TY  - CONF
AU  - Ivković, Branka
AU  - Radulović, Dušanka
AU  - Vujić, Zorica
AU  - Agbaba, Danica
AU  - Bešević, Ž.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/699
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Direct separation of beta-blockers enantiomers by thin-layer chromatography using D(-) tartaric acid as a chiral mobile phase additive
T1  - Razdvajanje enantiomera beta blokatora tankoslojnom hromatografijom pomoću D(-) vinske kiseline kao hiralnog aditiva u mobilnoj fazi
VL  - 56
IS  - 5
SP  - 738
EP  - 739
UR  - https://hdl.handle.net/21.15107/rcub_farfar_699
ER  - 

@conference{
author = "Ivković, Branka and Radulović, Dušanka and Vujić, Zorica and Agbaba, Danica and Bešević, Ž.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Direct separation of beta-blockers enantiomers by thin-layer chromatography using D(-) tartaric acid as a chiral mobile phase additive, Razdvajanje enantiomera beta blokatora tankoslojnom hromatografijom pomoću D(-) vinske kiseline kao hiralnog aditiva u mobilnoj fazi",
volume = "56",
number = "5",
pages = "738-739",
url = "https://hdl.handle.net/21.15107/rcub_farfar_699"
}

Ivković, B., Radulović, D., Vujić, Z., Agbaba, D.,& Bešević, Ž.. (2006). Direct separation of beta-blockers enantiomers by thin-layer chromatography using D(-) tartaric acid as a chiral mobile phase additive. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(5), 738-739.
https://hdl.handle.net/21.15107/rcub_farfar_699

Ivković B, Radulović D, Vujić Z, Agbaba D, Bešević Ž. Direct separation of beta-blockers enantiomers by thin-layer chromatography using D(-) tartaric acid as a chiral mobile phase additive. in Arhiv za farmaciju. 2006;56(5):738-739.
https://hdl.handle.net/21.15107/rcub_farfar_699 .

Ivković, Branka, Radulović, Dušanka, Vujić, Zorica, Agbaba, Danica, Bešević, Ž., "Direct separation of beta-blockers enantiomers by thin-layer chromatography using D(-) tartaric acid as a chiral mobile phase additive" in Arhiv za farmaciju, 56, no. 5 (2006):738-739,
https://hdl.handle.net/21.15107/rcub_farfar_699 .

TY  - JOUR
AU  - Lučić, Branka
AU  - Radulović, Dušanka
AU  - Vujić, Zorica
AU  - Agbaba, Danica
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/570
AB  - A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector
VL  - 18
IS  - 104
SP  - 294
EP  - 299
DO  - 10.1556/JPC.18.2005.4.8
ER  - 

@article{
author = "Lučić, Branka and Radulović, Dušanka and Vujić, Zorica and Agbaba, Danica",
year = "2005",
abstract = "A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector",
volume = "18",
number = "104",
pages = "294-299",
doi = "10.1556/JPC.18.2005.4.8"
}

Lučić, B., Radulović, D., Vujić, Z.,& Agbaba, D.. (2005). Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector. in Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 18(104), 294-299.
https://doi.org/10.1556/JPC.18.2005.4.8

Lučić B, Radulović D, Vujić Z, Agbaba D. Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector. in Journal of Planar Chromatography - Modern TLC. 2005;18(104):294-299.
doi:10.1556/JPC.18.2005.4.8 .

Lučić, Branka, Radulović, Dušanka, Vujić, Zorica, Agbaba, Danica, "Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector" in Journal of Planar Chromatography - Modern TLC, 18, no. 104 (2005):294-299,
https://doi.org/10.1556/JPC.18.2005.4.8 . .

TY  - CONF
AU  - Vujić, Zorica
AU  - Radulović, Dušanka
AU  - Vladimirov, Sote
AU  - Dogović, N.
AU  - Stojišić, D.
AU  - Lučić, Branka M.
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/345
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Synthesis of N-oxides as potential metabolites of desipramine, maprotiline and moclobemide
T1  - Sinteza N-oksida kao potencijalnih metabolita desipramina, maprotilina i moklobemida
VL  - 52
IS  - 4
SP  - 452
EP  - 453
UR  - https://hdl.handle.net/21.15107/rcub_farfar_345
ER  - 

@conference{
author = "Vujić, Zorica and Radulović, Dušanka and Vladimirov, Sote and Dogović, N. and Stojišić, D. and Lučić, Branka M.",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Synthesis of N-oxides as potential metabolites of desipramine, maprotiline and moclobemide, Sinteza N-oksida kao potencijalnih metabolita desipramina, maprotilina i moklobemida",
volume = "52",
number = "4",
pages = "452-453",
url = "https://hdl.handle.net/21.15107/rcub_farfar_345"
}

