TY  - JOUR
AU  - Đukić, Mirjana
AU  - Ćurčić-Jovanović, Marijana
AU  - Ninković, Milica
AU  - Vasijević, Ivana
AU  - Jovanović, Marina
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/908
AB  - The role of nitric oxide (NO) in paraquat (PQ)-induced neurotoxicity is still not fully understood. In this study we used N-G-nitro-L-arginine methyl ester (L-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, in order to examine the effects of NO, reactive oxygen species (ROS) generation and lipid peroxidation (LPO) development during PQ-mediated neurotoxicity. Oxidative stress development in the striatum of Wistar rats intrastriatally (i.s.) poisoned with PQ (and in some cases pre-treated with L-NAME) was investigated by measuring superoxide anion (O-2(center dot-)), malondialdehyde (MDA) and nitrate (NO3-), 30 min, 24 hours and 7 days after treatment. L-NAME pretreatment provided the possibility to distinguish the role of ROS from reactive nitrogen species (RNS) in oxidative stress development induced by PQ. Our results confirm the involvement of NO in PQ-mediated neurotoxicity and reduced LPO by L-NAME pretreatment implying that the latter has a protective role.
PB  - Inst Agricultural Medicine, Lublin
T2  - Annals of Agricultural and Environmental Medicine
T1  - The role of nitric oxide in paraquat-induced oxidative stress in rat striatum
VL  - 14
IS  - 2
SP  - 247
EP  - 252
UR  - https://hdl.handle.net/21.15107/rcub_farfar_908
ER  - 

@article{
author = "Đukić, Mirjana and Ćurčić-Jovanović, Marijana and Ninković, Milica and Vasijević, Ivana and Jovanović, Marina",
year = "2007",
abstract = "The role of nitric oxide (NO) in paraquat (PQ)-induced neurotoxicity is still not fully understood. In this study we used N-G-nitro-L-arginine methyl ester (L-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, in order to examine the effects of NO, reactive oxygen species (ROS) generation and lipid peroxidation (LPO) development during PQ-mediated neurotoxicity. Oxidative stress development in the striatum of Wistar rats intrastriatally (i.s.) poisoned with PQ (and in some cases pre-treated with L-NAME) was investigated by measuring superoxide anion (O-2(center dot-)), malondialdehyde (MDA) and nitrate (NO3-), 30 min, 24 hours and 7 days after treatment. L-NAME pretreatment provided the possibility to distinguish the role of ROS from reactive nitrogen species (RNS) in oxidative stress development induced by PQ. Our results confirm the involvement of NO in PQ-mediated neurotoxicity and reduced LPO by L-NAME pretreatment implying that the latter has a protective role.",
publisher = "Inst Agricultural Medicine, Lublin",
journal = "Annals of Agricultural and Environmental Medicine",
title = "The role of nitric oxide in paraquat-induced oxidative stress in rat striatum",
volume = "14",
number = "2",
pages = "247-252",
url = "https://hdl.handle.net/21.15107/rcub_farfar_908"
}

Đukić, M., Ćurčić-Jovanović, M., Ninković, M., Vasijević, I.,& Jovanović, M.. (2007). The role of nitric oxide in paraquat-induced oxidative stress in rat striatum. in Annals of Agricultural and Environmental Medicine
Inst Agricultural Medicine, Lublin., 14(2), 247-252.
https://hdl.handle.net/21.15107/rcub_farfar_908

Đukić M, Ćurčić-Jovanović M, Ninković M, Vasijević I, Jovanović M. The role of nitric oxide in paraquat-induced oxidative stress in rat striatum. in Annals of Agricultural and Environmental Medicine. 2007;14(2):247-252.
https://hdl.handle.net/21.15107/rcub_farfar_908 .

Đukić, Mirjana, Ćurčić-Jovanović, Marijana, Ninković, Milica, Vasijević, Ivana, Jovanović, Marina, "The role of nitric oxide in paraquat-induced oxidative stress in rat striatum" in Annals of Agricultural and Environmental Medicine, 14, no. 2 (2007):247-252,
https://hdl.handle.net/21.15107/rcub_farfar_908 .