TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Radoman Vujačić, Irena
AU  - Kostadinović, Jelena
AU  - Patoulias, Dimitrios
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5576
AB  - OBJECTIVE: Although it is assumed that novel-derived anthropometric indices can better reflect cardiometabolic risk than traditional ones, the results are conflicting. Previous studies have mainly focused on patients with type 2 diabetes mellitus. However, studies conducted on populations with prediabetes are scarce. The present study aimed to examine the potential relationship between prediabetes and novel anthropometric parameters [that is, cardiometabolic index (CMI), visceral adiposity index (VAI), lipid accumulation product index (LAP), body roundness index (BRI), and body adiposity index (BAI)] and traditional parameters [that is, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR)] in adults with prediabetes. PATIENTS AND METHODS: This case-control cross-sectional study included 177 patients with prediabetes and 609 control subjects. Biochemical and simple anthropometric parameters were measured (WC, HC, body weight, and height), whereas the other parameters were calculated. RESULTS: WC, CMI, VAI, and LAP independently correlated with prediabetes. Principal component analysis (PCA) was used to extract several factors that correlated with prediabetes. Significant predictive capability was demonstrated for non-traditional anthropometric/lipid-related factors and WHipR-related factors for prediabetes (OR=1.334 and OR=1.202, respectively). However, only non-traditional anthropometric/lipid-related factors (i.e., VAI, CMI, and LAP) demonstrated an independent significant positive relationship with prediabetes in multivariate binary regression analysis. CONCLUSIONS: CMI, VAI, and LAP could be superior to BAI, BRI, and conventional anthropometric parameters for discriminating patients with prediabetes in the adult population. Prospective trials are needed to confirm our results.
PB  - TREND MD
T2  - European review for medical and pharmacological sciences
T1  - Novel anthropometric parameters in the adult population with prediabetes
VL  - 27
IS  - 22
SP  - 11063
EP  - 11072
DO  - 10.26355/eurrev_202311_34475
ER  - 

@article{
author = "Klisić, Aleksandra and Radoman Vujačić, Irena and Kostadinović, Jelena and Patoulias, Dimitrios and Ninić, Ana",
year = "2023",
abstract = "OBJECTIVE: Although it is assumed that novel-derived anthropometric indices can better reflect cardiometabolic risk than traditional ones, the results are conflicting. Previous studies have mainly focused on patients with type 2 diabetes mellitus. However, studies conducted on populations with prediabetes are scarce. The present study aimed to examine the potential relationship between prediabetes and novel anthropometric parameters [that is, cardiometabolic index (CMI), visceral adiposity index (VAI), lipid accumulation product index (LAP), body roundness index (BRI), and body adiposity index (BAI)] and traditional parameters [that is, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR)] in adults with prediabetes. PATIENTS AND METHODS: This case-control cross-sectional study included 177 patients with prediabetes and 609 control subjects. Biochemical and simple anthropometric parameters were measured (WC, HC, body weight, and height), whereas the other parameters were calculated. RESULTS: WC, CMI, VAI, and LAP independently correlated with prediabetes. Principal component analysis (PCA) was used to extract several factors that correlated with prediabetes. Significant predictive capability was demonstrated for non-traditional anthropometric/lipid-related factors and WHipR-related factors for prediabetes (OR=1.334 and OR=1.202, respectively). However, only non-traditional anthropometric/lipid-related factors (i.e., VAI, CMI, and LAP) demonstrated an independent significant positive relationship with prediabetes in multivariate binary regression analysis. CONCLUSIONS: CMI, VAI, and LAP could be superior to BAI, BRI, and conventional anthropometric parameters for discriminating patients with prediabetes in the adult population. Prospective trials are needed to confirm our results.",
publisher = "TREND MD",
journal = "European review for medical and pharmacological sciences",
title = "Novel anthropometric parameters in the adult population with prediabetes",
volume = "27",
number = "22",
pages = "11063-11072",
doi = "10.26355/eurrev_202311_34475"
}

Klisić, A., Radoman Vujačić, I., Kostadinović, J., Patoulias, D.,& Ninić, A.. (2023). Novel anthropometric parameters in the adult population with prediabetes. in European review for medical and pharmacological sciences
TREND MD., 27(22), 11063-11072.
https://doi.org/10.26355/eurrev_202311_34475

Klisić A, Radoman Vujačić I, Kostadinović J, Patoulias D, Ninić A. Novel anthropometric parameters in the adult population with prediabetes. in European review for medical and pharmacological sciences. 2023;27(22):11063-11072.
doi:10.26355/eurrev_202311_34475 .