Vujić, Z., Radulović, D., Vladimirov, S., Dogović, N., Stojišić, D.,& Lučić, B. M.. (2002). Synthesis of N-oxides as potential metabolites of desipramine, maprotiline and moclobemide. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 452-453.
https://hdl.handle.net/21.15107/rcub_farfar_345

Vujić Z, Radulović D, Vladimirov S, Dogović N, Stojišić D, Lučić BM. Synthesis of N-oxides as potential metabolites of desipramine, maprotiline and moclobemide. in Arhiv za farmaciju. 2002;52(4):452-453.
https://hdl.handle.net/21.15107/rcub_farfar_345 .

Vujić, Zorica, Radulović, Dušanka, Vladimirov, Sote, Dogović, N., Stojišić, D., Lučić, Branka M., "Synthesis of N-oxides as potential metabolites of desipramine, maprotiline and moclobemide" in Arhiv za farmaciju, 52, no. 4 (2002):452-453,
https://hdl.handle.net/21.15107/rcub_farfar_345 .

TY  - CONF
AU  - Lučić, Branka M.
AU  - Radulović, Dušanka
AU  - Vujić, Zorica
AU  - Karljiković-Rajić, Katarina
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/352
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - The study of inclusion complex formation between metoprolol tartrate and beta-cyclodextrin by spectroscopic methods
T1  - Ispitivanje ravnoteže građenja inkluzionog kompleksa metoprolol-tartarata i beta-ciklodekstrina spektroskopskim metodama
VL  - 52
IS  - 4
SP  - 436
EP  - 437
UR  - https://hdl.handle.net/21.15107/rcub_farfar_352
ER  - 

@conference{
author = "Lučić, Branka M. and Radulović, Dušanka and Vujić, Zorica and Karljiković-Rajić, Katarina",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The study of inclusion complex formation between metoprolol tartrate and beta-cyclodextrin by spectroscopic methods, Ispitivanje ravnoteže građenja inkluzionog kompleksa metoprolol-tartarata i beta-ciklodekstrina spektroskopskim metodama",
volume = "52",
number = "4",
pages = "436-437",
url = "https://hdl.handle.net/21.15107/rcub_farfar_352"
}

Lučić, B. M., Radulović, D., Vujić, Z.,& Karljiković-Rajić, K.. (2002). The study of inclusion complex formation between metoprolol tartrate and beta-cyclodextrin by spectroscopic methods. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 436-437.
https://hdl.handle.net/21.15107/rcub_farfar_352

Lučić BM, Radulović D, Vujić Z, Karljiković-Rajić K. The study of inclusion complex formation between metoprolol tartrate and beta-cyclodextrin by spectroscopic methods. in Arhiv za farmaciju. 2002;52(4):436-437.
https://hdl.handle.net/21.15107/rcub_farfar_352 .

Lučić, Branka M., Radulović, Dušanka, Vujić, Zorica, Karljiković-Rajić, Katarina, "The study of inclusion complex formation between metoprolol tartrate and beta-cyclodextrin by spectroscopic methods" in Arhiv za farmaciju, 52, no. 4 (2002):436-437,
https://hdl.handle.net/21.15107/rcub_farfar_352 .

TY  - JOUR
AU  - Radulović, Dušanka
AU  - Karljiković-Rajić, Katarina
AU  - Lucić, BM
AU  - Vujić, Zorica
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/295
AB  - The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation
VL  - 24
IS  - 5-6
SP  - 871
EP  - 876
DO  - 10.1016/S0731-7085(00)00555-0
ER  - 

@article{
author = "Radulović, Dušanka and Karljiković-Rajić, Katarina and Lucić, BM and Vujić, Zorica",
year = "2001",
abstract = "The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation",
volume = "24",
number = "5-6",
pages = "871-876",
doi = "10.1016/S0731-7085(00)00555-0"
}

Radulović, D., Karljiković-Rajić, K., Lucić, B.,& Vujić, Z.. (2001). A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 871-876.
https://doi.org/10.1016/S0731-7085(00)00555-0

Radulović D, Karljiković-Rajić K, Lucić B, Vujić Z. A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation. in Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):871-876.
doi:10.1016/S0731-7085(00)00555-0 .

Radulović, Dušanka, Karljiković-Rajić, Katarina, Lucić, BM, Vujić, Zorica, "A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation" in Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):871-876,
https://doi.org/10.1016/S0731-7085(00)00555-0 . .

