TY  - JOUR
AU  - Pavlović, Dragana
AU  - Dobrić, Silva
AU  - Stojanović, Nikola
AU  - Zlatković, Bojan
AU  - Matejić, Jelena
AU  - Kovačević, Nada
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5568
AB  - There is little data on the phytochemical/pharmacological properties of Erica spiculifolia Salisb. (syn. Bruckentalia spiculifolia (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of E. spiculifolia in vitro on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test, BSA test, and two complementary antioxidant assays. Ethanolic extracts of leaves, flowers, and aboveground parts, and petroleum ether, ether, ethyl acetate, and water fractionations of the ethanol extract of E. spiculifolia applied at doses of 50–200 mg/kg p.o. exhibited dose-dependent anti-inflammatory activity comparable with indomethacin. All tested samples, except for the petroleum ether fraction, exerted excellent in vitro antioxidant activity, and all of them exhibited significant and similar inhibition of BSA denaturation comparable with diclofenac. Ethanolic extract of the aboveground parts obtained by percolation, ethyl acetate and water fractions had the highest efficiency, attenuating inflammation by more than 50% in the lowest applied concentration alongside exceptional radical scavenging activity.
PB  - Taylor & Francis
T2  - Natural Product Research
T1  - Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions
DO  - 10.1080/14786419.2023.2301677
DO  - 001141584900001
ER  - 

@article{
author = "Pavlović, Dragana and Dobrić, Silva and Stojanović, Nikola and Zlatković, Bojan and Matejić, Jelena and Kovačević, Nada",
year = "2024",
abstract = "There is little data on the phytochemical/pharmacological properties of Erica spiculifolia Salisb. (syn. Bruckentalia spiculifolia (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of E. spiculifolia in vitro on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test, BSA test, and two complementary antioxidant assays. Ethanolic extracts of leaves, flowers, and aboveground parts, and petroleum ether, ether, ethyl acetate, and water fractionations of the ethanol extract of E. spiculifolia applied at doses of 50–200 mg/kg p.o. exhibited dose-dependent anti-inflammatory activity comparable with indomethacin. All tested samples, except for the petroleum ether fraction, exerted excellent in vitro antioxidant activity, and all of them exhibited significant and similar inhibition of BSA denaturation comparable with diclofenac. Ethanolic extract of the aboveground parts obtained by percolation, ethyl acetate and water fractions had the highest efficiency, attenuating inflammation by more than 50% in the lowest applied concentration alongside exceptional radical scavenging activity.",
publisher = "Taylor & Francis",
journal = "Natural Product Research",
title = "Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions",
doi = "10.1080/14786419.2023.2301677, 001141584900001"
}

Pavlović, D., Dobrić, S., Stojanović, N., Zlatković, B., Matejić, J.,& Kovačević, N.. (2024). Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions. in Natural Product Research
Taylor & Francis..
https://doi.org/10.1080/14786419.2023.2301677

Pavlović D, Dobrić S, Stojanović N, Zlatković B, Matejić J, Kovačević N. Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions. in Natural Product Research. 2024;.
doi:10.1080/14786419.2023.2301677 .

Pavlović, Dragana, Dobrić, Silva, Stojanović, Nikola, Zlatković, Bojan, Matejić, Jelena, Kovačević, Nada, "Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions" in Natural Product Research (2024),
https://doi.org/10.1080/14786419.2023.2301677 . .

TY  - CONF
AU  - Koraćević, Maja
AU  - Jovanović, Aleksandar
AU  - Pavlović, Dragana
AU  - Catić-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4554
AB  - Today, there are a number of applications that allow you to monitor physical activity
and health parameters or schedule a medical examination, and can also help you recognize a
health problem and react in time (1, 2). The aim of the present study was to assess the usage
of health applications (HApps, health-related mobile and/or web applications) among
citizens in Serbia.
The anonymous online questionnaire was distributed via social media in the spring of
2020. Data were processed using the IBM SPSS. 506 respondents participated in the
research, of which 155 were from the health profession. The majority of respondents were
female (73.9%), and the average age was 36.88 ± 11.22. About half of the respondents
(48.2%) have a university degree, and 74.9% are employed. Installed HApps on
phone/computer have 18.2% of respondents, with a statistically significant difference (p
<0.01) between health professionals (25.8%) and non-health (14.8%). The most commonly
used HApps among health professionals are those related to their professional work
(14.7%), followed by general health (3.8%) and specific diseases (1.9%). Non-health
professional respondents mostly used applications related to general health (5.4%), fitness
(2.0%) and the chosen doctor (1.4%). Only 0.6% of citizens used COVID-19 pandemic
applications. The importance of HApps is still not sufficiently recognized in Serbia. Given the
potential in controlling chronic diseases and other health conditions, especially among a
population with limited access to health care and health information, they should be more
integrated into the health system.
AB  - Danas postoji niz aplikacija koje omogućavaju praćenje fizičke aktivnosti i
zdravstvenih parametara ili zakazivanje lekarskog pregleda, a mogu pomoći i u
prepoznavanju zdravstvenih problema obaveštavajući vas da reagujete na vreme (1, 2). Cilj
ove studije bio je da ispita upotrebu zdravstvenih aplikacija (HApps, mobilne i/ili web
aplikacije u vezi sa zdravljem) među građanima Srbije. Anonimni onlajn upitnik distribuiran
je putem društvenih mreža tokom proleća 2020. godine. Podaci su obrađeni korišćenjem
IBM SPSS. U istraživanju je učestvovalo 506 ispitanika, od kojih 155 iz zdravstvene struke.
Većina ispitanika su žene (73.9%), a prosečna starost bila je 36.88±11.22 godina. Oko
polovine ispitanika (48.2%) ima fakultetsko obrazovanje, a 74.9% je zaposleno. Instalirane
HApps na svom telefonu/računaru ima 18.2% ispitanika, sa statistički značajnom razlikom
(p<0.01) među ispitanicima iz zdravstvene struke (25.8%) i onih koji to nisu (14.8%).
Najkorišćenije HApps među ispitanicima zdravstvene struke su one koje se odnose na njihov
stručni rad (14.7%), opšte zdravlje (3.8%) i specifične bolesti (1.9%). Ispitanici koji nisu iz
zdravstvene struke najviše su koristili aplikacije koje se odnose na opšte zdravlje (5.4%),
fitnes (2.0%) i izabranog lekara (1.4%). Aplikacije u vezi sa COVID-19 pandemijom koristilo
je svega 0.6% građana. Značaj HApps još uvek nije dovoljno prepoznat u Srbiji. S obzirom na
potencijal u kontroli hroničnih bolesti i drugih zdravstvenih stanja, naročito među
populacijom sa ograničenim pristupom zdravstvenoj zaštiti i zdravstvenim informacijama,
trebalo bi ih više integrisati u zdravstveni sistem.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Mobile Health applications - untapped potential
T1  - Zdravstvene aplikacije – neiskorišćen potencijal
VL  - 72
IS  - 4 suplement
SP  - S347
EP  - S348
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4554
ER  - 

@conference{
author = "Koraćević, Maja and Jovanović, Aleksandar and Pavlović, Dragana and Catić-Đorđević, Aleksandra",
year = "2022",
abstract = "Today, there are a number of applications that allow you to monitor physical activity
and health parameters or schedule a medical examination, and can also help you recognize a
health problem and react in time (1, 2). The aim of the present study was to assess the usage
of health applications (HApps, health-related mobile and/or web applications) among
citizens in Serbia.
The anonymous online questionnaire was distributed via social media in the spring of
2020. Data were processed using the IBM SPSS. 506 respondents participated in the
research, of which 155 were from the health profession. The majority of respondents were
female (73.9%), and the average age was 36.88 ± 11.22. About half of the respondents
(48.2%) have a university degree, and 74.9% are employed. Installed HApps on
phone/computer have 18.2% of respondents, with a statistically significant difference (p
<0.01) between health professionals (25.8%) and non-health (14.8%). The most commonly
used HApps among health professionals are those related to their professional work
(14.7%), followed by general health (3.8%) and specific diseases (1.9%). Non-health
professional respondents mostly used applications related to general health (5.4%), fitness
(2.0%) and the chosen doctor (1.4%). Only 0.6% of citizens used COVID-19 pandemic
applications. The importance of HApps is still not sufficiently recognized in Serbia. Given the
potential in controlling chronic diseases and other health conditions, especially among a
population with limited access to health care and health information, they should be more
integrated into the health system., Danas postoji niz aplikacija koje omogućavaju praćenje fizičke aktivnosti i
zdravstvenih parametara ili zakazivanje lekarskog pregleda, a mogu pomoći i u
prepoznavanju zdravstvenih problema obaveštavajući vas da reagujete na vreme (1, 2). Cilj
ove studije bio je da ispita upotrebu zdravstvenih aplikacija (HApps, mobilne i/ili web
aplikacije u vezi sa zdravljem) među građanima Srbije. Anonimni onlajn upitnik distribuiran
je putem društvenih mreža tokom proleća 2020. godine. Podaci su obrađeni korišćenjem
IBM SPSS. U istraživanju je učestvovalo 506 ispitanika, od kojih 155 iz zdravstvene struke.
Većina ispitanika su žene (73.9%), a prosečna starost bila je 36.88±11.22 godina. Oko
polovine ispitanika (48.2%) ima fakultetsko obrazovanje, a 74.9% je zaposleno. Instalirane
HApps na svom telefonu/računaru ima 18.2% ispitanika, sa statistički značajnom razlikom
(p<0.01) među ispitanicima iz zdravstvene struke (25.8%) i onih koji to nisu (14.8%).
Najkorišćenije HApps među ispitanicima zdravstvene struke su one koje se odnose na njihov
stručni rad (14.7%), opšte zdravlje (3.8%) i specifične bolesti (1.9%). Ispitanici koji nisu iz
zdravstvene struke najviše su koristili aplikacije koje se odnose na opšte zdravlje (5.4%),
fitnes (2.0%) i izabranog lekara (1.4%). Aplikacije u vezi sa COVID-19 pandemijom koristilo
je svega 0.6% građana. Značaj HApps još uvek nije dovoljno prepoznat u Srbiji. S obzirom na
potencijal u kontroli hroničnih bolesti i drugih zdravstvenih stanja, naročito među
populacijom sa ograničenim pristupom zdravstvenoj zaštiti i zdravstvenim informacijama,
trebalo bi ih više integrisati u zdravstveni sistem.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Mobile Health applications - untapped potential, Zdravstvene aplikacije – neiskorišćen potencijal",
volume = "72",
number = "4 suplement",
pages = "S347-S348",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4554"
}

