TY  - JOUR
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Nikolić, L
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/284
AB  - Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
PB  - ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
T2  - Pharmazeutische Industrie
T1  - Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
VL  - 63
IS  - 7
SP  - 774
EP  - 779
UR  - https://hdl.handle.net/21.15107/rcub_farfar_284
ER  - 

@article{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Nikolić, L",
year = "2001",
abstract = "Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.",
publisher = "ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf",
journal = "Pharmazeutische Industrie",
title = "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design",
volume = "63",
number = "7",
pages = "774-779",
url = "https://hdl.handle.net/21.15107/rcub_farfar_284"
}

Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Nikolić, L.. (2001). Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Pharmazeutische Industrie
ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf., 63(7), 774-779.
https://hdl.handle.net/21.15107/rcub_farfar_284

Parojčić J, Đurić Z, Jovanović M, Ibrić S, Nikolić L. Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Pharmazeutische Industrie. 2001;63(7):774-779.
https://hdl.handle.net/21.15107/rcub_farfar_284 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Nikolić, L, "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design" in Pharmazeutische Industrie, 63, no. 7 (2001):774-779,
https://hdl.handle.net/21.15107/rcub_farfar_284 .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Nikolić, L
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/304
AB  - Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
PB  - Editio Cantor Verlag GmbH
T2  - Drugs Made in Germany
T1  - Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
VL  - 44
IS  - 1
SP  - 19
EP  - 24
UR  - https://hdl.handle.net/21.15107/rcub_farfar_304
ER  - 

@article{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Nikolić, L",
year = "2001",
abstract = "Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.",
publisher = "Editio Cantor Verlag GmbH",
journal = "Drugs Made in Germany",
title = "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design",
volume = "44",
number = "1",
pages = "19-24",
url = "https://hdl.handle.net/21.15107/rcub_farfar_304"
}

Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Nikolić, L.. (2001). Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Drugs Made in Germany
Editio Cantor Verlag GmbH., 44(1), 19-24.
https://hdl.handle.net/21.15107/rcub_farfar_304

Parojčić J, Đurić Z, Jovanović M, Ibrić S, Nikolić L. Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Drugs Made in Germany. 2001;44(1):19-24.
https://hdl.handle.net/21.15107/rcub_farfar_304 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Nikolić, L, "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design" in Drugs Made in Germany, 44, no. 1 (2001):19-24,
https://hdl.handle.net/21.15107/rcub_farfar_304 .

TY  - JOUR
AU  - Jovanović, M
AU  - Jovicić, G
AU  - Đurić, Zorica
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Radovanović, J
AU  - Nikolić, L
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/161
AB  - The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation.
PB  - Marcel Dekker Inc, New York
T2  - Drug Development and Industrial Pharmacy
T1  - Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets
VL  - 23
IS  - 6
SP  - 595
EP  - 602
DO  - 10.3109/03639049709149825
ER  - 

@article{
author = "Jovanović, M and Jovicić, G and Đurić, Zorica and Agbaba, Danica and Karljiković-Rajić, Katarina and Radovanović, J and Nikolić, L",
year = "1997",
abstract = "The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation.",
publisher = "Marcel Dekker Inc, New York",
journal = "Drug Development and Industrial Pharmacy",
title = "Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets",
volume = "23",
number = "6",
pages = "595-602",
doi = "10.3109/03639049709149825"
}

Jovanović, M., Jovicić, G., Đurić, Z., Agbaba, D., Karljiković-Rajić, K., Radovanović, J.,& Nikolić, L.. (1997). Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets. in Drug Development and Industrial Pharmacy
Marcel Dekker Inc, New York., 23(6), 595-602.
https://doi.org/10.3109/03639049709149825

Jovanović M, Jovicić G, Đurić Z, Agbaba D, Karljiković-Rajić K, Radovanović J, Nikolić L. Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets. in Drug Development and Industrial Pharmacy. 1997;23(6):595-602.
doi:10.3109/03639049709149825 .

Jovanović, M, Jovicić, G, Đurić, Zorica, Agbaba, Danica, Karljiković-Rajić, Katarina, Radovanović, J, Nikolić, L, "Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets" in Drug Development and Industrial Pharmacy, 23, no. 6 (1997):595-602,
https://doi.org/10.3109/03639049709149825 . .