TY  - JOUR
AU  - Vujić, Zorica
AU  - Radulović, Dušanka
AU  - Manojlović, S
PY  - 1999
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/230
AB  - A simple capillary zone electrophoresis method using a fused silica capillary was developed for the quantitation of maprotiline hydrochloride in Maprotilin tablets and Ludiomil ampoules. The sample was pressure-injected into the capillary (3 psis-1) in a run buffer of methanol-phosphate buffer. The optimum running voltage was 20kV and UV detection was at 200 nm. Linearity, precision and reproducibility of the method were good. The developed method is simple and rapid (approx. 10 min) and can be used for the routine analysis of maprotiline.
PB  - Pharmaceutical Press
T2  - Pharmacy and Pharmacology Communications
T1  - Determination of maprotiline hydrochloride by capillary zone electrophoresis
VL  - 5
IS  - 11
SP  - 623
EP  - 624
DO  - 10.1211/146080899128734253
ER  - 

@article{
author = "Vujić, Zorica and Radulović, Dušanka and Manojlović, S",
year = "1999",
abstract = "A simple capillary zone electrophoresis method using a fused silica capillary was developed for the quantitation of maprotiline hydrochloride in Maprotilin tablets and Ludiomil ampoules. The sample was pressure-injected into the capillary (3 psis-1) in a run buffer of methanol-phosphate buffer. The optimum running voltage was 20kV and UV detection was at 200 nm. Linearity, precision and reproducibility of the method were good. The developed method is simple and rapid (approx. 10 min) and can be used for the routine analysis of maprotiline.",
publisher = "Pharmaceutical Press",
journal = "Pharmacy and Pharmacology Communications",
title = "Determination of maprotiline hydrochloride by capillary zone electrophoresis",
volume = "5",
number = "11",
pages = "623-624",
doi = "10.1211/146080899128734253"
}

Vujić, Z., Radulović, D.,& Manojlović, S.. (1999). Determination of maprotiline hydrochloride by capillary zone electrophoresis. in Pharmacy and Pharmacology Communications
Pharmaceutical Press., 5(11), 623-624.
https://doi.org/10.1211/146080899128734253

Vujić Z, Radulović D, Manojlović S. Determination of maprotiline hydrochloride by capillary zone electrophoresis. in Pharmacy and Pharmacology Communications. 1999;5(11):623-624.
doi:10.1211/146080899128734253 .

Vujić, Zorica, Radulović, Dušanka, Manojlović, S, "Determination of maprotiline hydrochloride by capillary zone electrophoresis" in Pharmacy and Pharmacology Communications, 5, no. 11 (1999):623-624,
https://doi.org/10.1211/146080899128734253 . .

TY  - JOUR
AU  - Vujić, Zorica
AU  - Radulović, Dušanka
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/203
AB  - Spectrophotometric and UV-densitometric methods for the determination of celiprolol hydrochloride in tablet formulations were compared. Celiprolol hydrochloride and benzylorange react in a 1:1 ratio in the presence of phosphate buffer, producing a yellow, chloroform-extractable ion pair with an absorption maximum at 401 nm. The conditional stability constants were determined by Sommer and Job's method of non-equimolar solutions. The repeatability of the method was tested by analysing Selectol tablets. Spectrophotometric results were compared with those obtained UV-densitometrically on Silica Gel GF 254 plates with acetone-methanol-triethylamine as mobile phase. There was no significant difference in accuracy between the two methods, however the densitometric method was more rapid.
PB  - Wiley
T2  - Pharmacy and Pharmacology Communications
T1  - Comparison of spectrophotometric and UV-densitometric methods for the determination of celiprolol hydrochloride in tablets
VL  - 4
IS  - 10
SP  - 469
EP  - 471
DO  - https://doi.org/10.1111/j.2042-7158.1998.tb00655.x
ER  - 

@article{
author = "Vujić, Zorica and Radulović, Dušanka",
year = "1998",
abstract = "Spectrophotometric and UV-densitometric methods for the determination of celiprolol hydrochloride in tablet formulations were compared. Celiprolol hydrochloride and benzylorange react in a 1:1 ratio in the presence of phosphate buffer, producing a yellow, chloroform-extractable ion pair with an absorption maximum at 401 nm. The conditional stability constants were determined by Sommer and Job's method of non-equimolar solutions. The repeatability of the method was tested by analysing Selectol tablets. Spectrophotometric results were compared with those obtained UV-densitometrically on Silica Gel GF 254 plates with acetone-methanol-triethylamine as mobile phase. There was no significant difference in accuracy between the two methods, however the densitometric method was more rapid.",
publisher = "Wiley",
journal = "Pharmacy and Pharmacology Communications",
title = "Comparison of spectrophotometric and UV-densitometric methods for the determination of celiprolol hydrochloride in tablets",
volume = "4",
number = "10",
pages = "469-471",
doi = "https://doi.org/10.1111/j.2042-7158.1998.tb00655.x"
}

