TY  - JOUR
AU  - Dragičević-Curić, Nina
AU  - Winter, Sven
AU  - Krajišnik, Danina
AU  - Stupar, Mirjana
AU  - Milić, Jela
AU  - Graefe, Susanna
AU  - Fahr, Alfred
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1386
AB  - Temoporfin (mTHPC) is a potent second-generation synthetic photosensitizer. Topical delivery of mTHPC is of great interest for the photodynamic therapy of psoriasis and superficial skin cancer lesions. The aim of this study was to evaluate the stability of hydrophilic gels containing mTHPC-loaded liposomes. Two different mTHPC-loaded liposome dispersions, composed of 15 % (w/w) nonhydrogenated soybean lecithin of different phosphatidylcholine content, were prepared and incorporated (2:1 w/w) into hydrogels of different carbomer concentrations (1.5, 2.25, and 3%; w/w). Obtained liposomal hydrogels, containing 0.15% (w/w) mTHPC, 10% (w/w) phospholipids, and 0, 0.5, or 1% (w/w) carbomer, were analyzed for flow properties, liposome particle size, and polydispersity index (PDI), pH value, and mTHPC content after their preparation and at predetermined time intervals during 6 months of storage at 4 and 23 degrees C. All hydrogels showed, during the whole period of investigation, adequate characteristics for topical application (i.e., they revealed shear-thinning plastic flow behavior). Rheological parameters, particle size, and PDI of liposomes in hydrogels, mTHPC content, and pH value did not show remarkable changes during the storage of gels, which could make them unacceptable for topical use. The obtained results indicated physical and chemical stability of liposomal gels containing mTHPC during 6 months of storage at both temperatures.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Liposome Research
T1  - Stability evaluation of temoporfin-loaded liposomal gels for topical application
VL  - 20
IS  - 1
SP  - 38
EP  - 48
DO  - 10.3109/08982100903030263
ER  - 

@article{
author = "Dragičević-Curić, Nina and Winter, Sven and Krajišnik, Danina and Stupar, Mirjana and Milić, Jela and Graefe, Susanna and Fahr, Alfred",
year = "2010",
abstract = "Temoporfin (mTHPC) is a potent second-generation synthetic photosensitizer. Topical delivery of mTHPC is of great interest for the photodynamic therapy of psoriasis and superficial skin cancer lesions. The aim of this study was to evaluate the stability of hydrophilic gels containing mTHPC-loaded liposomes. Two different mTHPC-loaded liposome dispersions, composed of 15 % (w/w) nonhydrogenated soybean lecithin of different phosphatidylcholine content, were prepared and incorporated (2:1 w/w) into hydrogels of different carbomer concentrations (1.5, 2.25, and 3%; w/w). Obtained liposomal hydrogels, containing 0.15% (w/w) mTHPC, 10% (w/w) phospholipids, and 0, 0.5, or 1% (w/w) carbomer, were analyzed for flow properties, liposome particle size, and polydispersity index (PDI), pH value, and mTHPC content after their preparation and at predetermined time intervals during 6 months of storage at 4 and 23 degrees C. All hydrogels showed, during the whole period of investigation, adequate characteristics for topical application (i.e., they revealed shear-thinning plastic flow behavior). Rheological parameters, particle size, and PDI of liposomes in hydrogels, mTHPC content, and pH value did not show remarkable changes during the storage of gels, which could make them unacceptable for topical use. The obtained results indicated physical and chemical stability of liposomal gels containing mTHPC during 6 months of storage at both temperatures.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Liposome Research",
title = "Stability evaluation of temoporfin-loaded liposomal gels for topical application",
volume = "20",
number = "1",
pages = "38-48",
doi = "10.3109/08982100903030263"
}

Dragičević-Curić, N., Winter, S., Krajišnik, D., Stupar, M., Milić, J., Graefe, S.,& Fahr, A.. (2010). Stability evaluation of temoporfin-loaded liposomal gels for topical application. in Journal of Liposome Research
Taylor & Francis Ltd, Abingdon., 20(1), 38-48.
https://doi.org/10.3109/08982100903030263

Dragičević-Curić N, Winter S, Krajišnik D, Stupar M, Milić J, Graefe S, Fahr A. Stability evaluation of temoporfin-loaded liposomal gels for topical application. in Journal of Liposome Research. 2010;20(1):38-48.
doi:10.3109/08982100903030263 .

Dragičević-Curić, Nina, Winter, Sven, Krajišnik, Danina, Stupar, Mirjana, Milić, Jela, Graefe, Susanna, Fahr, Alfred, "Stability evaluation of temoporfin-loaded liposomal gels for topical application" in Journal of Liposome Research, 20, no. 1 (2010):38-48,
https://doi.org/10.3109/08982100903030263 . .