Koraćević, M., Jovanović, A., Pavlović, D.,& Catić-Đorđević, A.. (2022). Mobile Health applications - untapped potential. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S347-S348.
https://hdl.handle.net/21.15107/rcub_farfar_4554

Koraćević M, Jovanović A, Pavlović D, Catić-Đorđević A. Mobile Health applications - untapped potential. in Arhiv za farmaciju. 2022;72(4 suplement):S347-S348.
https://hdl.handle.net/21.15107/rcub_farfar_4554 .

Koraćević, Maja, Jovanović, Aleksandar, Pavlović, Dragana, Catić-Đorđević, Aleksandra, "Mobile Health applications - untapped potential" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S347-S348,
https://hdl.handle.net/21.15107/rcub_farfar_4554 .

TY  - CONF
AU  - Pavlović, Dragana
AU  - Stojanović, Nikola
AU  - Zlatković, Bojan
AU  - Radulović, Niko
AU  - Kovačević, Nada
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4579
AB  - According to our previous studies, Bruckenthalia spiculifolia Rchb. (Ericaceae) possess
strong antioxidant activity and hydrogel loaded with 2% ethanolic extract from its flowers
and leaves is a potential southing and wound healing agent (1). Ethanolic extracts of leaves,
flowers, and herba, alongside fractions obtained by systematic solvent extraction method
with solvents of the increasing polarity of liquid-liquid fractionation of areal parts of B.
spiculifolia, were prepared. To estimate in vitro anti-inflammatory activities of eight different
extracts and fractions, isolated rat peritoneal macrophages were employed. MTT test was
used for the cytotoxicity determination, while the anti-inflammatory potential
lipopolysaccharide-induced NO production model was utilized (2). Experimental procedures
with animals complied with the rules of the European Union Normative. Resident rat
peritoneal macrophages were harvested by peritoneal lavage and used for both procedures.
Phytochemical analysis was done by RP-HPLC coupled with DAD detection. Tested samples
statistically significantly decreased macrophage ability to metabolize MTT, mainly in a
concentration-dependent manner. All of them also significantly inhibited NO production
from macrophages stimulated with lipopolysaccharide, which can be related to either their
cytotoxic or anti-inflammatory activity. Quantified polar compounds (especially quercetin-3-
O-glucoside) could be associated with better antioxidant and anti-inflammatory effects, as
well as with a lower cytotoxic potential. Indeed, fractions obtained with ethyl acetate and
water, but also ethanol extract obtained after lipids removal with petroleum ether, showed
the most promising effects. These results point out that B. spiculifolia is worth further
investigation in order to detect new naturally occurring anti-inflammatory agents.
AB  - Prema našim prethodnim istraživanjima, Bruckenthalia spiculifolia Rchb. (Ericaceae)
poseduje jaku antioksidativnu aktivnost, a hidrogel sa 2% etanolnog ekstrakta cveta i lista
ove biljne vrste pospešuje zarastanje rana (1). Pripremljeni su etanolni ekstrakti listova,
cvetova i nadzemnog dela biljne vrste B. spiculifolia, kao i frakcije dobijene sistematskom
ekstrakcijom rastvaračima rastuć eg polariteta tečno-tečno frakcionisanjem nadzemnih
delova biljke. Za procenu lokalne antiinflamatorne aktivnosti ukupno osam različitih
ekstrakata i frakcija korišćeni su izolovani peritonealni makrofagi pacova. MTT test je služio
za određivanje citotoksičnosti, a model produkcije NO izazvane lipopolisaharidom za in vitro
kvantifikaciju antiinflamatornog potencijala (2). Eksperimentalne procedure sa životinjama
su usklađeni sa zahtevima Evropske unije. Peritonealni makrofagi pacova su sakupljeni
peritonealnim ispiranjem i korišćeni za obe procedure. Fitohemijska analiza je izvršna
pomoć u RP-HPLC sa DAD detekcijom. Testirani uzorci su statistički značajno smanjili
sposobnost makrofaga da metabolišu MTT i to uglavnom na dozno-zavisan način. Svi oni su
takođe značajno inhibirali proizvodnju NO iz makrofaga stimulisanih lipopolisaharidom, što
se može dovesti u vezu sa njihovom citotoksičnom ili antiinflamatornom aktivnošć u.
Kvantifikovana polarna jedinjenja (naročito kvercetin-3-O-glukozid) mogu biti povezana sa
boljim antioksidativnim i antiinflamatornim efektima, kao i sa nižim citotoksičnim
potencijalom. Zaista, frakcije dobijene sa etil acetatom i vodom, ali i etanolni ekstrakt dobijen
nakon uklanjanja lipida petroletrom, su pokazale najbolje efekte. Izloženi rezultati ukazuju
na to da vrstu B. spiculifolia treba dalje ispitati u cilju pronalaženja novih prirodnih
antiinflamatornih agensa.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - In vitro cytotoxic and anti-inflammatory activity of Bruckenthalia spiculifolia extracts and fractions
T1  - In vitro citotoksična i antiinflamatorna aktivnost ekstrakata i frakcija Bruckenthalia spiculifolia
VL  - 72
IS  - 4 suplement
SP  - S453
EP  - S454
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4579
ER  - 

@conference{
author = "Pavlović, Dragana and Stojanović, Nikola and Zlatković, Bojan and Radulović, Niko and Kovačević, Nada",
year = "2022",
abstract = "According to our previous studies, Bruckenthalia spiculifolia Rchb. (Ericaceae) possess
strong antioxidant activity and hydrogel loaded with 2% ethanolic extract from its flowers
and leaves is a potential southing and wound healing agent (1). Ethanolic extracts of leaves,
flowers, and herba, alongside fractions obtained by systematic solvent extraction method
with solvents of the increasing polarity of liquid-liquid fractionation of areal parts of B.
spiculifolia, were prepared. To estimate in vitro anti-inflammatory activities of eight different
extracts and fractions, isolated rat peritoneal macrophages were employed. MTT test was
used for the cytotoxicity determination, while the anti-inflammatory potential
lipopolysaccharide-induced NO production model was utilized (2). Experimental procedures
with animals complied with the rules of the European Union Normative. Resident rat
peritoneal macrophages were harvested by peritoneal lavage and used for both procedures.
Phytochemical analysis was done by RP-HPLC coupled with DAD detection. Tested samples
statistically significantly decreased macrophage ability to metabolize MTT, mainly in a
concentration-dependent manner. All of them also significantly inhibited NO production
from macrophages stimulated with lipopolysaccharide, which can be related to either their
cytotoxic or anti-inflammatory activity. Quantified polar compounds (especially quercetin-3-
O-glucoside) could be associated with better antioxidant and anti-inflammatory effects, as
well as with a lower cytotoxic potential. Indeed, fractions obtained with ethyl acetate and
water, but also ethanol extract obtained after lipids removal with petroleum ether, showed
the most promising effects. These results point out that B. spiculifolia is worth further
investigation in order to detect new naturally occurring anti-inflammatory agents., Prema našim prethodnim istraživanjima, Bruckenthalia spiculifolia Rchb. (Ericaceae)
poseduje jaku antioksidativnu aktivnost, a hidrogel sa 2% etanolnog ekstrakta cveta i lista
ove biljne vrste pospešuje zarastanje rana (1). Pripremljeni su etanolni ekstrakti listova,
cvetova i nadzemnog dela biljne vrste B. spiculifolia, kao i frakcije dobijene sistematskom
ekstrakcijom rastvaračima rastuć eg polariteta tečno-tečno frakcionisanjem nadzemnih
delova biljke. Za procenu lokalne antiinflamatorne aktivnosti ukupno osam različitih
ekstrakata i frakcija korišćeni su izolovani peritonealni makrofagi pacova. MTT test je služio
za određivanje citotoksičnosti, a model produkcije NO izazvane lipopolisaharidom za in vitro
kvantifikaciju antiinflamatornog potencijala (2). Eksperimentalne procedure sa životinjama
su usklađeni sa zahtevima Evropske unije. Peritonealni makrofagi pacova su sakupljeni
peritonealnim ispiranjem i korišćeni za obe procedure. Fitohemijska analiza je izvršna
pomoć u RP-HPLC sa DAD detekcijom. Testirani uzorci su statistički značajno smanjili
sposobnost makrofaga da metabolišu MTT i to uglavnom na dozno-zavisan način. Svi oni su
takođe značajno inhibirali proizvodnju NO iz makrofaga stimulisanih lipopolisaharidom, što
se može dovesti u vezu sa njihovom citotoksičnom ili antiinflamatornom aktivnošć u.
Kvantifikovana polarna jedinjenja (naročito kvercetin-3-O-glukozid) mogu biti povezana sa
boljim antioksidativnim i antiinflamatornim efektima, kao i sa nižim citotoksičnim
potencijalom. Zaista, frakcije dobijene sa etil acetatom i vodom, ali i etanolni ekstrakt dobijen
nakon uklanjanja lipida petroletrom, su pokazale najbolje efekte. Izloženi rezultati ukazuju
na to da vrstu B. spiculifolia treba dalje ispitati u cilju pronalaženja novih prirodnih
antiinflamatornih agensa.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "In vitro cytotoxic and anti-inflammatory activity of Bruckenthalia spiculifolia extracts and fractions, In vitro citotoksična i antiinflamatorna aktivnost ekstrakata i frakcija Bruckenthalia spiculifolia",
volume = "72",
number = "4 suplement",
pages = "S453-S454",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4579"
}

