TY  - JOUR
AU  - Đuričić, Ivana
AU  - Calder, Philip C.
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5617
AB  - Managing atherosclerotic cardiovascular disease (ASCVD) often involves a combination of lifestyle modifications and medications aiming to decrease the risk of cardiovascular outcomes, such as myocardial infarction and stroke. The aim of this article is to discuss possible omega-3 (n-3) fatty acid–statin interactions in the prevention and treatment of ASCVD and to provide evidence to consider for clinical practice, highlighting novel insights in this field. Statins and n-3 fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) are commonly used to control cardiovascular risk factors in order to treat ASCVD. Statins are an important lipid-lowering therapy, primarily targeting low-density lipoprotein cholesterol (LDL-C) levels, while n-3 fatty acids address triglyceride (TG) concentrations. Both statins and n-3 fatty acids have pleiotropic actions which overlap, including improving endothelial function, modulation of inflammation, and stabilizing atherosclerotic plaques. Thus, both statins and n-3 fatty acids potentially mitigate the residual cardiovascular risk that remains beyond lipid lowering, such as persistent inflammation. EPA and DHA are both substrates for the synthesis of so-called specialized pro-resolving mediators (SPMs), a relatively recently recognized feature of their ability to combat inflammation. Interestingly, statins seem to have the ability to promote the production of some SPMs, suggesting a largely unrecognized interaction between statins and n-3 fatty acids with relevance to the control of inflammation. Although n-3 fatty acids are the major substrates for the production of SPMs, these signaling molecules may have additional therapeutic benefits beyond those provided by the precursor n-3 fatty acids themselves. In this article, we discuss the accumulating evidence that supports SPMs as a novel therapeutic tool and the possible statin–n-3 fatty acid interactions relevant to the prevention and treatment of ASCVD.
PB  - MDPI
T2  - Nutrients
T1  - Omega-3 (n-3) Fatty Acid-Statin Interaction: Evidence for a Novel Therapeutic Strategy for Atherosclerotic Cardiovascular Disease
VL  - 16
IS  - 7
DO  - 10.3390/nu16070962
ER  - 

@article{
author = "Đuričić, Ivana and Calder, Philip C.",
year = "2024",
abstract = "Managing atherosclerotic cardiovascular disease (ASCVD) often involves a combination of lifestyle modifications and medications aiming to decrease the risk of cardiovascular outcomes, such as myocardial infarction and stroke. The aim of this article is to discuss possible omega-3 (n-3) fatty acid–statin interactions in the prevention and treatment of ASCVD and to provide evidence to consider for clinical practice, highlighting novel insights in this field. Statins and n-3 fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) are commonly used to control cardiovascular risk factors in order to treat ASCVD. Statins are an important lipid-lowering therapy, primarily targeting low-density lipoprotein cholesterol (LDL-C) levels, while n-3 fatty acids address triglyceride (TG) concentrations. Both statins and n-3 fatty acids have pleiotropic actions which overlap, including improving endothelial function, modulation of inflammation, and stabilizing atherosclerotic plaques. Thus, both statins and n-3 fatty acids potentially mitigate the residual cardiovascular risk that remains beyond lipid lowering, such as persistent inflammation. EPA and DHA are both substrates for the synthesis of so-called specialized pro-resolving mediators (SPMs), a relatively recently recognized feature of their ability to combat inflammation. Interestingly, statins seem to have the ability to promote the production of some SPMs, suggesting a largely unrecognized interaction between statins and n-3 fatty acids with relevance to the control of inflammation. Although n-3 fatty acids are the major substrates for the production of SPMs, these signaling molecules may have additional therapeutic benefits beyond those provided by the precursor n-3 fatty acids themselves. In this article, we discuss the accumulating evidence that supports SPMs as a novel therapeutic tool and the possible statin–n-3 fatty acid interactions relevant to the prevention and treatment of ASCVD.",
publisher = "MDPI",
journal = "Nutrients",
title = "Omega-3 (n-3) Fatty Acid-Statin Interaction: Evidence for a Novel Therapeutic Strategy for Atherosclerotic Cardiovascular Disease",
volume = "16",
number = "7",
doi = "10.3390/nu16070962"
}

Đuričić, I.,& Calder, P. C.. (2024). Omega-3 (n-3) Fatty Acid-Statin Interaction: Evidence for a Novel Therapeutic Strategy for Atherosclerotic Cardiovascular Disease. in Nutrients
MDPI., 16(7).
https://doi.org/10.3390/nu16070962

Đuričić I, Calder PC. Omega-3 (n-3) Fatty Acid-Statin Interaction: Evidence for a Novel Therapeutic Strategy for Atherosclerotic Cardiovascular Disease. in Nutrients. 2024;16(7).
doi:10.3390/nu16070962 .

Đuričić, Ivana, Calder, Philip C., "Omega-3 (n-3) Fatty Acid-Statin Interaction: Evidence for a Novel Therapeutic Strategy for Atherosclerotic Cardiovascular Disease" in Nutrients, 16, no. 7 (2024),
https://doi.org/10.3390/nu16070962 . .

TY  - JOUR
AU  - Jovanović-Macura, Irena
AU  - Đuričić, Ivana
AU  - Major, Tamara
AU  - Milanović, Desanka
AU  - Šobajić, Slađana
AU  - Kanazir, Selma
AU  - Ivković, Sanja
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5543
AB  - Introduction: During fetal development, the proper development of neural and visual systems relies on the maternal supplementation of omega-3 fatty acids through placental transfer. Pregnant women are strongly advised to augment their diet with additional sources of omega-3, such as fish oil (FO). This supplementation has been linked to a reduced risk of preterm birth, pre-eclampsia, and perinatal depression. Recently, higher doses of omega-3 supplementation have been recommended for pregnant women. Considering that omega-3 fatty acids, particularly docosahexaenoic acid (DHA), play a crucial role in maintaining the delicate homeostasis required for the proper functioning of the retina and photoreceptors the effects of high-dose fish oil (FO) supplementation during pregnancy and lactation on the retina and retinal pigmented epithelium (RPE) in healthy offspring warrant better understanding. Methods: The fatty acid content and the changes in the expression of the genes regulating cholesterol homeostasis and DHA transport in the retina and RPE were evaluated following the high-dose FO supplementation. Results: Our study demonstrated that despite the high-dose FO treatment during pregnancy and lactation, the rigorous DHA homeostasis in the retina and RPE of the two-month-old offspring remained balanced. Another significant finding of this study is the increase in the expression levels of major facilitator superfamily domain-containing protein (Mfsd2a), a primary DHA transporter. Mfsd2a also serves as a major regulator of transcytosis during development, and a reduction in Mfsd2a levels poses a major risk for the development of leaky blood vessels. Conclusion: Impairment of the blood-retinal barrier (BRB) is associated with the development of numerous ocular diseases, and a better understanding of how to manipulate transcytosis in the BRB during development can enhance drug delivery through the BRB or contribute to the repair of central nervous system (CNS) barriers.
PB  - Frontiers Media SA
T2  - Frontiers in Nutrition
T1  - The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring
VL  - 10
SP  - 1330414
DO  - 10.3389/fnut.2023.1330414
ER  - 

@article{
author = "Jovanović-Macura, Irena and Đuričić, Ivana and Major, Tamara and Milanović, Desanka and Šobajić, Slađana and Kanazir, Selma and Ivković, Sanja",
year = "2023",
abstract = "Introduction: During fetal development, the proper development of neural and visual systems relies on the maternal supplementation of omega-3 fatty acids through placental transfer. Pregnant women are strongly advised to augment their diet with additional sources of omega-3, such as fish oil (FO). This supplementation has been linked to a reduced risk of preterm birth, pre-eclampsia, and perinatal depression. Recently, higher doses of omega-3 supplementation have been recommended for pregnant women. Considering that omega-3 fatty acids, particularly docosahexaenoic acid (DHA), play a crucial role in maintaining the delicate homeostasis required for the proper functioning of the retina and photoreceptors the effects of high-dose fish oil (FO) supplementation during pregnancy and lactation on the retina and retinal pigmented epithelium (RPE) in healthy offspring warrant better understanding. Methods: The fatty acid content and the changes in the expression of the genes regulating cholesterol homeostasis and DHA transport in the retina and RPE were evaluated following the high-dose FO supplementation. Results: Our study demonstrated that despite the high-dose FO treatment during pregnancy and lactation, the rigorous DHA homeostasis in the retina and RPE of the two-month-old offspring remained balanced. Another significant finding of this study is the increase in the expression levels of major facilitator superfamily domain-containing protein (Mfsd2a), a primary DHA transporter. Mfsd2a also serves as a major regulator of transcytosis during development, and a reduction in Mfsd2a levels poses a major risk for the development of leaky blood vessels. Conclusion: Impairment of the blood-retinal barrier (BRB) is associated with the development of numerous ocular diseases, and a better understanding of how to manipulate transcytosis in the BRB during development can enhance drug delivery through the BRB or contribute to the repair of central nervous system (CNS) barriers.",
publisher = "Frontiers Media SA",
journal = "Frontiers in Nutrition",
title = "The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring",
volume = "10",
pages = "1330414",
doi = "10.3389/fnut.2023.1330414"
}

Jovanović-Macura, I., Đuričić, I., Major, T., Milanović, D., Šobajić, S., Kanazir, S.,& Ivković, S.. (2023). The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring. in Frontiers in Nutrition
Frontiers Media SA., 10, 1330414.
https://doi.org/10.3389/fnut.2023.1330414

Jovanović-Macura I, Đuričić I, Major T, Milanović D, Šobajić S, Kanazir S, Ivković S. The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring. in Frontiers in Nutrition. 2023;10:1330414.
doi:10.3389/fnut.2023.1330414 .

Jovanović-Macura, Irena, Đuričić, Ivana, Major, Tamara, Milanović, Desanka, Šobajić, Slađana, Kanazir, Selma, Ivković, Sanja, "The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring" in Frontiers in Nutrition, 10 (2023):1330414,
https://doi.org/10.3389/fnut.2023.1330414 . .

TY  - JOUR
AU  - Ivanović, Nevena
AU  - Ilić, Tijana
AU  - Zrnić-Ćirić, Milica
AU  - Todorović, Vanja
AU  - Đuričić, Ivana
AU  - Dabetić, Nevena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4979
AB  - The disposal of waste generated in the agri-food industry is one of the greatest challenges
in achieving sustainable development. Although agri-food residues are a potential source of
bioactive compounds with proven health benefits, they are largely unused and disposed of as
organic waste. The recovery of bioactive compounds from agri-food waste to obtain products
with high biological value, such as functional foods and nutraceuticals, is an idea that stems from
the concept of bioeconomy and combines environmental issues with economically viable
production. Some of the main agri-food wastes in Serbia that have the potential to be recycled
into value-added products are apple, plum, grape, tomato, and beet pomace, and oilseed cakes.
Bioactive compounds isolated from these wastes include polyphenols, fibers, essential fatty acids,
minerals, various volatiles and pigments. This article focuses on the most common food wastes
and the potential reuse of these undervalued material to produce value-added products such as
functional foods, nutraceuticals or food additives.
AB  - Odlaganje otpada koji nastaje u prehrambenoj industriji jedan je od najvećih izazova u
postizanju održivog razvoja. Iako su nusproizvodi koji nastaju u prehrambenoj industriji
potencijalni izvor bioaktivnih jedinjenja sa dokazanim pozitivnim zdravstvenim efektima, oni se
uglavnom odlažu kao organski otpad. Iskorišćenje bioaktivnih jedinjenja iz ovih nusproizvoda u
cilju dobijanja proizvoda sa dodatom nutritivnom i biološkom vrednošću, kao što su funkcionalna
hrana i nutraceutici, ideja je koja proizilazi iz koncepta bioekonomije i kombinuje ekološki aspekt
sa ekonomski održivom proizvodnjom. Neki od glavnih nusproizvoda koji se generišu u Srbiji sa
potencijalom da se iskoriste u proizvodnji proizvoda sa dodatom vrednošću su trop jabuke, trop
šljive, komina grožđa, trop paradajza, uljane pogače i dr. Bioaktivna jedinjenja izolovana iz ovih
otpada uključuju polifenole, peptide, vlakna, esencijalne masne kiseline, minerale, različite
isparljive materije i pigmente. Ovaj članak se fokusira na najčešće otpade prehrambene industrije
i potencijalnu ponovnu upotrebu ovog još uvek neiskorišćenog otpadnog materijala za
proizvodnju proizvoda sa dodatom vrednošću kao što su funkcionalna hrana, nutraceutici ili
aditivi.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
T2  - Arhiv za farmaciju
T1  - Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals
T1  - Nusproizvodi agro-industrije kao izvor održivih sastojaka za proizvodnju funkcionalne hrane i nutraceutika
VL  - 73
IS  - 3
SP  - 190
EP  - 204
DO  - 10.5937/arhfarm73-44481
ER  - 

@article{
author = "Ivanović, Nevena and Ilić, Tijana and Zrnić-Ćirić, Milica and Todorović, Vanja and Đuričić, Ivana and Dabetić, Nevena",
year = "2023",
abstract = "The disposal of waste generated in the agri-food industry is one of the greatest challenges
in achieving sustainable development. Although agri-food residues are a potential source of
bioactive compounds with proven health benefits, they are largely unused and disposed of as
organic waste. The recovery of bioactive compounds from agri-food waste to obtain products
with high biological value, such as functional foods and nutraceuticals, is an idea that stems from
the concept of bioeconomy and combines environmental issues with economically viable
production. Some of the main agri-food wastes in Serbia that have the potential to be recycled
into value-added products are apple, plum, grape, tomato, and beet pomace, and oilseed cakes.
Bioactive compounds isolated from these wastes include polyphenols, fibers, essential fatty acids,
minerals, various volatiles and pigments. This article focuses on the most common food wastes
and the potential reuse of these undervalued material to produce value-added products such as
functional foods, nutraceuticals or food additives., Odlaganje otpada koji nastaje u prehrambenoj industriji jedan je od najvećih izazova u
postizanju održivog razvoja. Iako su nusproizvodi koji nastaju u prehrambenoj industriji
potencijalni izvor bioaktivnih jedinjenja sa dokazanim pozitivnim zdravstvenim efektima, oni se
uglavnom odlažu kao organski otpad. Iskorišćenje bioaktivnih jedinjenja iz ovih nusproizvoda u
cilju dobijanja proizvoda sa dodatom nutritivnom i biološkom vrednošću, kao što su funkcionalna
hrana i nutraceutici, ideja je koja proizilazi iz koncepta bioekonomije i kombinuje ekološki aspekt
sa ekonomski održivom proizvodnjom. Neki od glavnih nusproizvoda koji se generišu u Srbiji sa
potencijalom da se iskoriste u proizvodnji proizvoda sa dodatom vrednošću su trop jabuke, trop
šljive, komina grožđa, trop paradajza, uljane pogače i dr. Bioaktivna jedinjenja izolovana iz ovih
otpada uključuju polifenole, peptide, vlakna, esencijalne masne kiseline, minerale, različite
isparljive materije i pigmente. Ovaj članak se fokusira na najčešće otpade prehrambene industrije
i potencijalnu ponovnu upotrebu ovog još uvek neiskorišćenog otpadnog materijala za
proizvodnju proizvoda sa dodatom vrednošću kao što su funkcionalna hrana, nutraceutici ili
aditivi.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals, Nusproizvodi agro-industrije kao izvor održivih sastojaka za proizvodnju funkcionalne hrane i nutraceutika",
volume = "73",
number = "3",
pages = "190-204",
doi = "10.5937/arhfarm73-44481"
}

Ivanović, N., Ilić, T., Zrnić-Ćirić, M., Todorović, V., Đuričić, I.,& Dabetić, N.. (2023). Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 73(3), 190-204.
https://doi.org/10.5937/arhfarm73-44481

Ivanović N, Ilić T, Zrnić-Ćirić M, Todorović V, Đuričić I, Dabetić N. Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals. in Arhiv za farmaciju. 2023;73(3):190-204.
doi:10.5937/arhfarm73-44481 .

