

Ilić, Tijana, Vidović, Bojana, Kotur-Stevuljević, Jelena, Ostanek, Barbara, "Association of redox status and lifestyle factors with telomere length in healthy subjects" in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade (2020):38-38,
https://hdl.handle.net/21.15107/rcub_farfar_5518 .

TY  - JOUR
AU  - Ilić, Tijana
AU  - Dodevska, Margarita
AU  - Marčetić, Mirjana
AU  - Božić, Dragana
AU  - Kodranov, Igor
AU  - Vidović, Bojana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3925
AB  - Since the fruits of Lycium L. species (Fructus lycii, goji berries) are promoted as a “superfood”
with plenty of health benefits, there is extensive research interest in their nutritional and phytochemical
composition. In the present study, the nutritional value, minerals, fatty acid composition, and bioactive
compounds of L. barbarum L., red, yellow, and black goji berry (L. ruthenicum Murray.) cultivated
in Serbia were investigated. Antioxidant and antimicrobial properties of their methanol extracts
were assessed. Red goji berry had the highest content of fats, dietary fiber, iron, total carotenoids,
and 2-O- -d-glucopyranosyl-l-ascorbic acid (AA-2 G). The yellow goji berry extract showed the
highest level of flavonoids and the most prominent antimicrobial (especially against Gram-negative
bacteria) properties. The highest total phenolic content and the most potent antioxidant activity were
observed for the extract of black goji berry. Therefore, all goji berries could be a valuable source of
bioactive compounds in the food and pharmaceutical industry.
PB  - MDPI AG
T2  - Foods
T1  - Chemical characterization, antioxidant and antimicrobial properties of goji berries cultivated in Serbia
VL  - 9
IS  - 11
DO  - 10.3390/foods9111614
ER  - 

@article{
author = "Ilić, Tijana and Dodevska, Margarita and Marčetić, Mirjana and Božić, Dragana and Kodranov, Igor and Vidović, Bojana",
year = "2020",
abstract = "Since the fruits of Lycium L. species (Fructus lycii, goji berries) are promoted as a “superfood”
with plenty of health benefits, there is extensive research interest in their nutritional and phytochemical
composition. In the present study, the nutritional value, minerals, fatty acid composition, and bioactive
compounds of L. barbarum L., red, yellow, and black goji berry (L. ruthenicum Murray.) cultivated
in Serbia were investigated. Antioxidant and antimicrobial properties of their methanol extracts
were assessed. Red goji berry had the highest content of fats, dietary fiber, iron, total carotenoids,
and 2-O- -d-glucopyranosyl-l-ascorbic acid (AA-2 G). The yellow goji berry extract showed the
highest level of flavonoids and the most prominent antimicrobial (especially against Gram-negative
bacteria) properties. The highest total phenolic content and the most potent antioxidant activity were
observed for the extract of black goji berry. Therefore, all goji berries could be a valuable source of
bioactive compounds in the food and pharmaceutical industry.",
publisher = "MDPI AG",
journal = "Foods",
title = "Chemical characterization, antioxidant and antimicrobial properties of goji berries cultivated in Serbia",
volume = "9",
number = "11",
doi = "10.3390/foods9111614"
}

Ilić, T., Dodevska, M., Marčetić, M., Božić, D., Kodranov, I.,& Vidović, B.. (2020). Chemical characterization, antioxidant and antimicrobial properties of goji berries cultivated in Serbia. in Foods
MDPI AG., 9(11).
https://doi.org/10.3390/foods9111614

Ilić T, Dodevska M, Marčetić M, Božić D, Kodranov I, Vidović B. Chemical characterization, antioxidant and antimicrobial properties of goji berries cultivated in Serbia. in Foods. 2020;9(11).
doi:10.3390/foods9111614 .

Ilić, Tijana, Dodevska, Margarita, Marčetić, Mirjana, Božić, Dragana, Kodranov, Igor, Vidović, Bojana, "Chemical characterization, antioxidant and antimicrobial properties of goji berries cultivated in Serbia" in Foods, 9, no. 11 (2020),
https://doi.org/10.3390/foods9111614 . .