Klisić, Aleksandra, Radoman Vujačić, Irena, Kostadinović, Jelena, Patoulias, Dimitrios, Ninić, Ana, "Novel anthropometric parameters in the adult population with prediabetes" in European review for medical and pharmacological sciences, 27, no. 22 (2023):11063-11072,
https://doi.org/10.26355/eurrev_202311_34475 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Radoman-Vujačić, Irena
AU  - Kostadinović, Jelena
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5360
AB  - Background: To our knowledge, the mutual involvement of a variety of metabolic and renal biomarkers and vitamin D (determined as 25-hydroxyvitamin D [25(OH)D]) in postmenopausal women has not been examined yet. Therefore, we aimed to explore such a relationship by a thorough statistical multimarker approach. Methods: A total of 150 (diabetes and cardiovascular disease-free) postmenopausal women were included. Anthropometric and biochemical parameters were measured. The fatty liver index (FLI) and Homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. Univariate and multivariate binary logistic regression analyses were used to test the predictions of cardiometabolic markers for [25(OH)D] status. Principal component analysis (PCA) was applied to explore the effect of examined biomarkers on [25(OH)D] status. Results: Univariate binary regression analysis revealed positive associations between FLI and [25(OH)D] [OR=1.036 (1.020–1.052), P<0.001] and HOMA-IR with [25(OH)D] [OR=2.385 (1.601–3.551), P<0.001]. Multivariate logistic regression analysis with backward selection enabled us to find the best model consisted of two markers, i.e. FLI [OR=1.032 (1.016–1.048), P<0.001] and glucose [OR=2.167 (1.001–4.693), P=0.050] associated with the first tertile of [25(OH)D]. PCA extracted 2 significant factors: Renal function-related factor and Metabolic syndrome-related factor. Renal function-related factor [i.e. creatinine, uric acid, retinol-binding protein 4 (RBP4) and cystatin C] explained 29% of the variance. Also, Metabolic syndrome-related factor (i.e. HOMA-IR, FLI, hsCRP and fibrinogen) explained 29% of the variance of the tested parameters. Moreover, binary logistic regression analysis revealed significant positive predictive ability of both factors, i.e. Renal function-related factor and Metabolic syndrome-related factor (P=0.044 and P<0.001, respectively) towards [25(OH)D] status.
Conclusion: The joint involvement of renal function
biomarkers and metabolic syndrome-related features (i.e.
insulin resistance, inflammation and non-alcoholic fatty
liver disease) can differentiate postmenopausal women
with lower [25(OH)D] levels from other women.
AB  - Uvod: Prema našem saznanju zajednički uticaj različitih
metaboličkih i renalnih biomarkera na nivo vitamin D
(odre|enog kao 25-hidroksivitamin D [25(OH)D]) kod
žena u postmenopauzi još uvijek nije ispitivan. Stoga je cilj
istraživanja bio da se ispita povezanost ovih biomarkera
primenom temeljne statističke analize koja uključuje više
navedenih biomarkera.
Metode: Ukupno 150 žena u postmenopauzi (koje nemaju
dijabetes, ni kardiovaskularna oboljenja) je uključeno u
istraživanje. Mereni su antropometrijski i biohemijski parametri. Indeks masne jetre (FLI) i indeks insulinske rezistencije (HOMA-IR) su izračunati. Univarijantna i multivarijantna
binarna logistička regresija su primenjene da bi se odredili
kardiometabolički prediktori nivoa [25(OH)D].
Rezultati: Univarijantna binarna regresiona analiza je
pokazala pozitivnu korelaciju izme|u FLI i [25(OH)D]
[OR=1.036 (1.020–1.052), P<0,001] i HOMA-IR sa
[25(OH)D] [OR=2.385 (1.601–3.551), P<0,001].
Multivarijantna logistička regresiona analiza je pokazala
najbolji model sa 2 markera, tj. FLI [OR=1.032 (1.016–
1.048), P<0,001] i glukoza [OR=2.167 (1.001–4.693),
P=0,050] koji su korelirali sa prvom tercilom vrednosti
[25(OH)D]. PCA je izdvojila 2 značajna faktora: Renal
function-related faktor i Metabolic syndrome-related faktor.
Renal function-related faktor [tj. kreatinin, mokraćna kiselina, retinolvezujui protein 4 (RBP4) i cistatin C] su
objasnili 29% varijanse. Takođe, Metabolic syndrome-
related faktor (tj. HOMA-IR, FLI, hsCRP i fibrinogen) su
objasnili 29% varijanse ispitivanih parametara. štaviše,
binarna logistička regresiona analiza je pokazala pozitivnu
prediktivnu sposobnost oba faktora, tj. Renal function-
related faktora i Metabolic syndrome-related faktora
(P=0,044 i P<0,001) za nivo [25(OH)D].
Zaključak: Zajedničko dejstvo renalnih biomarkera i
markera metaboličkog sindroma (tj. insulinska rezistencija,
inflamacija i nealkoholna steatoza jetre) mogu diferencirati
žene u postmenopauzi sa nižim nivoom [25(OH)D] u
odnosu na ostale žene.
PB  - Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women
T1  - Korelacija renalnih i metaboličkih biomarkera sa nivoom vitamina D kod žena u postmenopauzi
VL  - 42
IS  - 4
SP  - 565
EP  - 573
DO  - 10.5937/jomb0-41044
ER  - 