Ivanović, Nevena, Ilić, Tijana, Zrnić-Ćirić, Milica, Todorović, Vanja, Đuričić, Ivana, Dabetić, Nevena, "Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals" in Arhiv za farmaciju, 73, no. 3 (2023):190-204,
https://doi.org/10.5937/arhfarm73-44481 . .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Calder, Philip C.
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4422
AB  - The long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found in seafood, supplements, and concentrated pharmaceutical preparations. Prospective cohort studies demonstrate an association between higher intakes of EPA+DHA or higher levels of EPA and DHA in the body and lower risk of developing cardiovascular disease (CVD), especially coronary heart disease and myocardial infarction, and of cardiovascular mortality in the general population. The cardioprotective effect of EPA and DHA is due to the beneficial modulation of a number of risk factors for CVD. Some large trials support the use of EPA+DHA (or EPA alone) in high-risk patients, although the evidence is inconsistent. This review presents key studies of EPA and DHA in the primary and secondary prevention of CVD, briefly describes potential mechanisms of action, and discusses recently published RCTs and meta-analyses. Potential adverse aspects of long-chain omega-3 fatty acids in relation to CVD are discussed.
PB  - Annual Reviews Inc
T2  - Annual review of pharmacology and toxicology
T1  - Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health
VL  - 63
SP  - 383
EP  - 406
DO  - 10.1146/annurev-pharmtox-051921-090208
ER  - 

@article{
author = "Đuričić, Ivana and Calder, Philip C.",
year = "2023",
abstract = "The long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found in seafood, supplements, and concentrated pharmaceutical preparations. Prospective cohort studies demonstrate an association between higher intakes of EPA+DHA or higher levels of EPA and DHA in the body and lower risk of developing cardiovascular disease (CVD), especially coronary heart disease and myocardial infarction, and of cardiovascular mortality in the general population. The cardioprotective effect of EPA and DHA is due to the beneficial modulation of a number of risk factors for CVD. Some large trials support the use of EPA+DHA (or EPA alone) in high-risk patients, although the evidence is inconsistent. This review presents key studies of EPA and DHA in the primary and secondary prevention of CVD, briefly describes potential mechanisms of action, and discusses recently published RCTs and meta-analyses. Potential adverse aspects of long-chain omega-3 fatty acids in relation to CVD are discussed.",
publisher = "Annual Reviews Inc",
journal = "Annual review of pharmacology and toxicology",
title = "Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health",
volume = "63",
pages = "383-406",
doi = "10.1146/annurev-pharmtox-051921-090208"
}

Đuričić, I.,& Calder, P. C.. (2023). Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health. in Annual review of pharmacology and toxicology
Annual Reviews Inc., 63, 383-406.
https://doi.org/10.1146/annurev-pharmtox-051921-090208

Đuričić I, Calder PC. Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health. in Annual review of pharmacology and toxicology. 2023;63:383-406.
doi:10.1146/annurev-pharmtox-051921-090208 .

Đuričić, Ivana, Calder, Philip C., "Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health" in Annual review of pharmacology and toxicology, 63 (2023):383-406,
https://doi.org/10.1146/annurev-pharmtox-051921-090208 . .

TY  - JOUR
AU  - Jovanović Macura, Irena
AU  - Đuričić, Ivana
AU  - Major, Tamara
AU  - Milanović, Desanka
AU  - Brkić, Marjana
AU  - Šobajić, Slađana
AU  - Kanazir, Selma
AU  - Ivković, Sanja
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4309
AB  - The recommended fish oil (FO) supplementation doses often yield low omega-3 polyunsaturated fatty acids (PUFAs) tissue bioavailability, and higher doses (up to 10 g per day) have been increasingly recommended. However, the exact effects of such FO supplementation on the healthy retina and retinal pigmented epithelium (RPE) are unknown. Our study showed that the high dose FO treatment did not imbalance the rigorous docosahexaenoic acid (DHA, C22:6n3) homeostasis in the retina and RPE in the three-month-old female B6/SLJ mice. Instead, we have found the significant increase in the expression of Mfsd2a, the main DHA transporter. Mfsd2a is also an essential regulator of blood vessel transcytosis and the decrease in Mfsd2a expression can be a risk factor for developing leaky blood vessels. Therefore, the high-dose FO supplementation emerges as the prophylactic fortifier of the retinal blood vessels.
PB  - Elsevier Ltd
T2  - Journal of Functional Foods
T1  - The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice
VL  - 99
DO  - 10.1016/j.jff.2022.105302
ER  - 

@article{
author = "Jovanović Macura, Irena and Đuričić, Ivana and Major, Tamara and Milanović, Desanka and Brkić, Marjana and Šobajić, Slađana and Kanazir, Selma and Ivković, Sanja",
year = "2022",
abstract = "The recommended fish oil (FO) supplementation doses often yield low omega-3 polyunsaturated fatty acids (PUFAs) tissue bioavailability, and higher doses (up to 10 g per day) have been increasingly recommended. However, the exact effects of such FO supplementation on the healthy retina and retinal pigmented epithelium (RPE) are unknown. Our study showed that the high dose FO treatment did not imbalance the rigorous docosahexaenoic acid (DHA, C22:6n3) homeostasis in the retina and RPE in the three-month-old female B6/SLJ mice. Instead, we have found the significant increase in the expression of Mfsd2a, the main DHA transporter. Mfsd2a is also an essential regulator of blood vessel transcytosis and the decrease in Mfsd2a expression can be a risk factor for developing leaky blood vessels. Therefore, the high-dose FO supplementation emerges as the prophylactic fortifier of the retinal blood vessels.",
publisher = "Elsevier Ltd",
journal = "Journal of Functional Foods",
title = "The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice",
volume = "99",
doi = "10.1016/j.jff.2022.105302"
}

Jovanović Macura, I., Đuričić, I., Major, T., Milanović, D., Brkić, M., Šobajić, S., Kanazir, S.,& Ivković, S.. (2022). The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice. in Journal of Functional Foods
Elsevier Ltd., 99.
https://doi.org/10.1016/j.jff.2022.105302

Jovanović Macura I, Đuričić I, Major T, Milanović D, Brkić M, Šobajić S, Kanazir S, Ivković S. The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice. in Journal of Functional Foods. 2022;99.
doi:10.1016/j.jff.2022.105302 .

Jovanović Macura, Irena, Đuričić, Ivana, Major, Tamara, Milanović, Desanka, Brkić, Marjana, Šobajić, Slađana, Kanazir, Selma, Ivković, Sanja, "The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice" in Journal of Functional Foods, 99 (2022),
https://doi.org/10.1016/j.jff.2022.105302 . .

TY  - CONF
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Zrnić-Ćirić, Milica
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4499
AB  - Wine industry generates enormous quantities of solid organic waste consisted of
stems, skins and seeds. Grape seeds are considered the most valuable part of a pomace, since
it is rich in oil and containing numerous bioactive compounds. Grape seed oil (GSO)
composition depends mainly on grape variety, but also on environmental factors and
maturation degree. The aim of this study was to investigate the diversity of chemical
composition among seed oils obtained from different grape varieties. Eight varieties were
collected from the same wine region and at the same maturity phase. Investigation of fatty
acid composition was done using GC/FID, while HPLC/FD was employed for vitamin E
analyses. Linoleic acid was the most abundant in all samples, followed by oleic acid.
Saturated fatty acids, such as palmitic and stearic acid, were also present (up to 20 % of the
total fatty acid methyl esters). Vitamin E concentrations were significantly affected by grape
variety (p<0.01). α-tocopherol was found in high concentration in all samples. GSO from
Shiraz variety had about 25 mg α-tocopherol per kg of oil, while Gamay GSO contained more
than six times less amounts of this vitamin E isoform. Sum of β and γ tocopherol also varied
considerable, although Shiraz again stood out with the highest content. Finally, δ tocopherol
was found in four varieties, in minor quantities. Generally, considering variety diversification
on vitamin E composition of GSO, investigations that will include as much varieties as
possible, are needed to single out ones with the highest bio-oil potential.
AB  - Industrija vina ostavlja za sobom ogromne količine čvrstog organskog otpada koji se
sastoji od peteljki, pokožice i semenki grožđa. Semenke se smatraju najvrednijim delom
komine, jer su bogate uljem i sadrže brojna bioaktivna jedinjenja. Sastav ulja iz semenki
grožđa zavisi pre svega od sorte vinove loze, ali i od faktora sredine i stepena zrelosti ploda.
Cilj ovog rada bilo je ispitivanje raznolikosti hemijskog sastava ulja dobijenog iz semenki
različitih sorti grožđa. U tu svrhu, prikupljeno je osam sorti u istoj fazi zrelosti i iz istog
vinskog regiona. Ispitivanje sastava masnih kiselina vršeno je korišćenjem GC/FID, dok je
HPLC/FD korišćen za analizu koncentracije vitamina E. Linolna kiselina je bila
najzastupljenija u svim uzorcima, zatim oleinska kiselina. Zasićene masne kiseline, kao što su
palmitinska i stearinska kiselina, takođe su bile prisutne (do 20 % od ukupnih metil estara
masnih kiselina). Sorta vinove loze je značajno uticala na sadržaj vitamina E (p<0,01). α-
tokoferol je pronađen u visokim koncentracijama u svim uzorcima. Ulje iz semenki sorte
Širaz sadržalo je oko 25 miligrama α-tokoferola po kilogramu, dok je u ulju sorte Game
kvantifikovana šest puta manja koncentracija ove izoforme vitamina E. Zbir β i γ tokoferola
takođe je značajno varirao, iako se Širaz ponovo istakao sa najvećim sadržajem. δ tokoferol je
pronađen u ulju četiri sorte, u manjim količinama. Generalno, s obzirom na raznovrsnost
sastava vitamina E u ulju iz semenki grožđa, potrebna su opsežnija istraživanja koja će
obuhvatiti veći broj sorti vinove loze kako bi se izdvojile one sa najvećim potencijalom bio-
ulja.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Diversity of chemical composition among seed oils obtained from different grape varieties
T1  - Raznolikost hemijskog sastava ulja dobijenog iz semenki različitih sorti grožđa
VL  - 72
IS  - 4 suplement
SP  - S217
EP  - S218
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4499
ER  - 

@conference{
author = "Dabetić, Nevena and Todorović, Vanja and Zrnić-Ćirić, Milica and Đuričić, Ivana and Šobajić, Slađana",
year = "2022",
abstract = "Wine industry generates enormous quantities of solid organic waste consisted of
stems, skins and seeds. Grape seeds are considered the most valuable part of a pomace, since
it is rich in oil and containing numerous bioactive compounds. Grape seed oil (GSO)
composition depends mainly on grape variety, but also on environmental factors and
maturation degree. The aim of this study was to investigate the diversity of chemical
composition among seed oils obtained from different grape varieties. Eight varieties were
collected from the same wine region and at the same maturity phase. Investigation of fatty
acid composition was done using GC/FID, while HPLC/FD was employed for vitamin E
analyses. Linoleic acid was the most abundant in all samples, followed by oleic acid.
Saturated fatty acids, such as palmitic and stearic acid, were also present (up to 20 % of the
total fatty acid methyl esters). Vitamin E concentrations were significantly affected by grape
variety (p<0.01). α-tocopherol was found in high concentration in all samples. GSO from
Shiraz variety had about 25 mg α-tocopherol per kg of oil, while Gamay GSO contained more
than six times less amounts of this vitamin E isoform. Sum of β and γ tocopherol also varied
considerable, although Shiraz again stood out with the highest content. Finally, δ tocopherol
was found in four varieties, in minor quantities. Generally, considering variety diversification
on vitamin E composition of GSO, investigations that will include as much varieties as
possible, are needed to single out ones with the highest bio-oil potential., Industrija vina ostavlja za sobom ogromne količine čvrstog organskog otpada koji se
sastoji od peteljki, pokožice i semenki grožđa. Semenke se smatraju najvrednijim delom
komine, jer su bogate uljem i sadrže brojna bioaktivna jedinjenja. Sastav ulja iz semenki
grožđa zavisi pre svega od sorte vinove loze, ali i od faktora sredine i stepena zrelosti ploda.
Cilj ovog rada bilo je ispitivanje raznolikosti hemijskog sastava ulja dobijenog iz semenki
različitih sorti grožđa. U tu svrhu, prikupljeno je osam sorti u istoj fazi zrelosti i iz istog
vinskog regiona. Ispitivanje sastava masnih kiselina vršeno je korišćenjem GC/FID, dok je
HPLC/FD korišćen za analizu koncentracije vitamina E. Linolna kiselina je bila
najzastupljenija u svim uzorcima, zatim oleinska kiselina. Zasićene masne kiseline, kao što su
palmitinska i stearinska kiselina, takođe su bile prisutne (do 20 % od ukupnih metil estara
masnih kiselina). Sorta vinove loze je značajno uticala na sadržaj vitamina E (p<0,01). α-
tokoferol je pronađen u visokim koncentracijama u svim uzorcima. Ulje iz semenki sorte
Širaz sadržalo je oko 25 miligrama α-tokoferola po kilogramu, dok je u ulju sorte Game
kvantifikovana šest puta manja koncentracija ove izoforme vitamina E. Zbir β i γ tokoferola
takođe je značajno varirao, iako se Širaz ponovo istakao sa najvećim sadržajem. δ tokoferol je
pronađen u ulju četiri sorte, u manjim količinama. Generalno, s obzirom na raznovrsnost
sastava vitamina E u ulju iz semenki grožđa, potrebna su opsežnija istraživanja koja će
obuhvatiti veći broj sorti vinove loze kako bi se izdvojile one sa najvećim potencijalom bio-
ulja.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Diversity of chemical composition among seed oils obtained from different grape varieties, Raznolikost hemijskog sastava ulja dobijenog iz semenki različitih sorti grožđa",
volume = "72",
number = "4 suplement",
pages = "S217-S218",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4499"
}

Dabetić, N., Todorović, V., Zrnić-Ćirić, M., Đuričić, I.,& Šobajić, S.. (2022). Diversity of chemical composition among seed oils obtained from different grape varieties. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S217-S218.
https://hdl.handle.net/21.15107/rcub_farfar_4499

Dabetić N, Todorović V, Zrnić-Ćirić M, Đuričić I, Šobajić S. Diversity of chemical composition among seed oils obtained from different grape varieties. in Arhiv za farmaciju. 2022;72(4 suplement):S217-S218.
https://hdl.handle.net/21.15107/rcub_farfar_4499 .