Pavlović, D., Stojanović, N., Zlatković, B., Radulović, N.,& Kovačević, N.. (2022). In vitro cytotoxic and anti-inflammatory activity of Bruckenthalia spiculifolia extracts and fractions. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S453-S454.
https://hdl.handle.net/21.15107/rcub_farfar_4579

Pavlović D, Stojanović N, Zlatković B, Radulović N, Kovačević N. In vitro cytotoxic and anti-inflammatory activity of Bruckenthalia spiculifolia extracts and fractions. in Arhiv za farmaciju. 2022;72(4 suplement):S453-S454.
https://hdl.handle.net/21.15107/rcub_farfar_4579 .

Pavlović, Dragana, Stojanović, Nikola, Zlatković, Bojan, Radulović, Niko, Kovačević, Nada, "In vitro cytotoxic and anti-inflammatory activity of Bruckenthalia spiculifolia extracts and fractions" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S453-S454,
https://hdl.handle.net/21.15107/rcub_farfar_4579 .

TY  - CONF
AU  - Milijić Petrović, Valentina
AU  - Marković, Mirjana
AU  - Pavlović, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Popović, Ivana
AU  - Anđelković, Jasna
AU  - Stojkov, Svetlana
AU  - Gigov, Slobodan
AU  - Drenić, Dušan
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4553
AB  - Exact number of masters of pharmacy, level of their education, and jobs they are
engaged in is not known in Serbia. The number of pharmacists employed in health
institutions in Serbia is known (data is regularly updated by Pharmaceutical Chamber of
Serbia (FCC) because pharmacists must be licensed and registered). According to the FCC, in
Serbia, there are 6,814 Masters of Pharmacy licensed to work in healthcare institutions (1).
However, their arrangement and number by pharmacy, type and level of services are
unknown. Although all health institutions are now obliged to register through Business
Registers Agency (2), actual number of pharmacies and number of responsible pharmacists
per pharmacy remained invisible. The big question is whether all masters of pharmacy are
aware of their legal obligations, responsibilities, and professional opportunities. The number
of masters of pharmacy employed in other sectors is completely unknown. There is no
register of colleagues with completed health and academic specializations, master and
doctoral studies. The legal opportunity to acquire title of subspecialist in pharmacy should
be used and enable further training and recognition of work to colleagues who deal with
narrowly specialized pharmaceutical jobs. Funds for creating database of pharmacists (who
they are, what positions they hold, and what their level of education is) are minimal. It is only
necessary to recognize the importance of such database and connect key stakeholders. The
intersection of current situation would enable development and improvement of
pharmaceutical profession and would be step forward towards modernization of Serbian
health care system.
AB  - U Srbiji nije poznat precizan broj magistara farmacije, stepen njihovog
poslediplomskog obrazovanja i radna mesta na kojima su angažovani. Broj farmaceuta
zaposlenih u zdravstvenim ustanovama u Srbiji je poznat (podatke redovno ažurira
Farmaceutska komora Srbije (FKS), jer farmaceuti moraju imati licencu i moraju biti upisani
u FKS). Prema podacima FKS u Srbiji 6.814 magistara farmacije poseduje licencu za rad u
zdravstvenim ustanovama (1). Ipak, njihov raspored i broj po apotekama, vrsta i nivoi
njihovih usluga su nepoznati. Nakon promene zakonske regulative, sada sve zdavstvene
ustanove imaju obavezu da se registruju preko Agencije za privredne registre (2), i dalje je
ostao nevidljiv stvaran broj apoteka i odgovornih farmaceuta po svakoj apoteci. Veliko je
pitanje i da li su svi magistri farmacije svesni svojih zakonskih obaveza, odgovornosti i
profesionalnih mogućnosti. Broj magistara farmacije zaposlenih u ostalim sektorima je
potpuno nepoznat. Ne postoji ni registar kolega sa završenim zdravstvenim i akademskim
specijalizacijama, magistarskim i doktorskim studijama. Zakonsku mogućnost za sticanje
zvanja subspecijalista u farmaciji treba iskoristiti i omogućiti dalje usavršavanje i
priznavanje rada kolegama koji se bave uskostručnim farmaceutskim poslovima (npr.
onkološka farmacija). Sredstva za izradu baze farmaceuta (ko su, na kojim pozicijama rade i
kog su nivoa obrazovanja) su minimalna, a ljudski resursi već postoje. Potrebno je samo
prepoznati važnost ovakve baze i povezati ključne zainteresovane strane (FKS, Privrednu
komoru Srbije, akademiju, Savez farmaceutskih udruženja Srbije, farmaceutsku industriju).
Presek zatečenog stanja putem baze farmaceuta bi omogućio dalji razvoj i unapređenje
farmaceutske struke, i bio bi korak napred ka modernizaciji zdravstvenog sistema Srbije.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Why do we need a pharmacist database and a reminder of the pharmacist’s job description?
T1  - Zašto nam je potrebna baza farmaceuta i podsećanje na opis poslova magistra farmacije?
VL  - 72
IS  - 4 suplement
SP  - S345
EP  - S346
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4553
ER  - 

@conference{
author = "Milijić Petrović, Valentina and Marković, Mirjana and Pavlović, Dragana and Buha-Đorđević, Aleksandra and Popović, Ivana and Anđelković, Jasna and Stojkov, Svetlana and Gigov, Slobodan and Drenić, Dušan",
year = "2022",
abstract = "Exact number of masters of pharmacy, level of their education, and jobs they are
engaged in is not known in Serbia. The number of pharmacists employed in health
institutions in Serbia is known (data is regularly updated by Pharmaceutical Chamber of
Serbia (FCC) because pharmacists must be licensed and registered). According to the FCC, in
Serbia, there are 6,814 Masters of Pharmacy licensed to work in healthcare institutions (1).
However, their arrangement and number by pharmacy, type and level of services are
unknown. Although all health institutions are now obliged to register through Business
Registers Agency (2), actual number of pharmacies and number of responsible pharmacists
per pharmacy remained invisible. The big question is whether all masters of pharmacy are
aware of their legal obligations, responsibilities, and professional opportunities. The number
of masters of pharmacy employed in other sectors is completely unknown. There is no
register of colleagues with completed health and academic specializations, master and
doctoral studies. The legal opportunity to acquire title of subspecialist in pharmacy should
be used and enable further training and recognition of work to colleagues who deal with
narrowly specialized pharmaceutical jobs. Funds for creating database of pharmacists (who
they are, what positions they hold, and what their level of education is) are minimal. It is only
necessary to recognize the importance of such database and connect key stakeholders. The
intersection of current situation would enable development and improvement of
pharmaceutical profession and would be step forward towards modernization of Serbian
health care system., U Srbiji nije poznat precizan broj magistara farmacije, stepen njihovog
poslediplomskog obrazovanja i radna mesta na kojima su angažovani. Broj farmaceuta
zaposlenih u zdravstvenim ustanovama u Srbiji je poznat (podatke redovno ažurira
Farmaceutska komora Srbije (FKS), jer farmaceuti moraju imati licencu i moraju biti upisani
u FKS). Prema podacima FKS u Srbiji 6.814 magistara farmacije poseduje licencu za rad u
zdravstvenim ustanovama (1). Ipak, njihov raspored i broj po apotekama, vrsta i nivoi
njihovih usluga su nepoznati. Nakon promene zakonske regulative, sada sve zdavstvene
ustanove imaju obavezu da se registruju preko Agencije za privredne registre (2), i dalje je
ostao nevidljiv stvaran broj apoteka i odgovornih farmaceuta po svakoj apoteci. Veliko je
pitanje i da li su svi magistri farmacije svesni svojih zakonskih obaveza, odgovornosti i
profesionalnih mogućnosti. Broj magistara farmacije zaposlenih u ostalim sektorima je
potpuno nepoznat. Ne postoji ni registar kolega sa završenim zdravstvenim i akademskim
specijalizacijama, magistarskim i doktorskim studijama. Zakonsku mogućnost za sticanje
zvanja subspecijalista u farmaciji treba iskoristiti i omogućiti dalje usavršavanje i
priznavanje rada kolegama koji se bave uskostručnim farmaceutskim poslovima (npr.
onkološka farmacija). Sredstva za izradu baze farmaceuta (ko su, na kojim pozicijama rade i
kog su nivoa obrazovanja) su minimalna, a ljudski resursi već postoje. Potrebno je samo
prepoznati važnost ovakve baze i povezati ključne zainteresovane strane (FKS, Privrednu
komoru Srbije, akademiju, Savez farmaceutskih udruženja Srbije, farmaceutsku industriju).
Presek zatečenog stanja putem baze farmaceuta bi omogućio dalji razvoj i unapređenje
farmaceutske struke, i bio bi korak napred ka modernizaciji zdravstvenog sistema Srbije.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Why do we need a pharmacist database and a reminder of the pharmacist’s job description?, Zašto nam je potrebna baza farmaceuta i podsećanje na opis poslova magistra farmacije?",
volume = "72",
number = "4 suplement",
pages = "S345-S346",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4553"
}

Milijić Petrović, V., Marković, M., Pavlović, D., Buha-Đorđević, A., Popović, I., Anđelković, J., Stojkov, S., Gigov, S.,& Drenić, D.. (2022). Why do we need a pharmacist database and a reminder of the pharmacist’s job description?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S345-S346.
https://hdl.handle.net/21.15107/rcub_farfar_4553

Milijić Petrović V, Marković M, Pavlović D, Buha-Đorđević A, Popović I, Anđelković J, Stojkov S, Gigov S, Drenić D. Why do we need a pharmacist database and a reminder of the pharmacist’s job description?. in Arhiv za farmaciju. 2022;72(4 suplement):S345-S346.
https://hdl.handle.net/21.15107/rcub_farfar_4553 .