@article{
author = "Klisić, Aleksandra and Radoman-Vujačić, Irena and Kostadinović, Jelena and Ninić, Ana",
year = "2023",
abstract = "Background: To our knowledge, the mutual involvement of a variety of metabolic and renal biomarkers and vitamin D (determined as 25-hydroxyvitamin D [25(OH)D]) in postmenopausal women has not been examined yet. Therefore, we aimed to explore such a relationship by a thorough statistical multimarker approach. Methods: A total of 150 (diabetes and cardiovascular disease-free) postmenopausal women were included. Anthropometric and biochemical parameters were measured. The fatty liver index (FLI) and Homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. Univariate and multivariate binary logistic regression analyses were used to test the predictions of cardiometabolic markers for [25(OH)D] status. Principal component analysis (PCA) was applied to explore the effect of examined biomarkers on [25(OH)D] status. Results: Univariate binary regression analysis revealed positive associations between FLI and [25(OH)D] [OR=1.036 (1.020–1.052), P<0.001] and HOMA-IR with [25(OH)D] [OR=2.385 (1.601–3.551), P<0.001]. Multivariate logistic regression analysis with backward selection enabled us to find the best model consisted of two markers, i.e. FLI [OR=1.032 (1.016–1.048), P<0.001] and glucose [OR=2.167 (1.001–4.693), P=0.050] associated with the first tertile of [25(OH)D]. PCA extracted 2 significant factors: Renal function-related factor and Metabolic syndrome-related factor. Renal function-related factor [i.e. creatinine, uric acid, retinol-binding protein 4 (RBP4) and cystatin C] explained 29% of the variance. Also, Metabolic syndrome-related factor (i.e. HOMA-IR, FLI, hsCRP and fibrinogen) explained 29% of the variance of the tested parameters. Moreover, binary logistic regression analysis revealed significant positive predictive ability of both factors, i.e. Renal function-related factor and Metabolic syndrome-related factor (P=0.044 and P<0.001, respectively) towards [25(OH)D] status.
Conclusion: The joint involvement of renal function
biomarkers and metabolic syndrome-related features (i.e.
insulin resistance, inflammation and non-alcoholic fatty
liver disease) can differentiate postmenopausal women
with lower [25(OH)D] levels from other women., Uvod: Prema našem saznanju zajednički uticaj različitih
metaboličkih i renalnih biomarkera na nivo vitamin D
(odre|enog kao 25-hidroksivitamin D [25(OH)D]) kod
žena u postmenopauzi još uvijek nije ispitivan. Stoga je cilj
istraživanja bio da se ispita povezanost ovih biomarkera
primenom temeljne statističke analize koja uključuje više
navedenih biomarkera.
Metode: Ukupno 150 žena u postmenopauzi (koje nemaju
dijabetes, ni kardiovaskularna oboljenja) je uključeno u
istraživanje. Mereni su antropometrijski i biohemijski parametri. Indeks masne jetre (FLI) i indeks insulinske rezistencije (HOMA-IR) su izračunati. Univarijantna i multivarijantna
binarna logistička regresija su primenjene da bi se odredili
kardiometabolički prediktori nivoa [25(OH)D].
Rezultati: Univarijantna binarna regresiona analiza je
pokazala pozitivnu korelaciju izme|u FLI i [25(OH)D]
[OR=1.036 (1.020–1.052), P<0,001] i HOMA-IR sa
[25(OH)D] [OR=2.385 (1.601–3.551), P<0,001].
Multivarijantna logistička regresiona analiza je pokazala
najbolji model sa 2 markera, tj. FLI [OR=1.032 (1.016–
1.048), P<0,001] i glukoza [OR=2.167 (1.001–4.693),
P=0,050] koji su korelirali sa prvom tercilom vrednosti
[25(OH)D]. PCA je izdvojila 2 značajna faktora: Renal
function-related faktor i Metabolic syndrome-related faktor.
Renal function-related faktor [tj. kreatinin, mokraćna kiselina, retinolvezujui protein 4 (RBP4) i cistatin C] su
objasnili 29% varijanse. Takođe, Metabolic syndrome-
related faktor (tj. HOMA-IR, FLI, hsCRP i fibrinogen) su
objasnili 29% varijanse ispitivanih parametara. štaviše,
binarna logistička regresiona analiza je pokazala pozitivnu
prediktivnu sposobnost oba faktora, tj. Renal function-
related faktora i Metabolic syndrome-related faktora
(P=0,044 i P<0,001) za nivo [25(OH)D].
Zaključak: Zajedničko dejstvo renalnih biomarkera i
markera metaboličkog sindroma (tj. insulinska rezistencija,
inflamacija i nealkoholna steatoza jetre) mogu diferencirati
žene u postmenopauzi sa nižim nivoom [25(OH)D] u
odnosu na ostale žene.",
publisher = "Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women, Korelacija renalnih i metaboličkih biomarkera sa nivoom vitamina D kod žena u postmenopauzi",
volume = "42",
number = "4",
pages = "565-573",
doi = "10.5937/jomb0-41044"
}