Dabetić, Nevena, Todorović, Vanja, Zrnić-Ćirić, Milica, Đuričić, Ivana, Šobajić, Slađana, "Diversity of chemical composition among seed oils obtained from different grape varieties" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S217-S218,
https://hdl.handle.net/21.15107/rcub_farfar_4499 .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Todorović, Vanja
AU  - Dabetić, Nevena
AU  - Zrnić-Ćirić, Milica
AU  - Ivanović, Nevena
AU  - Vidović, Bojana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4404
AB  - Besides iodine deficiency, autoimmune Hashimoto thyroiditis is the leading cause of
hypothyroidism globally, characterized by the increased titer of thyroid autoantibodies and
destruction of thyroid cells. Graves' disease is the most common etiology of hyperthyroidism
worldwide. Patients with thyroid dysfunction often require dietary modifications. Popular
interventions include supplementation with certain vitamins and minerals, as well as trace
elements such as iodine and selenium. The intake of food containing goitrogens should be limited.
Goitrogens are substances of plant origin that interfere with the production of thyroid hormones,
increasing the risk for goiter and hypothyroidism. The primary dietary sources of goitrogens are
cruciferous vegetables, soy products, starchy plants, and some fruits. Beyond essential nutrients,
there has been an increasing interest in using specific nutraceuticals, including myoinositol, L-
carnitine, melatonin, and resveratrol, as potential preventive and therapeutic agents in thyroid
diseases. Even though current evidence promotes some beneficial outcomes of these
nutraceuticals, further investigations are needed to clarify dose-dependent effects, duration of
supplementation, combination in different clinical settings, and the exact mechanism of their
action in thyroid disorders.
AB  - Pored nedostatka joda, najčešća etiologija hipotireoze u razvijenim zemljama je Hašimoto tireoiditis, koji karakteriše povišen nivo serum autoantitela i limfocitna infiltracija štitaste žlezde. Grejvsova bolest je vodeći uzrok hipertireoza na globalnom nivou. Pacijenti sa oboljenjem štitaste žlezde često zahtevaju modifikaciju dijetarnog režima. Popularne intervencije uključuju suplementaciju određenim vitaminima, mineralima i mikroelementima kao što su jod i selen. Preporučuje se ograničen unos namirnica koje sadrže goitrogene supstance jer ometaju normalnu sintezu tiroidnih hormona, povećavajući rizik za nastanak strume i hipotireoze. Primarni izvori goitrogena u ishrani su kruciferno povrće, proizvodi od soje, skrobne biljke i pojedine vrste voća. Osim esencijalnih nutrijenata, postoji sve veće interesovanje za primenu specifičnih nutraceutika u prevenciji i koterapiji bolesti štitaste žlezde, kao što su mioinozitol, L-karnitin, melatonin i rezveratrol. Trenutni dokazi ukazuju na moguće promotivne efekte ovih jedinjenja u oboljenjima štitaste žlezde. Potrebna su dalja ispitivanja koja bi pratila uticaj doze i dužine suplementacije nutraceutika i potvrdila tačne mehanizme njihovog delovanja u poremećajima funkcije štitaste žlezde.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Dietary factors and thyroid dysfunction
T1  - Dijetarni faktori i tiroidna disfunkcija
VL  - 72
IS  - 5
SP  - 455
EP  - 467
DO  - 10.5937/arhfarm72-39624
ER  - 

@article{
author = "Đuričić, Ivana and Todorović, Vanja and Dabetić, Nevena and Zrnić-Ćirić, Milica and Ivanović, Nevena and Vidović, Bojana",
year = "2022",
abstract = "Besides iodine deficiency, autoimmune Hashimoto thyroiditis is the leading cause of
hypothyroidism globally, characterized by the increased titer of thyroid autoantibodies and
destruction of thyroid cells. Graves' disease is the most common etiology of hyperthyroidism
worldwide. Patients with thyroid dysfunction often require dietary modifications. Popular
interventions include supplementation with certain vitamins and minerals, as well as trace
elements such as iodine and selenium. The intake of food containing goitrogens should be limited.
Goitrogens are substances of plant origin that interfere with the production of thyroid hormones,
increasing the risk for goiter and hypothyroidism. The primary dietary sources of goitrogens are
cruciferous vegetables, soy products, starchy plants, and some fruits. Beyond essential nutrients,
there has been an increasing interest in using specific nutraceuticals, including myoinositol, L-
carnitine, melatonin, and resveratrol, as potential preventive and therapeutic agents in thyroid
diseases. Even though current evidence promotes some beneficial outcomes of these
nutraceuticals, further investigations are needed to clarify dose-dependent effects, duration of
supplementation, combination in different clinical settings, and the exact mechanism of their
action in thyroid disorders., Pored nedostatka joda, najčešća etiologija hipotireoze u razvijenim zemljama je Hašimoto tireoiditis, koji karakteriše povišen nivo serum autoantitela i limfocitna infiltracija štitaste žlezde. Grejvsova bolest je vodeći uzrok hipertireoza na globalnom nivou. Pacijenti sa oboljenjem štitaste žlezde često zahtevaju modifikaciju dijetarnog režima. Popularne intervencije uključuju suplementaciju određenim vitaminima, mineralima i mikroelementima kao što su jod i selen. Preporučuje se ograničen unos namirnica koje sadrže goitrogene supstance jer ometaju normalnu sintezu tiroidnih hormona, povećavajući rizik za nastanak strume i hipotireoze. Primarni izvori goitrogena u ishrani su kruciferno povrće, proizvodi od soje, skrobne biljke i pojedine vrste voća. Osim esencijalnih nutrijenata, postoji sve veće interesovanje za primenu specifičnih nutraceutika u prevenciji i koterapiji bolesti štitaste žlezde, kao što su mioinozitol, L-karnitin, melatonin i rezveratrol. Trenutni dokazi ukazuju na moguće promotivne efekte ovih jedinjenja u oboljenjima štitaste žlezde. Potrebna su dalja ispitivanja koja bi pratila uticaj doze i dužine suplementacije nutraceutika i potvrdila tačne mehanizme njihovog delovanja u poremećajima funkcije štitaste žlezde.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Dietary factors and thyroid dysfunction, Dijetarni faktori i tiroidna disfunkcija",
volume = "72",
number = "5",
pages = "455-467",
doi = "10.5937/arhfarm72-39624"
}

Đuričić, I., Todorović, V., Dabetić, N., Zrnić-Ćirić, M., Ivanović, N.,& Vidović, B.. (2022). Dietary factors and thyroid dysfunction. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(5), 455-467.
https://doi.org/10.5937/arhfarm72-39624

Đuričić I, Todorović V, Dabetić N, Zrnić-Ćirić M, Ivanović N, Vidović B. Dietary factors and thyroid dysfunction. in Arhiv za farmaciju. 2022;72(5):455-467.
doi:10.5937/arhfarm72-39624 .

Đuričić, Ivana, Todorović, Vanja, Dabetić, Nevena, Zrnić-Ćirić, Milica, Ivanović, Nevena, Vidović, Bojana, "Dietary factors and thyroid dysfunction" in Arhiv za farmaciju, 72, no. 5 (2022):455-467,
https://doi.org/10.5937/arhfarm72-39624 . .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Gojković, Tamara
AU  - Antonijević, Biljana
AU  - Šobajić, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4060
AB  - Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of hypercholesterolaemic fatty acids (OFA) for the freshwater group was 18.70 (17.40‒21.30) while the seawater group had a similar range of values 18.90 (17.55‒22.75). Hypocholesterol-aemic fatty acids (DFA) also showed similar ranges for both groups: 68.80 (66‒70.20) for freshwater and 68.40 (64.85‒73.05) for seawater group. The ratio of DHA/EPA ranged from 1.8 for sardine samples and up to 10 for tuna samples, indicating that the amount of DHA in natural samples exceeds the amount of EPA in many cases. The values of ath-erogenic (AI) and thrombogenic index (TI) were lower than 1 for all analysed samples. Conclusion. Sardine and mackerel had the highest content of n-3 LC-PUFA and presented the least expensive sources of EPA and DHA. The low values of AI and TI obtained from studied fish indicate its benefits from a health point of view.
AB  - Uvod/Cilj. Unos n-3 polinezasićenih masnih kiselina (PMK) je od velike važnosti u prevenciji i tretmanu različitih oboljen-ja. Generalno posmatrajući, prosečan unos n-3 PMK je obično značajno niži od utvrđenih preporuka. Lipidi riba sadrže masne kiseline n-3 serije od kojih su najvažnije ei-kozapentaenska (20:5 n-3, EPA) i dokozaheksaenska (20:6 n-3, DHA) masna kiselina. Cilj ove studije bio je odrediti i uporediti lipidni profil i lipidne indekse u 10 različitih vrsta riba dostupnih na tržištu Srbije. Takođe, određen je odnos cene i nutritivne vrednosti odabranih vrsta. Metode. Ispiti-vane su rečne ribe Dunava iz Beogradskog regiona, dok su morske ribe uglavnom vodile poreklo iz Jadranskog mora. Gasna hromatografija sa jonskim detektorom je korišćena za određivanje masnih kiselina u 40 uzoraka nakon lipidne ekstrakcije. Cost-minimization analiza je korišćena za procenu ekonomske koristi. Rezultati. Morske ribe su imale značajno veće vrednosti za parametar flash lipid quality u odnosu na rečne ribe (p < 0,05). Vrednosti hiperholesterolemijskih mas-nih kiselina za grupu rečnih riba [18,70 (17,40‒21,30)] bile su slične vrednostima dobijenim za morske ribe [18,90 (17,55‒22,75)]. Hipoholesterolemijske masne kiseline su takođe pokazale sličan raspon vrednosti za rečne [68.80 (66–70.20)] i morske ribe [68.40 (64.85–73.05)]. Odnos DHA/EPA kretao se od 1,8 za uzorke sardine, do 10 za uzorke tune, što potvrđuje činjenicu da DHA prevazilazi vrednosti za EPA u svim ispitivanim uzorcima. Vrednosti za aterogeni i trombogeni indeks su bile niže od 1 za sve ana-lizirane uzorke. Zaključak. Sardine i skuša su imale najveći sadržaj n-3 PMK i predstavljale su najekonomičniji izvor EPA i DHA. Niske vrednosti za aterogeni i trombogeni in-deks ukazuju na potencijalno povoljan zdravstveni efekat ispitivanih vrsta.
PB  - Belgrade : Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T1  - Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia
T1  - Lipidni profil i zdravstveni značaj najčešće konzumiranih rečnih i morskih riba u populaciji Srbije
VL  - 79
IS  - 1
SP  - 8
EP  - 16
DO  - 10.2298/VSP200212054D
ER  - 

@article{
author = "Đuričić, Ivana and Gojković, Tamara and Antonijević, Biljana and Šobajić, Slađana",
year = "2022",
abstract = "Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of hypercholesterolaemic fatty acids (OFA) for the freshwater group was 18.70 (17.40‒21.30) while the seawater group had a similar range of values 18.90 (17.55‒22.75). Hypocholesterol-aemic fatty acids (DFA) also showed similar ranges for both groups: 68.80 (66‒70.20) for freshwater and 68.40 (64.85‒73.05) for seawater group. The ratio of DHA/EPA ranged from 1.8 for sardine samples and up to 10 for tuna samples, indicating that the amount of DHA in natural samples exceeds the amount of EPA in many cases. The values of ath-erogenic (AI) and thrombogenic index (TI) were lower than 1 for all analysed samples. Conclusion. Sardine and mackerel had the highest content of n-3 LC-PUFA and presented the least expensive sources of EPA and DHA. The low values of AI and TI obtained from studied fish indicate its benefits from a health point of view., Uvod/Cilj. Unos n-3 polinezasićenih masnih kiselina (PMK) je od velike važnosti u prevenciji i tretmanu različitih oboljen-ja. Generalno posmatrajući, prosečan unos n-3 PMK je obično značajno niži od utvrđenih preporuka. Lipidi riba sadrže masne kiseline n-3 serije od kojih su najvažnije ei-kozapentaenska (20:5 n-3, EPA) i dokozaheksaenska (20:6 n-3, DHA) masna kiselina. Cilj ove studije bio je odrediti i uporediti lipidni profil i lipidne indekse u 10 različitih vrsta riba dostupnih na tržištu Srbije. Takođe, određen je odnos cene i nutritivne vrednosti odabranih vrsta. Metode. Ispiti-vane su rečne ribe Dunava iz Beogradskog regiona, dok su morske ribe uglavnom vodile poreklo iz Jadranskog mora. Gasna hromatografija sa jonskim detektorom je korišćena za određivanje masnih kiselina u 40 uzoraka nakon lipidne ekstrakcije. Cost-minimization analiza je korišćena za procenu ekonomske koristi. Rezultati. Morske ribe su imale značajno veće vrednosti za parametar flash lipid quality u odnosu na rečne ribe (p < 0,05). Vrednosti hiperholesterolemijskih mas-nih kiselina za grupu rečnih riba [18,70 (17,40‒21,30)] bile su slične vrednostima dobijenim za morske ribe [18,90 (17,55‒22,75)]. Hipoholesterolemijske masne kiseline su takođe pokazale sličan raspon vrednosti za rečne [68.80 (66–70.20)] i morske ribe [68.40 (64.85–73.05)]. Odnos DHA/EPA kretao se od 1,8 za uzorke sardine, do 10 za uzorke tune, što potvrđuje činjenicu da DHA prevazilazi vrednosti za EPA u svim ispitivanim uzorcima. Vrednosti za aterogeni i trombogeni indeks su bile niže od 1 za sve ana-lizirane uzorke. Zaključak. Sardine i skuša su imale najveći sadržaj n-3 PMK i predstavljale su najekonomičniji izvor EPA i DHA. Niske vrednosti za aterogeni i trombogeni in-deks ukazuju na potencijalno povoljan zdravstveni efekat ispitivanih vrsta.",
publisher = "Belgrade : Military Medical Academy, INI",
journal = "Vojnosanitetski pregled",
title = "Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia, Lipidni profil i zdravstveni značaj najčešće konzumiranih rečnih i morskih riba u populaciji Srbije",
volume = "79",
number = "1",
pages = "8-16",
doi = "10.2298/VSP200212054D"
}

Đuričić, I., Gojković, T., Antonijević, B.,& Šobajić, S.. (2022). Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia. in Vojnosanitetski pregled
Belgrade : Military Medical Academy, INI., 79(1), 8-16.
https://doi.org/10.2298/VSP200212054D

Đuričić I, Gojković T, Antonijević B, Šobajić S. Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia. in Vojnosanitetski pregled. 2022;79(1):8-16.
doi:10.2298/VSP200212054D .

Đuričić, Ivana, Gojković, Tamara, Antonijević, Biljana, Šobajić, Slađana, "Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia" in Vojnosanitetski pregled, 79, no. 1 (2022):8-16,
https://doi.org/10.2298/VSP200212054D . .