TY  - JOUR
AU  - Dragičević-Curić, Nina
AU  - Winter, Sven
AU  - Stupar, Mirjana
AU  - Milić, Jela
AU  - Krajišnik, Danina
AU  - Gitter, Burkhard
AU  - Fahr, Alfred
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1231
AB  - Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration
VL  - 373
IS  - 1-2
SP  - 77
EP  - 84
DO  - 10.1016/j.ijpharm.2009.02.010
ER  - 

@article{
author = "Dragičević-Curić, Nina and Winter, Sven and Stupar, Mirjana and Milić, Jela and Krajišnik, Danina and Gitter, Burkhard and Fahr, Alfred",
year = "2009",
abstract = "Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration",
volume = "373",
number = "1-2",
pages = "77-84",
doi = "10.1016/j.ijpharm.2009.02.010"
}

Dragičević-Curić, N., Winter, S., Stupar, M., Milić, J., Krajišnik, D., Gitter, B.,& Fahr, A.. (2009). Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 373(1-2), 77-84.
https://doi.org/10.1016/j.ijpharm.2009.02.010

Dragičević-Curić N, Winter S, Stupar M, Milić J, Krajišnik D, Gitter B, Fahr A. Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration. in International Journal of Pharmaceutics. 2009;373(1-2):77-84.
doi:10.1016/j.ijpharm.2009.02.010 .

Dragičević-Curić, Nina, Winter, Sven, Stupar, Mirjana, Milić, Jela, Krajišnik, Danina, Gitter, Burkhard, Fahr, Alfred, "Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration" in International Journal of Pharmaceutics, 373, no. 1-2 (2009):77-84,
https://doi.org/10.1016/j.ijpharm.2009.02.010 . .

TY  - JOUR
AU  - Stanojević, M
AU  - Krusić, MK
AU  - Filipović, J
AU  - Parojčić, Jelena
AU  - Stupar, Mirjana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/846
AB  - The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition and crosslinking degree to find materials with satisfactory swelling and drug release properties. Samples were characterized by measuring the swelling behavior and in vitro release of paracetamol as a model drug in aqueous media with different pH values. The two-factor, three-level experimental design and response surface methodology were applied to statistically evaluate the influence of investigated factors.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Delivery
T1  - An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media
VL  - 13
IS  - 1
SP  - 1
EP  - 7
DO  - 10.1080/10717540500313034
ER  - 

@article{
author = "Stanojević, M and Krusić, MK and Filipović, J and Parojčić, Jelena and Stupar, Mirjana",
year = "2006",
abstract = "The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition and crosslinking degree to find materials with satisfactory swelling and drug release properties. Samples were characterized by measuring the swelling behavior and in vitro release of paracetamol as a model drug in aqueous media with different pH values. The two-factor, three-level experimental design and response surface methodology were applied to statistically evaluate the influence of investigated factors.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Delivery",
title = "An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media",
volume = "13",
number = "1",
pages = "1-7",
doi = "10.1080/10717540500313034"
}

Stanojević, M., Krusić, M., Filipović, J., Parojčić, J.,& Stupar, M.. (2006). An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media. in Drug Delivery
Taylor & Francis Ltd, Abingdon., 13(1), 1-7.
https://doi.org/10.1080/10717540500313034

Stanojević M, Krusić M, Filipović J, Parojčić J, Stupar M. An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media. in Drug Delivery. 2006;13(1):1-7.
doi:10.1080/10717540500313034 .

Stanojević, M, Krusić, MK, Filipović, J, Parojčić, Jelena, Stupar, Mirjana, "An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media" in Drug Delivery, 13, no. 1 (2006):1-7,
https://doi.org/10.1080/10717540500313034 . .

TY  - JOUR
AU  - Dragičević-Curić, Nina
AU  - Stupar, Mirjana
AU  - Milić, J.
AU  - Zorić, T
AU  - Krajišnik, Danina
AU  - Vasiljević, D
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/574
AB  - The aim of this study was to develop and characterize hydrophilic gels containing chlorophyllin(CHL)loaded liposomes as well as to evaluate their stability. Two different CHL-loaded liposome dispersions using non-hydrogenated and hydrogenated soybean lecithin were prepared, characterized for their particle size, polydispersity index and trapping efficiency and incorporated in Carbopol(R) 940 NF hydrogel. The gels obtained were analyzed for flow properties, pH values and CHL content. The control liposome-free gel was obtained by incorporating the CHL solution in the hydrogel. The stability of the gels was evaluated in terms of rheological properties, pH values and CHL content during 6 months' storage at 20 +/- 2 degrees C. Suitable gel formulations for topical use were obtained revealing shear-thinning plastic flow behaviour without significant thixotropy during the whole period of examination. High yield values of the samples during the whole period indicated a long-term stability of the gel formulations. The gel formulations expressed a mild acid value acceptable for topical preparations. After 6 months' storage the CHL content was highest in the gel containing non-hydrogenated lecithin liposomes, followed by the gel containing hydrogenated lecithin liposomes and liposome-free gel, indicating that the encapsulation of CHL in liposomes led to a greater stability of CHL.
PB  - Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation
VL  - 60
IS  - 8
SP  - 588
EP  - 592
UR  - https://hdl.handle.net/21.15107/rcub_farfar_574
ER  - 