TY  - JOUR
AU  - Jovanović, M
AU  - Jovičić, G
AU  - Đurić, Zorica
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Nikolić, L
AU  - Radovanović, J
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/168
AB  - The effect of four Eudragits used as matrix substances on the physical characteristics of tablets and on the dissolution rate of acetylsalicylic acid has been investigated. The concentration of matrix substance necessary for achieving the appropriate effect of sustained release of acetylsalicylic acid (ASA) depends on the type of Eudragit used. For tablets prepared using Eudragit RS-100, Eudragit L-100-55 and Eudragit S-100, the acceptable dissolution rate of ASA was obtained with only 3% of polymer. In the case of Eudragit RL-100, to obtain the same effect, 10% of polymer was required. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. The following mathematical models were employed: zero order equation, first order kinetics, Hixon-Crowell's cube root kinetics and diffusion model. The results indicated that the fitness of the kinetic model was dependent on the type of Eudragit used.
PB  - Magyar Gyogyszereszeti Tarsasag
T2  - Acta Pharmaceutica Hungarica
T1  - The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets
VL  - 67
IS  - 6
SP  - 229
EP  - 234
UR  - https://hdl.handle.net/21.15107/rcub_farfar_168
ER  - 

@article{
author = "Jovanović, M and Jovičić, G and Đurić, Zorica and Agbaba, Danica and Karljiković-Rajić, Katarina and Nikolić, L and Radovanović, J",
year = "1997",
abstract = "The effect of four Eudragits used as matrix substances on the physical characteristics of tablets and on the dissolution rate of acetylsalicylic acid has been investigated. The concentration of matrix substance necessary for achieving the appropriate effect of sustained release of acetylsalicylic acid (ASA) depends on the type of Eudragit used. For tablets prepared using Eudragit RS-100, Eudragit L-100-55 and Eudragit S-100, the acceptable dissolution rate of ASA was obtained with only 3% of polymer. In the case of Eudragit RL-100, to obtain the same effect, 10% of polymer was required. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. The following mathematical models were employed: zero order equation, first order kinetics, Hixon-Crowell's cube root kinetics and diffusion model. The results indicated that the fitness of the kinetic model was dependent on the type of Eudragit used.",
publisher = "Magyar Gyogyszereszeti Tarsasag",
journal = "Acta Pharmaceutica Hungarica",
title = "The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets",
volume = "67",
number = "6",
pages = "229-234",
url = "https://hdl.handle.net/21.15107/rcub_farfar_168"
}

Jovanović, M., Jovičić, G., Đurić, Z., Agbaba, D., Karljiković-Rajić, K., Nikolić, L.,& Radovanović, J.. (1997). The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets. in Acta Pharmaceutica Hungarica
Magyar Gyogyszereszeti Tarsasag., 67(6), 229-234.
https://hdl.handle.net/21.15107/rcub_farfar_168

Jovanović M, Jovičić G, Đurić Z, Agbaba D, Karljiković-Rajić K, Nikolić L, Radovanović J. The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets. in Acta Pharmaceutica Hungarica. 1997;67(6):229-234.
https://hdl.handle.net/21.15107/rcub_farfar_168 .

Jovanović, M, Jovičić, G, Đurić, Zorica, Agbaba, Danica, Karljiković-Rajić, Katarina, Nikolić, L, Radovanović, J, "The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets" in Acta Pharmaceutica Hungarica, 67, no. 6 (1997):229-234,
https://hdl.handle.net/21.15107/rcub_farfar_168 .

TY  - JOUR
AU  - Nikolić, L
AU  - Tasić, Ljiljana
AU  - Jovanović, M
AU  - Đurić, Zorica
PY  - 1995
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/116
AB  - The effect of some direct compression excipients (Avicel® PH 101 (I), Avicel PH 101 + mannitol (II), Avicel PH 112 (III), Cellactose® (IV), and Pharmatose® DCL 40 (V)) under different storage conditions (22, 43 and 73% relative humidity, resp.) on the physico-chemical properties and dissolution rate of acetylsalicylic acid tablets was evaluated. Disintegration time, cruching strength, and friability were changed remarkably in the tablet formulations I, II, and III being humidity dependent. Formulations IV and V had no tendency to changes in physical characteristics under storage at different relative humidities for 90 days, whereas the dissolution profiles of samples I, II, and III were increased with increasing humidity. No changes in dissolution rate after storage at different humidities were observed in the lactose-based formulations IV and V. Analytical data (acetylsalicylic acid and salicylic acid content) revealed a high stability of formulations IV and V compared to the others. According to the obtained results, formulations IV and V could be suggested as excipients for high quality acetylsalicylic acid tablets.
PB  - Editio Cantor Verlag GmbH
T2  - Pharmazeutische Industrie
T1  - Effect of selected direct compression excipients on the stability of acetylsalicylic acid tablets
VL  - 57
IS  - 11
SP  - 958
EP  - 963
UR  - https://hdl.handle.net/21.15107/rcub_farfar_116
ER  - 