TY  - CONF
AU  - Đuričić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4440
AB  - Numerous vitamins and minerals have a critical role in supporting innate and
adaptive immune systems. The European Food Safety Authority (EFSA) has approved health
claims for vitamins A, B6, folate, B12, C and D and minerals Zn, Se, Fe and Cu based on
scientific evidence of their contribution to the normal immune system functioning. Existing
evidence suggests their role in maintaining physical barriers (i.e., skin, mucose membranes),
cellular response, regulation of inflammation, proliferation and differentiation of T and B
cells (1). In addition to essential nutrients, other bioactive ingredients such as alpha-lipoic
acid, quercetin, probiotics, and omega-3 fatty acids, stimulate the immune response. Vitamin
C maintains redox homeostasis and protects cells from oxidative damage, regenerates other
essential antioxidants (glutathione, vitamin E), modulates cytokine production and reduces
histamine levels. Vitamin D appears to increase the oxidative potential of macrophages,
reduce pro-inflammatory, and increase the expression of anti-inflammatory cytokines. The
minerals Zn, Se, and Mg are involved in antibody production, metabolism, and immune
tolerance (2). Omega-3 fatty acids are precursors of signaling molecules and specialized
mediators that initiate the resolution of inflammation. Probiotics affect the innate and
adaptive immune response by regulating the functions of immune cells and reducing
inflammation. Due to its ability to mediate inflammatory pathways, alpha-lipoic acid seems
to be helpful in the prevention and treatment of many diseases. Quercetin promotes
increasing antioxidant enzymes and non-enzymatic antioxidants and the expression of
specific pro-inflammatory mediators and chemokines. All mentioned bioactive compounds
have promising effects in the promotion of immune response.
AB  - Brojni vitamini i minerali imaju ključnu ulogu u funkcionisanju urođenog i adaptivnog
imunskog sistema. Evropska agencija za bezbednost hrane (EFSA) je odobrila zdravstvene
izjave za vitamine A, B6, folate, B12, C i D i minerale Zn, Se, Fe i Cu na osnovu naučnih
procena njihovog doprinosa normalnom funkcionisanju imunskog sistema. Učestvuju u
održavanju fizičke barijere (koža, mukozne membrane), celularnom odgovoru, regulaciji
inflamacije, proliferaciji i diferencijaciji B i T ćelija (1). Pored esenijalnih nutrijenata i drugi
bioaktivni sastojci kao što su alfa-lipoinska kiselina, kvercetin, probiotici, omega-3 masne
kiseline, stimulišu imunološki odgovor. Vitamin C održava redoks homeostazu i štiti ćelije od
oksidativnog oštećenja, regeneriše druge važne antioksidanse (glutation, vitamin E),
moduliše produkciju citokina i smanjuje nivo histamina. Vitamin D povećava oksidativni
potencijal makrofaga, redukuje ekspresiju proinflamatornih i povećava ekspresiju
antiinflamatornih citokina. Minerali Zn, Se, Mg su važni u proizvodnji i metabolizmu antitela i
u održavanju imunološke tolerancije (2). Omega-3 masne kiseline su prekursori signalnih
molekula i specijalizovanih medijatora koji iniciraju rezoluciju inflamacije. Omega-3 masne
kiseline moduliraju neke od funkcija imunskih ćelija kao što su makrofage i neutrofili,
aktiviraju antigen-specifične odgovore stvarajuć i antitela i dugotrajnu zaštitu specifičnu za
isti patogen. Probiotici utiču na urođeni i adaptivni imunski odgovor tako što regulišu
funkcije imunskih ćelija i smanjuju upalne procese. Zbog svoje sposobnosti da posreduje u
inflamatornim putevima, alfa-lipoinska kiselina ima ulogu u prevenciji i lečenju mnogih
oboljenja. Kvercetin promoviše poveć anje antioksidativnih enzima i neenzimskih
antioksidanasa, kao i ekspresiju specifičnih proinflamatornih medijatora i hemokina. Sva
navedena biološki aktivna jedinjenja pokazuju značajan potencijal u imunološkom odgovoru.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Bioactive compounds of food and immunity
T1  - Bioaktivni sastojci hrane i imunitet
VL  - 72
IS  - 4 suplement
SP  - S13
EP  - S14
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4440
ER  - 

@conference{
author = "Đuričić, Ivana",
year = "2022",
abstract = "Numerous vitamins and minerals have a critical role in supporting innate and
adaptive immune systems. The European Food Safety Authority (EFSA) has approved health
claims for vitamins A, B6, folate, B12, C and D and minerals Zn, Se, Fe and Cu based on
scientific evidence of their contribution to the normal immune system functioning. Existing
evidence suggests their role in maintaining physical barriers (i.e., skin, mucose membranes),
cellular response, regulation of inflammation, proliferation and differentiation of T and B
cells (1). In addition to essential nutrients, other bioactive ingredients such as alpha-lipoic
acid, quercetin, probiotics, and omega-3 fatty acids, stimulate the immune response. Vitamin
C maintains redox homeostasis and protects cells from oxidative damage, regenerates other
essential antioxidants (glutathione, vitamin E), modulates cytokine production and reduces
histamine levels. Vitamin D appears to increase the oxidative potential of macrophages,
reduce pro-inflammatory, and increase the expression of anti-inflammatory cytokines. The
minerals Zn, Se, and Mg are involved in antibody production, metabolism, and immune
tolerance (2). Omega-3 fatty acids are precursors of signaling molecules and specialized
mediators that initiate the resolution of inflammation. Probiotics affect the innate and
adaptive immune response by regulating the functions of immune cells and reducing
inflammation. Due to its ability to mediate inflammatory pathways, alpha-lipoic acid seems
to be helpful in the prevention and treatment of many diseases. Quercetin promotes
increasing antioxidant enzymes and non-enzymatic antioxidants and the expression of
specific pro-inflammatory mediators and chemokines. All mentioned bioactive compounds
have promising effects in the promotion of immune response., Brojni vitamini i minerali imaju ključnu ulogu u funkcionisanju urođenog i adaptivnog
imunskog sistema. Evropska agencija za bezbednost hrane (EFSA) je odobrila zdravstvene
izjave za vitamine A, B6, folate, B12, C i D i minerale Zn, Se, Fe i Cu na osnovu naučnih
procena njihovog doprinosa normalnom funkcionisanju imunskog sistema. Učestvuju u
održavanju fizičke barijere (koža, mukozne membrane), celularnom odgovoru, regulaciji
inflamacije, proliferaciji i diferencijaciji B i T ćelija (1). Pored esenijalnih nutrijenata i drugi
bioaktivni sastojci kao što su alfa-lipoinska kiselina, kvercetin, probiotici, omega-3 masne
kiseline, stimulišu imunološki odgovor. Vitamin C održava redoks homeostazu i štiti ćelije od
oksidativnog oštećenja, regeneriše druge važne antioksidanse (glutation, vitamin E),
moduliše produkciju citokina i smanjuje nivo histamina. Vitamin D povećava oksidativni
potencijal makrofaga, redukuje ekspresiju proinflamatornih i povećava ekspresiju
antiinflamatornih citokina. Minerali Zn, Se, Mg su važni u proizvodnji i metabolizmu antitela i
u održavanju imunološke tolerancije (2). Omega-3 masne kiseline su prekursori signalnih
molekula i specijalizovanih medijatora koji iniciraju rezoluciju inflamacije. Omega-3 masne
kiseline moduliraju neke od funkcija imunskih ćelija kao što su makrofage i neutrofili,
aktiviraju antigen-specifične odgovore stvarajuć i antitela i dugotrajnu zaštitu specifičnu za
isti patogen. Probiotici utiču na urođeni i adaptivni imunski odgovor tako što regulišu
funkcije imunskih ćelija i smanjuju upalne procese. Zbog svoje sposobnosti da posreduje u
inflamatornim putevima, alfa-lipoinska kiselina ima ulogu u prevenciji i lečenju mnogih
oboljenja. Kvercetin promoviše poveć anje antioksidativnih enzima i neenzimskih
antioksidanasa, kao i ekspresiju specifičnih proinflamatornih medijatora i hemokina. Sva
navedena biološki aktivna jedinjenja pokazuju značajan potencijal u imunološkom odgovoru.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Bioactive compounds of food and immunity, Bioaktivni sastojci hrane i imunitet",
volume = "72",
number = "4 suplement",
pages = "S13-S14",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4440"
}

Đuričić, I.. (2022). Bioactive compounds of food and immunity. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S13-S14.
https://hdl.handle.net/21.15107/rcub_farfar_4440

Đuričić I. Bioactive compounds of food and immunity. in Arhiv za farmaciju. 2022;72(4 suplement):S13-S14.
https://hdl.handle.net/21.15107/rcub_farfar_4440 .

Đuričić, Ivana, "Bioactive compounds of food and immunity" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S13-S14,
https://hdl.handle.net/21.15107/rcub_farfar_4440 .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Zrnić-Ćirić, Milica
AU  - Vidović, Bojana
AU  - Todorović, Vanja
AU  - Dabetić, Nevena
AU  - Ivanović, Nevena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5375
AB  - The immune system defends the host from many pathogen-
ic microorganisms such as viruses, bacteria, parasites and
fungi, including a large number of specific cell types, inter-
related molecules, and biological responses. Due to infec-
tions, heightened immune system activity is accompanied
by expanded metabolic activities, requiring appropriate
energy supply, precursors for biosynthesis and regulatory
molecules. Numerous vitamins and minerals play a crucial
role in supporting body’s immunity and fighting against
viral infections. Other bioactive compounds like omega-3
fatty acids, probiotics and antioxidants (alpha-lipoic acid,
quercetin) are also important in the immune response. CO-
VID-19 may develop mild symptoms to severe damage of
the respiratory epithelium followed by a cytokine storm.
Many studies show that vitamin C, vitamin D, zinc and selenium are critical in defending against SARS-CoV-2 infection.
Intestinal dysbiosis is a feature of many infectious diseases, including COVID-19, so dietary approaches to establishing a
healthy microbiota are essential for improving immune function. This paper reviews the data on the roles and potential
effectiveness of selected nutraceuticals in the prevention and treatment of COVID-19.
AB  - Imunski sistem štiti organizam od brojnih patogena (bakterija, virusa, gljivica, parazita) uključujući veliki broj specijalizovanih tipova ćelija, komunikacionih molekula i
funkcionalnih odgovora. Pojačana aktivnost imunskog si
stema usled infekcija praćena je povećanim metaboličkim
aktivnostima, što zahteva izvore energije, supstrate za biosintezu i regulatorne molekule. Brojni vitamini i minerali
imaju ključnu ulogu u podršci imunskom sistemu i smanjenju rizika od infekcija. Ostale bioaktivne komponente kao omega-3 masne kiseline, probiotici i antioksidansi (alfa-lipoinska kiselina, kvercetin) takođe su od značaja u imunološkom
odgovoru. COVID-19 karakterišu kliničke slike od blagih simptoma do teške infekcije respiratornog epitela praćene citokinskom olujom. Pokazano je da starije osobe sa hroničnim bolestima imaju smanjenu aktivnost odbrambenog sistema
i neadekvatan nutritivni status, zbog čega postoji veći rizik za pojavu fatalnih ishoda. Ispitivanja ukazuju da su vitamin
C, vitamin D, cink i selen posebno važni u odbrani od infekcije SARS-CoV-2. Disbioza creva je karakteristika mnogih zaraznih bolesti uključujući COVID-19, zato su dijetetski pristupi za uspostavljanje zdrave mikrobiote važni u poboljšanju
imunoloških funkcija. U ovom radu prikazan je pregled literature o ulozi i potencijalnoj primeni odabranih nutraceutika u
prevenciji i tretmanu COVID-19.
PB  - Društvo za ishranu Srbije, Beograd
T2  - Hrana i ishrana
T1  - Nutraceuticals in prevention and management of COVID-19
T1  - Nutraceutici u prevenciji i tretmanu COVID-19
VL  - 62
IS  - 2
SP  - 7
EP  - 14
DO  - 10.5937/hraIsh2102007D
ER  - 

@article{
author = "Đuričić, Ivana and Zrnić-Ćirić, Milica and Vidović, Bojana and Todorović, Vanja and Dabetić, Nevena and Ivanović, Nevena",
year = "2021",
abstract = "The immune system defends the host from many pathogen-
ic microorganisms such as viruses, bacteria, parasites and
fungi, including a large number of specific cell types, inter-
related molecules, and biological responses. Due to infec-
tions, heightened immune system activity is accompanied
by expanded metabolic activities, requiring appropriate
energy supply, precursors for biosynthesis and regulatory
molecules. Numerous vitamins and minerals play a crucial
role in supporting body’s immunity and fighting against
viral infections. Other bioactive compounds like omega-3
fatty acids, probiotics and antioxidants (alpha-lipoic acid,
quercetin) are also important in the immune response. CO-
VID-19 may develop mild symptoms to severe damage of
the respiratory epithelium followed by a cytokine storm.
Many studies show that vitamin C, vitamin D, zinc and selenium are critical in defending against SARS-CoV-2 infection.
Intestinal dysbiosis is a feature of many infectious diseases, including COVID-19, so dietary approaches to establishing a
healthy microbiota are essential for improving immune function. This paper reviews the data on the roles and potential
effectiveness of selected nutraceuticals in the prevention and treatment of COVID-19., Imunski sistem štiti organizam od brojnih patogena (bakterija, virusa, gljivica, parazita) uključujući veliki broj specijalizovanih tipova ćelija, komunikacionih molekula i
funkcionalnih odgovora. Pojačana aktivnost imunskog si
stema usled infekcija praćena je povećanim metaboličkim
aktivnostima, što zahteva izvore energije, supstrate za biosintezu i regulatorne molekule. Brojni vitamini i minerali
imaju ključnu ulogu u podršci imunskom sistemu i smanjenju rizika od infekcija. Ostale bioaktivne komponente kao omega-3 masne kiseline, probiotici i antioksidansi (alfa-lipoinska kiselina, kvercetin) takođe su od značaja u imunološkom
odgovoru. COVID-19 karakterišu kliničke slike od blagih simptoma do teške infekcije respiratornog epitela praćene citokinskom olujom. Pokazano je da starije osobe sa hroničnim bolestima imaju smanjenu aktivnost odbrambenog sistema
i neadekvatan nutritivni status, zbog čega postoji veći rizik za pojavu fatalnih ishoda. Ispitivanja ukazuju da su vitamin
C, vitamin D, cink i selen posebno važni u odbrani od infekcije SARS-CoV-2. Disbioza creva je karakteristika mnogih zaraznih bolesti uključujući COVID-19, zato su dijetetski pristupi za uspostavljanje zdrave mikrobiote važni u poboljšanju
imunoloških funkcija. U ovom radu prikazan je pregled literature o ulozi i potencijalnoj primeni odabranih nutraceutika u
prevenciji i tretmanu COVID-19.",
publisher = "Društvo za ishranu Srbije, Beograd",
journal = "Hrana i ishrana",
title = "Nutraceuticals in prevention and management of COVID-19, Nutraceutici u prevenciji i tretmanu COVID-19",
volume = "62",
number = "2",
pages = "7-14",
doi = "10.5937/hraIsh2102007D"
}

Đuričić, I., Zrnić-Ćirić, M., Vidović, B., Todorović, V., Dabetić, N.,& Ivanović, N.. (2021). Nutraceuticals in prevention and management of COVID-19. in Hrana i ishrana
Društvo za ishranu Srbije, Beograd., 62(2), 7-14.
https://doi.org/10.5937/hraIsh2102007D

Đuričić I, Zrnić-Ćirić M, Vidović B, Todorović V, Dabetić N, Ivanović N. Nutraceuticals in prevention and management of COVID-19. in Hrana i ishrana. 2021;62(2):7-14.
doi:10.5937/hraIsh2102007D .

