Manić, Luka

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  • Manić, Luka (5)
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Author's Bibliography

Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode

Božić, Dragica; Baralić, Katarina; Živanović, Jovana; Živančević, Katarina; Marić, Đurđica; Vukelić, Dragana; Manić, Luka; Grahovac, Lazar; Ćurčić, Marijana; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Bulat, Zorica; Antonijević, Biljana; Đukić-Ćosić, Danijela

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Manić, Luka
AU  - Grahovac, Lazar
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5513
AB  - In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ...
AB  - In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode
T1  - Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method
SP  - 154
EP  - 156
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5513
ER  - 
@conference{
author = "Božić, Dragica and Baralić, Katarina and Živanović, Jovana and Živančević, Katarina and Marić, Đurđica and Vukelić, Dragana and Manić, Luka and Grahovac, Lazar and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ..., In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode, Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method",
pages = "154-156",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5513"
}
Božić, D., Baralić, K., Živanović, J., Živančević, K., Marić, Đ., Vukelić, D., Manić, L., Grahovac, L., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513
Božić D, Baralić K, Živanović J, Živančević K, Marić Đ, Vukelić D, Manić L, Grahovac L, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513 .
Božić, Dragica, Baralić, Katarina, Živanović, Jovana, Živančević, Katarina, Marić, Đurđica, Vukelić, Dragana, Manić, Luka, Grahovac, Lazar, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):154-156,
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?

Manić, Luka; Đorđević, Vladimir; Grubor, Nikica; Bulat, Zorica; Antonijević, Biljana; Đukić-Ćosić, Danijela; Uysal-Onganer, Pinar; Mortoglou, Maria; Wallace, David; Buha-Đorđević, Aleksandra

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Manić, Luka
AU  - Đorđević, Vladimir
AU  - Grubor, Nikica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Uysal-Onganer, Pinar
AU  - Mortoglou, Maria
AU  - Wallace, David
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5512
AB  - Istraživanje u oblasti karcinoma pankreasa i zagađivača iz životne sredine sve je intenzivnije. Za neke od ovih zagađivača pretpostavlja se da su povezani sa nastankom ili progresijom karcinoma pankreasa. Nijedna meta-analiza o povezanosti navedenog nije sprovedena, dok bi rezultati iste mogli pomoći u tumačenju dostupnih podataka i usmeravanju budućeg istraživanja. ...
AB  - There is a rise in research on the connection between pancreatic cancer and environmental pollutants. Some of these pollutants are assumed to be associated with the onset or progression of pancreatic cancer. No meta-analyses summarizing the association between these two have been conducted yet, while the results of such an analysis could help interpret current and guide future research.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?
T1  - A meta-analysis excerpt: Is exposure to environmental pollutants associated with pancreatic cancer?
SP  - 143
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5512
ER  - 
@conference{
author = "Manić, Luka and Đorđević, Vladimir and Grubor, Nikica and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela and Uysal-Onganer, Pinar and Mortoglou, Maria and Wallace, David and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Istraživanje u oblasti karcinoma pankreasa i zagađivača iz životne sredine sve je intenzivnije. Za neke od ovih zagađivača pretpostavlja se da su povezani sa nastankom ili progresijom karcinoma pankreasa. Nijedna meta-analiza o povezanosti navedenog nije sprovedena, dok bi rezultati iste mogli pomoći u tumačenju dostupnih podataka i usmeravanju budućeg istraživanja. ..., There is a rise in research on the connection between pancreatic cancer and environmental pollutants. Some of these pollutants are assumed to be associated with the onset or progression of pancreatic cancer. No meta-analyses summarizing the association between these two have been conducted yet, while the results of such an analysis could help interpret current and guide future research.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?, A meta-analysis excerpt: Is exposure to environmental pollutants associated with pancreatic cancer?",
pages = "143-146",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5512"
}
Manić, L., Đorđević, V., Grubor, N., Bulat, Z., Antonijević, B., Đukić-Ćosić, D., Uysal-Onganer, P., Mortoglou, M., Wallace, D.,& Buha-Đorđević, A.. (2023). Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 143-146.
https://hdl.handle.net/21.15107/rcub_farfar_5512
Manić L, Đorđević V, Grubor N, Bulat Z, Antonijević B, Đukić-Ćosić D, Uysal-Onganer P, Mortoglou M, Wallace D, Buha-Đorđević A. Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:143-146.
https://hdl.handle.net/21.15107/rcub_farfar_5512 .
Manić, Luka, Đorđević, Vladimir, Grubor, Nikica, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, Uysal-Onganer, Pinar, Mortoglou, Maria, Wallace, David, Buha-Đorđević, Aleksandra, "Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):143-146,
https://hdl.handle.net/21.15107/rcub_farfar_5512 .

Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama

Bonderović, Vera; Manić, Luka; Živančević, Katarina; Baralić, Katarina; Vukelić, Dragana; Marić, Đurđica; Stojilković, Nikola; Jorgovanović, Dragica; Grahovac, Lazar; Anđelković, Milena; Repić, Aleksandra; Ćurčić, Marijana; Đukić-Ćosić, Danijela; Bulat, Zorica; Antonijević, Biljana; Buha-Đorđević, Aleksandra

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Bonderović, Vera
AU  - Manić, Luka
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Stojilković, Nikola
AU  - Jorgovanović, Dragica
AU  - Grahovac, Lazar
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5510
AB  - Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ...
AB  - In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama
T1  - Informed mom, healthy baby - How to live safely with chemicals
SP  - 117
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5510
ER  - 
@conference{
author = "Bonderović, Vera and Manić, Luka and Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Stojilković, Nikola and Jorgovanović, Dragica and Grahovac, Lazar and Anđelković, Milena and Repić, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ..., In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama, Informed mom, healthy baby - How to live safely with chemicals",
pages = "117-118",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5510"
}
Bonderović, V., Manić, L., Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Stojilković, N., Jorgovanović, D., Grahovac, L., Anđelković, M., Repić, A., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2023). Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510
Bonderović V, Manić L, Živančević K, Baralić K, Vukelić D, Marić Đ, Stojilković N, Jorgovanović D, Grahovac L, Anđelković M, Repić A, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B, Buha-Đorđević A. Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510 .
Bonderović, Vera, Manić, Luka, Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Stojilković, Nikola, Jorgovanović, Dragica, Grahovac, Lazar, Anđelković, Milena, Repić, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):117-118,
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs

Mortoglou, Maria; Manić, Luka; Buha-Đorđević, Aleksandra; Bulat, Zorica; Đorđević, Vladimir; Manis, Katherine; York, Lauren; Valle, Elizabeth; Wallace, David; Uysal-Onganer, Pinar

(MDPI, 2022)