@article{
author = "Dragičević-Curić, Nina and Stupar, Mirjana and Milić, J. and Zorić, T and Krajišnik, Danina and Vasiljević, D",
year = "2005",
abstract = "The aim of this study was to develop and characterize hydrophilic gels containing chlorophyllin(CHL)loaded liposomes as well as to evaluate their stability. Two different CHL-loaded liposome dispersions using non-hydrogenated and hydrogenated soybean lecithin were prepared, characterized for their particle size, polydispersity index and trapping efficiency and incorporated in Carbopol(R) 940 NF hydrogel. The gels obtained were analyzed for flow properties, pH values and CHL content. The control liposome-free gel was obtained by incorporating the CHL solution in the hydrogel. The stability of the gels was evaluated in terms of rheological properties, pH values and CHL content during 6 months' storage at 20 +/- 2 degrees C. Suitable gel formulations for topical use were obtained revealing shear-thinning plastic flow behaviour without significant thixotropy during the whole period of examination. High yield values of the samples during the whole period indicated a long-term stability of the gel formulations. The gel formulations expressed a mild acid value acceptable for topical preparations. After 6 months' storage the CHL content was highest in the gel containing non-hydrogenated lecithin liposomes, followed by the gel containing hydrogenated lecithin liposomes and liposome-free gel, indicating that the encapsulation of CHL in liposomes led to a greater stability of CHL.",
publisher = "Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation",
volume = "60",
number = "8",
pages = "588-592",
url = "https://hdl.handle.net/21.15107/rcub_farfar_574"
}

Dragičević-Curić, N., Stupar, M., Milić, J., Zorić, T., Krajišnik, D.,& Vasiljević, D.. (2005). Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation. in Pharmazie
Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn., 60(8), 588-592.
https://hdl.handle.net/21.15107/rcub_farfar_574

Dragičević-Curić N, Stupar M, Milić J, Zorić T, Krajišnik D, Vasiljević D. Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation. in Pharmazie. 2005;60(8):588-592.
https://hdl.handle.net/21.15107/rcub_farfar_574 .

Dragičević-Curić, Nina, Stupar, Mirjana, Milić, J., Zorić, T, Krajišnik, Danina, Vasiljević, D, "Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation" in Pharmazie, 60, no. 8 (2005):588-592,
https://hdl.handle.net/21.15107/rcub_farfar_574 .

TY  - JOUR
AU  - Đorđević, Ljiljana
AU  - Primorac, Marija
AU  - Stupar, Mirjana
AU  - Krajišnik, Danina
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/529
AB  - Microemulsion systems composed of water, isopropyl myristate, PEG-8 caprylic/captzc glycerides (Labrasol((R))), and polyglyceryl-6 dioleate (Plurol Oleique((R))), were investigated as potential drug delivery vehicles for an amphiphilic model drug (diclofenac diethylamine). Pseudo-ternary phase diagram of the investigated system, at constant surfactant/cosurfactant mass ratio (Km 4:1) was constructed at room temperature by titration, and the oil-to-surfactant/cosurfactant mass ratios (O/SC) that exhibit the maximum in the solubilization of water were found. This allowed the investigation of the continuous structural inversion from water-in-oil to oil-in-water microemulsions on dilution with water phase. Furthermore, electrical conductivity (sigma) of the system at Km 1:4, and O/SC 0.250 was studied, and the percolation phenomenon was observed. Conductivity and apparent viscosity (eta') measurement results well described colloidal microstructure of the selected formulations, including gradual changes during their formation. Moreover, sigma, eta', and pH values of six selected microemulsion vehicles which differ in water phase volume fraction (phi(W)) at the selected Km and O/SC values, were measured. In order to investigate the influence of the amphiphilic drug on the vehicle microstructures, each system was formulated with 1.16% (w/w) diclofenac diethylamine. Electrical conductivity, and eta' of the investigated systems were strongly affected by drug incorporation. The obtained results suggest that diclofenac diethylamine interacts with the specific microstructure of the investigated vehicles, and that the different drug release kinetics from these microemulsions may be expected. The investigated microemulsions should be very interesting as new drug carrier systems for dermal application of diclofenac diethylamine.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug
VL  - 271
IS  - 1-2
SP  - 11
EP  - 19
DO  - 10.1016/j.ijpharm.2003.10.037
ER  - 

@article{
author = "Đorđević, Ljiljana and Primorac, Marija and Stupar, Mirjana and Krajišnik, Danina",
year = "2004",
abstract = "Microemulsion systems composed of water, isopropyl myristate, PEG-8 caprylic/captzc glycerides (Labrasol((R))), and polyglyceryl-6 dioleate (Plurol Oleique((R))), were investigated as potential drug delivery vehicles for an amphiphilic model drug (diclofenac diethylamine). Pseudo-ternary phase diagram of the investigated system, at constant surfactant/cosurfactant mass ratio (Km 4:1) was constructed at room temperature by titration, and the oil-to-surfactant/cosurfactant mass ratios (O/SC) that exhibit the maximum in the solubilization of water were found. This allowed the investigation of the continuous structural inversion from water-in-oil to oil-in-water microemulsions on dilution with water phase. Furthermore, electrical conductivity (sigma) of the system at Km 1:4, and O/SC 0.250 was studied, and the percolation phenomenon was observed. Conductivity and apparent viscosity (eta') measurement results well described colloidal microstructure of the selected formulations, including gradual changes during their formation. Moreover, sigma, eta', and pH values of six selected microemulsion vehicles which differ in water phase volume fraction (phi(W)) at the selected Km and O/SC values, were measured. In order to investigate the influence of the amphiphilic drug on the vehicle microstructures, each system was formulated with 1.16% (w/w) diclofenac diethylamine. Electrical conductivity, and eta' of the investigated systems were strongly affected by drug incorporation. The obtained results suggest that diclofenac diethylamine interacts with the specific microstructure of the investigated vehicles, and that the different drug release kinetics from these microemulsions may be expected. The investigated microemulsions should be very interesting as new drug carrier systems for dermal application of diclofenac diethylamine.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug",
volume = "271",
number = "1-2",
pages = "11-19",
doi = "10.1016/j.ijpharm.2003.10.037"
}