Đuričić, Ivana, Zrnić-Ćirić, Milica, Vidović, Bojana, Todorović, Vanja, Dabetić, Nevena, Ivanović, Nevena, "Nutraceuticals in prevention and management of COVID-19" in Hrana i ishrana, 62, no. 2 (2021):7-14,
https://doi.org/10.5937/hraIsh2102007D . .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Calder, Philip
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3924
AB  - Oxidative stress and inflammation have been recognized as important contributors to the risk of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate the antioxidant signaling pathway and modulate inflammatory processes. They also influence hepatic lipid metabolism and physiological responses of other organs, including the heart. Longitudinal prospective cohort studies demonstrate that there is an association between moderate intake of the omega-6 PUFA linoleic acid and lower risk of cardiovascular diseases (CVDs), most likely as a result of lower blood cholesterol concentration. Current evidence suggests that increasing intake of arachidonic acid (up to 1500 mg/day) has no adverse effect on platelet aggregation and blood clotting, immune function and markers of inflammation, but may benefit muscle and cognitive performance. Many studies show that higher intakes of omega-3 PUFAs, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a lower incidence of chronic diseases characterized by elevated inflammation, including CVDs. This is because of the multiple molecular and cellular actions of EPA and DHA. Intervention trials using EPA + DHA indicate benefit on CVD mortality and a significant inverse linear dose–response relationship has been found between EPA + DHA intake and CVD outcomes. In addition to their antioxidant and anti-inflammatory roles, omega-3 fatty acids are considered to regulate platelet homeostasis and lower risk of thrombosis, which together indicate their potential use in COVID-19 therapy
PB  - MDPI AG
T2  - Nutrients
T1  - Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021
VL  - 13
IS  - 7
DO  - 10.3390/nu13072421
ER  - 

@article{
author = "Đuričić, Ivana and Calder, Philip",
year = "2021",
abstract = "Oxidative stress and inflammation have been recognized as important contributors to the risk of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate the antioxidant signaling pathway and modulate inflammatory processes. They also influence hepatic lipid metabolism and physiological responses of other organs, including the heart. Longitudinal prospective cohort studies demonstrate that there is an association between moderate intake of the omega-6 PUFA linoleic acid and lower risk of cardiovascular diseases (CVDs), most likely as a result of lower blood cholesterol concentration. Current evidence suggests that increasing intake of arachidonic acid (up to 1500 mg/day) has no adverse effect on platelet aggregation and blood clotting, immune function and markers of inflammation, but may benefit muscle and cognitive performance. Many studies show that higher intakes of omega-3 PUFAs, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a lower incidence of chronic diseases characterized by elevated inflammation, including CVDs. This is because of the multiple molecular and cellular actions of EPA and DHA. Intervention trials using EPA + DHA indicate benefit on CVD mortality and a significant inverse linear dose–response relationship has been found between EPA + DHA intake and CVD outcomes. In addition to their antioxidant and anti-inflammatory roles, omega-3 fatty acids are considered to regulate platelet homeostasis and lower risk of thrombosis, which together indicate their potential use in COVID-19 therapy",
publisher = "MDPI AG",
journal = "Nutrients",
title = "Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021",
volume = "13",
number = "7",
doi = "10.3390/nu13072421"
}

Đuričić, I.,& Calder, P.. (2021). Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021. in Nutrients
MDPI AG., 13(7).
https://doi.org/10.3390/nu13072421

Đuričić I, Calder P. Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021. in Nutrients. 2021;13(7).
doi:10.3390/nu13072421 .

Đuričić, Ivana, Calder, Philip, "Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021" in Nutrients, 13, no. 7 (2021),
https://doi.org/10.3390/nu13072421 . .

TY  - JOUR
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Đuričić, Ivana
AU  - Antić-Stanković, Jelena
AU  - Bašić, Zorica N.
AU  - Vujović, Dragan S.
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3608
AB  - The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); α-tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one. Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.
PB  - Wiley-VCH Verlag
T2  - European Journal of Lipid Science and Technology
T1  - Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment
VL  - 122
IS  - 6
DO  - DOI: 10.1002/ejlt.201900447
ER  - 

@article{
author = "Dabetić, Nevena and Todorović, Vanja and Đuričić, Ivana and Antić-Stanković, Jelena and Bašić, Zorica N. and Vujović, Dragan S. and Šobajić, Slađana",
year = "2020",
abstract = "The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); α-tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one. Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.",
publisher = "Wiley-VCH Verlag",
journal = "European Journal of Lipid Science and Technology",
title = "Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment",
volume = "122",
number = "6",
doi = "DOI: 10.1002/ejlt.201900447"
}

Dabetić, N., Todorović, V., Đuričić, I., Antić-Stanković, J., Bašić, Z. N., Vujović, D. S.,& Šobajić, S.. (2020). Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment. in European Journal of Lipid Science and Technology
Wiley-VCH Verlag., 122(6).
https://doi.org/DOI: 10.1002/ejlt.201900447

Dabetić N, Todorović V, Đuričić I, Antić-Stanković J, Bašić ZN, Vujović DS, Šobajić S. Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment. in European Journal of Lipid Science and Technology. 2020;122(6).
doi:DOI: 10.1002/ejlt.201900447 .

Dabetić, Nevena, Todorović, Vanja, Đuričić, Ivana, Antić-Stanković, Jelena, Bašić, Zorica N., Vujović, Dragan S., Šobajić, Slađana, "Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment" in European Journal of Lipid Science and Technology, 122, no. 6 (2020),
https://doi.org/DOI: 10.1002/ejlt.201900447 . .

TY  - JOUR
AU  - Grozdanić, Nađa
AU  - Đuričić, Ivana
AU  - Kosanić, Marijana
AU  - Zdunić, Gordana
AU  - Šavikin, Katarina
AU  - Etahiri, Samira
AU  - Assobhei, Omar
AU  - Benba, Jamila
AU  - Petović, Slavica
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana P.
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3605
AB  - Purpose: Sea macroalgae are an important source of biologically highly valuable compounds. The main aim of this study was to investigate the in vitro anticancer properties and chemical composition of the dichloromethane-methanol extract and three fractions of the Fucus spiralis from coastline of Morocco. Methods: Fractions were made from dichloromethane: methanol (1:1) extract of Fucus spiralis: petroleum-ether, ethyl-acetate and n-butanol. Extract and fractions were screened for in vitro cytotoxicity by MTT assay against human cervical adenocarcinoma (HeLa), colorectal adenocarcinoma (LS-174T), lung carcinoma (A549), and normal human lung fibroblasts (MRC-5). Cell cycle distribution of the HeLa cells was evaluated using flow cytometry. Acridine orange (AO)-ethidium bromide (EB) staining was used to assess morphological changes of HeLa cells under fluorescence microscope. Anti-migration and anti-angiogenic properties were investigated using scratch and tube formation assays against human endothelium-derived permanent EA.hy926 cell line. Antidiabetic activity was tested using anti-α-glucosidase assay. Antimicrobial effect was tested using micro- dilution method. Results: Petroleum-ether fraction оf Fucus spiralis rich in fatty acids exerted the highest cytotoxicity against HeLa cells. Ethyl-acetate and petroleum-ether fractions induced the highest accumulation of the HeLa cells in sub-G1 and G2/M phases. Extract and fractions showed proapoptotic effect on HeLa cells under fluorescent microscope. They exhibited antimigratory and antiangiogenic effects in vitro. IC50 value for α-glucosidase inhibitory activity was much stronger than standard acarbose. n-Butanol fraction exerted the highest antibacterial and antifungal activity. Conclusions: The investigation of various biological activities of the extract and fractions obtained from Fucus spiralis may suggest a promising anticancer and pharmacological potential of this edible macroalga.
PB  - Zerbinis Publications
T2  - Journal of B.U.ON.
T1  - Fucus spiralis extract and fractions: Anticancer and pharmacological potentials
VL  - 25
IS  - 2
SP  - 1219
EP  - 1229
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3605
ER  - 

@article{
author = "Grozdanić, Nađa and Đuričić, Ivana and Kosanić, Marijana and Zdunić, Gordana and Šavikin, Katarina and Etahiri, Samira and Assobhei, Omar and Benba, Jamila and Petović, Slavica and Matić, Ivana Z. and Stanojković, Tatjana P.",
year = "2020",
abstract = "Purpose: Sea macroalgae are an important source of biologically highly valuable compounds. The main aim of this study was to investigate the in vitro anticancer properties and chemical composition of the dichloromethane-methanol extract and three fractions of the Fucus spiralis from coastline of Morocco. Methods: Fractions were made from dichloromethane: methanol (1:1) extract of Fucus spiralis: petroleum-ether, ethyl-acetate and n-butanol. Extract and fractions were screened for in vitro cytotoxicity by MTT assay against human cervical adenocarcinoma (HeLa), colorectal adenocarcinoma (LS-174T), lung carcinoma (A549), and normal human lung fibroblasts (MRC-5). Cell cycle distribution of the HeLa cells was evaluated using flow cytometry. Acridine orange (AO)-ethidium bromide (EB) staining was used to assess morphological changes of HeLa cells under fluorescence microscope. Anti-migration and anti-angiogenic properties were investigated using scratch and tube formation assays against human endothelium-derived permanent EA.hy926 cell line. Antidiabetic activity was tested using anti-α-glucosidase assay. Antimicrobial effect was tested using micro- dilution method. Results: Petroleum-ether fraction оf Fucus spiralis rich in fatty acids exerted the highest cytotoxicity against HeLa cells. Ethyl-acetate and petroleum-ether fractions induced the highest accumulation of the HeLa cells in sub-G1 and G2/M phases. Extract and fractions showed proapoptotic effect on HeLa cells under fluorescent microscope. They exhibited antimigratory and antiangiogenic effects in vitro. IC50 value for α-glucosidase inhibitory activity was much stronger than standard acarbose. n-Butanol fraction exerted the highest antibacterial and antifungal activity. Conclusions: The investigation of various biological activities of the extract and fractions obtained from Fucus spiralis may suggest a promising anticancer and pharmacological potential of this edible macroalga.",
publisher = "Zerbinis Publications",
journal = "Journal of B.U.ON.",
title = "Fucus spiralis extract and fractions: Anticancer and pharmacological potentials",
volume = "25",
number = "2",
pages = "1219-1229",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3605"
}

Grozdanić, N., Đuričić, I., Kosanić, M., Zdunić, G., Šavikin, K., Etahiri, S., Assobhei, O., Benba, J., Petović, S., Matić, I. Z.,& Stanojković, T. P.. (2020). Fucus spiralis extract and fractions: Anticancer and pharmacological potentials. in Journal of B.U.ON.
Zerbinis Publications., 25(2), 1219-1229.
https://hdl.handle.net/21.15107/rcub_farfar_3605

Grozdanić N, Đuričić I, Kosanić M, Zdunić G, Šavikin K, Etahiri S, Assobhei O, Benba J, Petović S, Matić IZ, Stanojković TP. Fucus spiralis extract and fractions: Anticancer and pharmacological potentials. in Journal of B.U.ON.. 2020;25(2):1219-1229.
https://hdl.handle.net/21.15107/rcub_farfar_3605 .

Grozdanić, Nađa, Đuričić, Ivana, Kosanić, Marijana, Zdunić, Gordana, Šavikin, Katarina, Etahiri, Samira, Assobhei, Omar, Benba, Jamila, Petović, Slavica, Matić, Ivana Z., Stanojković, Tatjana P., "Fucus spiralis extract and fractions: Anticancer and pharmacological potentials" in Journal of B.U.ON., 25, no. 2 (2020):1219-1229,
https://hdl.handle.net/21.15107/rcub_farfar_3605 .

TY  - JOUR
AU  - Đuričić, Ivana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3597
AB  - Many  scientific  arguments  in  this  area,  implicate  low  level  of important  nutrients  in cognitive decline, simultaneously suggesting better nutritional status as an important goal in the management of cognitive aging. Key nutrients for the protection of cognitive function are B-group vitamins, polyphenols, vitamin D, and omega-3 polyunsaturated fatty acids (PUFAs). The body of scientific evidence widely  supports  the  roles  of  folic  acid  and  metabolically  related  B6  and  B12  vitamins  in protecting  cognitive  function  in  old  age.  High  concentrations  of  polyphenols  in  dementia therapy showed a significant increase in cerebral blood volume. Although low vitamin D blood levels were associated with a higher risk of developing dementia, vitamin D supplementation alone was not sufficient to improve cognitive outcomes. In relation to the role of omega-3 PUFAs, research findings indicate protective effects in individuals with cognitive decline. The importance  of  diets  and  a  healthy  lifestyle  in  the  prevention  of  cognitive  impairment  are extensively  accepted.  The  Mediterranean  diet  is  the  most  investigated  dietary  pattern  in observational studies. MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) is updated dietary approach of the Mediterranean-DASH diets. Its components are linked to dementia prevention and overall neuroprotection. It is also reported that regular physical activity maintains the brain function improving blood flow and oxygen supply.
AB  - Novi naučni dokazi u ovoj oblasti ukazuju na nedostatke određenih hranljivih materija u opadanju kognitivnih funkcija, istovremeno pokazujući da bolji nutritivni status može biti važan u očuvanju kognicije kod starijih osoba. Ključni nutrijenti za zaštitu kognitivnih funkcija su vitamini B grupe, polifenoli, vitamin D i omega-3 polinezasićene masne kiseline (PMK). Sveukupnost naučnih dokaza u ovom trenutku najjače podržava uloge folata i metabolički povezanih vitamina B6 i B12 u zaštiti kognitivnih funkcija u starijoj životnoj dobi. Visoke koncentracije polifenola u terapiji demencije pokazale su značajno povećanje volumena cerebralne krvi. Iako su niže koncentracije vitamina D u serumu bile povezane sa većim rizikom za razvoj demencije, suplementacija vitaminom D nije bila dovoljna za poboljšanje kognitivnih ishoda. U vezi sa ulogom omega-3 PMK, rezultati istraživanja ukazuju na zaštitne efekte kod osoba sa kognitivnim smetnjama. Dijetarni režim i zdrav stil života igraju značajnu ulogu u prevenciji kognitivnih poremećaja. Mediteranska ishrana je najčešće ispitivani dijetarni obrazac u observacionim studijama. Pokazano je da je koncept MIND dijete (Mediterranean-DASH Intervention for Neurodegenerative Delay) u vezi sa neuroprotektivnim efektima i prevencijom demencije. Redovna fizička aktivnost predstavlja značajnu komponentu zdravog životnog stila u održanju vitalnosti moždanih funkcija.
PB  - Belgrade : Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Nutritional aspects of cognitive impairment
T1  - Nutritivni aspekti poremećaja kognitivnih funkcija
VL  - 70
IS  - 2
SP  - 98
EP  - 108
DO  - 10.5937/arhfarm2002098Q
ER  - 

