TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Marković, Bojan
AU  - Daniels, Rolf
AU  - Vesić, Sonja
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2177
AB  - Context: Alkyl polyglucoside surfactants (APG) remain prominent natural origin stabilizers offering a prospect of combining satisfactory stability with mild dermatological properties and complete biodegradability. Objective: With the purpose of adjusting the dose to a patient's needs, dilution of commercial corticosteroid formulations is a practice which may modify efficacy uncontrolledly. The rational of the study was to investigate whether a simple change in ready-to-use bases (co-solvent addition) could address these needs in a more predictive manner. Methods: Hydrocortisone (HC) delivery from such emulsion systems was comparatively assessed employing two in vivo methods: the established human skin blanching assay versus skin stripping technique. Results: HC permeation data obtained after three dose durations showed better overall performance of the APG-stabilized bases relative to reference ones. Although the solubility study showed that all the assessed active samples retained equal thermodynamic activity, diverse HC permeation/penetration implies the importance of the applied base's colloidal structure and/or changes endured. Isopropyl alcohol (IPA) addition offered faster drug penetration enhancement, while glycerol as a moisturizing agent influenced HC penetration through the increase in skin hydration. Conclusion: Although the performed in vivo methods cannot be considered alternative, skin stripping technique proved to be a cost-efficient mode of percutaneous penetration assessment, providing additional information on vehicle-skin interactions.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Pharmaceutical Development and Technology
T1  - Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods
VL  - 19
IS  - 1
SP  - 55
EP  - 64
DO  - 10.3109/10837450.2012.751407
ER  - 

@article{
author = "Pantelić, Ivana and Lukić, Milica and Marković, Bojan and Daniels, Rolf and Vesić, Sonja and Vuleta, Gordana and Savić, Snežana",
year = "2014",
abstract = "Context: Alkyl polyglucoside surfactants (APG) remain prominent natural origin stabilizers offering a prospect of combining satisfactory stability with mild dermatological properties and complete biodegradability. Objective: With the purpose of adjusting the dose to a patient's needs, dilution of commercial corticosteroid formulations is a practice which may modify efficacy uncontrolledly. The rational of the study was to investigate whether a simple change in ready-to-use bases (co-solvent addition) could address these needs in a more predictive manner. Methods: Hydrocortisone (HC) delivery from such emulsion systems was comparatively assessed employing two in vivo methods: the established human skin blanching assay versus skin stripping technique. Results: HC permeation data obtained after three dose durations showed better overall performance of the APG-stabilized bases relative to reference ones. Although the solubility study showed that all the assessed active samples retained equal thermodynamic activity, diverse HC permeation/penetration implies the importance of the applied base's colloidal structure and/or changes endured. Isopropyl alcohol (IPA) addition offered faster drug penetration enhancement, while glycerol as a moisturizing agent influenced HC penetration through the increase in skin hydration. Conclusion: Although the performed in vivo methods cannot be considered alternative, skin stripping technique proved to be a cost-efficient mode of percutaneous penetration assessment, providing additional information on vehicle-skin interactions.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Pharmaceutical Development and Technology",
title = "Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods",
volume = "19",
number = "1",
pages = "55-64",
doi = "10.3109/10837450.2012.751407"
}

Pantelić, I., Lukić, M., Marković, B., Daniels, R., Vesić, S., Vuleta, G.,& Savić, S.. (2014). Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods. in Pharmaceutical Development and Technology
Taylor & Francis Ltd, Abingdon., 19(1), 55-64.
https://doi.org/10.3109/10837450.2012.751407

Pantelić I, Lukić M, Marković B, Daniels R, Vesić S, Vuleta G, Savić S. Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods. in Pharmaceutical Development and Technology. 2014;19(1):55-64.
doi:10.3109/10837450.2012.751407 .

Pantelić, Ivana, Lukić, Milica, Marković, Bojan, Daniels, Rolf, Vesić, Sonja, Vuleta, Gordana, Savić, Snežana, "Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods" in Pharmaceutical Development and Technology, 19, no. 1 (2014):55-64,
https://doi.org/10.3109/10837450.2012.751407 . .