@article{
author = "Nikolić, L and Tasić, Ljiljana and Jovanović, M and Đurić, Zorica",
year = "1995",
abstract = "The effect of some direct compression excipients (Avicel® PH 101 (I), Avicel PH 101 + mannitol (II), Avicel PH 112 (III), Cellactose® (IV), and Pharmatose® DCL 40 (V)) under different storage conditions (22, 43 and 73% relative humidity, resp.) on the physico-chemical properties and dissolution rate of acetylsalicylic acid tablets was evaluated. Disintegration time, cruching strength, and friability were changed remarkably in the tablet formulations I, II, and III being humidity dependent. Formulations IV and V had no tendency to changes in physical characteristics under storage at different relative humidities for 90 days, whereas the dissolution profiles of samples I, II, and III were increased with increasing humidity. No changes in dissolution rate after storage at different humidities were observed in the lactose-based formulations IV and V. Analytical data (acetylsalicylic acid and salicylic acid content) revealed a high stability of formulations IV and V compared to the others. According to the obtained results, formulations IV and V could be suggested as excipients for high quality acetylsalicylic acid tablets.",
publisher = "Editio Cantor Verlag GmbH",
journal = "Pharmazeutische Industrie",
title = "Effect of selected direct compression excipients on the stability of acetylsalicylic acid tablets",
volume = "57",
number = "11",
pages = "958-963",
url = "https://hdl.handle.net/21.15107/rcub_farfar_116"
}

Nikolić, L., Tasić, L., Jovanović, M.,& Đurić, Z.. (1995). Effect of selected direct compression excipients on the stability of acetylsalicylic acid tablets. in Pharmazeutische Industrie
Editio Cantor Verlag GmbH., 57(11), 958-963.
https://hdl.handle.net/21.15107/rcub_farfar_116

Nikolić L, Tasić L, Jovanović M, Đurić Z. Effect of selected direct compression excipients on the stability of acetylsalicylic acid tablets. in Pharmazeutische Industrie. 1995;57(11):958-963.
https://hdl.handle.net/21.15107/rcub_farfar_116 .

Nikolić, L, Tasić, Ljiljana, Jovanović, M, Đurić, Zorica, "Effect of selected direct compression excipients on the stability of acetylsalicylic acid tablets" in Pharmazeutische Industrie, 57, no. 11 (1995):958-963,
https://hdl.handle.net/21.15107/rcub_farfar_116 .

TY  - JOUR
AU  - Jovicić, G
AU  - Nikolić, L
AU  - Karijikovic Rajić, K
AU  - Agbaba, Danica
AU  - Jovanović, M
AU  - Đurić, Zorica
PY  - 1995
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/120
AB  - Third-order derivative spectrophotometry is proposed for simultaneous determination of acetylsalicylic acid and free salicylic acid in sustained-release tablets, and compared with TLC-densitometry. Both methods were evaluated through selectivity, and accuracy tests. Results for acetylsalicylic acid and salicylic acid in aspirin sustained-release tablets showed good agreement.
PB  - Societa Chimica Italiana
T2  - Farmaco
T1  - Third-order derivative UV spectrophotometry and densitometry for the simultaneous assay of acetylsalicylic acid and salicylic acid in tablet formulations
VL  - 50
IS  - 4
SP  - 285
EP  - 288
UR  - https://hdl.handle.net/21.15107/rcub_farfar_120
ER  - 

@article{
author = "Jovicić, G and Nikolić, L and Karijikovic Rajić, K and Agbaba, Danica and Jovanović, M and Đurić, Zorica",
year = "1995",
abstract = "Third-order derivative spectrophotometry is proposed for simultaneous determination of acetylsalicylic acid and free salicylic acid in sustained-release tablets, and compared with TLC-densitometry. Both methods were evaluated through selectivity, and accuracy tests. Results for acetylsalicylic acid and salicylic acid in aspirin sustained-release tablets showed good agreement.",
publisher = "Societa Chimica Italiana",
journal = "Farmaco",
title = "Third-order derivative UV spectrophotometry and densitometry for the simultaneous assay of acetylsalicylic acid and salicylic acid in tablet formulations",
volume = "50",
number = "4",
pages = "285-288",
url = "https://hdl.handle.net/21.15107/rcub_farfar_120"
}

Jovicić, G., Nikolić, L., Karijikovic Rajić, K., Agbaba, D., Jovanović, M.,& Đurić, Z.. (1995). Third-order derivative UV spectrophotometry and densitometry for the simultaneous assay of acetylsalicylic acid and salicylic acid in tablet formulations. in Farmaco
Societa Chimica Italiana., 50(4), 285-288.
https://hdl.handle.net/21.15107/rcub_farfar_120

Jovicić G, Nikolić L, Karijikovic Rajić K, Agbaba D, Jovanović M, Đurić Z. Third-order derivative UV spectrophotometry and densitometry for the simultaneous assay of acetylsalicylic acid and salicylic acid in tablet formulations. in Farmaco. 1995;50(4):285-288.
https://hdl.handle.net/21.15107/rcub_farfar_120 .

Jovicić, G, Nikolić, L, Karijikovic Rajić, K, Agbaba, Danica, Jovanović, M, Đurić, Zorica, "Third-order derivative UV spectrophotometry and densitometry for the simultaneous assay of acetylsalicylic acid and salicylic acid in tablet formulations" in Farmaco, 50, no. 4 (1995):285-288,
https://hdl.handle.net/21.15107/rcub_farfar_120 .