Klisić, A., Radoman-Vujačić, I., Kostadinović, J.,& Ninić, A.. (2023). The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women. in Journal of Medical Biochemistry
Society of Medical Biochemists of Serbia., 42(4), 565-573.
https://doi.org/10.5937/jomb0-41044

Klisić A, Radoman-Vujačić I, Kostadinović J, Ninić A. The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women. in Journal of Medical Biochemistry. 2023;42(4):565-573.
doi:10.5937/jomb0-41044 .

Klisić, Aleksandra, Radoman-Vujačić, Irena, Kostadinović, Jelena, Ninić, Ana, "The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women" in Journal of Medical Biochemistry, 42, no. 4 (2023):565-573,
https://doi.org/10.5937/jomb0-41044 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Malenica, Maja
AU  - Kostadinović, Jelena
AU  - Kocić, Gordana
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4646
AB  - Background: Given the fact that the studies that examined
oxidative stress in relation to obesity that included late
adolescents are scarce and show inconclusive results we
aimed to investigate a wide spectrum of nitro-oxidative
stress biomarkers  i.e., malondialdehyde (MDA), xanthine
oxidase (XO), xanthine oxidoreductase (XOD), xanthine
dehydrogenase (XDH), advanced oxidation protein
products (AOPP) and nitric oxide products (NOx), as well
as an antioxidative enzyme, i.e., catalase (CAT)  in relation
with obesity in the cohort of adolescent girls ages between
16 and 19 years old.
Methods: A total of 59 teenage girls were included in this
cross-sectional study. Binary logistic regression analysis was
performed to examine possible associations between bio-
chemical and nitro-oxidative stress markers and body mass
index (BMI).
Results: There were not significant differences between
oxidative stress markers between normal weight and
overweight/obese girls (i.e., AOPP, XOD, XO, XDH) and
CAT, except for MDA (p<0.001) and NOx (p=0.010)
concentrations which were significantly higher in overweight/obese adolescent girls. Positive associations
were evident between BMI and high sensitivity C-reactive
protein (hsCRP) (OR=2.495), BMI and uric acid
(OR=1.024) and BMI and MDA (OR=1.062).
Multivariable binary regression analysis demonstrated sig-
nificant independent associations of BMI and hsCRP
(OR=2.150) and BMI and MDA (OR=1.105). Even
76.3% of the variation in BMI could be explained with this
Model.
Conclusions: Inflammation (as measured with hsCRP) and
oxidative stress (as determined with MDA) independently
correlated with BMI in teenage girls.
AB  - Uvod: Imajući u vidu činjenicu da je malo studija koje su ispitivale povezanost oksidativnog stresa i gojaznosti kod adolescenata i da iste pokazuju oprečne rezultate, cilj istraživanja je bio da se ispita povezanost širokog spektra biomarkera nitro-oksidativnog stresa tj. malondialdehida (MDA), ksantin oksidaze (XO), ksantin oksidoreduktaze (XOD), ksantin dehidrogenaze (XDH), produkata uznapredovale oksidacije proteina (AOPP) i produkata azot-monoksida (NOx), kao i enzima antioksidativne zaštite, tj. katalaze (CAT) i gojaznosti u kohorti adolescentkinja starosne dobi izme|u 16 i 19 godina. Metode: Ukupno 59 tinejdžerki je uključeno u ovu studiju preseka. Binarna logistička regresija je primenjena u cilju ispitivanja potencijalne povezanosti između biohemijskih markera i markera nitro-oksidativnog stresa i indeksa telesne mase (ITM). Rezultati: Nije uočena razlika u biomarkerima oksidativnog stresa između normalno uhranjenih i predgojaznih/gojaznih adolescentkinja (odnosno AOPP, XOD, XO, XDH) i CAT, osim u vrednostima MDA (p<0,001) i NOx (p=0,010) koje su bile značajno veće kod predgojaznih/gojaznih adolescentkinja. Pozitivna korelacija je utvrđena izme|u ITM-a i visokosenzitivnog C-reaktivnog proteina (hsCRP) (OR=2,495), ITM-a i mokraćne kiseline (OR=1,024) i ITM-a i MDA (OR=1,062). Multivarijanta binarna regresija je pokazala nezavisnu povezanost ITM-a i hsCRP (OR=2,150), kao i ITM-a i MDA (OR=1,105). Čak 76,3% varijabiliteta ITM-a može biti objašnjeno ovim modelom. Zaključak: Inflamacija (merena hsCRP-om) i oksidativni stres (meren malondialdehidom) nezavisno koreliraju sa ITM kod adolescentkinja.
PB  - Društvo medicinskih biohemičara Srbije, Beograd
T2  - Journal of Medical Biochemistry
T1  - Malondialdehyde as an independent predictor of body mass index in adolescent girls
T1  - Malondialdehid kao nezavisan prediktor indeksa telesne mase kod adolescentkinja
VL  - 42
IS  - 2
SP  - 224
EP  - 231
DO  - 10.5937/jomb0-39044
ER  - 