TY  - JOUR
AU  - Mortoglou, Maria
AU  - Manić, Luka
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Đorđević, Vladimir
AU  - Manis, Katherine
AU  - York, Lauren
AU  - Valle, Elizabeth
AU  - Wallace, David
AU  - Uysal-Onganer, Pinar
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4352
AB  - Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types with a limited overall survival rate due to the asymptomatic progression of symptoms in metastatic stages of the malignancy and the lack of an early reliable diagnostic biomarker. MicroRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are closely linked to the development of numerous malignancies comprising PDAC. Recent studies have described the role of environmental pollutants such as nickel (Ni) in PDAC, but the mechanisms of Ni-mediated toxicity in cancer are still not completely understood. Specifically, Ni has been found to alter the expression and function of miRs in several malignancies, leading to changes in target gene expression. In this study, we found that levels of Ni were significantly higher in cancerous tissue, thus implicating Ni in pancreatic carcinogenesis. Hence, in vitro studies followed by using both normal and pancreatic tumor cell lines and increasing Ni concentration increased lethality. Comparing LC50 values, Ni-acetate groups demonstrated lower values needed than in NiCl2 groups, suggesting greater Ni-acetate. Panc-10.05 cell line appeared the most sensitive to Ni compounds. Exposure to Ni-acetate resulted in an increased phospho-AKT, and decreased FOXO1 expression in Panc-10.05 cells, while NiCl2 also increased PTEN expression in Panc-10.05 cells. Specifically, following NiCl2 exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. Hence, our study has suggested pilot insights to indicate that the environmental pollutant Ni plays an important role in the progression of PDAC by promoting an association between miRs and Ni exposure during PDAC pathogenesis.
PB  - MDPI
T2  - Toxics
T1  - Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs
VL  - 10
IS  - 3
DO  - 10.3390/toxics10030148
ER  - 
@article{
author = "Mortoglou, Maria and Manić, Luka and Buha-Đorđević, Aleksandra and Bulat, Zorica and Đorđević, Vladimir and Manis, Katherine and York, Lauren and Valle, Elizabeth and Wallace, David and Uysal-Onganer, Pinar",
year = "2022",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types with a limited overall survival rate due to the asymptomatic progression of symptoms in metastatic stages of the malignancy and the lack of an early reliable diagnostic biomarker. MicroRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are closely linked to the development of numerous malignancies comprising PDAC. Recent studies have described the role of environmental pollutants such as nickel (Ni) in PDAC, but the mechanisms of Ni-mediated toxicity in cancer are still not completely understood. Specifically, Ni has been found to alter the expression and function of miRs in several malignancies, leading to changes in target gene expression. In this study, we found that levels of Ni were significantly higher in cancerous tissue, thus implicating Ni in pancreatic carcinogenesis. Hence, in vitro studies followed by using both normal and pancreatic tumor cell lines and increasing Ni concentration increased lethality. Comparing LC50 values, Ni-acetate groups demonstrated lower values needed than in NiCl2 groups, suggesting greater Ni-acetate. Panc-10.05 cell line appeared the most sensitive to Ni compounds. Exposure to Ni-acetate resulted in an increased phospho-AKT, and decreased FOXO1 expression in Panc-10.05 cells, while NiCl2 also increased PTEN expression in Panc-10.05 cells. Specifically, following NiCl2 exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. Hence, our study has suggested pilot insights to indicate that the environmental pollutant Ni plays an important role in the progression of PDAC by promoting an association between miRs and Ni exposure during PDAC pathogenesis.",
publisher = "MDPI",
journal = "Toxics",
title = "Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs",
volume = "10",
number = "3",
doi = "10.3390/toxics10030148"
}
Mortoglou, M., Manić, L., Buha-Đorđević, A., Bulat, Z., Đorđević, V., Manis, K., York, L., Valle, E., Wallace, D.,& Uysal-Onganer, P.. (2022). Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs. in Toxics
MDPI., 10(3).
https://doi.org/10.3390/toxics10030148
Mortoglou M, Manić L, Buha-Đorđević A, Bulat Z, Đorđević V, Manis K, York L, Valle E, Wallace D, Uysal-Onganer P. Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs. in Toxics. 2022;10(3).
doi:10.3390/toxics10030148 .
Mortoglou, Maria, Manić, Luka, Buha-Đorđević, Aleksandra, Bulat, Zorica, Đorđević, Vladimir, Manis, Katherine, York, Lauren, Valle, Elizabeth, Wallace, David, Uysal-Onganer, Pinar, "Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs" in Toxics, 10, no. 3 (2022),
https://doi.org/10.3390/toxics10030148 . .
2
5
4

Epigenetic mechanisms in metal carcinogenesis

Manić, Luka; Wallace, David; Onganer, Pinar Uysal; Taalab, Yasmeen; Farooqi, Ammad; Antonijević, Biljana; Buha-Đorđević, Aleksandra

(Elsevier Inc., 2022)

TY  - JOUR
AU  - Manić, Luka
AU  - Wallace, David
AU  - Onganer, Pinar Uysal
AU  - Taalab, Yasmeen
AU  - Farooqi, Ammad
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4101
AB  - Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development.
PB  - Elsevier Inc.
T2  - Toxicology Reports
T1  - Epigenetic mechanisms in metal carcinogenesis
VL  - 9
SP  - 778
EP  - 787
DO  - 10.1016/j.toxrep.2022.03.037
ER  - 
@article{
author = "Manić, Luka and Wallace, David and Onganer, Pinar Uysal and Taalab, Yasmeen and Farooqi, Ammad and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2022",
abstract = "Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development.",
publisher = "Elsevier Inc.",
journal = "Toxicology Reports",
title = "Epigenetic mechanisms in metal carcinogenesis",
volume = "9",
pages = "778-787",
doi = "10.1016/j.toxrep.2022.03.037"
}
Manić, L., Wallace, D., Onganer, P. U., Taalab, Y., Farooqi, A., Antonijević, B.,& Buha-Đorđević, A.. (2022). Epigenetic mechanisms in metal carcinogenesis. in Toxicology Reports
Elsevier Inc.., 9, 778-787.
https://doi.org/10.1016/j.toxrep.2022.03.037
Manić L, Wallace D, Onganer PU, Taalab Y, Farooqi A, Antonijević B, Buha-Đorđević A. Epigenetic mechanisms in metal carcinogenesis. in Toxicology Reports. 2022;9:778-787.
doi:10.1016/j.toxrep.2022.03.037 .
Manić, Luka, Wallace, David, Onganer, Pinar Uysal, Taalab, Yasmeen, Farooqi, Ammad, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Epigenetic mechanisms in metal carcinogenesis" in Toxicology Reports, 9 (2022):778-787,
https://doi.org/10.1016/j.toxrep.2022.03.037 . .
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