TY  - CHAP
AU  - Tasić-Kostov, Marija
AU  - Vesić, Sonja
AU  - Savić, Snežana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2258
AB  - Emulsion systems are the most common vehicles for topical drugs/cosmetic actives. Absence of skin irritation potential is an important legislative requirement. Overcoming emulsion irritancy is usually achieved by selection of emulsifiers. Alkyl Polyglucoside (APG) emulsifiers, successfully used in cosmetics and popularly labelled as skin- and environmentally friendly, have attracted considerable interest. Non-invasive measurements of biophysical skin parameters, and approved in vitro methods, are used for reliable and objective determination of skin properties. This chapter discusses assessment of the performance of topical emulsions, particularly those based on APG-mixed emulsifiers, and interpretation of the results. Research into the safety and efficacy of APGs indicates that APG surfactants could be used for tailoring mild emulsion vehicles, showing benefits as carriers for actives with an unfavourable skin irritation profile.
PB  - Elsevier Inc.
T2  - Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems
T1  - Objective skin performance evaluation: How mild are APGs to the skin?
SP  - 135
EP  - 161
DO  - 10.1533/9781908818775.135
ER  - 

@inbook{
author = "Tasić-Kostov, Marija and Vesić, Sonja and Savić, Snežana",
year = "2014",
abstract = "Emulsion systems are the most common vehicles for topical drugs/cosmetic actives. Absence of skin irritation potential is an important legislative requirement. Overcoming emulsion irritancy is usually achieved by selection of emulsifiers. Alkyl Polyglucoside (APG) emulsifiers, successfully used in cosmetics and popularly labelled as skin- and environmentally friendly, have attracted considerable interest. Non-invasive measurements of biophysical skin parameters, and approved in vitro methods, are used for reliable and objective determination of skin properties. This chapter discusses assessment of the performance of topical emulsions, particularly those based on APG-mixed emulsifiers, and interpretation of the results. Research into the safety and efficacy of APGs indicates that APG surfactants could be used for tailoring mild emulsion vehicles, showing benefits as carriers for actives with an unfavourable skin irritation profile.",
publisher = "Elsevier Inc.",
journal = "Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems",
booktitle = "Objective skin performance evaluation: How mild are APGs to the skin?",
pages = "135-161",
doi = "10.1533/9781908818775.135"
}

Tasić-Kostov, M., Vesić, S.,& Savić, S.. (2014). Objective skin performance evaluation: How mild are APGs to the skin?. in Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems
Elsevier Inc.., 135-161.
https://doi.org/10.1533/9781908818775.135

Tasić-Kostov M, Vesić S, Savić S. Objective skin performance evaluation: How mild are APGs to the skin?. in Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems. 2014;:135-161.
doi:10.1533/9781908818775.135 .

Tasić-Kostov, Marija, Vesić, Sonja, Savić, Snežana, "Objective skin performance evaluation: How mild are APGs to the skin?" in Alkyl Polyglucosides: From Natural-Origin Surfactants to Prospective Delivery Systems (2014):135-161,
https://doi.org/10.1533/9781908818775.135 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Savić, M.
AU  - Tamburić, Slobodanka
AU  - Vuleta, G.
AU  - Vesić, Sonja
AU  - Mueller-Goymann, Christel
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/939
AB  - There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum. hydration (SCH). The vehicles based on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration. There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation
VL  - 30
IS  - 5
SP  - 441
EP  - 450
DO  - 10.1016/j.ejps.2007.01.006
ER  - 

@article{
author = "Savić, Snežana and Savić, M. and Tamburić, Slobodanka and Vuleta, G. and Vesić, Sonja and Mueller-Goymann, Christel",
year = "2007",
abstract = "There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum. hydration (SCH). The vehicles based on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration. There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation",
volume = "30",
number = "5",
pages = "441-450",
doi = "10.1016/j.ejps.2007.01.006"
}

Savić, S., Savić, M., Tamburić, S., Vuleta, G., Vesić, S.,& Mueller-Goymann, C.. (2007). An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 30(5), 441-450.
https://doi.org/10.1016/j.ejps.2007.01.006

Savić S, Savić M, Tamburić S, Vuleta G, Vesić S, Mueller-Goymann C. An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. in European Journal of Pharmaceutical Sciences. 2007;30(5):441-450.
doi:10.1016/j.ejps.2007.01.006 .