@article{
author = "Klisić, Aleksandra and Malenica, Maja and Kostadinović, Jelena and Kocić, Gordana and Ninić, Ana",
year = "2023",
abstract = "Background: Given the fact that the studies that examined
oxidative stress in relation to obesity that included late
adolescents are scarce and show inconclusive results we
aimed to investigate a wide spectrum of nitro-oxidative
stress biomarkers  i.e., malondialdehyde (MDA), xanthine
oxidase (XO), xanthine oxidoreductase (XOD), xanthine
dehydrogenase (XDH), advanced oxidation protein
products (AOPP) and nitric oxide products (NOx), as well
as an antioxidative enzyme, i.e., catalase (CAT)  in relation
with obesity in the cohort of adolescent girls ages between
16 and 19 years old.
Methods: A total of 59 teenage girls were included in this
cross-sectional study. Binary logistic regression analysis was
performed to examine possible associations between bio-
chemical and nitro-oxidative stress markers and body mass
index (BMI).
Results: There were not significant differences between
oxidative stress markers between normal weight and
overweight/obese girls (i.e., AOPP, XOD, XO, XDH) and
CAT, except for MDA (p<0.001) and NOx (p=0.010)
concentrations which were significantly higher in overweight/obese adolescent girls. Positive associations
were evident between BMI and high sensitivity C-reactive
protein (hsCRP) (OR=2.495), BMI and uric acid
(OR=1.024) and BMI and MDA (OR=1.062).
Multivariable binary regression analysis demonstrated sig-
nificant independent associations of BMI and hsCRP
(OR=2.150) and BMI and MDA (OR=1.105). Even
76.3% of the variation in BMI could be explained with this
Model.
Conclusions: Inflammation (as measured with hsCRP) and
oxidative stress (as determined with MDA) independently
correlated with BMI in teenage girls., Uvod: Imajući u vidu činjenicu da je malo studija koje su ispitivale povezanost oksidativnog stresa i gojaznosti kod adolescenata i da iste pokazuju oprečne rezultate, cilj istraživanja je bio da se ispita povezanost širokog spektra biomarkera nitro-oksidativnog stresa tj. malondialdehida (MDA), ksantin oksidaze (XO), ksantin oksidoreduktaze (XOD), ksantin dehidrogenaze (XDH), produkata uznapredovale oksidacije proteina (AOPP) i produkata azot-monoksida (NOx), kao i enzima antioksidativne zaštite, tj. katalaze (CAT) i gojaznosti u kohorti adolescentkinja starosne dobi izme|u 16 i 19 godina. Metode: Ukupno 59 tinejdžerki je uključeno u ovu studiju preseka. Binarna logistička regresija je primenjena u cilju ispitivanja potencijalne povezanosti između biohemijskih markera i markera nitro-oksidativnog stresa i indeksa telesne mase (ITM). Rezultati: Nije uočena razlika u biomarkerima oksidativnog stresa između normalno uhranjenih i predgojaznih/gojaznih adolescentkinja (odnosno AOPP, XOD, XO, XDH) i CAT, osim u vrednostima MDA (p<0,001) i NOx (p=0,010) koje su bile značajno veće kod predgojaznih/gojaznih adolescentkinja. Pozitivna korelacija je utvrđena izme|u ITM-a i visokosenzitivnog C-reaktivnog proteina (hsCRP) (OR=2,495), ITM-a i mokraćne kiseline (OR=1,024) i ITM-a i MDA (OR=1,062). Multivarijanta binarna regresija je pokazala nezavisnu povezanost ITM-a i hsCRP (OR=2,150), kao i ITM-a i MDA (OR=1,105). Čak 76,3% varijabiliteta ITM-a može biti objašnjeno ovim modelom. Zaključak: Inflamacija (merena hsCRP-om) i oksidativni stres (meren malondialdehidom) nezavisno koreliraju sa ITM kod adolescentkinja.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd",
journal = "Journal of Medical Biochemistry",
title = "Malondialdehyde as an independent predictor of body mass index in adolescent girls, Malondialdehid kao nezavisan prediktor indeksa telesne mase kod adolescentkinja",
volume = "42",
number = "2",
pages = "224-231",
doi = "10.5937/jomb0-39044"
}