Milijić Petrović, Valentina, Marković, Mirjana, Pavlović, Dragana, Buha-Đorđević, Aleksandra, Popović, Ivana, Anđelković, Jasna, Stojkov, Svetlana, Gigov, Slobodan, Drenić, Dušan, "Why do we need a pharmacist database and a reminder of the pharmacist’s job description?" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S345-S346,
https://hdl.handle.net/21.15107/rcub_farfar_4553 .

TY  - CONF
AU  - Anđelković, Jasna
AU  - Milijić Petrović, Valentina
AU  - Marković, Mirjana
AU  - Pavlović, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Popović, Ivana
AU  - Stojkov, Svetlana
AU  - Gigov, Slobodan
AU  - Drenić, Dušan
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4528
AB  - This paper presents a set of recommendations that can contribute to the improvement
of the pharmacy business. They resulted from a series of professional meetings and a
collection of opinions from masters of pharmacy employed in various health care institutions
in the Republic of Serbia. The general recommendation would imply strict compliance with
existing laws (Law on Medicines and Medical Devices (1), Law on Health Care (2)), but also
the adoption of the Law on Pharmacy, following the example of countries with developed
pharmacy practice. Individual key provisions that would bring improvement of pharmacy
and quality pharmaceutical services to patients in the short term are the mandatory
presence of at least one licensed pharmacist during the entire working hours in each
pharmacy, as well as compliance and control of prescription and over-the-counter medicines.
In the long term, strengthening national regulatory bodies in the field of medicines and
medical devices is important for improving the quality, safety, and efficacy of medicines and
the issuance and application of therapy. According to all standards, these jobs should be
entrusted exclusively to masters of pharmacy, and in certain cases to appropriate pharmacy
specialists. Development of specific clinical skills and introduction of additional services,
such as vaccination and disposal of pharmaceutical waste, would significantly contribute to
resource savings and contribute to the health system.
AB  - Ovaj rad predstavlja skup preporuka koje mogu doprineti poboljšanju apotekarske
delatnosti, a koje su proistekle iz niza stručnih sastanaka i prikupljanja mišljenja od
magistara farmacije zaposlenih u različitim zdravstvenim ustanovama u Republici Srbiji.
Opšta preporuka bi podrazumevala strogo poštovanje postojećih zakona (Zakona o lekovima
i medicinskim sredstavima (1), Zakon o zdravstvenoj zaštiti (2)), ali i donošenje Zakona o
apotekarskoj delatnosti, po ugledu na države sa razvijenom apotekarskom praksom.
Pojedinačne ključne odredbe koje bi u kratkom vremenskom roku donele unapređenje
apotekarske delatnosti i kvalitetne farmaceutske usluge ka pacijentima su obavezno
prisustvo najmanje jednog diplomiranog farmaceuta sa licencom tokom celokupnog radnog
vremena u svakoj apoteci, kao i poštovanje i kontrola režima izdavanja lekova na recept i
lekova bez recepta. Na dugi rok, jačanje nacionalnih regulatornih tela u oblasti lekova i
medicinskih sredstava je značajno radi poboljšanja kvaliteta, bezbednosti i efikasnosti lekova
i izdavanja i primene terapije. Ovi poslovi bi prema svim standardima morali biti povereni
isključivo magistrima farmacije, a u određenim slučajevima i odgovarajućim specijalistima
farmacije. Razvoj specifičnih kliničkih veština i uvođenje dodatnih usluga, kao što su npr.
vakcinacija i zbrinjavanje farmaceutskog otpada, bi značajno doprineli uštedama resursa i
doprineli zdravstvenom sistemu u celini.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Development of pharmacy activity in Serbia - what do we need?
T1  - Razvoj apotekarske delatnosti u srbiji‐ šta nam je potrebno?
VL  - 72
IS  - 4 suplement
SP  - S284
EP  - S285
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4528
ER  - 

@conference{
author = "Anđelković, Jasna and Milijić Petrović, Valentina and Marković, Mirjana and Pavlović, Dragana and Buha-Đorđević, Aleksandra and Popović, Ivana and Stojkov, Svetlana and Gigov, Slobodan and Drenić, Dušan",
year = "2022",
abstract = "This paper presents a set of recommendations that can contribute to the improvement
of the pharmacy business. They resulted from a series of professional meetings and a
collection of opinions from masters of pharmacy employed in various health care institutions
in the Republic of Serbia. The general recommendation would imply strict compliance with
existing laws (Law on Medicines and Medical Devices (1), Law on Health Care (2)), but also
the adoption of the Law on Pharmacy, following the example of countries with developed
pharmacy practice. Individual key provisions that would bring improvement of pharmacy
and quality pharmaceutical services to patients in the short term are the mandatory
presence of at least one licensed pharmacist during the entire working hours in each
pharmacy, as well as compliance and control of prescription and over-the-counter medicines.
In the long term, strengthening national regulatory bodies in the field of medicines and
medical devices is important for improving the quality, safety, and efficacy of medicines and
the issuance and application of therapy. According to all standards, these jobs should be
entrusted exclusively to masters of pharmacy, and in certain cases to appropriate pharmacy
specialists. Development of specific clinical skills and introduction of additional services,
such as vaccination and disposal of pharmaceutical waste, would significantly contribute to
resource savings and contribute to the health system., Ovaj rad predstavlja skup preporuka koje mogu doprineti poboljšanju apotekarske
delatnosti, a koje su proistekle iz niza stručnih sastanaka i prikupljanja mišljenja od
magistara farmacije zaposlenih u različitim zdravstvenim ustanovama u Republici Srbiji.
Opšta preporuka bi podrazumevala strogo poštovanje postojećih zakona (Zakona o lekovima
i medicinskim sredstavima (1), Zakon o zdravstvenoj zaštiti (2)), ali i donošenje Zakona o
apotekarskoj delatnosti, po ugledu na države sa razvijenom apotekarskom praksom.
Pojedinačne ključne odredbe koje bi u kratkom vremenskom roku donele unapređenje
apotekarske delatnosti i kvalitetne farmaceutske usluge ka pacijentima su obavezno
prisustvo najmanje jednog diplomiranog farmaceuta sa licencom tokom celokupnog radnog
vremena u svakoj apoteci, kao i poštovanje i kontrola režima izdavanja lekova na recept i
lekova bez recepta. Na dugi rok, jačanje nacionalnih regulatornih tela u oblasti lekova i
medicinskih sredstava je značajno radi poboljšanja kvaliteta, bezbednosti i efikasnosti lekova
i izdavanja i primene terapije. Ovi poslovi bi prema svim standardima morali biti povereni
isključivo magistrima farmacije, a u određenim slučajevima i odgovarajućim specijalistima
farmacije. Razvoj specifičnih kliničkih veština i uvođenje dodatnih usluga, kao što su npr.
vakcinacija i zbrinjavanje farmaceutskog otpada, bi značajno doprineli uštedama resursa i
doprineli zdravstvenom sistemu u celini.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Development of pharmacy activity in Serbia - what do we need?, Razvoj apotekarske delatnosti u srbiji‐ šta nam je potrebno?",
volume = "72",
number = "4 suplement",
pages = "S284-S285",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4528"
}

Anđelković, J., Milijić Petrović, V., Marković, M., Pavlović, D., Buha-Đorđević, A., Popović, I., Stojkov, S., Gigov, S.,& Drenić, D.. (2022). Development of pharmacy activity in Serbia - what do we need?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S284-S285.
https://hdl.handle.net/21.15107/rcub_farfar_4528

Anđelković J, Milijić Petrović V, Marković M, Pavlović D, Buha-Đorđević A, Popović I, Stojkov S, Gigov S, Drenić D. Development of pharmacy activity in Serbia - what do we need?. in Arhiv za farmaciju. 2022;72(4 suplement):S284-S285.
https://hdl.handle.net/21.15107/rcub_farfar_4528 .

Anđelković, Jasna, Milijić Petrović, Valentina, Marković, Mirjana, Pavlović, Dragana, Buha-Đorđević, Aleksandra, Popović, Ivana, Stojkov, Svetlana, Gigov, Slobodan, Drenić, Dušan, "Development of pharmacy activity in Serbia - what do we need?" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S284-S285,
https://hdl.handle.net/21.15107/rcub_farfar_4528 .