Đorđević, L., Primorac, M., Stupar, M.,& Krajišnik, D.. (2004). Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 271(1-2), 11-19.
https://doi.org/10.1016/j.ijpharm.2003.10.037

Đorđević L, Primorac M, Stupar M, Krajišnik D. Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. in International Journal of Pharmaceutics. 2004;271(1-2):11-19.
doi:10.1016/j.ijpharm.2003.10.037 .

Đorđević, Ljiljana, Primorac, Marija, Stupar, Mirjana, Krajišnik, Danina, "Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug" in International Journal of Pharmaceutics, 271, no. 1-2 (2004):11-19,
https://doi.org/10.1016/j.ijpharm.2003.10.037 . .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Milić-Aškrabić, Jela
AU  - Vuleta, Gordana
AU  - Stupar, Mirjana
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/506
AB  - In this work results of model creams investigation containing polymeric emulsifier in the form of „Liquid Dispersion Polymers”, Salcare® SC 91 (Sodium acrylates/paraffinum liquidum/PPG-1 Trideceth-6; 3 % (m/m)) and 30 % (m/m) of different polarity oil phases (paraffin, light liqiud; medium-chain triglycerides and almond oil) are presented. For physico-chemical characterization and physical stability assessment of prepared creams investigations of appearance, physical stability, pH value and electrical conductivity alongside with rheological measurements (rotational and oscillatory) in the period of three months were performed. All the tested samples had good macroscopic behavior and physical stability and their pH values were acceptable for topical application. Rheological measurements revealed that oil phase type had great influence on applicative characteristics and stability of emulsion systems. Model cream samples prepared with more polar oil phases had better stability than cream containing less polar phase.
AB  - U radu su prikazani rezultati ispitivanja model kremova izrađenih sa polimernim emulgatorom u formi tečne disperzije, Salcare® SC 91 (Natrijum Akrilat Kopolimer/Tečni parafin/PPG-1 Tridecet-6; 3 % (m/m)) i 30 % (m/m) masne faze različite polarnosti (tečni laki parafin, trigliceridi srednje dužine lanca i bademovo ulje). U cilju fizičko-hemijske karakterizacije i procene stabilnosti izrađenih kremova sprovedena su ispitivanja izgleda, fizičke stabilnosti, pH vrednosti i električne provodljivosti kao i reološka analiza (kontinualna i oscilatorna) u periodu od 3 meseca. Svi ispitivani uzorci pokazali su zadovoljavajući izgled i fizičku stabilnost a vrednosti pH bile su u opsegu prihvatljivom za preparate za primenu na kožu. Reološka merenja su pokazala da tip upotrebljene masne faze može imati znatan uticaj na aplikativne karakteristike i stabilnosti datih emulzionih sistema. Uzorci model kremova izrađenih sa masnim fazama veće polarnosti pokazali su se stabilnijim u odnosu na krem sa najmanje polarnom masnom fazom.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - The influence of oil phase type on physicochemical and rheological properties of creams stabilized with polymeric emulsifier Salcare® SC 91
T1  - Uticaj tipa masne faze na fizičko-hemijske i reološke osobine kremova stabilisanih polimernim emulgatorom Salcare SC 91
VL  - 54
IS  - 5
SP  - 613
EP  - 628
UR  - https://hdl.handle.net/21.15107/rcub_farfar_506
ER  - 