Savić, Snežana, Savić, M., Tamburić, Slobodanka, Vuleta, G., Vesić, Sonja, Mueller-Goymann, Christel, "An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation" in European Journal of Pharmaceutical Sciences, 30, no. 5 (2007):441-450,
https://doi.org/10.1016/j.ejps.2007.01.006 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Savić, Miroslav
AU  - Vesić, Sonja
AU  - Vuleta, Gordana
AU  - Mueller-Goymann, Christel
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/691
AB  - An emerging class of natural surfactants, named alkylpolyglucosides, which can form both, the thermotropic and the lyotropic, liquid crystalline phases, were focused. The aim of the study was to integrate some physicochemical properties (characterised through the polarization and transmission electron microscopy, wide-angle X-ray diffraction, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, with the in vitro (the artificial skin constructs) and in vivo bioavailability of hydrocortisone (HQ, in comparison with a standard pharmacopoeial vehicle. The parameters measured in vivo were erythema index (an instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum hydration. A complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type was deduced for sugar surfactant-based vehicles. In dependence on surfactant/water/oil ratio, several thermodinamically variable fractions of water were predicted. Rheological profile of the vehicle appeared to influence the in vitro profile of permeation. A surplus of total amount of drug permeated in vitro from the alkylpolyglucoside-based vehicles coincided with the more pronounced increase of TEWL and less marked blanching action of HC from the selected alkylpolyglucoside-based vehicle tested in vivo, related to the pharmacopoeial one. These findings imply an enhanced delivery of HC from this vehicle and its putative penetration enhancing effect, probably dependent on specific distribution of the vehicle's inherent water.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation
VL  - 320
IS  - 1-2
SP  - 86
EP  - 95
DO  - 10.1016/j.ijpharm.2006.04.019
ER  - 

@article{
author = "Savić, Snežana and Savić, Miroslav and Vesić, Sonja and Vuleta, Gordana and Mueller-Goymann, Christel",
year = "2006",
abstract = "An emerging class of natural surfactants, named alkylpolyglucosides, which can form both, the thermotropic and the lyotropic, liquid crystalline phases, were focused. The aim of the study was to integrate some physicochemical properties (characterised through the polarization and transmission electron microscopy, wide-angle X-ray diffraction, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, with the in vitro (the artificial skin constructs) and in vivo bioavailability of hydrocortisone (HQ, in comparison with a standard pharmacopoeial vehicle. The parameters measured in vivo were erythema index (an instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum hydration. A complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type was deduced for sugar surfactant-based vehicles. In dependence on surfactant/water/oil ratio, several thermodinamically variable fractions of water were predicted. Rheological profile of the vehicle appeared to influence the in vitro profile of permeation. A surplus of total amount of drug permeated in vitro from the alkylpolyglucoside-based vehicles coincided with the more pronounced increase of TEWL and less marked blanching action of HC from the selected alkylpolyglucoside-based vehicle tested in vivo, related to the pharmacopoeial one. These findings imply an enhanced delivery of HC from this vehicle and its putative penetration enhancing effect, probably dependent on specific distribution of the vehicle's inherent water.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation",
volume = "320",
number = "1-2",
pages = "86-95",
doi = "10.1016/j.ijpharm.2006.04.019"
}

Savić, S., Savić, M., Vesić, S., Vuleta, G.,& Mueller-Goymann, C.. (2006). Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 320(1-2), 86-95.
https://doi.org/10.1016/j.ijpharm.2006.04.019

Savić S, Savić M, Vesić S, Vuleta G, Mueller-Goymann C. Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation. in International Journal of Pharmaceutics. 2006;320(1-2):86-95.
doi:10.1016/j.ijpharm.2006.04.019 .