@article{
author = "Đuričić, Ivana",
year = "2020",
abstract = "Many  scientific  arguments  in  this  area,  implicate  low  level  of important  nutrients  in cognitive decline, simultaneously suggesting better nutritional status as an important goal in the management of cognitive aging. Key nutrients for the protection of cognitive function are B-group vitamins, polyphenols, vitamin D, and omega-3 polyunsaturated fatty acids (PUFAs). The body of scientific evidence widely  supports  the  roles  of  folic  acid  and  metabolically  related  B6  and  B12  vitamins  in protecting  cognitive  function  in  old  age.  High  concentrations  of  polyphenols  in  dementia therapy showed a significant increase in cerebral blood volume. Although low vitamin D blood levels were associated with a higher risk of developing dementia, vitamin D supplementation alone was not sufficient to improve cognitive outcomes. In relation to the role of omega-3 PUFAs, research findings indicate protective effects in individuals with cognitive decline. The importance  of  diets  and  a  healthy  lifestyle  in  the  prevention  of  cognitive  impairment  are extensively  accepted.  The  Mediterranean  diet  is  the  most  investigated  dietary  pattern  in observational studies. MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) is updated dietary approach of the Mediterranean-DASH diets. Its components are linked to dementia prevention and overall neuroprotection. It is also reported that regular physical activity maintains the brain function improving blood flow and oxygen supply., Novi naučni dokazi u ovoj oblasti ukazuju na nedostatke određenih hranljivih materija u opadanju kognitivnih funkcija, istovremeno pokazujući da bolji nutritivni status može biti važan u očuvanju kognicije kod starijih osoba. Ključni nutrijenti za zaštitu kognitivnih funkcija su vitamini B grupe, polifenoli, vitamin D i omega-3 polinezasićene masne kiseline (PMK). Sveukupnost naučnih dokaza u ovom trenutku najjače podržava uloge folata i metabolički povezanih vitamina B6 i B12 u zaštiti kognitivnih funkcija u starijoj životnoj dobi. Visoke koncentracije polifenola u terapiji demencije pokazale su značajno povećanje volumena cerebralne krvi. Iako su niže koncentracije vitamina D u serumu bile povezane sa većim rizikom za razvoj demencije, suplementacija vitaminom D nije bila dovoljna za poboljšanje kognitivnih ishoda. U vezi sa ulogom omega-3 PMK, rezultati istraživanja ukazuju na zaštitne efekte kod osoba sa kognitivnim smetnjama. Dijetarni režim i zdrav stil života igraju značajnu ulogu u prevenciji kognitivnih poremećaja. Mediteranska ishrana je najčešće ispitivani dijetarni obrazac u observacionim studijama. Pokazano je da je koncept MIND dijete (Mediterranean-DASH Intervention for Neurodegenerative Delay) u vezi sa neuroprotektivnim efektima i prevencijom demencije. Redovna fizička aktivnost predstavlja značajnu komponentu zdravog životnog stila u održanju vitalnosti moždanih funkcija.",
publisher = "Belgrade : Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Nutritional aspects of cognitive impairment, Nutritivni aspekti poremećaja kognitivnih funkcija",
volume = "70",
number = "2",
pages = "98-108",
doi = "10.5937/arhfarm2002098Q"
}

Đuričić, I.. (2020). Nutritional aspects of cognitive impairment. in Arhiv za farmaciju
Belgrade : Pharmaceutical Association of Serbia., 70(2), 98-108.
https://doi.org/10.5937/arhfarm2002098Q

Đuričić I. Nutritional aspects of cognitive impairment. in Arhiv za farmaciju. 2020;70(2):98-108.
doi:10.5937/arhfarm2002098Q .

Đuričić, Ivana, "Nutritional aspects of cognitive impairment" in Arhiv za farmaciju, 70, no. 2 (2020):98-108,
https://doi.org/10.5937/arhfarm2002098Q . .

TY  - JOUR
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Arsenijević, Jelena
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3185
AB  - Introduction: Cholesterol homeostasis disruption contributes to the development of different pathologies. Non cholesterol sterols (NCSs) serve as cholesterol synthesis markers (desmosterol and lathosterol), and cholesterol absorption surrogate markers (campesterol, stigmasterol and beta-sitosterol). The study aimed to resolve certain new pre-analytical and analytical problems and ensure a reliable and validated method. Materials and methods: Method optimization, validation and stability studies were executed in human serum and plasma. Freeze-thaw cycles were done with and without antioxidant. Gas chromatography-mass spectrometer (GC-MS) was used for NCSs confirmation and plasticizer identification, while GC-flame ionization detector (GC-FID) was used for NCSs quantitation. Results: Infra-and inter-assay variabilities for all NCSs were 2.75-9.55% and 5.80-7.75% for plasma and 3.10-5.72% and 3.05-10.92% for serum, respectively. Recovery studies showed satisfactory percentage errors for all NCSs: 93.4-105.7% in plasma and 87.5-106.9 in serum. Derivatized samples were stable up to 7 days at 20 degrees C and derivatization yield was affected by presence of plasticizers. Fatty acid amids were identified as interfering plastic leachates. Statistically different NCSs concentrations were observed after the 1st freeze-thaw cycle, in antioxidant-free samples, and after the 4th cycle in antioxidant-enriched samples. Conclusions: All of the in-house procedures proved to be useful for minimizing the preanalytical and analytical variations, as proven by the validation results.
PB  - Elsevier Science BV, Amsterdam
T2  - Clinica Chimica Acta
T1  - Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers
VL  - 478
SP  - 74
EP  - 81
DO  - 10.1016/j.cca.2017.12.032
ER  - 

@article{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Arsenijević, Jelena and Đuričić, Ivana and Šobajić, Slađana and Jelić-Ivanović, Zorana",
year = "2018",
abstract = "Introduction: Cholesterol homeostasis disruption contributes to the development of different pathologies. Non cholesterol sterols (NCSs) serve as cholesterol synthesis markers (desmosterol and lathosterol), and cholesterol absorption surrogate markers (campesterol, stigmasterol and beta-sitosterol). The study aimed to resolve certain new pre-analytical and analytical problems and ensure a reliable and validated method. Materials and methods: Method optimization, validation and stability studies were executed in human serum and plasma. Freeze-thaw cycles were done with and without antioxidant. Gas chromatography-mass spectrometer (GC-MS) was used for NCSs confirmation and plasticizer identification, while GC-flame ionization detector (GC-FID) was used for NCSs quantitation. Results: Infra-and inter-assay variabilities for all NCSs were 2.75-9.55% and 5.80-7.75% for plasma and 3.10-5.72% and 3.05-10.92% for serum, respectively. Recovery studies showed satisfactory percentage errors for all NCSs: 93.4-105.7% in plasma and 87.5-106.9 in serum. Derivatized samples were stable up to 7 days at 20 degrees C and derivatization yield was affected by presence of plasticizers. Fatty acid amids were identified as interfering plastic leachates. Statistically different NCSs concentrations were observed after the 1st freeze-thaw cycle, in antioxidant-free samples, and after the 4th cycle in antioxidant-enriched samples. Conclusions: All of the in-house procedures proved to be useful for minimizing the preanalytical and analytical variations, as proven by the validation results.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Clinica Chimica Acta",
title = "Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers",
volume = "478",
pages = "74-81",
doi = "10.1016/j.cca.2017.12.032"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Arsenijević, J., Đuričić, I., Šobajić, S.,& Jelić-Ivanović, Z.. (2018). Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers. in Clinica Chimica Acta
Elsevier Science BV, Amsterdam., 478, 74-81.
https://doi.org/10.1016/j.cca.2017.12.032

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Arsenijević J, Đuričić I, Šobajić S, Jelić-Ivanović Z. Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers. in Clinica Chimica Acta. 2018;478:74-81.
doi:10.1016/j.cca.2017.12.032 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Arsenijević, Jelena, Đuričić, Ivana, Šobajić, Slađana, Jelić-Ivanović, Zorana, "Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers" in Clinica Chimica Acta, 478 (2018):74-81,
https://doi.org/10.1016/j.cca.2017.12.032 . .

TY  - JOUR
AU  - Timić, Jasmina
AU  - Đuričić, Ivana
AU  - Ristić-Medić, Danijela K.
AU  - Šobajić, Slađana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3238
AB  - The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & flips products, Cereal products) were analyzed. The fatty acid composition was determined using gas chromatography. Total fat content ranged from 3.1 % in expanded rice to 35.7 % in potato chips. Palmitic, oleic and linoleic acids constituted > 80 % of all fatty acids (FAs) in categories Baked products and Chips & flips. Linoleic acid was more abundant in the category Cereal products (15.5-49.3 %). The trans-FAs elaidic (C18:1 - 9t) and linolelaidic FAs (18: 2 - 9t, 12t) were identified in 66 % of the products. The flips products had the highest average t-FAs content (16.3 %), followed by flips group (9.3 %). Potential t-FAs intake from 100 g of analyzed products was in range 0.1-4.9 g. This study provided a large database on saturated fatty acids and t-FAs content in salty snack products and indicated that by consuming only one package of some products, the t-FAs intake could surpass the recommended maximum of 1 % of daily energy.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market
VL  - 83
IS  - 6
SP  - 685
EP  - 698
DO  - 10.2298/JSC180207039T
ER  - 

@article{
author = "Timić, Jasmina and Đuričić, Ivana and Ristić-Medić, Danijela K. and Šobajić, Slađana",
year = "2018",
abstract = "The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & flips products, Cereal products) were analyzed. The fatty acid composition was determined using gas chromatography. Total fat content ranged from 3.1 % in expanded rice to 35.7 % in potato chips. Palmitic, oleic and linoleic acids constituted > 80 % of all fatty acids (FAs) in categories Baked products and Chips & flips. Linoleic acid was more abundant in the category Cereal products (15.5-49.3 %). The trans-FAs elaidic (C18:1 - 9t) and linolelaidic FAs (18: 2 - 9t, 12t) were identified in 66 % of the products. The flips products had the highest average t-FAs content (16.3 %), followed by flips group (9.3 %). Potential t-FAs intake from 100 g of analyzed products was in range 0.1-4.9 g. This study provided a large database on saturated fatty acids and t-FAs content in salty snack products and indicated that by consuming only one package of some products, the t-FAs intake could surpass the recommended maximum of 1 % of daily energy.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market",
volume = "83",
number = "6",
pages = "685-698",
doi = "10.2298/JSC180207039T"
}

Timić, J., Đuričić, I., Ristić-Medić, D. K.,& Šobajić, S.. (2018). Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 83(6), 685-698.
https://doi.org/10.2298/JSC180207039T

Timić J, Đuričić I, Ristić-Medić DK, Šobajić S. Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market. in Journal of the Serbian Chemical Society. 2018;83(6):685-698.
doi:10.2298/JSC180207039T .

Timić, Jasmina, Đuričić, Ivana, Ristić-Medić, Danijela K., Šobajić, Slađana, "Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market" in Journal of the Serbian Chemical Society, 83, no. 6 (2018):685-698,
https://doi.org/10.2298/JSC180207039T . .

TY  - CONF
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Miljković, Milica
AU  - Stefanović, Aleksandra
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Đuričić, Ivana
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3071
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration
VL  - 275
SP  - e60
EP  - e60
DO  - 10.1016/j.atherosclerosis.2018.06.164
ER  - 

@conference{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Miljković, Milica and Stefanović, Aleksandra and Kalimanovska-Oštrić, Dimitra and Đuričić, Ivana and Jelić-Ivanović, Zorana",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration",
volume = "275",
pages = "e60-e60",
doi = "10.1016/j.atherosclerosis.2018.06.164"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Miljković, M., Stefanović, A., Kalimanovska-Oštrić, D., Đuričić, I.,& Jelić-Ivanović, Z.. (2018). Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 275, e60-e60.
https://doi.org/10.1016/j.atherosclerosis.2018.06.164

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Miljković M, Stefanović A, Kalimanovska-Oštrić D, Đuričić I, Jelić-Ivanović Z. Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration. in Atherosclerosis. 2018;275:e60-e60.
doi:10.1016/j.atherosclerosis.2018.06.164 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Miljković, Milica, Stefanović, Aleksandra, Kalimanovska-Oštrić, Dimitra, Đuričić, Ivana, Jelić-Ivanović, Zorana, "Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration" in Atherosclerosis, 275 (2018):e60-e60,
https://doi.org/10.1016/j.atherosclerosis.2018.06.164 . .

TY  - JOUR
AU  - Milović, Sanja
AU  - Kundaković, Tatjana
AU  - Macić, Vesna
AU  - Antić-Stanković, Jelena
AU  - Grozdanić, Nada
AU  - Đuričić, Ivana
AU  - Stanković, Ivan
AU  - Stanojković, Tatjana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2866
AB  - The aim of the present study was to reveal the potential biological activities of the dichlorometane: methanol (1:1) dry extract (DME) and the nutritional value of selected seaweeds: Cymodocea nodosa, Halimeda tuna, Cystoseira barbata and Codium bursa, collected from the Adriatic coast, Montenegro. We assessed the chemical composition and several biological activities such as: anti-a-glucosidase, antitumour, antimicrobial and antioxidative activity. H. tuna had the best cytotoxic activity against human colon carcinoma cell line, LS174 (IC50 = 17.92 +/- 1.54 mu g/mL). C. nodosa demonstrated strong cytotoxicity against human adenocarcinoma cell line, HeLa (IC50 = 13.28 +/- 0.39 mu g/mL) and human chronic myelogenous leukaemia cell line, K562 (IC50 = 19.64 +/- 1.55 mu g/mL). C. barbata had the best anti a-glucosidase (IC50 = 9.98 +/- 3.34 mu g/mL) and antimicrobial activity (minimal inhibitory concentration of 100 mu g/mL) for Staphylococcus aureus and Bacillus subtilis. C. bursa showed the highest nutritional value (490.4 kcal).
PB  - Soc Stinte Farmaceutice Romania, Bucuresti
T2  - Farmacia
T1  - Anti α-glucosidase, antitumour, antioxidative, antimicrobial activity, nutritive and health protective potential of some seaweeds from the Adriatic coast of Montenegro
VL  - 65
IS  - 5
SP  - 731
EP  - 740
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2866
ER  - 

@article{
author = "Milović, Sanja and Kundaković, Tatjana and Macić, Vesna and Antić-Stanković, Jelena and Grozdanić, Nada and Đuričić, Ivana and Stanković, Ivan and Stanojković, Tatjana",
year = "2017",
abstract = "The aim of the present study was to reveal the potential biological activities of the dichlorometane: methanol (1:1) dry extract (DME) and the nutritional value of selected seaweeds: Cymodocea nodosa, Halimeda tuna, Cystoseira barbata and Codium bursa, collected from the Adriatic coast, Montenegro. We assessed the chemical composition and several biological activities such as: anti-a-glucosidase, antitumour, antimicrobial and antioxidative activity. H. tuna had the best cytotoxic activity against human colon carcinoma cell line, LS174 (IC50 = 17.92 +/- 1.54 mu g/mL). C. nodosa demonstrated strong cytotoxicity against human adenocarcinoma cell line, HeLa (IC50 = 13.28 +/- 0.39 mu g/mL) and human chronic myelogenous leukaemia cell line, K562 (IC50 = 19.64 +/- 1.55 mu g/mL). C. barbata had the best anti a-glucosidase (IC50 = 9.98 +/- 3.34 mu g/mL) and antimicrobial activity (minimal inhibitory concentration of 100 mu g/mL) for Staphylococcus aureus and Bacillus subtilis. C. bursa showed the highest nutritional value (490.4 kcal).",
publisher = "Soc Stinte Farmaceutice Romania, Bucuresti",
journal = "Farmacia",
title = "Anti α-glucosidase, antitumour, antioxidative, antimicrobial activity, nutritive and health protective potential of some seaweeds from the Adriatic coast of Montenegro",
volume = "65",
number = "5",
pages = "731-740",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2866"
}

Milović, S., Kundaković, T., Macić, V., Antić-Stanković, J., Grozdanić, N., Đuričić, I., Stanković, I.,& Stanojković, T.. (2017). Anti α-glucosidase, antitumour, antioxidative, antimicrobial activity, nutritive and health protective potential of some seaweeds from the Adriatic coast of Montenegro. in Farmacia
Soc Stinte Farmaceutice Romania, Bucuresti., 65(5), 731-740.
https://hdl.handle.net/21.15107/rcub_farfar_2866

Milović S, Kundaković T, Macić V, Antić-Stanković J, Grozdanić N, Đuričić I, Stanković I, Stanojković T. Anti α-glucosidase, antitumour, antioxidative, antimicrobial activity, nutritive and health protective potential of some seaweeds from the Adriatic coast of Montenegro. in Farmacia. 2017;65(5):731-740.
https://hdl.handle.net/21.15107/rcub_farfar_2866 .