@article{
author = "Krajišnik, Danina and Milić-Aškrabić, Jela and Vuleta, Gordana and Stupar, Mirjana",
year = "2004",
abstract = "In this work results of model creams investigation containing polymeric emulsifier in the form of „Liquid Dispersion Polymers”, Salcare® SC 91 (Sodium acrylates/paraffinum liquidum/PPG-1 Trideceth-6; 3 % (m/m)) and 30 % (m/m) of different polarity oil phases (paraffin, light liqiud; medium-chain triglycerides and almond oil) are presented. For physico-chemical characterization and physical stability assessment of prepared creams investigations of appearance, physical stability, pH value and electrical conductivity alongside with rheological measurements (rotational and oscillatory) in the period of three months were performed. All the tested samples had good macroscopic behavior and physical stability and their pH values were acceptable for topical application. Rheological measurements revealed that oil phase type had great influence on applicative characteristics and stability of emulsion systems. Model cream samples prepared with more polar oil phases had better stability than cream containing less polar phase., U radu su prikazani rezultati ispitivanja model kremova izrađenih sa polimernim emulgatorom u formi tečne disperzije, Salcare® SC 91 (Natrijum Akrilat Kopolimer/Tečni parafin/PPG-1 Tridecet-6; 3 % (m/m)) i 30 % (m/m) masne faze različite polarnosti (tečni laki parafin, trigliceridi srednje dužine lanca i bademovo ulje). U cilju fizičko-hemijske karakterizacije i procene stabilnosti izrađenih kremova sprovedena su ispitivanja izgleda, fizičke stabilnosti, pH vrednosti i električne provodljivosti kao i reološka analiza (kontinualna i oscilatorna) u periodu od 3 meseca. Svi ispitivani uzorci pokazali su zadovoljavajući izgled i fizičku stabilnost a vrednosti pH bile su u opsegu prihvatljivom za preparate za primenu na kožu. Reološka merenja su pokazala da tip upotrebljene masne faze može imati znatan uticaj na aplikativne karakteristike i stabilnosti datih emulzionih sistema. Uzorci model kremova izrađenih sa masnim fazama veće polarnosti pokazali su se stabilnijim u odnosu na krem sa najmanje polarnom masnom fazom.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The influence of oil phase type on physicochemical and rheological properties of creams stabilized with polymeric emulsifier Salcare® SC 91, Uticaj tipa masne faze na fizičko-hemijske i reološke osobine kremova stabilisanih polimernim emulgatorom Salcare SC 91",
volume = "54",
number = "5",
pages = "613-628",
url = "https://hdl.handle.net/21.15107/rcub_farfar_506"
}

Krajišnik, D., Milić-Aškrabić, J., Vuleta, G.,& Stupar, M.. (2004). The influence of oil phase type on physicochemical and rheological properties of creams stabilized with polymeric emulsifier Salcare® SC 91. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 54(5), 613-628.
https://hdl.handle.net/21.15107/rcub_farfar_506

Krajišnik D, Milić-Aškrabić J, Vuleta G, Stupar M. The influence of oil phase type on physicochemical and rheological properties of creams stabilized with polymeric emulsifier Salcare® SC 91. in Arhiv za farmaciju. 2004;54(5):613-628.
https://hdl.handle.net/21.15107/rcub_farfar_506 .

Krajišnik, Danina, Milić-Aškrabić, Jela, Vuleta, Gordana, Stupar, Mirjana, "The influence of oil phase type on physicochemical and rheological properties of creams stabilized with polymeric emulsifier Salcare® SC 91" in Arhiv za farmaciju, 54, no. 5 (2004):613-628,
https://hdl.handle.net/21.15107/rcub_farfar_506 .

TY  - CONF
AU  - Ilić, Tanja
AU  - Primorac, Marija
AU  - Stupar, Mirjana
AU  - Đorđević, Ljiljana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/375
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Phase behaviour of the microemulsion systems based on sucrose esters
T1  - Fazno ponašanje mikroemulzionih sistema na bazi estara saharoze
VL  - 52
IS  - 4
SP  - 584
EP  - 585
UR  - https://hdl.handle.net/21.15107/rcub_farfar_375
ER  - 

@conference{
author = "Ilić, Tanja and Primorac, Marija and Stupar, Mirjana and Đorđević, Ljiljana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Phase behaviour of the microemulsion systems based on sucrose esters, Fazno ponašanje mikroemulzionih sistema na bazi estara saharoze",
volume = "52",
number = "4",
pages = "584-585",
url = "https://hdl.handle.net/21.15107/rcub_farfar_375"
}

Ilić, T., Primorac, M., Stupar, M.,& Đorđević, L.. (2002). Phase behaviour of the microemulsion systems based on sucrose esters. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 584-585.
https://hdl.handle.net/21.15107/rcub_farfar_375

Ilić T, Primorac M, Stupar M, Đorđević L. Phase behaviour of the microemulsion systems based on sucrose esters. in Arhiv za farmaciju. 2002;52(4):584-585.
https://hdl.handle.net/21.15107/rcub_farfar_375 .

Ilić, Tanja, Primorac, Marija, Stupar, Mirjana, Đorđević, Ljiljana, "Phase behaviour of the microemulsion systems based on sucrose esters" in Arhiv za farmaciju, 52, no. 4 (2002):584-585,
https://hdl.handle.net/21.15107/rcub_farfar_375 .

TY  - CONF
AU  - Cvetkovski, A.
AU  - Tasić, Ljiljana
AU  - Stupar, Mirjana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/369
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Approach to choise and selection of methods for preformulation studies of solid dosage forms
T1  - Izbor i selekcija metoda za predformulaciona istraživanja čvrstih lekovitih oblika
VL  - 52
IS  - 4
SP  - 532
EP  - 533
UR  - https://hdl.handle.net/21.15107/rcub_farfar_369
ER  - 

@conference{
author = "Cvetkovski, A. and Tasić, Ljiljana and Stupar, Mirjana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Approach to choise and selection of methods for preformulation studies of solid dosage forms, Izbor i selekcija metoda za predformulaciona istraživanja čvrstih lekovitih oblika",
volume = "52",
number = "4",
pages = "532-533",
url = "https://hdl.handle.net/21.15107/rcub_farfar_369"
}

Cvetkovski, A., Tasić, L.,& Stupar, M.. (2002). Approach to choise and selection of methods for preformulation studies of solid dosage forms. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 532-533.
https://hdl.handle.net/21.15107/rcub_farfar_369

Cvetkovski A, Tasić L, Stupar M. Approach to choise and selection of methods for preformulation studies of solid dosage forms. in Arhiv za farmaciju. 2002;52(4):532-533.
https://hdl.handle.net/21.15107/rcub_farfar_369 .

