TY  - JOUR
AU  - Džoljić, Eleonora
AU  - Sarić-Matutinović, Marija
AU  - Stojković, Oliver
AU  - Veličković, Jelena
AU  - Milinković, Neda
AU  - Kostić, Vladimir
AU  - Ignjatović, Svetlana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5179
AB  - Background: Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson's disease (PD). We aimed to clarify the relationship between hypovitaminosis D and the predisposition for PD and its clinical presentation. An additional aim was to examine the specific gene polymorphisms associated with vitamin D level. Material and methods: Total level of 25(OH)-vitamin D (25(OH)D) was measured in the serum of parkinsonian patients (n = 113) and controls (n = 82) using a commercial immunoassay. Genetic analyses were performed using Taqman assays on Real Time PCR amplification system. Results: Higher frequency of vitamin D deficiency (<50 nmol/L) was observed in PD patients, compared to controls (40.7% and 23.2%, respectively, P = 0.010). It was also a positive predictive marker of PD (OR, 2.27; 95% CI, 1.206–4.298; P < 0.011). Significantly higher UPDRS (35.85 ± 1.35 and 32.09 ± 0.99, respectively, P = 0.023) and HY scores (2(1.5–2.5) and 1.5(1.0–2.0), respectively, P = 0.005) were present in patients with 25(OH)D level < 50 nmol/L compared to patients with 25(OH)D level ≥ 50 nmol/L. Despite some trends observed, differences in allelic and genotypic distribution between controls and patients, as well as between subgroups, did not reach the level of significance (P > 0.05). Conclusions: Findings of this study confirm the hypothesis of a significant relationship between hypovitaminosis D and PD. We demonstrated higher prevalence of vitamin D deficiency in PD patients, as well as its predictive potential for the onset and progression of PD.
PB  - Elsevier Ltd
T2  - Neuroscience
T1  - Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease
VL  - 533
SP  - 53
EP  - 62
DO  - 10.1016/j.neuroscience.2023.10.004
ER  - 

@article{
author = "Džoljić, Eleonora and Sarić-Matutinović, Marija and Stojković, Oliver and Veličković, Jelena and Milinković, Neda and Kostić, Vladimir and Ignjatović, Svetlana",
year = "2023",
abstract = "Background: Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson's disease (PD). We aimed to clarify the relationship between hypovitaminosis D and the predisposition for PD and its clinical presentation. An additional aim was to examine the specific gene polymorphisms associated with vitamin D level. Material and methods: Total level of 25(OH)-vitamin D (25(OH)D) was measured in the serum of parkinsonian patients (n = 113) and controls (n = 82) using a commercial immunoassay. Genetic analyses were performed using Taqman assays on Real Time PCR amplification system. Results: Higher frequency of vitamin D deficiency (<50 nmol/L) was observed in PD patients, compared to controls (40.7% and 23.2%, respectively, P = 0.010). It was also a positive predictive marker of PD (OR, 2.27; 95% CI, 1.206–4.298; P < 0.011). Significantly higher UPDRS (35.85 ± 1.35 and 32.09 ± 0.99, respectively, P = 0.023) and HY scores (2(1.5–2.5) and 1.5(1.0–2.0), respectively, P = 0.005) were present in patients with 25(OH)D level < 50 nmol/L compared to patients with 25(OH)D level ≥ 50 nmol/L. Despite some trends observed, differences in allelic and genotypic distribution between controls and patients, as well as between subgroups, did not reach the level of significance (P > 0.05). Conclusions: Findings of this study confirm the hypothesis of a significant relationship between hypovitaminosis D and PD. We demonstrated higher prevalence of vitamin D deficiency in PD patients, as well as its predictive potential for the onset and progression of PD.",
publisher = "Elsevier Ltd",
journal = "Neuroscience",
title = "Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease",
volume = "533",
pages = "53-62",
doi = "10.1016/j.neuroscience.2023.10.004"
}

Džoljić, E., Sarić-Matutinović, M., Stojković, O., Veličković, J., Milinković, N., Kostić, V.,& Ignjatović, S.. (2023). Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease. in Neuroscience
Elsevier Ltd., 533, 53-62.
https://doi.org/10.1016/j.neuroscience.2023.10.004

Džoljić E, Sarić-Matutinović M, Stojković O, Veličković J, Milinković N, Kostić V, Ignjatović S. Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease. in Neuroscience. 2023;533:53-62.
doi:10.1016/j.neuroscience.2023.10.004 .

Džoljić, Eleonora, Sarić-Matutinović, Marija, Stojković, Oliver, Veličković, Jelena, Milinković, Neda, Kostić, Vladimir, Ignjatović, Svetlana, "Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease" in Neuroscience, 533 (2023):53-62,
https://doi.org/10.1016/j.neuroscience.2023.10.004 . .