Klisić, A., Malenica, M., Kostadinović, J., Kocić, G.,& Ninić, A.. (2023). Malondialdehyde as an independent predictor of body mass index in adolescent girls. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd., 42(2), 224-231.
https://doi.org/10.5937/jomb0-39044

Klisić A, Malenica M, Kostadinović J, Kocić G, Ninić A. Malondialdehyde as an independent predictor of body mass index in adolescent girls. in Journal of Medical Biochemistry. 2023;42(2):224-231.
doi:10.5937/jomb0-39044 .

Klisić, Aleksandra, Malenica, Maja, Kostadinović, Jelena, Kocić, Gordana, Ninić, Ana, "Malondialdehyde as an independent predictor of body mass index in adolescent girls" in Journal of Medical Biochemistry, 42, no. 2 (2023):224-231,
https://doi.org/10.5937/jomb0-39044 . .

TY  - JOUR
AU  - Subošić, Branko
AU  - Kotur-Stevuljević, Jelena
AU  - Brborić, Jasmina
AU  - Janković, Tamara
AU  - Milenković, Marina
AU  - Ivković, Branka
AU  - Kostadinović, Jelena
AU  - Savić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5146
AB  - The interplay between oxidative stress and inflammation is implicated in many chronic diseases including Alzheimer`s disease, cardiovascular diseases, diabetes and cancer. Thirteen β-hydroxy-β-arylalkanoic acids were previously synthesized and evaluated for their anti-inflammatory activity. The aim of this study was to asses ex vivo antioxidant activity of synthesized acids, as well as ibuprofen and to identify the compounds with the most promising results for further investigation on their capacity to counteract in vivo oxidative stress triggered by inflammation. The antioxidant potential of tested compounds was evaluated by determining the concentrations of total antioxidative status, total oxidative status, prooxidant antioxidant balance and the total sulfhydryl groups. Z score statistics were used to calculate the summary scores for antioxidative activity, prooxidative activity and oxy score. The tested compounds and ibuprofen demonstrated mild prooxidative activity ex vivo. Seven acids with substituents on one benzene ring exhibited better results than ibuprofen and were selected for in vivo testing. In vivo results demonstrated better antioxidant protection compared to ex vivo results. Compound g which contains nitro group on the benzene ring demonstrated the lowest oxy score, and four compounds exhibited better results than ibuprofen.
PB  - Pakistan Journal of Pharmaceutical Sciences
T2  - Pakistan Journal of Pharmaceutical Sciences
T1  - Ex vivo and in vivo antioxidant activity of β-hydroxy-β-arylalkanoic acids
VL  - 36
IS  - 5
SP  - 1367
EP  - 1374
DO  - 10.36721/PJPS.2023.36.5.REG.1367-1374.1
ER  - 