TY  - CONF
AU  - Pavlović, Dragana
AU  - Vukelić-Nikolić, Marija
AU  - Marčetić, Mirjana
AU  - Kitić, Dušanka
AU  - Kostić, Milica
AU  - Milutinović, Milica
AU  - Miladinović, Bojana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5305
AB  - Rubus idaeus L., folium (raspberry leaf) is according to EMA/HMPC
monograph indicated as traditional herbal medicinal product for: the symptomatic
relief of minor spasm associated with menstrual periods, the symptomatic treatment
of mild inflammation in the mouth or throat and the symptomatic treatment of mild
diarrhea. The aim of this work was quantitative determination of phenolic compounds
(namely: total polyphenols, tannins, flavonoids, arbutin and hydroquinone) and
antioxidant capacity of the different leaves extracts of wild and cultivated Rubus
ideus. Total polyphenols, tannins and flavonoids were determined
spectrophotometrically, HPLC method was employed for quantification of arbutin
and hydroquinone. DPPH test was used for fast antioxidant screening. Arbutin and
hydroquinone were absent in all samples despite some literature date on arbutin
presence in Rubus idaeus. Our phytochemical study showed that raspberry leaves
extracts contain significant amounts of polyphenolic compounds, which could be
useful in its quality estimation. Cultured raspberry leaf extracts seem to be reacher
source of this secondary metabolites while hydromethanolic extracts of wild growing
plant material exhibited the strongest antioxidant activity. Polyphenolic content and
demonstrated activity could, at least in part, explain pharmacological effects of
raspberry leaves.
PB  - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
PB  - Institute for Nature Conservation of Serbia
C3  - 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts
T1  - Assessment of polyphenol content and in vitro antioxidant potential of wild growing and cultured raspberry leaf
SP  - 178
EP  - 178
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5305
ER  - 

@conference{
author = "Pavlović, Dragana and Vukelić-Nikolić, Marija and Marčetić, Mirjana and Kitić, Dušanka and Kostić, Milica and Milutinović, Milica and Miladinović, Bojana",
year = "2019",
abstract = "Rubus idaeus L., folium (raspberry leaf) is according to EMA/HMPC
monograph indicated as traditional herbal medicinal product for: the symptomatic
relief of minor spasm associated with menstrual periods, the symptomatic treatment
of mild inflammation in the mouth or throat and the symptomatic treatment of mild
diarrhea. The aim of this work was quantitative determination of phenolic compounds
(namely: total polyphenols, tannins, flavonoids, arbutin and hydroquinone) and
antioxidant capacity of the different leaves extracts of wild and cultivated Rubus
ideus. Total polyphenols, tannins and flavonoids were determined
spectrophotometrically, HPLC method was employed for quantification of arbutin
and hydroquinone. DPPH test was used for fast antioxidant screening. Arbutin and
hydroquinone were absent in all samples despite some literature date on arbutin
presence in Rubus idaeus. Our phytochemical study showed that raspberry leaves
extracts contain significant amounts of polyphenolic compounds, which could be
useful in its quality estimation. Cultured raspberry leaf extracts seem to be reacher
source of this secondary metabolites while hydromethanolic extracts of wild growing
plant material exhibited the strongest antioxidant activity. Polyphenolic content and
demonstrated activity could, at least in part, explain pharmacological effects of
raspberry leaves.",
publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia",
journal = "13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts",
title = "Assessment of polyphenol content and in vitro antioxidant potential of wild growing and cultured raspberry leaf",
pages = "178-178",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5305"
}

Pavlović, D., Vukelić-Nikolić, M., Marčetić, M., Kitić, D., Kostić, M., Milutinović, M.,& Miladinović, B.. (2019). Assessment of polyphenol content and in vitro antioxidant potential of wild growing and cultured raspberry leaf. in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts
Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 178-178.
https://hdl.handle.net/21.15107/rcub_farfar_5305

Pavlović D, Vukelić-Nikolić M, Marčetić M, Kitić D, Kostić M, Milutinović M, Miladinović B. Assessment of polyphenol content and in vitro antioxidant potential of wild growing and cultured raspberry leaf. in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts. 2019;:178-178.
https://hdl.handle.net/21.15107/rcub_farfar_5305 .

Pavlović, Dragana, Vukelić-Nikolić, Marija, Marčetić, Mirjana, Kitić, Dušanka, Kostić, Milica, Milutinović, Milica, Miladinović, Bojana, "Assessment of polyphenol content and in vitro antioxidant potential of wild growing and cultured raspberry leaf" in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts (2019):178-178,
https://hdl.handle.net/21.15107/rcub_farfar_5305 .

TY  - JOUR
AU  - Pavlović, Dragana R.
AU  - Veljković, Milica
AU  - Stojanović, Nikola M.
AU  - Gocmanac-Ignjatović, Marija
AU  - Mihailov-Krstev, Tatjana
AU  - Branković, Suzana
AU  - Sokolović, Dušan
AU  - Marčetić, Mirjana
AU  - Radulović, Niko
AU  - Radenković, Mirjana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2802
AB  - ObjectivesAs there are no previous studies of the European wild-garlic (Allium ursinum) effects on the gastrointestinal system, despite its traditional applications in gastrointestinal disorders' treatment and regular use in the human diet, we have quantified and compared spasmolytic, antimicrobial and antioxidant activities of its different leaf extracts. MethodsWild-garlic extracts were tested for spasmolytic activity on isolated rat ileum, antimicrobial activity on selected Gram-positive and Gram-negative bacteria and fungi by microdilution method and antioxidant capacity by DPPH radical-scavenging assay. Key findingsWild-garlic extracts were found to decrease ileal basal tone. As the relaxation of K+-induced contractions was similar to one caused by papaverin, the observed spasmolytic effect was most likely mediated through Ca2+-channel inhibition. Ethanolic extract (with the highest phenolic and high alk(en)yl cysteine sulphoxides' levels) produced the strongest spasmolytic activity. In case of acetylcholine-induced contractions, only hydromethanolic extract showed no statistical difference in comparison with positive control. All samples exhibited certain antioxidant potential and strong antimicrobial activity against tested enteropathogenic strains (Salmonella enteritidis was the most sensitive, followed by Escherichia coli, Proteus mirabilis and Enterococcus faecalis). ConclusionBesides other already established health-promoting effects, wild garlic could be useful in treatment of mild gastrointestinal disturbances.
PB  - Wiley, Hoboken
T2  - Journal of Pharmacy and Pharmacology
T1  - Influence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant properties
VL  - 69
IS  - 9
SP  - 1208
EP  - 1218
DO  - 10.1111/jphp.12746
ER  - 

@article{
author = "Pavlović, Dragana R. and Veljković, Milica and Stojanović, Nikola M. and Gocmanac-Ignjatović, Marija and Mihailov-Krstev, Tatjana and Branković, Suzana and Sokolović, Dušan and Marčetić, Mirjana and Radulović, Niko and Radenković, Mirjana",
year = "2017",
abstract = "ObjectivesAs there are no previous studies of the European wild-garlic (Allium ursinum) effects on the gastrointestinal system, despite its traditional applications in gastrointestinal disorders' treatment and regular use in the human diet, we have quantified and compared spasmolytic, antimicrobial and antioxidant activities of its different leaf extracts. MethodsWild-garlic extracts were tested for spasmolytic activity on isolated rat ileum, antimicrobial activity on selected Gram-positive and Gram-negative bacteria and fungi by microdilution method and antioxidant capacity by DPPH radical-scavenging assay. Key findingsWild-garlic extracts were found to decrease ileal basal tone. As the relaxation of K+-induced contractions was similar to one caused by papaverin, the observed spasmolytic effect was most likely mediated through Ca2+-channel inhibition. Ethanolic extract (with the highest phenolic and high alk(en)yl cysteine sulphoxides' levels) produced the strongest spasmolytic activity. In case of acetylcholine-induced contractions, only hydromethanolic extract showed no statistical difference in comparison with positive control. All samples exhibited certain antioxidant potential and strong antimicrobial activity against tested enteropathogenic strains (Salmonella enteritidis was the most sensitive, followed by Escherichia coli, Proteus mirabilis and Enterococcus faecalis). ConclusionBesides other already established health-promoting effects, wild garlic could be useful in treatment of mild gastrointestinal disturbances.",
publisher = "Wiley, Hoboken",
journal = "Journal of Pharmacy and Pharmacology",
title = "Influence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant properties",
volume = "69",
number = "9",
pages = "1208-1218",
doi = "10.1111/jphp.12746"
}

Pavlović, D. R., Veljković, M., Stojanović, N. M., Gocmanac-Ignjatović, M., Mihailov-Krstev, T., Branković, S., Sokolović, D., Marčetić, M., Radulović, N.,& Radenković, M.. (2017). Influence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant properties. in Journal of Pharmacy and Pharmacology
Wiley, Hoboken., 69(9), 1208-1218.
https://doi.org/10.1111/jphp.12746

Pavlović DR, Veljković M, Stojanović NM, Gocmanac-Ignjatović M, Mihailov-Krstev T, Branković S, Sokolović D, Marčetić M, Radulović N, Radenković M. Influence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant properties. in Journal of Pharmacy and Pharmacology. 2017;69(9):1208-1218.
doi:10.1111/jphp.12746 .

