TY  - JOUR
AU  - Vasiljević, D
AU  - Parojčić, Jelena
AU  - Primorac, Marija
AU  - Vuleta, G
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/842
AB  - Multiple W/O/W emulsions with high content of inner phase (Phi 1 = Phi 2 = 0.8) were prepared using relatively low concentrations of lipophilic polymeric primary emulsifier, PEG 30-dipolyhydroxystearate, and diclofenac diethylamine (DDA) as a model drug. The investigated formulations were characterized and their stability over the time was evaluated by dynamic and oscillatory rheological measurements, microscopic analysis and in vitro drug release study. In vitro release profiles of the selected model drug were evaluated in terms of the effective diffusion coefficients and flux of the released drug. The multiple emulsion samples exhibited good stability during the ageing time. Concentration of the lipophilic primary emulsifier markedly affected rheological behaviour as well as the droplet size and in vitro drug release kinetics of the investigated systems. The multiple emulsion systems with highest concentration (2.4%, w/w) of the primary emulsifier had the lowest droplet size and the highest apparent viscosity and highest elastic characteristics. Drug release data indicated predominately diffusional drug release mechanism with sustained and prolonged drug release accomplished with 2.4% (w/w) of lipophilic emulsifier employed.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier
VL  - 309
IS  - 1-2
SP  - 171
EP  - 177
DO  - 10.1016/j.ijpharm.2005.11.034
ER  - 

@article{
author = "Vasiljević, D and Parojčić, Jelena and Primorac, Marija and Vuleta, G",
year = "2006",
abstract = "Multiple W/O/W emulsions with high content of inner phase (Phi 1 = Phi 2 = 0.8) were prepared using relatively low concentrations of lipophilic polymeric primary emulsifier, PEG 30-dipolyhydroxystearate, and diclofenac diethylamine (DDA) as a model drug. The investigated formulations were characterized and their stability over the time was evaluated by dynamic and oscillatory rheological measurements, microscopic analysis and in vitro drug release study. In vitro release profiles of the selected model drug were evaluated in terms of the effective diffusion coefficients and flux of the released drug. The multiple emulsion samples exhibited good stability during the ageing time. Concentration of the lipophilic primary emulsifier markedly affected rheological behaviour as well as the droplet size and in vitro drug release kinetics of the investigated systems. The multiple emulsion systems with highest concentration (2.4%, w/w) of the primary emulsifier had the lowest droplet size and the highest apparent viscosity and highest elastic characteristics. Drug release data indicated predominately diffusional drug release mechanism with sustained and prolonged drug release accomplished with 2.4% (w/w) of lipophilic emulsifier employed.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier",
volume = "309",
number = "1-2",
pages = "171-177",
doi = "10.1016/j.ijpharm.2005.11.034"
}

Vasiljević, D., Parojčić, J., Primorac, M.,& Vuleta, G.. (2006). An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 309(1-2), 171-177.
https://doi.org/10.1016/j.ijpharm.2005.11.034

Vasiljević D, Parojčić J, Primorac M, Vuleta G. An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier. in International Journal of Pharmaceutics. 2006;309(1-2):171-177.
doi:10.1016/j.ijpharm.2005.11.034 .

Vasiljević, D, Parojčić, Jelena, Primorac, Marija, Vuleta, G, "An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier" in International Journal of Pharmaceutics, 309, no. 1-2 (2006):171-177,
https://doi.org/10.1016/j.ijpharm.2005.11.034 . .

TY  - JOUR
AU  - Dragičević-Curić, Nina
AU  - Stupar, Mirjana
AU  - Milić, J.
AU  - Zorić, T
AU  - Krajišnik, Danina
AU  - Vasiljević, D
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/574
AB  - The aim of this study was to develop and characterize hydrophilic gels containing chlorophyllin(CHL)loaded liposomes as well as to evaluate their stability. Two different CHL-loaded liposome dispersions using non-hydrogenated and hydrogenated soybean lecithin were prepared, characterized for their particle size, polydispersity index and trapping efficiency and incorporated in Carbopol(R) 940 NF hydrogel. The gels obtained were analyzed for flow properties, pH values and CHL content. The control liposome-free gel was obtained by incorporating the CHL solution in the hydrogel. The stability of the gels was evaluated in terms of rheological properties, pH values and CHL content during 6 months' storage at 20 +/- 2 degrees C. Suitable gel formulations for topical use were obtained revealing shear-thinning plastic flow behaviour without significant thixotropy during the whole period of examination. High yield values of the samples during the whole period indicated a long-term stability of the gel formulations. The gel formulations expressed a mild acid value acceptable for topical preparations. After 6 months' storage the CHL content was highest in the gel containing non-hydrogenated lecithin liposomes, followed by the gel containing hydrogenated lecithin liposomes and liposome-free gel, indicating that the encapsulation of CHL in liposomes led to a greater stability of CHL.
PB  - Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation
VL  - 60
IS  - 8
SP  - 588
EP  - 592
UR  - https://hdl.handle.net/21.15107/rcub_farfar_574
ER  - 