@article{
author = "Subošić, Branko and Kotur-Stevuljević, Jelena and Brborić, Jasmina and Janković, Tamara and Milenković, Marina and Ivković, Branka and Kostadinović, Jelena and Savić, Jelena",
year = "2023",
abstract = "The interplay between oxidative stress and inflammation is implicated in many chronic diseases including Alzheimer`s disease, cardiovascular diseases, diabetes and cancer. Thirteen β-hydroxy-β-arylalkanoic acids were previously synthesized and evaluated for their anti-inflammatory activity. The aim of this study was to asses ex vivo antioxidant activity of synthesized acids, as well as ibuprofen and to identify the compounds with the most promising results for further investigation on their capacity to counteract in vivo oxidative stress triggered by inflammation. The antioxidant potential of tested compounds was evaluated by determining the concentrations of total antioxidative status, total oxidative status, prooxidant antioxidant balance and the total sulfhydryl groups. Z score statistics were used to calculate the summary scores for antioxidative activity, prooxidative activity and oxy score. The tested compounds and ibuprofen demonstrated mild prooxidative activity ex vivo. Seven acids with substituents on one benzene ring exhibited better results than ibuprofen and were selected for in vivo testing. In vivo results demonstrated better antioxidant protection compared to ex vivo results. Compound g which contains nitro group on the benzene ring demonstrated the lowest oxy score, and four compounds exhibited better results than ibuprofen.",
publisher = "Pakistan Journal of Pharmaceutical Sciences",
journal = "Pakistan Journal of Pharmaceutical Sciences",
title = "Ex vivo and in vivo antioxidant activity of β-hydroxy-β-arylalkanoic acids",
volume = "36",
number = "5",
pages = "1367-1374",
doi = "10.36721/PJPS.2023.36.5.REG.1367-1374.1"
}

Subošić, B., Kotur-Stevuljević, J., Brborić, J., Janković, T., Milenković, M., Ivković, B., Kostadinović, J.,& Savić, J.. (2023). Ex vivo and in vivo antioxidant activity of β-hydroxy-β-arylalkanoic acids. in Pakistan Journal of Pharmaceutical Sciences
Pakistan Journal of Pharmaceutical Sciences., 36(5), 1367-1374.
https://doi.org/10.36721/PJPS.2023.36.5.REG.1367-1374.1

Subošić B, Kotur-Stevuljević J, Brborić J, Janković T, Milenković M, Ivković B, Kostadinović J, Savić J. Ex vivo and in vivo antioxidant activity of β-hydroxy-β-arylalkanoic acids. in Pakistan Journal of Pharmaceutical Sciences. 2023;36(5):1367-1374.
doi:10.36721/PJPS.2023.36.5.REG.1367-1374.1 .

Subošić, Branko, Kotur-Stevuljević, Jelena, Brborić, Jasmina, Janković, Tamara, Milenković, Marina, Ivković, Branka, Kostadinović, Jelena, Savić, Jelena, "Ex vivo and in vivo antioxidant activity of β-hydroxy-β-arylalkanoic acids" in Pakistan Journal of Pharmaceutical Sciences, 36, no. 5 (2023):1367-1374,
https://doi.org/10.36721/PJPS.2023.36.5.REG.1367-1374.1 . .

TY  - JOUR
AU  - Kostadinović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanović, Nevena
AU  - Andrić, Zoran
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5374
AB  - Malnutrition as a consequence of the disease occurs most
often in cancer patients, not only because of the cancer
itself, but also because of the oncological treatment. The
most important cause is chemotherapy, followed by ra-
diotherapy and onco-surgery. Therefore, efforts are being
made all over the world to find different ways to solve this
difficult medical problem. Given that the mechanism of
malnutrition caused by cancer is not sufficiently elucidat-
ed, the efforts made to design an adequate approach and
treatment of this disorder are often unsuccessful. In order
to improve the nutritional status of oncology patients, their
nutritional disorder should be adequately diagnosed and
then specific measurements should be performed (deter-
mination of body composition, the proportion of water, fat,
muscle, as well as the determination of various biomarkers
in the blood, for example markers inflammation). In this way, it is possible to formulate a multimodal approach to the
treatment of malnutrition in oncology patients, which would include the intake of adequate foods, increased physical
activity and personalized supplementation.
AB  - Pothranjenost kao posledica bolesti se najčešće javlja kod
onkoloških pacijenata i to ne samo zbog samog kancera,
već i zbog onkološkog lečenja. Najznačajniji uzročnik je
hemioterapija, potom radioterapija i onko-hirurgija. Zbog
toga se širom sveta ulažu napori i pronalaze različiti načini
za rešavanje ovog teškog medicinskog problema. S obzirom
na to da mehanizam nastanka pothranjenosti uzrokovane
karcinomom nije dovoljno rasvetljen, napori koji se ulažu
da se osmisli adekvatan pristup i tretman ovog poremećaja se često neuspešno završe. Da bi se nutritivni status onko-
loških pacijenata popravio njima pre svega treba da bude dijagnostikovan nutritivni poremećaj, a zatim da se sprovedu
specifična merenja (određivanje sastava tela, udeo vode, masti, mišića, kao i da se u krvi odrede različiti biomarkeri, na
primer markeri zapaljenja). Na taj način je moguće formulisati multimodalni pristup u lečenju pothranjenosti onkoloških
bolesnika koji bi obuhvatio unos adekvatnih namirnica, povećanje fizičke aktivnosti i personalizovanu suplementaciju.
PB  - Društvo za ishranu Srbije, Beograd
T2  - Hrana i ishrana
T1  - Malnutrition induced by cancer and oncology treatment
T1  - Malnutricija uzrokovana karcinomom i onkološkom terapijom
VL  - 63
IS  - 1
SP  - 9
EP  - 16
DO  - 10.5937/hraIsh2201009K
ER  - 