Vujić, Z.,& Radulović, D.. (1998). Comparison of spectrophotometric and UV-densitometric methods for the determination of celiprolol hydrochloride in tablets. in Pharmacy and Pharmacology Communications
Wiley., 4(10), 469-471.
https://doi.org/https://doi.org/10.1111/j.2042-7158.1998.tb00655.x

Vujić Z, Radulović D. Comparison of spectrophotometric and UV-densitometric methods for the determination of celiprolol hydrochloride in tablets. in Pharmacy and Pharmacology Communications. 1998;4(10):469-471.
doi:https://doi.org/10.1111/j.2042-7158.1998.tb00655.x .

Vujić, Zorica, Radulović, Dušanka, "Comparison of spectrophotometric and UV-densitometric methods for the determination of celiprolol hydrochloride in tablets" in Pharmacy and Pharmacology Communications, 4, no. 10 (1998):469-471,
https://doi.org/https://doi.org/10.1111/j.2042-7158.1998.tb00655.x . .

TY  - JOUR
AU  - Vujić, Zorica
AU  - Radulović, Dušanka
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/200
AB  - A reversed-phase high performance liquid chromatographic method for the determination of maprotilin in bulk drugs, ampoules and tablets is described. To achieve maximum quantity, optimum conditions were used. In order to investigate the effect of each factor and their interaction a three variable, two-level, full-factorial design was chosen. A response-surface diagram was developed to identify the optimum experimental conditions. Maximum response was obtained on a Bondesil C18 column (5μm × 4.6mm × 250mm) with acetonitril-methanol (pH adjusted 4.5 with 0.1 mol/l CH3COOH) mobile phase (1:1, v/v ) and UV detection (λ.=272nm). Peak area responses were linearly related to concentrations of maprotilin in the range 4μg/ml-60μg/ml. The regression equation is y= -1.06574 + 564.095x with correlation coefficient r=0.996. The reliability of the proposed method was checked up at three different concentrations (RSD varied from 0.592 to 2.675%). The described method applied for the determination of maprotilin in tablets and ampoules gave precise and reproducible results; recovery was 98.61% for tablets and 98.92% for ampoules. The developed method can be recommended for the routine analysis of maprotilin in tablets and ampoules.
T2  - Journal de Pharmacie de Belgique
T1  - Statistical optimization applied to the HPLC determination of maprotilin
VL  - 53
IS  - 3
SP  - 267
UR  - https://hdl.handle.net/21.15107/rcub_farfar_200
ER  - 

@article{
author = "Vujić, Zorica and Radulović, Dušanka",
year = "1998",
abstract = "A reversed-phase high performance liquid chromatographic method for the determination of maprotilin in bulk drugs, ampoules and tablets is described. To achieve maximum quantity, optimum conditions were used. In order to investigate the effect of each factor and their interaction a three variable, two-level, full-factorial design was chosen. A response-surface diagram was developed to identify the optimum experimental conditions. Maximum response was obtained on a Bondesil C18 column (5μm × 4.6mm × 250mm) with acetonitril-methanol (pH adjusted 4.5 with 0.1 mol/l CH3COOH) mobile phase (1:1, v/v ) and UV detection (λ.=272nm). Peak area responses were linearly related to concentrations of maprotilin in the range 4μg/ml-60μg/ml. The regression equation is y= -1.06574 + 564.095x with correlation coefficient r=0.996. The reliability of the proposed method was checked up at three different concentrations (RSD varied from 0.592 to 2.675%). The described method applied for the determination of maprotilin in tablets and ampoules gave precise and reproducible results; recovery was 98.61% for tablets and 98.92% for ampoules. The developed method can be recommended for the routine analysis of maprotilin in tablets and ampoules.",
journal = "Journal de Pharmacie de Belgique",
title = "Statistical optimization applied to the HPLC determination of maprotilin",
volume = "53",
number = "3",
pages = "267",
url = "https://hdl.handle.net/21.15107/rcub_farfar_200"
}

Vujić, Z.,& Radulović, D.. (1998). Statistical optimization applied to the HPLC determination of maprotilin. in Journal de Pharmacie de Belgique, 53(3), 267.
https://hdl.handle.net/21.15107/rcub_farfar_200

Vujić Z, Radulović D. Statistical optimization applied to the HPLC determination of maprotilin. in Journal de Pharmacie de Belgique. 1998;53(3):267.
https://hdl.handle.net/21.15107/rcub_farfar_200 .