@article{
author = "Dragičević-Curić, Nina and Stupar, Mirjana and Milić, J. and Zorić, T and Krajišnik, Danina and Vasiljević, D",
year = "2005",
abstract = "The aim of this study was to develop and characterize hydrophilic gels containing chlorophyllin(CHL)loaded liposomes as well as to evaluate their stability. Two different CHL-loaded liposome dispersions using non-hydrogenated and hydrogenated soybean lecithin were prepared, characterized for their particle size, polydispersity index and trapping efficiency and incorporated in Carbopol(R) 940 NF hydrogel. The gels obtained were analyzed for flow properties, pH values and CHL content. The control liposome-free gel was obtained by incorporating the CHL solution in the hydrogel. The stability of the gels was evaluated in terms of rheological properties, pH values and CHL content during 6 months' storage at 20 +/- 2 degrees C. Suitable gel formulations for topical use were obtained revealing shear-thinning plastic flow behaviour without significant thixotropy during the whole period of examination. High yield values of the samples during the whole period indicated a long-term stability of the gel formulations. The gel formulations expressed a mild acid value acceptable for topical preparations. After 6 months' storage the CHL content was highest in the gel containing non-hydrogenated lecithin liposomes, followed by the gel containing hydrogenated lecithin liposomes and liposome-free gel, indicating that the encapsulation of CHL in liposomes led to a greater stability of CHL.",
publisher = "Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation",
volume = "60",
number = "8",
pages = "588-592",
url = "https://hdl.handle.net/21.15107/rcub_farfar_574"
}

Dragičević-Curić, N., Stupar, M., Milić, J., Zorić, T., Krajišnik, D.,& Vasiljević, D.. (2005). Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation. in Pharmazie
Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn., 60(8), 588-592.
https://hdl.handle.net/21.15107/rcub_farfar_574

Dragičević-Curić N, Stupar M, Milić J, Zorić T, Krajišnik D, Vasiljević D. Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation. in Pharmazie. 2005;60(8):588-592.
https://hdl.handle.net/21.15107/rcub_farfar_574 .

Dragičević-Curić, Nina, Stupar, Mirjana, Milić, J., Zorić, T, Krajišnik, Danina, Vasiljević, D, "Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation" in Pharmazie, 60, no. 8 (2005):588-592,
https://hdl.handle.net/21.15107/rcub_farfar_574 .

TY  - CONF
AU  - Mladenović, B.
AU  - Milić-Aškrabić, Jela
AU  - Krajišnik, Danina
AU  - Vasiljević, D.
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/403
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Possibility of manufacturing and properties of W/O emulsions with emulsifiers based on polyglycerol esters
T1  - Mogućnosti izrade i osobine V/U kremova sa emulgatorima na bazi poliglicerol estara
VL  - 52
IS  - 4
SP  - 576
EP  - 577
UR  - https://hdl.handle.net/21.15107/rcub_farfar_403
ER  - 

@conference{
author = "Mladenović, B. and Milić-Aškrabić, Jela and Krajišnik, Danina and Vasiljević, D.",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Possibility of manufacturing and properties of W/O emulsions with emulsifiers based on polyglycerol esters, Mogućnosti izrade i osobine V/U kremova sa emulgatorima na bazi poliglicerol estara",
volume = "52",
number = "4",
pages = "576-577",
url = "https://hdl.handle.net/21.15107/rcub_farfar_403"
}

Mladenović, B., Milić-Aškrabić, J., Krajišnik, D.,& Vasiljević, D.. (2002). Possibility of manufacturing and properties of W/O emulsions with emulsifiers based on polyglycerol esters. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 576-577.
https://hdl.handle.net/21.15107/rcub_farfar_403

Mladenović B, Milić-Aškrabić J, Krajišnik D, Vasiljević D. Possibility of manufacturing and properties of W/O emulsions with emulsifiers based on polyglycerol esters. in Arhiv za farmaciju. 2002;52(4):576-577.
https://hdl.handle.net/21.15107/rcub_farfar_403 .

Mladenović, B., Milić-Aškrabić, Jela, Krajišnik, Danina, Vasiljević, D., "Possibility of manufacturing and properties of W/O emulsions with emulsifiers based on polyglycerol esters" in Arhiv za farmaciju, 52, no. 4 (2002):576-577,
https://hdl.handle.net/21.15107/rcub_farfar_403 .