TY  - JOUR
AU  - Stojanov, Marina
AU  - Stefanović, Aleksandra
AU  - Dzingalasević, Gordana
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
AU  - Mandić-Radić, Slavka
AU  - Prostran, Milica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1862
AB  - Objective: The aim of this study was to investigate whether high bilirubin concentration is a protective factor in cardiovascular disease (CAD) and how it correlates with parameters of oxidative stress in young males and females. Methods: The study comprised 628 healthy subjects of both genders, 18-22 years of age. In fasting sera the concentration of total bilirubin (Tbil), parameters of cardiovascular risk and oxidative stress were determined. The results were analyzed by appropriate statistical methods. Results: We found no gender differences in body mass index (BMI), blood pressure and lipid profile between subjects with low and high Tbil level. Men with high Tbil had higher concentrations of albumin and uric acid (p  lt  0.001) and lower of oxLDL ( lt 0.05), while women had higher albumin (p  lt  0.05) and lower TBARS (p  lt 0.05). Significant positive correlation in men was found between Tbil, uric acid and albumin, while for glucose and TSARS this association was negative. In female significant positive correlation was between Tbil, HDL-C, fibrinogen, albumin and uric acid and negative between Tbil and TBARS. The high concentration of Tbil in men was independently associated with uric acid (p  lt  0.05) and oxLDL (p  lt  0.001), while in women it was independently associated with TBARS (p  lt 0.05). After adjustment for traditional lipid parameters the predictive power of high bilirubin in men remained for uric acid (p  lt  0.001) and TBARS in women (p  lt  0.05). Conclusion: These findings jointly support the concept that bilirubin via its antioxidant potential has a protective effect against cardiovascular disease in young male and female.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases
VL  - 46
IS  - 15
SP  - 1516
EP  - 1519
DO  - 10.1016/j.clinbiochem.2013.06.020
ER  - 

@article{
author = "Stojanov, Marina and Stefanović, Aleksandra and Dzingalasević, Gordana and Ivanišević, Jasmina and Miljković, Milica and Mandić-Radić, Slavka and Prostran, Milica",
year = "2013",
abstract = "Objective: The aim of this study was to investigate whether high bilirubin concentration is a protective factor in cardiovascular disease (CAD) and how it correlates with parameters of oxidative stress in young males and females. Methods: The study comprised 628 healthy subjects of both genders, 18-22 years of age. In fasting sera the concentration of total bilirubin (Tbil), parameters of cardiovascular risk and oxidative stress were determined. The results were analyzed by appropriate statistical methods. Results: We found no gender differences in body mass index (BMI), blood pressure and lipid profile between subjects with low and high Tbil level. Men with high Tbil had higher concentrations of albumin and uric acid (p  lt  0.001) and lower of oxLDL ( lt 0.05), while women had higher albumin (p  lt  0.05) and lower TBARS (p  lt 0.05). Significant positive correlation in men was found between Tbil, uric acid and albumin, while for glucose and TSARS this association was negative. In female significant positive correlation was between Tbil, HDL-C, fibrinogen, albumin and uric acid and negative between Tbil and TBARS. The high concentration of Tbil in men was independently associated with uric acid (p  lt  0.05) and oxLDL (p  lt  0.001), while in women it was independently associated with TBARS (p  lt 0.05). After adjustment for traditional lipid parameters the predictive power of high bilirubin in men remained for uric acid (p  lt  0.001) and TBARS in women (p  lt  0.05). Conclusion: These findings jointly support the concept that bilirubin via its antioxidant potential has a protective effect against cardiovascular disease in young male and female.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases",
volume = "46",
number = "15",
pages = "1516-1519",
doi = "10.1016/j.clinbiochem.2013.06.020"
}

Stojanov, M., Stefanović, A., Dzingalasević, G., Ivanišević, J., Miljković, M., Mandić-Radić, S.,& Prostran, M.. (2013). Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 46(15), 1516-1519.
https://doi.org/10.1016/j.clinbiochem.2013.06.020

Stojanov M, Stefanović A, Dzingalasević G, Ivanišević J, Miljković M, Mandić-Radić S, Prostran M. Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases. in Clinical Biochemistry. 2013;46(15):1516-1519.
doi:10.1016/j.clinbiochem.2013.06.020 .