@article{
author = "Kostadinović, Jelena and Kotur-Stevuljević, Jelena and Ivanović, Nevena and Andrić, Zoran",
year = "2022",
abstract = "Malnutrition as a consequence of the disease occurs most
often in cancer patients, not only because of the cancer
itself, but also because of the oncological treatment. The
most important cause is chemotherapy, followed by ra-
diotherapy and onco-surgery. Therefore, efforts are being
made all over the world to find different ways to solve this
difficult medical problem. Given that the mechanism of
malnutrition caused by cancer is not sufficiently elucidat-
ed, the efforts made to design an adequate approach and
treatment of this disorder are often unsuccessful. In order
to improve the nutritional status of oncology patients, their
nutritional disorder should be adequately diagnosed and
then specific measurements should be performed (deter-
mination of body composition, the proportion of water, fat,
muscle, as well as the determination of various biomarkers
in the blood, for example markers inflammation). In this way, it is possible to formulate a multimodal approach to the
treatment of malnutrition in oncology patients, which would include the intake of adequate foods, increased physical
activity and personalized supplementation., Pothranjenost kao posledica bolesti se najčešće javlja kod
onkoloških pacijenata i to ne samo zbog samog kancera,
već i zbog onkološkog lečenja. Najznačajniji uzročnik je
hemioterapija, potom radioterapija i onko-hirurgija. Zbog
toga se širom sveta ulažu napori i pronalaze različiti načini
za rešavanje ovog teškog medicinskog problema. S obzirom
na to da mehanizam nastanka pothranjenosti uzrokovane
karcinomom nije dovoljno rasvetljen, napori koji se ulažu
da se osmisli adekvatan pristup i tretman ovog poremećaja se često neuspešno završe. Da bi se nutritivni status onko-
loških pacijenata popravio njima pre svega treba da bude dijagnostikovan nutritivni poremećaj, a zatim da se sprovedu
specifična merenja (određivanje sastava tela, udeo vode, masti, mišića, kao i da se u krvi odrede različiti biomarkeri, na
primer markeri zapaljenja). Na taj način je moguće formulisati multimodalni pristup u lečenju pothranjenosti onkoloških
bolesnika koji bi obuhvatio unos adekvatnih namirnica, povećanje fizičke aktivnosti i personalizovanu suplementaciju.",
publisher = "Društvo za ishranu Srbije, Beograd",
journal = "Hrana i ishrana",
title = "Malnutrition induced by cancer and oncology treatment, Malnutricija uzrokovana karcinomom i onkološkom terapijom",
volume = "63",
number = "1",
pages = "9-16",
doi = "10.5937/hraIsh2201009K"
}

Kostadinović, J., Kotur-Stevuljević, J., Ivanović, N.,& Andrić, Z.. (2022). Malnutrition induced by cancer and oncology treatment. in Hrana i ishrana
Društvo za ishranu Srbije, Beograd., 63(1), 9-16.
https://doi.org/10.5937/hraIsh2201009K

Kostadinović J, Kotur-Stevuljević J, Ivanović N, Andrić Z. Malnutrition induced by cancer and oncology treatment. in Hrana i ishrana. 2022;63(1):9-16.
doi:10.5937/hraIsh2201009K .

Kostadinović, Jelena, Kotur-Stevuljević, Jelena, Ivanović, Nevena, Andrić, Zoran, "Malnutrition induced by cancer and oncology treatment" in Hrana i ishrana, 63, no. 1 (2022):9-16,
https://doi.org/10.5937/hraIsh2201009K . .