Milović, Sanja, Kundaković, Tatjana, Macić, Vesna, Antić-Stanković, Jelena, Grozdanić, Nada, Đuričić, Ivana, Stanković, Ivan, Stanojković, Tatjana, "Anti α-glucosidase, antitumour, antioxidative, antimicrobial activity, nutritive and health protective potential of some seaweeds from the Adriatic coast of Montenegro" in Farmacia, 65, no. 5 (2017):731-740,
https://hdl.handle.net/21.15107/rcub_farfar_2866 .

TY  - JOUR
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2954
AB  - Background: Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study investigates associations of different cholesterol homeostasis patterns with low-density (LDL) and high-density lipoproteins (HDL) subclasses distribution in statin-treated and statin-untreated CAD patients, and potential use of aforementioned markers for CAD treatment optimization. Methods: The study included 78 CAD patients (47 statin-untreated and 31 statin-treated) and 31 controls (CG). NCSs concentrations were quantified using gas chromatography-flame ionization detection (GC-FID). Lipoprotein subclasses were separated by gradient gel electrophoresis. Results: In patients, cholesterol-synthesis markers were significantly higher comparing to CG. Cholesterol-synthesis markers were inversely associated with LDL size in all groups. For cholesterol homeostasis estimation, each group was divided to good and/or poor synthetizers and/or absorbers according to desmosterol and beta-sitosterol median values. In CG, participants with reduced cholesterol absorption, the relative proportion of small, dense LDL was higher in those with increased cholesterol synthesis compared to those with reduced synthesis (p lt 0.01). LDL I fraction was significantly higher in poor synthetizers/poor absorbers subgroup compared to poor synthetizers/good absorbers (p lt 0.01), and good synthetizers/poor absorbers (p lt 0.01). Statin-treated patients with increased cholesterol absorption had increased proportion of LDL IVB (p lt 0.05). Conclusions: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis. Desmosterol/beta-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?
VL  - 55
IS  - 3
SP  - 447
EP  - 457
DO  - 10.1515/cclm-2016-0505
ER  - 

@article{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Kalimanovska-Oštrić, Dimitra and Đuričić, Ivana and Šobajić, Slađana and Jelić-Ivanović, Zorana",
year = "2017",
abstract = "Background: Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study investigates associations of different cholesterol homeostasis patterns with low-density (LDL) and high-density lipoproteins (HDL) subclasses distribution in statin-treated and statin-untreated CAD patients, and potential use of aforementioned markers for CAD treatment optimization. Methods: The study included 78 CAD patients (47 statin-untreated and 31 statin-treated) and 31 controls (CG). NCSs concentrations were quantified using gas chromatography-flame ionization detection (GC-FID). Lipoprotein subclasses were separated by gradient gel electrophoresis. Results: In patients, cholesterol-synthesis markers were significantly higher comparing to CG. Cholesterol-synthesis markers were inversely associated with LDL size in all groups. For cholesterol homeostasis estimation, each group was divided to good and/or poor synthetizers and/or absorbers according to desmosterol and beta-sitosterol median values. In CG, participants with reduced cholesterol absorption, the relative proportion of small, dense LDL was higher in those with increased cholesterol synthesis compared to those with reduced synthesis (p lt 0.01). LDL I fraction was significantly higher in poor synthetizers/poor absorbers subgroup compared to poor synthetizers/good absorbers (p lt 0.01), and good synthetizers/poor absorbers (p lt 0.01). Statin-treated patients with increased cholesterol absorption had increased proportion of LDL IVB (p lt 0.05). Conclusions: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis. Desmosterol/beta-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?",
volume = "55",
number = "3",
pages = "447-457",
doi = "10.1515/cclm-2016-0505"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Kalimanovska-Oštrić, D., Đuričić, I., Šobajić, S.,& Jelić-Ivanović, Z.. (2017). Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 55(3), 447-457.
https://doi.org/10.1515/cclm-2016-0505

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Kalimanovska-Oštrić D, Đuričić I, Šobajić S, Jelić-Ivanović Z. Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. in Clinical Chemistry and Laboratory Medicine. 2017;55(3):447-457.
doi:10.1515/cclm-2016-0505 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Kalimanovska-Oštrić, Dimitra, Đuričić, Ivana, Šobajić, Slađana, Jelić-Ivanović, Zorana, "Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?" in Clinical Chemistry and Laboratory Medicine, 55, no. 3 (2017):447-457,
https://doi.org/10.1515/cclm-2016-0505 . .

TY  - JOUR
AU  - Jorgačević, B
AU  - Vučević, D
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
AU  - Mladenović, Dušan
AU  - Vesković, M
AU  - Vukićević, R.J
AU  - Radosavljević, Tatjana S.
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2915
AB  - We used rimonabant to investigate the role of CB1 receptor on hepatic FFAs profile during NAFLD. Male mice C57BL/6 were divided into: control group fed with control diet 20 weeks (C; n = 6); group fed with HFD 20 weeks (HF; n = 6); group fed with control diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Rimonabant (10 mg/kg) was administered daily to HFR and R group by oral gavage. Rimonabant decreased liver palmitic acid proportion in HFR group compared to HF group (p  lt  0.05). Liver stearic and oleic acid proportions were decreased in R group compared to control (p  lt  0.01 respectively). Rimonabant increased liver linoleic and arachidonic acid proportions in HFR group compared to HF group (p  lt  0.01 respectively). CB1 blockade may be useful in the treatment of HFD-induced NAFLD due to modulation of plasma lipid and hepatic FFA profile.
PB  - Elsevier Ireland Ltd
T2  - Chemistry and Physics of Lipids
T1  - The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease
VL  - 204
SP  - 85
EP  - 93
DO  - 10.1016/j.chemphyslip.2017.03.009
ER  - 

@article{
author = "Jorgačević, B and Vučević, D and Đuričić, Ivana and Šobajić, Slađana and Mladenović, Dušan and Vesković, M and Vukićević, R.J and Radosavljević, Tatjana S.",
year = "2017",
abstract = "We used rimonabant to investigate the role of CB1 receptor on hepatic FFAs profile during NAFLD. Male mice C57BL/6 were divided into: control group fed with control diet 20 weeks (C; n = 6); group fed with HFD 20 weeks (HF; n = 6); group fed with control diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Rimonabant (10 mg/kg) was administered daily to HFR and R group by oral gavage. Rimonabant decreased liver palmitic acid proportion in HFR group compared to HF group (p  lt  0.05). Liver stearic and oleic acid proportions were decreased in R group compared to control (p  lt  0.01 respectively). Rimonabant increased liver linoleic and arachidonic acid proportions in HFR group compared to HF group (p  lt  0.01 respectively). CB1 blockade may be useful in the treatment of HFD-induced NAFLD due to modulation of plasma lipid and hepatic FFA profile.",
publisher = "Elsevier Ireland Ltd",
journal = "Chemistry and Physics of Lipids",
title = "The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease",
volume = "204",
pages = "85-93",
doi = "10.1016/j.chemphyslip.2017.03.009"
}

Jorgačević, B., Vučević, D., Đuričić, I., Šobajić, S., Mladenović, D., Vesković, M., Vukićević, R.J,& Radosavljević, T. S.. (2017). The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease. in Chemistry and Physics of Lipids
Elsevier Ireland Ltd., 204, 85-93.
https://doi.org/10.1016/j.chemphyslip.2017.03.009

Jorgačević B, Vučević D, Đuričić I, Šobajić S, Mladenović D, Vesković M, Vukićević R, Radosavljević TS. The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease. in Chemistry and Physics of Lipids. 2017;204:85-93.
doi:10.1016/j.chemphyslip.2017.03.009 .

Jorgačević, B, Vučević, D, Đuričić, Ivana, Šobajić, Slađana, Mladenović, Dušan, Vesković, M, Vukićević, R.J, Radosavljević, Tatjana S., "The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease" in Chemistry and Physics of Lipids, 204 (2017):85-93,
https://doi.org/10.1016/j.chemphyslip.2017.03.009 . .

TY  - JOUR
AU  - Ivanović, Nevena
AU  - Minić, Rajna
AU  - Đuričić, Ivana
AU  - Radojević-Skodrić, Sanja
AU  - Živković, Irena
AU  - Šobajić, Slađana
AU  - Đorđević, Brižita
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2770
AB  - Western life style, and high calorie diet in particular is causing major health problems such as insulin resistance, hepatic steatosis and heart disease in the modern age. High fat diet (HFD) induces similar changes in mice, such as increased body weight, hypercholesterolemia and accumulation of triglycerides in the liver. These changes can be ameliorated by the administration of some Lactobacillus species. The focus of this study was to analyze the fatty acid content of liver, heart and brain tissues of mice fed HFD and administered with either Lactobacillus plantarum WCFS1 or Lactobacillus rhamnosus LA68, and to analyze the fatty acid content of these organs after a two months washout period. The fatty acid composition of mouse liver tissue changed significantly due to probiotic administration during a 12 weeks HFD regime and active Lactobacillus administration had a slightly reversing effect toward the standard mouse diet group, but after the washout period these changes disappeared. The fatty acid composition of the heart and brain tissues was significantly changed in the HFD regime but probiotic administration had no significant influence on the fatty acid profile of these two organs. Upon the 8 weeks washout period the only remaining beneficial effect was the significantly lower mouse weight in the supplemented groups compared to the HFD group.
PB  - Royal Soc Chemistry, Cambridge
T2  - Food & Function
T1  - Active Lactobacillus rhamnosus LA68 or Lactobacillus plantarum WCFS1 administration positively influences liver fatty acid composition in mice on a HFD regime
VL  - 7
IS  - 6
SP  - 2840
EP  - 2848
DO  - 10.1039/c5fo01432h
ER  - 

@article{
author = "Ivanović, Nevena and Minić, Rajna and Đuričić, Ivana and Radojević-Skodrić, Sanja and Živković, Irena and Šobajić, Slađana and Đorđević, Brižita",
year = "2016",
abstract = "Western life style, and high calorie diet in particular is causing major health problems such as insulin resistance, hepatic steatosis and heart disease in the modern age. High fat diet (HFD) induces similar changes in mice, such as increased body weight, hypercholesterolemia and accumulation of triglycerides in the liver. These changes can be ameliorated by the administration of some Lactobacillus species. The focus of this study was to analyze the fatty acid content of liver, heart and brain tissues of mice fed HFD and administered with either Lactobacillus plantarum WCFS1 or Lactobacillus rhamnosus LA68, and to analyze the fatty acid content of these organs after a two months washout period. The fatty acid composition of mouse liver tissue changed significantly due to probiotic administration during a 12 weeks HFD regime and active Lactobacillus administration had a slightly reversing effect toward the standard mouse diet group, but after the washout period these changes disappeared. The fatty acid composition of the heart and brain tissues was significantly changed in the HFD regime but probiotic administration had no significant influence on the fatty acid profile of these two organs. Upon the 8 weeks washout period the only remaining beneficial effect was the significantly lower mouse weight in the supplemented groups compared to the HFD group.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Food & Function",
title = "Active Lactobacillus rhamnosus LA68 or Lactobacillus plantarum WCFS1 administration positively influences liver fatty acid composition in mice on a HFD regime",
volume = "7",
number = "6",
pages = "2840-2848",
doi = "10.1039/c5fo01432h"
}

Ivanović, N., Minić, R., Đuričić, I., Radojević-Skodrić, S., Živković, I., Šobajić, S.,& Đorđević, B.. (2016). Active Lactobacillus rhamnosus LA68 or Lactobacillus plantarum WCFS1 administration positively influences liver fatty acid composition in mice on a HFD regime. in Food & Function
Royal Soc Chemistry, Cambridge., 7(6), 2840-2848.
https://doi.org/10.1039/c5fo01432h

Ivanović N, Minić R, Đuričić I, Radojević-Skodrić S, Živković I, Šobajić S, Đorđević B. Active Lactobacillus rhamnosus LA68 or Lactobacillus plantarum WCFS1 administration positively influences liver fatty acid composition in mice on a HFD regime. in Food & Function. 2016;7(6):2840-2848.
doi:10.1039/c5fo01432h .

Ivanović, Nevena, Minić, Rajna, Đuričić, Ivana, Radojević-Skodrić, Sanja, Živković, Irena, Šobajić, Slađana, Đorđević, Brižita, "Active Lactobacillus rhamnosus LA68 or Lactobacillus plantarum WCFS1 administration positively influences liver fatty acid composition in mice on a HFD regime" in Food & Function, 7, no. 6 (2016):2840-2848,
https://doi.org/10.1039/c5fo01432h . .