Stojanov, Marina, Stefanović, Aleksandra, Dzingalasević, Gordana, Ivanišević, Jasmina, Miljković, Milica, Mandić-Radić, Slavka, Prostran, Milica, "Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases" in Clinical Biochemistry, 46, no. 15 (2013):1516-1519,
https://doi.org/10.1016/j.clinbiochem.2013.06.020 . .

TY  - JOUR
AU  - Stojanov, Marina
AU  - Stefanović, Aleksandra
AU  - Dzingalasević, Gordana
AU  - Mandić-Radić, Slavka
AU  - Prostran, Milica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1568
AB  - Objective: We investigated the relationship between butyrylcholinesterase (BuChE) and cardiovascular risk factors in young male and female. Design and methods: The study comprised 1512 healthy subjects, 18-25 years of age. In fasting sera the concentrations of BuChE and cardiovascular risk factors were estimated. Results: Analysis of variance indicated significant increase in body mass index (BMI), total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL) (p lt 0.05) and albumin (p lt 0.001) with BuChE activity increment in males. In females glucose and albumin (p lt 0.05) increased with BuChE activity. Negative but not significant correlation between BuChE and high-density lipoprotein cholesterol (HDL-C) was detected for both genders. Conclusion: The tendency towards overweight in young male could explain our results on BMI as an independent risk factor for higher BuChE in young male. Glucose as an independent risk factor for higher BuChE activity in females indicates that BuChE may be a predictor of diabetes.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Butyrylcholinesterase activity in young men and women: Association with cardiovascular risk factors
VL  - 44
IS  - 8-9
SP  - 623
EP  - 626
DO  - 10.1016/j.clinbiochem.2011.03.028
ER  - 

@article{
author = "Stojanov, Marina and Stefanović, Aleksandra and Dzingalasević, Gordana and Mandić-Radić, Slavka and Prostran, Milica",
year = "2011",
abstract = "Objective: We investigated the relationship between butyrylcholinesterase (BuChE) and cardiovascular risk factors in young male and female. Design and methods: The study comprised 1512 healthy subjects, 18-25 years of age. In fasting sera the concentrations of BuChE and cardiovascular risk factors were estimated. Results: Analysis of variance indicated significant increase in body mass index (BMI), total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL) (p lt 0.05) and albumin (p lt 0.001) with BuChE activity increment in males. In females glucose and albumin (p lt 0.05) increased with BuChE activity. Negative but not significant correlation between BuChE and high-density lipoprotein cholesterol (HDL-C) was detected for both genders. Conclusion: The tendency towards overweight in young male could explain our results on BMI as an independent risk factor for higher BuChE in young male. Glucose as an independent risk factor for higher BuChE activity in females indicates that BuChE may be a predictor of diabetes.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Butyrylcholinesterase activity in young men and women: Association with cardiovascular risk factors",
volume = "44",
number = "8-9",
pages = "623-626",
doi = "10.1016/j.clinbiochem.2011.03.028"
}

Stojanov, M., Stefanović, A., Dzingalasević, G., Mandić-Radić, S.,& Prostran, M.. (2011). Butyrylcholinesterase activity in young men and women: Association with cardiovascular risk factors. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 44(8-9), 623-626.
https://doi.org/10.1016/j.clinbiochem.2011.03.028

Stojanov M, Stefanović A, Dzingalasević G, Mandić-Radić S, Prostran M. Butyrylcholinesterase activity in young men and women: Association with cardiovascular risk factors. in Clinical Biochemistry. 2011;44(8-9):623-626.
doi:10.1016/j.clinbiochem.2011.03.028 .

Stojanov, Marina, Stefanović, Aleksandra, Dzingalasević, Gordana, Mandić-Radić, Slavka, Prostran, Milica, "Butyrylcholinesterase activity in young men and women: Association with cardiovascular risk factors" in Clinical Biochemistry, 44, no. 8-9 (2011):623-626,
https://doi.org/10.1016/j.clinbiochem.2011.03.028 . .