Pavlović, Dragana R., Veljković, Milica, Stojanović, Nikola M., Gocmanac-Ignjatović, Marija, Mihailov-Krstev, Tatjana, Branković, Suzana, Sokolović, Dušan, Marčetić, Mirjana, Radulović, Niko, Radenković, Mirjana, "Influence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant properties" in Journal of Pharmacy and Pharmacology, 69, no. 9 (2017):1208-1218,
https://doi.org/10.1111/jphp.12746 . .

TY  - JOUR
AU  - Pavlović, Dragana R.
AU  - Lakušić, Branislava
AU  - Kitić, Dušanka
AU  - Milutinović, Milica
AU  - Kostić, Milica
AU  - Miladinović, Bojana
AU  - Kovačević, Nada
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2239
AB  - Uvae ursi folium (Arctostaphylos uva ursi, Ericaceae) is the best known and most widely used herbal urinary antiseptic. In traditional medicine, other Ericaceae species are also used for the treatment of urinary tract infections. The present study investigates antimicrobial activity of five species of Ericaceae family native to the Balkan Peninsula: Arbutus unedo, Bruckenthalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea. Ethanolic extracts were tested against 10 different gram-positive and gram-negative bacteria by the disc diffusion technique, where standard tetracycline, streptomycin and penicillin discs and discs containing crystal violet (1 mg/ml) and solvent (70.0% v/v ethanol) were used as controls. The most prominent antibacterial effect was achieved on Staphylococcus aureus with extracts of Calluna vulgaris and Erica carnea. Tested samples showed no activity against the gram-negative strains Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. Inhibitory effects on the growth of gram-positive bacteria were more potent. The exception is Arbutus unedo ethanol extract which exhibited certain activity against a laboratory strain of wild Escherichia coli. Antimicrobial activity of the ethanolic extracts against 10 tested strains of bacteria in disc diffusion assay was generally weak, even for sample in which HPLC determination confirmed the presence of arbutin (secondary metabolite responsible for most of the antibacterial activity of Uvaeursi folium).
AB  - Najpoznatiji i najviše korišćeni biljni uroantiseptik je list uve, Uvaeursi folium (Arctostaphylos uva ursi, Ericaceae). U tradicionalnoj medicini često se i druge vrste familije Ericaceae spominju u lečenju urinarnih infekcija. Provera antimikrobne aktivnosti izvršena je za sledeće biljne vrste ove familije koje samostalno rastu u flori Balkanskog poluostrva: Arbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea i Erica carnea. Antimikrobna aktivnost etanolnih ekstrakata listova ispitivana je diskdifuzionom metodom, korišćenjem 10 sojeva gram pozitivnih i gram negativnih bakterija, pri čemu su kao kontrole korišćeni standardni diskovi tetraciklina, streptomicina i penicilina, kao i diskovi sa rastvorom kristalvioleta (1 mg/ml) i rastvarača (70.0% v/v etanol). Pseudomonas aeruginosa, Escherichia coli i Klebsiella pneumoniae nisu osetljive ni na jedan od ispitivanih ekstrakata. Kao najbolji rezultati mogu se izdvojiti aktivnosti ekstrakta Calluna vulgaris i Erica carnea na bakterijski soj Staphylococcus aureus. Testirani uzorci uglavnom ispoljavaju antimikrobnu aktivnost prema gram pozitivnim sojevima. Izuzetak je etanolni ekstrakt vrste Arbutus unedo, koji ispoljava određenu antimikrobnu aktivnost prema laboratorijskom soju Escherichia coli. Antimikrobna aktivnost etanolnih ekstrakata prema 10 testiranih bakterijskih sojeva u diskdifuzionoj metodi je veoma slaba, čak i za uzorak za koji je HPLC analizom utvrđeno prisustvo arbutina (sekundarni metabolit odgovoran za uroantiseptično dejstvo lista uve).
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš
T2  - Acta Facultatis Medicae Naissensis
T1  - Antimicrobial activity of selected plant species of genera Arbutus L., Bruckenthalia Rchb., Calluna Salisb. and Erica L. (Ericaceae)
T1  - Antimikrobna aktivnost odabranih biljnih vrsta rodova Arbutus L., Bruckenthalia rchb., Calluna salisb. i Erica L. (Ericaceae)
VL  - 31
IS  - 1
SP  - 81
EP  - 85
DO  - 10.2478/afmnai-2014-0009
ER  - 

@article{
author = "Pavlović, Dragana R. and Lakušić, Branislava and Kitić, Dušanka and Milutinović, Milica and Kostić, Milica and Miladinović, Bojana and Kovačević, Nada",
year = "2014",
abstract = "Uvae ursi folium (Arctostaphylos uva ursi, Ericaceae) is the best known and most widely used herbal urinary antiseptic. In traditional medicine, other Ericaceae species are also used for the treatment of urinary tract infections. The present study investigates antimicrobial activity of five species of Ericaceae family native to the Balkan Peninsula: Arbutus unedo, Bruckenthalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea. Ethanolic extracts were tested against 10 different gram-positive and gram-negative bacteria by the disc diffusion technique, where standard tetracycline, streptomycin and penicillin discs and discs containing crystal violet (1 mg/ml) and solvent (70.0% v/v ethanol) were used as controls. The most prominent antibacterial effect was achieved on Staphylococcus aureus with extracts of Calluna vulgaris and Erica carnea. Tested samples showed no activity against the gram-negative strains Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. Inhibitory effects on the growth of gram-positive bacteria were more potent. The exception is Arbutus unedo ethanol extract which exhibited certain activity against a laboratory strain of wild Escherichia coli. Antimicrobial activity of the ethanolic extracts against 10 tested strains of bacteria in disc diffusion assay was generally weak, even for sample in which HPLC determination confirmed the presence of arbutin (secondary metabolite responsible for most of the antibacterial activity of Uvaeursi folium)., Najpoznatiji i najviše korišćeni biljni uroantiseptik je list uve, Uvaeursi folium (Arctostaphylos uva ursi, Ericaceae). U tradicionalnoj medicini često se i druge vrste familije Ericaceae spominju u lečenju urinarnih infekcija. Provera antimikrobne aktivnosti izvršena je za sledeće biljne vrste ove familije koje samostalno rastu u flori Balkanskog poluostrva: Arbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea i Erica carnea. Antimikrobna aktivnost etanolnih ekstrakata listova ispitivana je diskdifuzionom metodom, korišćenjem 10 sojeva gram pozitivnih i gram negativnih bakterija, pri čemu su kao kontrole korišćeni standardni diskovi tetraciklina, streptomicina i penicilina, kao i diskovi sa rastvorom kristalvioleta (1 mg/ml) i rastvarača (70.0% v/v etanol). Pseudomonas aeruginosa, Escherichia coli i Klebsiella pneumoniae nisu osetljive ni na jedan od ispitivanih ekstrakata. Kao najbolji rezultati mogu se izdvojiti aktivnosti ekstrakta Calluna vulgaris i Erica carnea na bakterijski soj Staphylococcus aureus. Testirani uzorci uglavnom ispoljavaju antimikrobnu aktivnost prema gram pozitivnim sojevima. Izuzetak je etanolni ekstrakt vrste Arbutus unedo, koji ispoljava određenu antimikrobnu aktivnost prema laboratorijskom soju Escherichia coli. Antimikrobna aktivnost etanolnih ekstrakata prema 10 testiranih bakterijskih sojeva u diskdifuzionoj metodi je veoma slaba, čak i za uzorak za koji je HPLC analizom utvrđeno prisustvo arbutina (sekundarni metabolit odgovoran za uroantiseptično dejstvo lista uve).",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš",
journal = "Acta Facultatis Medicae Naissensis",
title = "Antimicrobial activity of selected plant species of genera Arbutus L., Bruckenthalia Rchb., Calluna Salisb. and Erica L. (Ericaceae), Antimikrobna aktivnost odabranih biljnih vrsta rodova Arbutus L., Bruckenthalia rchb., Calluna salisb. i Erica L. (Ericaceae)",
volume = "31",
number = "1",
pages = "81-85",
doi = "10.2478/afmnai-2014-0009"
}

Pavlović, D. R., Lakušić, B., Kitić, D., Milutinović, M., Kostić, M., Miladinović, B.,& Kovačević, N.. (2014). Antimicrobial activity of selected plant species of genera Arbutus L., Bruckenthalia Rchb., Calluna Salisb. and Erica L. (Ericaceae). in Acta Facultatis Medicae Naissensis
Univerzitet u Nišu - Medicinski fakultet, Niš., 31(1), 81-85.
https://doi.org/10.2478/afmnai-2014-0009

Pavlović DR, Lakušić B, Kitić D, Milutinović M, Kostić M, Miladinović B, Kovačević N. Antimicrobial activity of selected plant species of genera Arbutus L., Bruckenthalia Rchb., Calluna Salisb. and Erica L. (Ericaceae). in Acta Facultatis Medicae Naissensis. 2014;31(1):81-85.
doi:10.2478/afmnai-2014-0009 .

Pavlović, Dragana R., Lakušić, Branislava, Kitić, Dušanka, Milutinović, Milica, Kostić, Milica, Miladinović, Bojana, Kovačević, Nada, "Antimicrobial activity of selected plant species of genera Arbutus L., Bruckenthalia Rchb., Calluna Salisb. and Erica L. (Ericaceae)" in Acta Facultatis Medicae Naissensis, 31, no. 1 (2014):81-85,
https://doi.org/10.2478/afmnai-2014-0009 . .