TY  - CONF
AU  - Đuričić, Ivana
AU  - Stanković, Ivan
AU  - Ivanović, Nevena
AU  - Todorović, Vanja
AU  - Timić, Jasmina
AU  - Šobajić, Slađana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2339
AB  - Introduction: It is well known that long-term and regular intakes
of long chain (LC) n-3 polyunsaturated fatty acids (PUFAs) from fish
or fish oil supplements are useful in improving n-3 fatty status. Dietary
guidelines recommend use of these fatty acids in purpose of cardio-
vascular primary and secondary preventions.
Objectives: The objective of this study was to explore the difference in plasma fatty acid profile following general recommendations for
fish intake or fish oil supplement usage.
Method / Design: Participants were randomised to receive
salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/
day in cross-over trial over 8 weeks period separated by the 6 months
washout period. Fatty acids were extracted from plasma and analysed
by gas chromatography.
Results: The initial plasma concentration of fatty acids was not
different between groups at baseline and after the washout phase. After
8 weeks, there was a significant increase in the level of EPA, DHA and
total n-3 fatty acids in plasma of both groups. The percentage values
of EPA increased by 135% in salmon group (p<0.0001) and 152% in
fish oil group (p<0.0001), whereas DHA increased by 145% in salmon
(p<0.0001) and 121% in fish oil group (p<0.010). The increase of plasma total n-3 fatty acids observed after 8 wks of the salmon consumption was greater when compared with fish oil (45% vs 27%) (p<0.05)
and mirrored the content in used dietary sources.
Conclusions: Plasma n-3 fatty acid profile was remarkably increased with both salmon and fish oil capsules intervention. Increase
of plasma EPA and DHA levels was dose-dependent.
PB  - Karger, Basel
C3  - Annals of Nutrition and Metabolism
T1  - Plasma fatty acid profile after nutritionally relevant intakes of oily fish and fish oil supplement
VL  - 67
IS  - Supplement 1
SP  - 137
EP  - 137
DO  - 10.1159/000440895
ER  - 

@conference{
author = "Đuričić, Ivana and Stanković, Ivan and Ivanović, Nevena and Todorović, Vanja and Timić, Jasmina and Šobajić, Slađana",
year = "2015",
abstract = "Introduction: It is well known that long-term and regular intakes
of long chain (LC) n-3 polyunsaturated fatty acids (PUFAs) from fish
or fish oil supplements are useful in improving n-3 fatty status. Dietary
guidelines recommend use of these fatty acids in purpose of cardio-
vascular primary and secondary preventions.
Objectives: The objective of this study was to explore the difference in plasma fatty acid profile following general recommendations for
fish intake or fish oil supplement usage.
Method / Design: Participants were randomised to receive
salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/
day in cross-over trial over 8 weeks period separated by the 6 months
washout period. Fatty acids were extracted from plasma and analysed
by gas chromatography.
Results: The initial plasma concentration of fatty acids was not
different between groups at baseline and after the washout phase. After
8 weeks, there was a significant increase in the level of EPA, DHA and
total n-3 fatty acids in plasma of both groups. The percentage values
of EPA increased by 135% in salmon group (p<0.0001) and 152% in
fish oil group (p<0.0001), whereas DHA increased by 145% in salmon
(p<0.0001) and 121% in fish oil group (p<0.010). The increase of plasma total n-3 fatty acids observed after 8 wks of the salmon consumption was greater when compared with fish oil (45% vs 27%) (p<0.05)
and mirrored the content in used dietary sources.
Conclusions: Plasma n-3 fatty acid profile was remarkably increased with both salmon and fish oil capsules intervention. Increase
of plasma EPA and DHA levels was dose-dependent.",
publisher = "Karger, Basel",
journal = "Annals of Nutrition and Metabolism",
title = "Plasma fatty acid profile after nutritionally relevant intakes of oily fish and fish oil supplement",
volume = "67",
number = "Supplement 1",
pages = "137-137",
doi = "10.1159/000440895"
}

Đuričić, I., Stanković, I., Ivanović, N., Todorović, V., Timić, J.,& Šobajić, S.. (2015). Plasma fatty acid profile after nutritionally relevant intakes of oily fish and fish oil supplement. in Annals of Nutrition and Metabolism
Karger, Basel., 67(Supplement 1), 137-137.
https://doi.org/10.1159/000440895

Đuričić I, Stanković I, Ivanović N, Todorović V, Timić J, Šobajić S. Plasma fatty acid profile after nutritionally relevant intakes of oily fish and fish oil supplement. in Annals of Nutrition and Metabolism. 2015;67(Supplement 1):137-137.
doi:10.1159/000440895 .

Đuričić, Ivana, Stanković, Ivan, Ivanović, Nevena, Todorović, Vanja, Timić, Jasmina, Šobajić, Slađana, "Plasma fatty acid profile after nutritionally relevant intakes of oily fish and fish oil supplement" in Annals of Nutrition and Metabolism, 67, no. Supplement 1 (2015):137-137,
https://doi.org/10.1159/000440895 . .

TY  - CONF
AU  - Đuričić, Ivana
AU  - Marinković, Danica
AU  - Dodevska, Margarita
AU  - Zrnić-Ćirić, Milica
AU  - Šobajić, Slađana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2345
AB  - Introduction: There is a growing number of epidemiological evidences that wholegrain products may reduce the risk of cardiovascular
diseases, type 2 diabetes, some forms of cancers, as well as obesity. The
beneficial health effects are due to the presence of many biologically
active compounds, which are located in the outer layer and germ fraction of the grain. Therefore, the higher intake of wholegrain foodstuffs
is recommended. Wholegrain bread, locally known as brown bread, is
the most common foodstuff of this type in Serbian diet.
Objectives: The objective of this paper was to assess the quality
indicators, basic chemical composition, and fiber profile of wholegrain
breads sampled from Belgrade supermarkets and bakeries.
Method / Design: In total 8 different samples of wholegrain
bread were analyzed. The nutritional quality of samples was evaluated by common physicochemical analyses (contents of protein, ash, water, crude fiber, acid degree, sodium chloride, starch). Enzymatic
methods were used for determination of fiber profile (resistant starch,
beta-glucan, fructans, and arabinoxylan). Also, sensory characteristics
were assessed.
Results: During evaluation of the sensory quality all samples
fulfilled the regulatory requirements. All analyzed samples received
high marks for each individual property of quality. However, the varia-
bility of acid degree, as well as some nutrient content (protein, crude
fiber, starch) among samples was great. On the other hand, other
parameters were similar between different bread samples (content of
water, ash, sodium chloride). The fiber fractions that were analyzed in
wholegrain bread samples revealed that resistant starch, fructans and
arabonoxylan were the major fiber fractions, while cellulose content
was unexpectedly low.
Conclusions: Obtained results indicated that wholegrain bread
from Belgrade market is of the standard quality and could be an important source of specific fiber fractions in everyday diet.
PB  - Karger, Basel
C3  - Annals of Nutrition and Metabolism
T1  - Chemical composition and nutritional quality of wholegrain bread from Belgrade market
VL  - 67
IS  - Supplement 1
SP  - 546
EP  - 547
DO  - 10.1159/000440895
ER  - 

@conference{
author = "Đuričić, Ivana and Marinković, Danica and Dodevska, Margarita and Zrnić-Ćirić, Milica and Šobajić, Slađana",
year = "2015",
abstract = "Introduction: There is a growing number of epidemiological evidences that wholegrain products may reduce the risk of cardiovascular
diseases, type 2 diabetes, some forms of cancers, as well as obesity. The
beneficial health effects are due to the presence of many biologically
active compounds, which are located in the outer layer and germ fraction of the grain. Therefore, the higher intake of wholegrain foodstuffs
is recommended. Wholegrain bread, locally known as brown bread, is
the most common foodstuff of this type in Serbian diet.
Objectives: The objective of this paper was to assess the quality
indicators, basic chemical composition, and fiber profile of wholegrain
breads sampled from Belgrade supermarkets and bakeries.
Method / Design: In total 8 different samples of wholegrain
bread were analyzed. The nutritional quality of samples was evaluated by common physicochemical analyses (contents of protein, ash, water, crude fiber, acid degree, sodium chloride, starch). Enzymatic
methods were used for determination of fiber profile (resistant starch,
beta-glucan, fructans, and arabinoxylan). Also, sensory characteristics
were assessed.
Results: During evaluation of the sensory quality all samples
fulfilled the regulatory requirements. All analyzed samples received
high marks for each individual property of quality. However, the varia-
bility of acid degree, as well as some nutrient content (protein, crude
fiber, starch) among samples was great. On the other hand, other
parameters were similar between different bread samples (content of
water, ash, sodium chloride). The fiber fractions that were analyzed in
wholegrain bread samples revealed that resistant starch, fructans and
arabonoxylan were the major fiber fractions, while cellulose content
was unexpectedly low.
Conclusions: Obtained results indicated that wholegrain bread
from Belgrade market is of the standard quality and could be an important source of specific fiber fractions in everyday diet.",
publisher = "Karger, Basel",
journal = "Annals of Nutrition and Metabolism",
title = "Chemical composition and nutritional quality of wholegrain bread from Belgrade market",
volume = "67",
number = "Supplement 1",
pages = "546-547",
doi = "10.1159/000440895"
}

Đuričić, I., Marinković, D., Dodevska, M., Zrnić-Ćirić, M.,& Šobajić, S.. (2015). Chemical composition and nutritional quality of wholegrain bread from Belgrade market. in Annals of Nutrition and Metabolism
Karger, Basel., 67(Supplement 1), 546-547.
https://doi.org/10.1159/000440895

Đuričić I, Marinković D, Dodevska M, Zrnić-Ćirić M, Šobajić S. Chemical composition and nutritional quality of wholegrain bread from Belgrade market. in Annals of Nutrition and Metabolism. 2015;67(Supplement 1):546-547.
doi:10.1159/000440895 .

Đuričić, Ivana, Marinković, Danica, Dodevska, Margarita, Zrnić-Ćirić, Milica, Šobajić, Slađana, "Chemical composition and nutritional quality of wholegrain bread from Belgrade market" in Annals of Nutrition and Metabolism, 67, no. Supplement 1 (2015):546-547,
https://doi.org/10.1159/000440895 . .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Miljković, Milica
AU  - Kerkez, Mirko
AU  - Đorđević, Vladimir
AU  - Đurasić, Ljubomir
AU  - Šobajić, Slađana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2431
AB  - Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p  lt  0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p  lt  0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population
VL  - 34
IS  - 3
SP  - 304
EP  - 313
DO  - 10.2478/jomb-2014-0039
ER  - 

@article{
author = "Đuričić, Ivana and Kotur-Stevuljević, Jelena and Miljković, Milica and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Šobajić, Slađana",
year = "2015",
abstract = "Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p  lt  0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p  lt  0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population",
volume = "34",
number = "3",
pages = "304-313",
doi = "10.2478/jomb-2014-0039"
}

Đuričić, I., Kotur-Stevuljević, J., Miljković, M., Kerkez, M., Đorđević, V., Đurasić, L.,& Šobajić, S.. (2015). Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(3), 304-313.
https://doi.org/10.2478/jomb-2014-0039

Đuričić I, Kotur-Stevuljević J, Miljković M, Kerkez M, Đorđević V, Đurasić L, Šobajić S. Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry. 2015;34(3):304-313.
doi:10.2478/jomb-2014-0039 .

Đuričić, Ivana, Kotur-Stevuljević, Jelena, Miljković, Milica, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Šobajić, Slađana, "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population" in Journal of Medical Biochemistry, 34, no. 3 (2015):304-313,
https://doi.org/10.2478/jomb-2014-0039 . .

TY  - JOUR
AU  - Ivanović, Nevena
AU  - Minić, Rajna
AU  - Đuričić, Ivana
AU  - Dimitrijević, Ljiljana
AU  - Šobajić, Slađana
AU  - Živković, Irena
AU  - Đorđević, Brižita
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2399
AB  - Recent reports suggest that the metabolic activity of the enteric microbiota may influence the fatty acid composition of the host tissue. There are many studies dealing with the influence of lactobacilli on various pathological conditions, and some of the effects are strain-specific. This study was designed to test the effects of a particular Lactobacillus strain, Lactobacillus rhamnosus LA68 on fatty acid composition of the liver and the brain of C57BL/6 mice in the absence of an underlying pathological condition. Female mice were supplemented with live L. rhamnosus LA68 bacteria for the duration of 1 month. Serum biochemistry was analyzed and liver and brain fatty acid composition was assessed by gas-liquid chromatography. Significant changes in liver and brain fatty acid composition were detected. In the liver tissue we detected an increase in palmitoleic acid (p = 0.038), while in the brain compartment we found an increase in palmitic (p = 0.042), stearic (p = 0.017), arachidonic acid (p = 0.009) and docosahexaenoic acid (p = 0.004) for control versus experimental group. These results show discrete changes caused by LA68 strain consumption. Even short duration of administration of LA68 influences the fatty acid composition of the host which adds to the existing knowledge about Lactobacillus host interaction, and adds to the growing knowledge of metabolic intervention possibilities.
PB  - Informa Healthcare, London
T2  - International Journal of Food Sciences and Nutrition
T1  - Brain and liver fatty acid composition changes upon consumption of Lactobacillus rhamnosus LA68
VL  - 66
IS  - 1
SP  - 93
EP  - 97
DO  - 10.3109/09637486.2014.979313
ER  - 

@article{
author = "Ivanović, Nevena and Minić, Rajna and Đuričić, Ivana and Dimitrijević, Ljiljana and Šobajić, Slađana and Živković, Irena and Đorđević, Brižita",
year = "2015",
abstract = "Recent reports suggest that the metabolic activity of the enteric microbiota may influence the fatty acid composition of the host tissue. There are many studies dealing with the influence of lactobacilli on various pathological conditions, and some of the effects are strain-specific. This study was designed to test the effects of a particular Lactobacillus strain, Lactobacillus rhamnosus LA68 on fatty acid composition of the liver and the brain of C57BL/6 mice in the absence of an underlying pathological condition. Female mice were supplemented with live L. rhamnosus LA68 bacteria for the duration of 1 month. Serum biochemistry was analyzed and liver and brain fatty acid composition was assessed by gas-liquid chromatography. Significant changes in liver and brain fatty acid composition were detected. In the liver tissue we detected an increase in palmitoleic acid (p = 0.038), while in the brain compartment we found an increase in palmitic (p = 0.042), stearic (p = 0.017), arachidonic acid (p = 0.009) and docosahexaenoic acid (p = 0.004) for control versus experimental group. These results show discrete changes caused by LA68 strain consumption. Even short duration of administration of LA68 influences the fatty acid composition of the host which adds to the existing knowledge about Lactobacillus host interaction, and adds to the growing knowledge of metabolic intervention possibilities.",
publisher = "Informa Healthcare, London",
journal = "International Journal of Food Sciences and Nutrition",
title = "Brain and liver fatty acid composition changes upon consumption of Lactobacillus rhamnosus LA68",
volume = "66",
number = "1",
pages = "93-97",
doi = "10.3109/09637486.2014.979313"
}

Ivanović, N., Minić, R., Đuričić, I., Dimitrijević, L., Šobajić, S., Živković, I.,& Đorđević, B.. (2015). Brain and liver fatty acid composition changes upon consumption of Lactobacillus rhamnosus LA68. in International Journal of Food Sciences and Nutrition
Informa Healthcare, London., 66(1), 93-97.
https://doi.org/10.3109/09637486.2014.979313

Ivanović N, Minić R, Đuričić I, Dimitrijević L, Šobajić S, Živković I, Đorđević B. Brain and liver fatty acid composition changes upon consumption of Lactobacillus rhamnosus LA68. in International Journal of Food Sciences and Nutrition. 2015;66(1):93-97.
doi:10.3109/09637486.2014.979313 .

Ivanović, Nevena, Minić, Rajna, Đuričić, Ivana, Dimitrijević, Ljiljana, Šobajić, Slađana, Živković, Irena, Đorđević, Brižita, "Brain and liver fatty acid composition changes upon consumption of Lactobacillus rhamnosus LA68" in International Journal of Food Sciences and Nutrition, 66, no. 1 (2015):93-97,
https://doi.org/10.3109/09637486.2014.979313 . .