Cvetkovski, A., Tasić, Ljiljana, Stupar, Mirjana, "Approach to choise and selection of methods for preformulation studies of solid dosage forms" in Arhiv za farmaciju, 52, no. 4 (2002):532-533,
https://hdl.handle.net/21.15107/rcub_farfar_369 .

TY  - CONF
AU  - Vasiljević, Dragana
AU  - Vuleta, Gordana
AU  - Primorac, Marija
AU  - Stupar, Mirjana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/359
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - The characterization of W/O/W multiple emulsions with cetyl dimethicone copolyol as primary emulsifier
T1  - Karakterizacija višestrukih emulzija V/U/V tipa izrađenih sa cetildimetikon-kopoliolom kao primarnim emulgatorom
VL  - 52
IS  - 4
SP  - 578
EP  - 579
UR  - https://hdl.handle.net/21.15107/rcub_farfar_359
ER  - 

@conference{
author = "Vasiljević, Dragana and Vuleta, Gordana and Primorac, Marija and Stupar, Mirjana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The characterization of W/O/W multiple emulsions with cetyl dimethicone copolyol as primary emulsifier, Karakterizacija višestrukih emulzija V/U/V tipa izrađenih sa cetildimetikon-kopoliolom kao primarnim emulgatorom",
volume = "52",
number = "4",
pages = "578-579",
url = "https://hdl.handle.net/21.15107/rcub_farfar_359"
}

Vasiljević, D., Vuleta, G., Primorac, M.,& Stupar, M.. (2002). The characterization of W/O/W multiple emulsions with cetyl dimethicone copolyol as primary emulsifier. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 578-579.
https://hdl.handle.net/21.15107/rcub_farfar_359

Vasiljević D, Vuleta G, Primorac M, Stupar M. The characterization of W/O/W multiple emulsions with cetyl dimethicone copolyol as primary emulsifier. in Arhiv za farmaciju. 2002;52(4):578-579.
https://hdl.handle.net/21.15107/rcub_farfar_359 .

Vasiljević, Dragana, Vuleta, Gordana, Primorac, Marija, Stupar, Mirjana, "The characterization of W/O/W multiple emulsions with cetyl dimethicone copolyol as primary emulsifier" in Arhiv za farmaciju, 52, no. 4 (2002):578-579,
https://hdl.handle.net/21.15107/rcub_farfar_359 .

TY  - CONF
AU  - Stanojević, M.
AU  - Tubić, M.
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Stupar, Mirjana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/385
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Comparative evaluation of drug dissolution from comercial Diazepam tablets
T1  - Uporedno ispitivanje brzine rastvaranja Diazepama iz uzoraka komercijalnih tableta
VL  - 52
IS  - 4
SP  - 564
EP  - 565
UR  - https://hdl.handle.net/21.15107/rcub_farfar_385
ER  - 

@conference{
author = "Stanojević, M. and Tubić, M. and Ibrić, Svetlana and Parojčić, Jelena and Stupar, Mirjana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Comparative evaluation of drug dissolution from comercial Diazepam tablets, Uporedno ispitivanje brzine rastvaranja Diazepama iz uzoraka komercijalnih tableta",
volume = "52",
number = "4",
pages = "564-565",
url = "https://hdl.handle.net/21.15107/rcub_farfar_385"
}

Stanojević, M., Tubić, M., Ibrić, S., Parojčić, J.,& Stupar, M.. (2002). Comparative evaluation of drug dissolution from comercial Diazepam tablets. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 564-565.
https://hdl.handle.net/21.15107/rcub_farfar_385

Stanojević M, Tubić M, Ibrić S, Parojčić J, Stupar M. Comparative evaluation of drug dissolution from comercial Diazepam tablets. in Arhiv za farmaciju. 2002;52(4):564-565.
https://hdl.handle.net/21.15107/rcub_farfar_385 .

Stanojević, M., Tubić, M., Ibrić, Svetlana, Parojčić, Jelena, Stupar, Mirjana, "Comparative evaluation of drug dissolution from comercial Diazepam tablets" in Arhiv za farmaciju, 52, no. 4 (2002):564-565,
https://hdl.handle.net/21.15107/rcub_farfar_385 .