Savić, Snežana, Savić, Miroslav, Vesić, Sonja, Vuleta, Gordana, Mueller-Goymann, Christel, "Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation" in International Journal of Pharmaceutics, 320, no. 1-2 (2006):86-95,
https://doi.org/10.1016/j.ijpharm.2006.04.019 . .

TY  - JOUR
AU  - Cekić, Nebojša
AU  - Milić-Aškrabić, Jela
AU  - Savić, Snežana
AU  - Vuleta, Gordana
AU  - Vesić, Sonja
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/526
AB  - Taking into account the latest discoveries in the structure and functions of ceramides (sphingolipids, sphingoids), manufacturers of cosmetic raw materials propagate to use ceramides (nature-identical ceramides, ceramide analogues, pseudoceramides) for the purpose of restoration of the natural intercellular lipid barrier. Despite putative importance, there is no consistent data on the benefits of ceramides when used in conventional, consumer products on skin that has suffered minor barrier damage. Transepidermal water loss (TEWL) and skin moisture content are two parameters frequently used for assessment of the influence of cosmetic/pharmaceutical products on barrier function. The ceramides-containing cream-gel has been formulated, and its influence on barrier function during 14 days, compared to “placebo” containing no sphingolipids, assessed on six volunteers with no apparent barrier damage. It was shown that the cream-gel improved skin moisture content, as well as the overall barrier function quality. The lack of significant differences in the influence of the cream-gel and “placebo” on the measured parameters indicated that, for such a kind of product, there was no evidence for the beneficial effects of ceramides on the skin that has suffered minor barrier damage.
AB  - Novija otkrića u vezi strukture i funkcije ceramida (sfingolipida, sfingoida) kože, poslužila su proizvođačima kozmetičkih sirovina da često nekontrolisano i neargumentovano propagiraju upotrebu ceramida u kozmetičkim proizvodima u svrhe reparacije prirodne intercelularne lipidne barijere. Rezultati ispitivanja efekata ceramida na koži često ne daju čvrste dokaze da primena konvencionalnih kozmetičkih proizvoda sa ceramidima može da popravi neznatno oštećenu kožu. Pouzdana metoda za procenu uticaja kozmetičkih/farmaceutskih preparata na funkciju kožne barijere, odnosno efikasnosti i/ili prihvatljivosti formulacije predstavlja ispitivanje transepidermalnog gubitka vode (TEGV) iz kože. Savremena formulacija krem-gela sa ceramidima je aplikovana na kožu i ispitan je njen uticaj na funkciju kožne barijere na panelu od 6 ispitanika sa zdravom kožom, u vremenskom periodu od 14 dana, prema unapred zadatom programu u odnosu na “placebo” formulaciju. Pokazano je da ispitivani krem-gel pozitivno utiče na hidratisanost (vlažnost) stratum corneuma (SC) i transepidermalni gubitak vode, odnosno kvalitet kožne barijere. Sa druge strane, odsustvo statistički značajnih razlika TEGV i vlažnosti kože pod uticajem ispitivanih formulacija ukazuje da, u ovom slučaju, nema dovoljno dokaza o prednostima prisustva ceramida u "aktivnom" krem-gelu u odnosu na “placebo” formulaciju, kada su primenjeni na neznatno oštećenu ili neoštećenu kožu ispitanika.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Cream-gel with ceramides (part II): An evaluation of the effects on skin hydration and transepidermal water loss
T1  - Krem-gel sa ceramidima (II deo) - procena efekta na hidratisanost kože i transepidermalni gubitak vode iz kože
VL  - 54
IS  - 6
SP  - 747
EP  - 759
UR  - https://hdl.handle.net/21.15107/rcub_farfar_526
ER  - 