TY  - JOUR
AU  - Pavlović, Dragana R.
AU  - Tasić-Kostov, Marija
AU  - Marčetić, Mirjana
AU  - Lakušić, Branislava
AU  - Kitić, Dušanka
AU  - Savić, Snežana
AU  - Kovačević, Nada
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1885
AB  - Arbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea possess strong antioxidant activity and they are traditionally used for the treatment of various skin diseases. The present study investigated the total phenylpropanoid content, antioxidant properties and phenolic composition of dry leaf ethanol extracts of these species. Furthermore, the in vivo effects of gels, each containing 2% of a single extract were tested on the artificially irritated human skin using the objective methods of skin biophysical measurements (erythema index (EI), pH of the skin and electrical capacitance (EC) as a measure of skin hydration level were assessed). In total, 13 components were identified by RP-HPLC coupled with DAD detection; quercitrin, quercetin 3-O-glucoside and gallic acid were detected in all investigated samples while chlorogenic acid and quercetin were present in 4 samples. Regarding the in vivo study, all investigated gels significantly decreased the skin irritation level and reversed the pH of the skin disturbed by preirritation, while results were contradictory regarding skin hydration measurements. In conclusion, the assessed in vivo topical effects of investigated extracts matched well with their phenylpropanoid content as well as with assessed antioxidant activities.
PB  - Innovhub Ssi-Area Ssog, Milano
T2  - RSC Advances
T1  - Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts
VL  - 90
IS  - 4
SP  - 255
EP  - 264
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1885
ER  - 

@article{
author = "Pavlović, Dragana R. and Tasić-Kostov, Marija and Marčetić, Mirjana and Lakušić, Branislava and Kitić, Dušanka and Savić, Snežana and Kovačević, Nada",
year = "2013",
abstract = "Arbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea possess strong antioxidant activity and they are traditionally used for the treatment of various skin diseases. The present study investigated the total phenylpropanoid content, antioxidant properties and phenolic composition of dry leaf ethanol extracts of these species. Furthermore, the in vivo effects of gels, each containing 2% of a single extract were tested on the artificially irritated human skin using the objective methods of skin biophysical measurements (erythema index (EI), pH of the skin and electrical capacitance (EC) as a measure of skin hydration level were assessed). In total, 13 components were identified by RP-HPLC coupled with DAD detection; quercitrin, quercetin 3-O-glucoside and gallic acid were detected in all investigated samples while chlorogenic acid and quercetin were present in 4 samples. Regarding the in vivo study, all investigated gels significantly decreased the skin irritation level and reversed the pH of the skin disturbed by preirritation, while results were contradictory regarding skin hydration measurements. In conclusion, the assessed in vivo topical effects of investigated extracts matched well with their phenylpropanoid content as well as with assessed antioxidant activities.",
publisher = "Innovhub Ssi-Area Ssog, Milano",
journal = "RSC Advances",
title = "Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts",
volume = "90",
number = "4",
pages = "255-264",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1885"
}

Pavlović, D. R., Tasić-Kostov, M., Marčetić, M., Lakušić, B., Kitić, D., Savić, S.,& Kovačević, N.. (2013). Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts. in RSC Advances
Innovhub Ssi-Area Ssog, Milano., 90(4), 255-264.
https://hdl.handle.net/21.15107/rcub_farfar_1885

Pavlović DR, Tasić-Kostov M, Marčetić M, Lakušić B, Kitić D, Savić S, Kovačević N. Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts. in RSC Advances. 2013;90(4):255-264.
https://hdl.handle.net/21.15107/rcub_farfar_1885 .

Pavlović, Dragana R., Tasić-Kostov, Marija, Marčetić, Mirjana, Lakušić, Branislava, Kitić, Dušanka, Savić, Snežana, Kovačević, Nada, "Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts" in RSC Advances, 90, no. 4 (2013):255-264,
https://hdl.handle.net/21.15107/rcub_farfar_1885 .

TY  - JOUR
AU  - Tasić-Kostov, Marija
AU  - Pavlović, Dragana R.
AU  - Lukić, Milica
AU  - Jaksić, I.
AU  - Arsić, I.
AU  - Savić, Snežana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1643
AB  - Synopsis Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The a-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for a-tocopherol in the same vehicle.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Cosmetic Science
T1  - Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation
VL  - 34
IS  - 5
SP  - 424
EP  - 434
DO  - 10.1111/j.1468-2494.2012.00732.x
ER  - 

@article{
author = "Tasić-Kostov, Marija and Pavlović, Dragana R. and Lukić, Milica and Jaksić, I. and Arsić, I. and Savić, Snežana",
year = "2012",
abstract = "Synopsis Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The a-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for a-tocopherol in the same vehicle.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Cosmetic Science",
title = "Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation",
volume = "34",
number = "5",
pages = "424-434",
doi = "10.1111/j.1468-2494.2012.00732.x"
}

Tasić-Kostov, M., Pavlović, D. R., Lukić, M., Jaksić, I., Arsić, I.,& Savić, S.. (2012). Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation. in International Journal of Cosmetic Science
Wiley-Blackwell, Hoboken., 34(5), 424-434.
https://doi.org/10.1111/j.1468-2494.2012.00732.x

Tasić-Kostov M, Pavlović DR, Lukić M, Jaksić I, Arsić I, Savić S. Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation. in International Journal of Cosmetic Science. 2012;34(5):424-434.
doi:10.1111/j.1468-2494.2012.00732.x .

Tasić-Kostov, Marija, Pavlović, Dragana R., Lukić, Milica, Jaksić, I., Arsić, I., Savić, Snežana, "Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation" in International Journal of Cosmetic Science, 34, no. 5 (2012):424-434,
https://doi.org/10.1111/j.1468-2494.2012.00732.x . .

TY  - JOUR
AU  - Pavlović, Dragana R.
AU  - Branković, Suzana
AU  - Kovačević, Nada
AU  - Kitić, Dušanka
AU  - Veljković, Slavimir
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1574
AB  - Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p  lt  0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was higher in dry plant material collected in Montenegro. Copyright
PB  - Wiley-Blackwell, Malden
T2  - Phytotherapy Research
T1  - Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece
VL  - 25
IS  - 5
SP  - 749
EP  - 754
DO  - 10.1002/ptr.3460
ER  - 

@article{
author = "Pavlović, Dragana R. and Branković, Suzana and Kovačević, Nada and Kitić, Dušanka and Veljković, Slavimir",
year = "2011",
abstract = "Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p  lt  0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was higher in dry plant material collected in Montenegro. Copyright",
publisher = "Wiley-Blackwell, Malden",
journal = "Phytotherapy Research",
title = "Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece",
volume = "25",
number = "5",
pages = "749-754",
doi = "10.1002/ptr.3460"
}

Pavlović, D. R., Branković, S., Kovačević, N., Kitić, D.,& Veljković, S.. (2011). Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece. in Phytotherapy Research
Wiley-Blackwell, Malden., 25(5), 749-754.
https://doi.org/10.1002/ptr.3460

Pavlović DR, Branković S, Kovačević N, Kitić D, Veljković S. Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece. in Phytotherapy Research. 2011;25(5):749-754.
doi:10.1002/ptr.3460 .

Pavlović, Dragana R., Branković, Suzana, Kovačević, Nada, Kitić, Dušanka, Veljković, Slavimir, "Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece" in Phytotherapy Research, 25, no. 5 (2011):749-754,
https://doi.org/10.1002/ptr.3460 . .