TY  - JOUR
AU  - Tasić, Ljiljana
AU  - Milić, Jela
AU  - Stupar, Mirjana
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/198
AB  - Cyclodextrins are oligosaccharides which have recently been recognized as useful pharmaceutical excipients. The objective of this review is to summarized recent findings and applications of both unmodified and modified cyclodextrins for drug delivery. Its ability to form inclusion complexes with many drugs, were explored for designing of a particular drug carrier system. Cyclodextrin inclusion complexes demonstrate great potential against improvement of solubility, stability, dissolution rate, enhancement through biological membrane, etc. Furthermore, its safety profiles, via a variety of administration routes (oral, parenteral, transmucosal) are addressed. Finally, this paper is primarily focused on the findings related to the effects of cyclodextrins/anticancer drugs and cyclodextrins/prostaglandins delivery systems, and on the therapeutical potentiality of drugs.
PB  - Institut za onkologiju, Sremska Kamenica
T2  - Archive of Oncology
T1  - Cyclodextrins: New materials for drug disposition
VL  - 6
IS  - 3
SP  - 125
EP  - 129
UR  - https://hdl.handle.net/21.15107/rcub_farfar_198
ER  - 

@article{
author = "Tasić, Ljiljana and Milić, Jela and Stupar, Mirjana",
year = "1998",
abstract = "Cyclodextrins are oligosaccharides which have recently been recognized as useful pharmaceutical excipients. The objective of this review is to summarized recent findings and applications of both unmodified and modified cyclodextrins for drug delivery. Its ability to form inclusion complexes with many drugs, were explored for designing of a particular drug carrier system. Cyclodextrin inclusion complexes demonstrate great potential against improvement of solubility, stability, dissolution rate, enhancement through biological membrane, etc. Furthermore, its safety profiles, via a variety of administration routes (oral, parenteral, transmucosal) are addressed. Finally, this paper is primarily focused on the findings related to the effects of cyclodextrins/anticancer drugs and cyclodextrins/prostaglandins delivery systems, and on the therapeutical potentiality of drugs.",
publisher = "Institut za onkologiju, Sremska Kamenica",
journal = "Archive of Oncology",
title = "Cyclodextrins: New materials for drug disposition",
volume = "6",
number = "3",
pages = "125-129",
url = "https://hdl.handle.net/21.15107/rcub_farfar_198"
}

Tasić, L., Milić, J.,& Stupar, M.. (1998). Cyclodextrins: New materials for drug disposition. in Archive of Oncology
Institut za onkologiju, Sremska Kamenica., 6(3), 125-129.
https://hdl.handle.net/21.15107/rcub_farfar_198

Tasić L, Milić J, Stupar M. Cyclodextrins: New materials for drug disposition. in Archive of Oncology. 1998;6(3):125-129.
https://hdl.handle.net/21.15107/rcub_farfar_198 .

Tasić, Ljiljana, Milić, Jela, Stupar, Mirjana, "Cyclodextrins: New materials for drug disposition" in Archive of Oncology, 6, no. 3 (1998):125-129,
https://hdl.handle.net/21.15107/rcub_farfar_198 .

TY  - CONF
AU  - Primorac, Marija
AU  - Stupar, Mirjana
AU  - Milić, Jela
AU  - Vasiljević, Dragana
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/163
PB  - Slovenian Pharmaceutical Society
C3  - Farmacevtski Vestnik
T1  - Rheological and conductivity studies of the microemulsion system water - Crodafos N 10 - Volpo N 5-glycerol - Paraffin oil
VL  - 48
IS  - SPEC. ISS.
SP  - 346
EP  - 347
UR  - https://hdl.handle.net/21.15107/rcub_farfar_163
ER  - 

@conference{
author = "Primorac, Marija and Stupar, Mirjana and Milić, Jela and Vasiljević, Dragana",
year = "1997",
publisher = "Slovenian Pharmaceutical Society",
journal = "Farmacevtski Vestnik",
title = "Rheological and conductivity studies of the microemulsion system water - Crodafos N 10 - Volpo N 5-glycerol - Paraffin oil",
volume = "48",
number = "SPEC. ISS.",
pages = "346-347",
url = "https://hdl.handle.net/21.15107/rcub_farfar_163"
}

Primorac, M., Stupar, M., Milić, J.,& Vasiljević, D.. (1997). Rheological and conductivity studies of the microemulsion system water - Crodafos N 10 - Volpo N 5-glycerol - Paraffin oil. in Farmacevtski Vestnik
Slovenian Pharmaceutical Society., 48(SPEC. ISS.), 346-347.
https://hdl.handle.net/21.15107/rcub_farfar_163

Primorac M, Stupar M, Milić J, Vasiljević D. Rheological and conductivity studies of the microemulsion system water - Crodafos N 10 - Volpo N 5-glycerol - Paraffin oil. in Farmacevtski Vestnik. 1997;48(SPEC. ISS.):346-347.
https://hdl.handle.net/21.15107/rcub_farfar_163 .

Primorac, Marija, Stupar, Mirjana, Milić, Jela, Vasiljević, Dragana, "Rheological and conductivity studies of the microemulsion system water - Crodafos N 10 - Volpo N 5-glycerol - Paraffin oil" in Farmacevtski Vestnik, 48, no. SPEC. ISS. (1997):346-347,
https://hdl.handle.net/21.15107/rcub_farfar_163 .