@article{
author = "Cekić, Nebojša and Milić-Aškrabić, Jela and Savić, Snežana and Vuleta, Gordana and Vesić, Sonja",
year = "2004",
abstract = "Taking into account the latest discoveries in the structure and functions of ceramides (sphingolipids, sphingoids), manufacturers of cosmetic raw materials propagate to use ceramides (nature-identical ceramides, ceramide analogues, pseudoceramides) for the purpose of restoration of the natural intercellular lipid barrier. Despite putative importance, there is no consistent data on the benefits of ceramides when used in conventional, consumer products on skin that has suffered minor barrier damage. Transepidermal water loss (TEWL) and skin moisture content are two parameters frequently used for assessment of the influence of cosmetic/pharmaceutical products on barrier function. The ceramides-containing cream-gel has been formulated, and its influence on barrier function during 14 days, compared to “placebo” containing no sphingolipids, assessed on six volunteers with no apparent barrier damage. It was shown that the cream-gel improved skin moisture content, as well as the overall barrier function quality. The lack of significant differences in the influence of the cream-gel and “placebo” on the measured parameters indicated that, for such a kind of product, there was no evidence for the beneficial effects of ceramides on the skin that has suffered minor barrier damage., Novija otkrića u vezi strukture i funkcije ceramida (sfingolipida, sfingoida) kože, poslužila su proizvođačima kozmetičkih sirovina da često nekontrolisano i neargumentovano propagiraju upotrebu ceramida u kozmetičkim proizvodima u svrhe reparacije prirodne intercelularne lipidne barijere. Rezultati ispitivanja efekata ceramida na koži često ne daju čvrste dokaze da primena konvencionalnih kozmetičkih proizvoda sa ceramidima može da popravi neznatno oštećenu kožu. Pouzdana metoda za procenu uticaja kozmetičkih/farmaceutskih preparata na funkciju kožne barijere, odnosno efikasnosti i/ili prihvatljivosti formulacije predstavlja ispitivanje transepidermalnog gubitka vode (TEGV) iz kože. Savremena formulacija krem-gela sa ceramidima je aplikovana na kožu i ispitan je njen uticaj na funkciju kožne barijere na panelu od 6 ispitanika sa zdravom kožom, u vremenskom periodu od 14 dana, prema unapred zadatom programu u odnosu na “placebo” formulaciju. Pokazano je da ispitivani krem-gel pozitivno utiče na hidratisanost (vlažnost) stratum corneuma (SC) i transepidermalni gubitak vode, odnosno kvalitet kožne barijere. Sa druge strane, odsustvo statistički značajnih razlika TEGV i vlažnosti kože pod uticajem ispitivanih formulacija ukazuje da, u ovom slučaju, nema dovoljno dokaza o prednostima prisustva ceramida u "aktivnom" krem-gelu u odnosu na “placebo” formulaciju, kada su primenjeni na neznatno oštećenu ili neoštećenu kožu ispitanika.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Cream-gel with ceramides (part II): An evaluation of the effects on skin hydration and transepidermal water loss, Krem-gel sa ceramidima (II deo) - procena efekta na hidratisanost kože i transepidermalni gubitak vode iz kože",
volume = "54",
number = "6",
pages = "747-759",
url = "https://hdl.handle.net/21.15107/rcub_farfar_526"
}

Cekić, N., Milić-Aškrabić, J., Savić, S., Vuleta, G.,& Vesić, S.. (2004). Cream-gel with ceramides (part II): An evaluation of the effects on skin hydration and transepidermal water loss. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 54(6), 747-759.
https://hdl.handle.net/21.15107/rcub_farfar_526

Cekić N, Milić-Aškrabić J, Savić S, Vuleta G, Vesić S. Cream-gel with ceramides (part II): An evaluation of the effects on skin hydration and transepidermal water loss. in Arhiv za farmaciju. 2004;54(6):747-759.
https://hdl.handle.net/21.15107/rcub_farfar_526 .

Cekić, Nebojša, Milić-Aškrabić, Jela, Savić, Snežana, Vuleta, Gordana, Vesić, Sonja, "Cream-gel with ceramides (part II): An evaluation of the effects on skin hydration and transepidermal water loss" in Arhiv za farmaciju, 54, no. 6 (2004):747-759,
https://hdl.handle.net/21.15107/rcub_farfar_526 .