TY  - JOUR
AU  - Becarević, Mirjana
AU  - Cabarkapa, Velibor
AU  - Derić, Mirjana
AU  - Ignjatović, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3006
AB  - Objective: Antiphospholipid antibodies (aPL Abs) represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with antiphospholipid syndrome, but their role in diabetic nephropathy is not elucidated. Therefore, we evaluated the association of aPL Abs with the renal impairment parameters in patients with diabetic nephropathy. Methods: Concentrations of analyzed antibodies were measured by enzyme-linked immunosorbent assay. Results: Cystatin C and anticardiolipin (aCL) antibodies of the immunoglobulin (Ig) G (r = .349, P = .004) and the IgM isotype (r = .316, P = .009) were in positive correlation. The IgG isotype of the aCL Abs was in positive correlation with creatinine (r = .252, P = .038), urea (r = .241, P = .048), and uric acid (r = .271, P = .025). The concentrations of the IgG isotype of the aCL Abs were significantly different between subgroups of patients with diabetic polyneuropathy and patients without this clinical finding (Mann-Whitney, P = .033). Conclusion: This is the first report on positive correlation between aCL Abs and renal impairment parameters. Larger studies are necessary for elucidation whether this association is involved in further progression of the disease.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Clinical and Applied Thrombosis-Hemostasis
T1  - Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data
VL  - 23
IS  - 4
SP  - 379
EP  - 383
DO  - 10.1177/1076029616642512
ER  - 

@article{
author = "Becarević, Mirjana and Cabarkapa, Velibor and Derić, Mirjana and Ignjatović, Svetlana",
year = "2017",
abstract = "Objective: Antiphospholipid antibodies (aPL Abs) represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with antiphospholipid syndrome, but their role in diabetic nephropathy is not elucidated. Therefore, we evaluated the association of aPL Abs with the renal impairment parameters in patients with diabetic nephropathy. Methods: Concentrations of analyzed antibodies were measured by enzyme-linked immunosorbent assay. Results: Cystatin C and anticardiolipin (aCL) antibodies of the immunoglobulin (Ig) G (r = .349, P = .004) and the IgM isotype (r = .316, P = .009) were in positive correlation. The IgG isotype of the aCL Abs was in positive correlation with creatinine (r = .252, P = .038), urea (r = .241, P = .048), and uric acid (r = .271, P = .025). The concentrations of the IgG isotype of the aCL Abs were significantly different between subgroups of patients with diabetic polyneuropathy and patients without this clinical finding (Mann-Whitney, P = .033). Conclusion: This is the first report on positive correlation between aCL Abs and renal impairment parameters. Larger studies are necessary for elucidation whether this association is involved in further progression of the disease.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Clinical and Applied Thrombosis-Hemostasis",
title = "Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data",
volume = "23",
number = "4",
pages = "379-383",
doi = "10.1177/1076029616642512"
}

Becarević, M., Cabarkapa, V., Derić, M.,& Ignjatović, S.. (2017). Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data. in Clinical and Applied Thrombosis-Hemostasis
Sage Publications Inc, Thousand Oaks., 23(4), 379-383.
https://doi.org/10.1177/1076029616642512

Becarević M, Cabarkapa V, Derić M, Ignjatović S. Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data. in Clinical and Applied Thrombosis-Hemostasis. 2017;23(4):379-383.
doi:10.1177/1076029616642512 .

Becarević, Mirjana, Cabarkapa, Velibor, Derić, Mirjana, Ignjatović, Svetlana, "Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data" in Clinical and Applied Thrombosis-Hemostasis, 23, no. 4 (2017):379-383,
https://doi.org/10.1177/1076029616642512 . .