TY  - JOUR
AU  - Pavlović, Dragana R.
AU  - Vuleta, Gordana
AU  - Kovačević, Nada
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1440
AB  - Herbal medicinal products and traditional herbal medicinal products consist of one or more herbal drugs (substances) and/or herbal drug preparations (herbal preparations). The main request for the quality of herbal drugs and herbal drug preparations are given in the pharmacopoeias. This paper deals with comparative analyses of the monographs for the active constituents of herbal products/traditional herbal products which are presented in the European Pharmacopoeia sixth edition (Ph.Eur.6.0) and Yugoslav pharmacopoeia 2000. (Ph.Jug.V). Ph.Eur.6.0 contains general monographs for Herbal drugs, Herbal drug preparations and Extracts (Tinctures, Liquid extracts, Dry extracts and Soft extracts). Further, Ph.Eur.6.0 contains monographs about Herbal teas. Ph.Jug.V contains only general monographs for Extracts and Tinctures. Both pharmacopoeias, in the first part and through the general monographs define some methods and procedures for the herbal drugs/herbal drugs preparations testing and assessment. The values of different parameters are given in the general monographs of herbal drugs/herbal drugs preparations or in the individual monographs. In both documents, without some important differences, procedures for some test and parameters are given in the part 2. Methods of analyses within chapters 2.1. Apparatus, 2.2. Physical and physicochemical methods, 2.4. Limit tests, 2.5. Assays, 2.6. Biological test and 2.8. Methods in pharmacognosy. Regarding health safety, in addition to microbiological safety, Ph.Eur.6.0 as well as Ph.Jug.V requires testing on heavy metals, pesticides and radioactivity. Further, Ph.Eur.6.0 requests confirmation that starting material is free from myco-toxins (aflatoxin) and viruses (for animal drugs). The presence of general monographs for Herbal drugs, Herbal drug preparations, Extracts and Herbal teas in the Ph.Eur.6.0 enable quality control during the process of production of herbal medicinal products/traditional herbal medicinal products: control of row material, interphase control and control of final products. General monographs in the Ph.Eur.6.0 can bee apply for the control of the un-officinal herbal drugs. This is very important for improvement of the production process and quality of products, as well as for the inspection of herbal medicinal products/traditional herbal medicinal products taken from the market.
AB  - Biljni lekovi i tradicionalni biljni lekovi, kao aktivne sastojke, sadrže biljne droge i/ili preparate biljnih droga, pojedinačne ili u kombinaciji. Osnovni elementi i zahtevi za kvalitet, pogotovo aktivnih komponenti, definisani su u farmakopejama. Evropska farmakopeja, šesto izdanje (Evropska farmakopeja 6.0; Ph.Eur.6.0) sadrži opšte monografije za biljne droge, preparate biljnih droga i ekstrakte (sa podelom na tinkture, tečne, meke i suve ekstrakte). Takođe, Ph.Eur.6.0 sadrži monografiju o biljnim čajevima. Jugoslovenska farmakopeja 2000 (Ph.Jug.V) sadrži opšte monografije samo za ekstrakte i za tinkture. Obe farmakopeje, kroz uvodni deo i u opštim monografijama, definišu određene postupke i metode za ispitivanje biljnih droga i preparata biljnih droga. Vrednosti za određene parametre dati su ili kroz opšte monografije ili u okviru svake pojedinačne monografije za konkretnu biljnu drogu ili preparat biljne droge. U obe farmakopeje, bez značajnijih razlika, sam postupak određivanja vrednosti parametara je definisan u delu 2. Metode analize u okviru poglavlja 2.1. Aparature, 2.2. Fizičke i fizičko-hemijske metode, 2.4. Ispitivanja dozvoljenih graničnih vrednosti, 2.5. Određivanja, 2.6.0 Biološki testovi i 2.8. Metode u farmakognoziji. Sa aspekta zdravstvene ispravnosti, Ph.Eur.6.0 i Ph.Jug.V zahtevaju proveru mikrobiološkog kvaliteta i ostataka pesticida, kao i određivanje sadržaja teških metala. Ph.Eur.6.0 zahteva i testove na prisustvo mikotoksina (aflatoksina) i virusa (kada se kao sirovina koristi materijal životinjskog porekla). Uvođenjem opštih monografija za biljne droge, preparate biljnih droga, ekstrakte i biljne čajeve, Ph.Eur.6.0 daje bolju osnovu i pristup kontroli biljne sirovine, međuproizvoda i finalnih proizvoda, što olakšava rad tokom procesa proizvodnje i kontrolu uzoraka na tržištu. Evropska farmakopeja omogućuje upotrebu i kontrolu značajno većeg broja prirodnih sirovina, odnosno i biljnih droga koje nisu oficijalne. Na ove biljne droge se mogu primeniti parametri definisani kroz opšte monografije, ali i pristup identifikaciji (preko definisanja njihovih makroskopskih, mikroskopskih i hemijskih karakteristika) i kontrola kvaliteta što je preciznije definisano u pojedinačnim monografijama biljnih droga i preparata.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Comparative review of the requirements of the European pharmacopoeia 6.0 and the pharmacopea Yugoslavia 2000 for herbal drugs and herbal drug preparations
T1  - Uporedni pregled zahteva Evropske farmakopeje 6.0 i Jugoslovenske farmakopeje 2000 za kvalitet biljnih droga i preparata biljnih droga
VL  - 60
IS  - 6
SP  - 1274
EP  - 1294
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1440
ER  - 

@article{
author = "Pavlović, Dragana R. and Vuleta, Gordana and Kovačević, Nada",
year = "2010",
abstract = "Herbal medicinal products and traditional herbal medicinal products consist of one or more herbal drugs (substances) and/or herbal drug preparations (herbal preparations). The main request for the quality of herbal drugs and herbal drug preparations are given in the pharmacopoeias. This paper deals with comparative analyses of the monographs for the active constituents of herbal products/traditional herbal products which are presented in the European Pharmacopoeia sixth edition (Ph.Eur.6.0) and Yugoslav pharmacopoeia 2000. (Ph.Jug.V). Ph.Eur.6.0 contains general monographs for Herbal drugs, Herbal drug preparations and Extracts (Tinctures, Liquid extracts, Dry extracts and Soft extracts). Further, Ph.Eur.6.0 contains monographs about Herbal teas. Ph.Jug.V contains only general monographs for Extracts and Tinctures. Both pharmacopoeias, in the first part and through the general monographs define some methods and procedures for the herbal drugs/herbal drugs preparations testing and assessment. The values of different parameters are given in the general monographs of herbal drugs/herbal drugs preparations or in the individual monographs. In both documents, without some important differences, procedures for some test and parameters are given in the part 2. Methods of analyses within chapters 2.1. Apparatus, 2.2. Physical and physicochemical methods, 2.4. Limit tests, 2.5. Assays, 2.6. Biological test and 2.8. Methods in pharmacognosy. Regarding health safety, in addition to microbiological safety, Ph.Eur.6.0 as well as Ph.Jug.V requires testing on heavy metals, pesticides and radioactivity. Further, Ph.Eur.6.0 requests confirmation that starting material is free from myco-toxins (aflatoxin) and viruses (for animal drugs). The presence of general monographs for Herbal drugs, Herbal drug preparations, Extracts and Herbal teas in the Ph.Eur.6.0 enable quality control during the process of production of herbal medicinal products/traditional herbal medicinal products: control of row material, interphase control and control of final products. General monographs in the Ph.Eur.6.0 can bee apply for the control of the un-officinal herbal drugs. This is very important for improvement of the production process and quality of products, as well as for the inspection of herbal medicinal products/traditional herbal medicinal products taken from the market., Biljni lekovi i tradicionalni biljni lekovi, kao aktivne sastojke, sadrže biljne droge i/ili preparate biljnih droga, pojedinačne ili u kombinaciji. Osnovni elementi i zahtevi za kvalitet, pogotovo aktivnih komponenti, definisani su u farmakopejama. Evropska farmakopeja, šesto izdanje (Evropska farmakopeja 6.0; Ph.Eur.6.0) sadrži opšte monografije za biljne droge, preparate biljnih droga i ekstrakte (sa podelom na tinkture, tečne, meke i suve ekstrakte). Takođe, Ph.Eur.6.0 sadrži monografiju o biljnim čajevima. Jugoslovenska farmakopeja 2000 (Ph.Jug.V) sadrži opšte monografije samo za ekstrakte i za tinkture. Obe farmakopeje, kroz uvodni deo i u opštim monografijama, definišu određene postupke i metode za ispitivanje biljnih droga i preparata biljnih droga. Vrednosti za određene parametre dati su ili kroz opšte monografije ili u okviru svake pojedinačne monografije za konkretnu biljnu drogu ili preparat biljne droge. U obe farmakopeje, bez značajnijih razlika, sam postupak određivanja vrednosti parametara je definisan u delu 2. Metode analize u okviru poglavlja 2.1. Aparature, 2.2. Fizičke i fizičko-hemijske metode, 2.4. Ispitivanja dozvoljenih graničnih vrednosti, 2.5. Određivanja, 2.6.0 Biološki testovi i 2.8. Metode u farmakognoziji. Sa aspekta zdravstvene ispravnosti, Ph.Eur.6.0 i Ph.Jug.V zahtevaju proveru mikrobiološkog kvaliteta i ostataka pesticida, kao i određivanje sadržaja teških metala. Ph.Eur.6.0 zahteva i testove na prisustvo mikotoksina (aflatoksina) i virusa (kada se kao sirovina koristi materijal životinjskog porekla). Uvođenjem opštih monografija za biljne droge, preparate biljnih droga, ekstrakte i biljne čajeve, Ph.Eur.6.0 daje bolju osnovu i pristup kontroli biljne sirovine, međuproizvoda i finalnih proizvoda, što olakšava rad tokom procesa proizvodnje i kontrolu uzoraka na tržištu. Evropska farmakopeja omogućuje upotrebu i kontrolu značajno većeg broja prirodnih sirovina, odnosno i biljnih droga koje nisu oficijalne. Na ove biljne droge se mogu primeniti parametri definisani kroz opšte monografije, ali i pristup identifikaciji (preko definisanja njihovih makroskopskih, mikroskopskih i hemijskih karakteristika) i kontrola kvaliteta što je preciznije definisano u pojedinačnim monografijama biljnih droga i preparata.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Comparative review of the requirements of the European pharmacopoeia 6.0 and the pharmacopea Yugoslavia 2000 for herbal drugs and herbal drug preparations, Uporedni pregled zahteva Evropske farmakopeje 6.0 i Jugoslovenske farmakopeje 2000 za kvalitet biljnih droga i preparata biljnih droga",
volume = "60",
number = "6",
pages = "1274-1294",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1440"
}

Pavlović, D. R., Vuleta, G.,& Kovačević, N.. (2010). Comparative review of the requirements of the European pharmacopoeia 6.0 and the pharmacopea Yugoslavia 2000 for herbal drugs and herbal drug preparations. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 60(6), 1274-1294.
https://hdl.handle.net/21.15107/rcub_farfar_1440

Pavlović DR, Vuleta G, Kovačević N. Comparative review of the requirements of the European pharmacopoeia 6.0 and the pharmacopea Yugoslavia 2000 for herbal drugs and herbal drug preparations. in Arhiv za farmaciju. 2010;60(6):1274-1294.
https://hdl.handle.net/21.15107/rcub_farfar_1440 .

Pavlović, Dragana R., Vuleta, Gordana, Kovačević, Nada, "Comparative review of the requirements of the European pharmacopoeia 6.0 and the pharmacopea Yugoslavia 2000 for herbal drugs and herbal drug preparations" in Arhiv za farmaciju, 60, no. 6 (2010):1274-1294,
https://hdl.handle.net/21.15107/rcub_farfar_1440 .