TY  - JOUR
AU  - Primorac, Marija
AU  - Daković, L.J
AU  - Stupar, Mirjana
AU  - Vasiljević, Dragana
PY  - 1994
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/114
T2  - Pharmazie
T1  - The influence of temperature on the rheological behaviour of microemulsions
VL  - 49
IS  - 10
SP  - 780
EP  - 781
UR  - https://hdl.handle.net/21.15107/rcub_farfar_114
ER  - 

@article{
author = "Primorac, Marija and Daković, L.J and Stupar, Mirjana and Vasiljević, Dragana",
year = "1994",
journal = "Pharmazie",
title = "The influence of temperature on the rheological behaviour of microemulsions",
volume = "49",
number = "10",
pages = "780-781",
url = "https://hdl.handle.net/21.15107/rcub_farfar_114"
}

Primorac, M., Daković, L.J, Stupar, M.,& Vasiljević, D.. (1994). The influence of temperature on the rheological behaviour of microemulsions. in Pharmazie, 49(10), 780-781.
https://hdl.handle.net/21.15107/rcub_farfar_114

Primorac M, Daković L, Stupar M, Vasiljević D. The influence of temperature on the rheological behaviour of microemulsions. in Pharmazie. 1994;49(10):780-781.
https://hdl.handle.net/21.15107/rcub_farfar_114 .

Primorac, Marija, Daković, L.J, Stupar, Mirjana, Vasiljević, Dragana, "The influence of temperature on the rheological behaviour of microemulsions" in Pharmazie, 49, no. 10 (1994):780-781,
https://hdl.handle.net/21.15107/rcub_farfar_114 .

TY  - JOUR
AU  - Primorac, Marija
AU  - Stupar, Mirjana
AU  - Vasiljević, Dragana
AU  - Milić-Aškrabić, Jela
PY  - 1994
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/110
PB  - Govi-Verlag Pharmazeutischer Verlag GmbH
T2  - Pharmazie
T1  - Conductivity study of the microemulsion system water-Crodafos N3-Volpo N5-glycerol-paraffin oil
VL  - 49
IS  - 9
SP  - 695
EP  - 696
UR  - https://hdl.handle.net/21.15107/rcub_farfar_110
ER  - 

@article{
author = "Primorac, Marija and Stupar, Mirjana and Vasiljević, Dragana and Milić-Aškrabić, Jela",
year = "1994",
publisher = "Govi-Verlag Pharmazeutischer Verlag GmbH",
journal = "Pharmazie",
title = "Conductivity study of the microemulsion system water-Crodafos N3-Volpo N5-glycerol-paraffin oil",
volume = "49",
number = "9",
pages = "695-696",
url = "https://hdl.handle.net/21.15107/rcub_farfar_110"
}

Primorac, M., Stupar, M., Vasiljević, D.,& Milić-Aškrabić, J.. (1994). Conductivity study of the microemulsion system water-Crodafos N3-Volpo N5-glycerol-paraffin oil. in Pharmazie
Govi-Verlag Pharmazeutischer Verlag GmbH., 49(9), 695-696.
https://hdl.handle.net/21.15107/rcub_farfar_110

Primorac M, Stupar M, Vasiljević D, Milić-Aškrabić J. Conductivity study of the microemulsion system water-Crodafos N3-Volpo N5-glycerol-paraffin oil. in Pharmazie. 1994;49(9):695-696.
https://hdl.handle.net/21.15107/rcub_farfar_110 .

Primorac, Marija, Stupar, Mirjana, Vasiljević, Dragana, Milić-Aškrabić, Jela, "Conductivity study of the microemulsion system water-Crodafos N3-Volpo N5-glycerol-paraffin oil" in Pharmazie, 49, no. 9 (1994):695-696,
https://hdl.handle.net/21.15107/rcub_farfar_110 .

TY  - JOUR
AU  - Primorac, Marija
AU  - Stupar, Mirjana
AU  - Vuleta, Gordana
AU  - Vasiljević, Dragana
PY  - 1992
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/98
T2  - Pharmazie
T1  - Rheological properties of oil/water microemulsions
VL  - 47
IS  - 8
SP  - 645
EP  - 646
UR  - https://hdl.handle.net/21.15107/rcub_farfar_98
ER  - 

@article{
author = "Primorac, Marija and Stupar, Mirjana and Vuleta, Gordana and Vasiljević, Dragana",
year = "1992",
journal = "Pharmazie",
title = "Rheological properties of oil/water microemulsions",
volume = "47",
number = "8",
pages = "645-646",
url = "https://hdl.handle.net/21.15107/rcub_farfar_98"
}

Primorac, M., Stupar, M., Vuleta, G.,& Vasiljević, D.. (1992). Rheological properties of oil/water microemulsions. in Pharmazie, 47(8), 645-646.
https://hdl.handle.net/21.15107/rcub_farfar_98

Primorac M, Stupar M, Vuleta G, Vasiljević D. Rheological properties of oil/water microemulsions. in Pharmazie. 1992;47(8):645-646.
https://hdl.handle.net/21.15107/rcub_farfar_98 .

Primorac, Marija, Stupar, Mirjana, Vuleta, Gordana, Vasiljević, Dragana, "Rheological properties of oil/water microemulsions" in Pharmazie, 47, no. 8 (1992):645-646,
https://hdl.handle.net/21.15107/rcub_farfar_98 .