Vujić, Zorica, Radulović, Dušanka, "Statistical optimization applied to the HPLC determination of maprotilin" in Journal de Pharmacie de Belgique, 53, no. 3 (1998):267,
https://hdl.handle.net/21.15107/rcub_farfar_200 .

TY  - JOUR
AU  - Vujić, Zorica
AU  - Radulović, Dušanka
AU  - Živanović, Ljiljana
PY  - 1995
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/119
AB  - A sensitive spectrophotometric method for the determination of metoprolol tartrate in tablets and ampoules is presented. Using spectrophotometric measurements, it was found that metoprolol tartrate and benzyl orange form a chloroform soluble ion-pair complex with an absorption maximum at 401 nm. The composition of the ion-pair complex was determined by applying Job's method to equimolar solutions of metoprolol tartrate: benzyl orange (1:2); molar absorptivity 7.39 x 103 mol-1 cm-1. Extraction of the ion-pair complex in chloroform was accomplished easily at a Britton-Robinson's buffered optimum pH = 5.2, μ = 0.1 mol/dm3. The relative stability constant, calculated according to the method of Sommer and Job's non-equimolar solutions, was log K = 9.72 (avg. value). Beer's law was obeyed up to 3.42 μg/ml of metoprolol tartrate (the detection limit was also 3.42 μg/ml). The precision of the method was checked at three different concentrations. The RSD (n = 7) varied from 0.51 to 2.03%. Reproducibility was examined by analysing Lopresor® tablets and ampoules. Recoveries varied from 99-101%. The reported method, applied to the assay of metoprolol tartrate in tablets and ampoules, gives precise and reproducible results.
T2  - Farmaco
T1  - Spectrophotometric investigation of metopropol-benzyl orange reaction and its application to the assay in pharmaceutical dosage forms
VL  - 50
IS  - 4
SP  - 281
EP  - 284
UR  - https://hdl.handle.net/21.15107/rcub_farfar_119
ER  - 

@article{
author = "Vujić, Zorica and Radulović, Dušanka and Živanović, Ljiljana",
year = "1995",
abstract = "A sensitive spectrophotometric method for the determination of metoprolol tartrate in tablets and ampoules is presented. Using spectrophotometric measurements, it was found that metoprolol tartrate and benzyl orange form a chloroform soluble ion-pair complex with an absorption maximum at 401 nm. The composition of the ion-pair complex was determined by applying Job's method to equimolar solutions of metoprolol tartrate: benzyl orange (1:2); molar absorptivity 7.39 x 103 mol-1 cm-1. Extraction of the ion-pair complex in chloroform was accomplished easily at a Britton-Robinson's buffered optimum pH = 5.2, μ = 0.1 mol/dm3. The relative stability constant, calculated according to the method of Sommer and Job's non-equimolar solutions, was log K = 9.72 (avg. value). Beer's law was obeyed up to 3.42 μg/ml of metoprolol tartrate (the detection limit was also 3.42 μg/ml). The precision of the method was checked at three different concentrations. The RSD (n = 7) varied from 0.51 to 2.03%. Reproducibility was examined by analysing Lopresor® tablets and ampoules. Recoveries varied from 99-101%. The reported method, applied to the assay of metoprolol tartrate in tablets and ampoules, gives precise and reproducible results.",
journal = "Farmaco",
title = "Spectrophotometric investigation of metopropol-benzyl orange reaction and its application to the assay in pharmaceutical dosage forms",
volume = "50",
number = "4",
pages = "281-284",
url = "https://hdl.handle.net/21.15107/rcub_farfar_119"
}

Vujić, Z., Radulović, D.,& Živanović, L.. (1995). Spectrophotometric investigation of metopropol-benzyl orange reaction and its application to the assay in pharmaceutical dosage forms. in Farmaco, 50(4), 281-284.
https://hdl.handle.net/21.15107/rcub_farfar_119

Vujić Z, Radulović D, Živanović L. Spectrophotometric investigation of metopropol-benzyl orange reaction and its application to the assay in pharmaceutical dosage forms. in Farmaco. 1995;50(4):281-284.
https://hdl.handle.net/21.15107/rcub_farfar_119 .

Vujić, Zorica, Radulović, Dušanka, Živanović, Ljiljana, "Spectrophotometric investigation of metopropol-benzyl orange reaction and its application to the assay in pharmaceutical dosage forms" in Farmaco, 50, no. 4 (1995):281-284,
https://hdl.handle.net/21.15107/rcub_farfar_119 .