TY  - JOUR
AU  - Bojanin, Dragana
AU  - Vekić, Jelena
AU  - Milenković, Tatjana
AU  - Vuković, Rade
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Janać, Jelena
AU  - Ivanišević, Jasmina
AU  - Mitrović, Katarina
AU  - Miljković, Milica
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3326
AB  - Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p  lt  0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid parameters only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p  lt  0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p  lt  0.001), but negatively with HDL size (p  lt  0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control
VL  - 280
SP  - 14
EP  - 20
DO  - 10.1016/j.atherosclerosis.2018.11.020
ER  - 

@article{
author = "Bojanin, Dragana and Vekić, Jelena and Milenković, Tatjana and Vuković, Rade and Zeljković, Aleksandra and Stefanović, Aleksandra and Janać, Jelena and Ivanišević, Jasmina and Mitrović, Katarina and Miljković, Milica and Spasojević-Kalimanovska, Vesna",
year = "2019",
abstract = "Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p  lt  0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid parameters only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p  lt  0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p  lt  0.001), but negatively with HDL size (p  lt  0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control",
volume = "280",
pages = "14-20",
doi = "10.1016/j.atherosclerosis.2018.11.020"
}

Bojanin, D., Vekić, J., Milenković, T., Vuković, R., Zeljković, A., Stefanović, A., Janać, J., Ivanišević, J., Mitrović, K., Miljković, M.,& Spasojević-Kalimanovska, V.. (2019). Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 280, 14-20.
https://doi.org/10.1016/j.atherosclerosis.2018.11.020

Bojanin D, Vekić J, Milenković T, Vuković R, Zeljković A, Stefanović A, Janać J, Ivanišević J, Mitrović K, Miljković M, Spasojević-Kalimanovska V. Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control. in Atherosclerosis. 2019;280:14-20.
doi:10.1016/j.atherosclerosis.2018.11.020 .

Bojanin, Dragana, Vekić, Jelena, Milenković, Tatjana, Vuković, Rade, Zeljković, Aleksandra, Stefanović, Aleksandra, Janać, Jelena, Ivanišević, Jasmina, Mitrović, Katarina, Miljković, Milica, Spasojević-Kalimanovska, Vesna, "Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control" in Atherosclerosis, 280 (2019):14-20,
https://doi.org/10.1016/j.atherosclerosis.2018.11.020 . .

Vuković, R., Zeljković, A., Bufan, B., Spasojević-Kalimanovska, V., Milenković, T.,& Vekić, J.. (2019). Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review. in Frontiers in Endocrinology
Frontiers Media S.A.., 10.
https://doi.org/10.3389/fendo.2019.00868

Vuković R, Zeljković A, Bufan B, Spasojević-Kalimanovska V, Milenković T, Vekić J. Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review. in Frontiers in Endocrinology. 2019;10.
doi:10.3389/fendo.2019.00868 .

Vuković, Rade, Zeljković, Aleksandra, Bufan, Biljana, Spasojević-Kalimanovska, Vesna, Milenković, Tatjana, Vekić, Jelena, "Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review" in Frontiers in Endocrinology, 10 (2019),
https://doi.org/10.3389/fendo.2019.00868 . .

TY  - JOUR
AU  - Bojanin, Dragana
AU  - Milenković, Tatjana
AU  - Vekić, Jelena
AU  - Vuković, Rade
AU  - Zeljković, Aleksandra
AU  - Janać, Jelena
AU  - Ivanišević, Jasmina
AU  - Todorović, Slađana
AU  - Mazibrada, Ilijana
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3153
AB  - Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P  lt  0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P  lt  0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P  lt  0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P  lt  0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P  lt  0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus
VL  - 54
SP  - 11
EP  - 17
DO  - 10.1016/j.clinbiochem.2018.01.026
ER  - 

@article{
author = "Bojanin, Dragana and Milenković, Tatjana and Vekić, Jelena and Vuković, Rade and Zeljković, Aleksandra and Janać, Jelena and Ivanišević, Jasmina and Todorović, Slađana and Mazibrada, Ilijana and Spasojević-Kalimanovska, Vesna",
year = "2018",
abstract = "Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P  lt  0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P  lt  0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P  lt  0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P  lt  0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P  lt  0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus",
volume = "54",
pages = "11-17",
doi = "10.1016/j.clinbiochem.2018.01.026"
}

Bojanin, D., Milenković, T., Vekić, J., Vuković, R., Zeljković, A., Janać, J., Ivanišević, J., Todorović, S., Mazibrada, I.,& Spasojević-Kalimanovska, V.. (2018). Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 54, 11-17.
https://doi.org/10.1016/j.clinbiochem.2018.01.026

Bojanin D, Milenković T, Vekić J, Vuković R, Zeljković A, Janać J, Ivanišević J, Todorović S, Mazibrada I, Spasojević-Kalimanovska V. Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus. in Clinical Biochemistry. 2018;54:11-17.
doi:10.1016/j.clinbiochem.2018.01.026 .

Bojanin, Dragana, Milenković, Tatjana, Vekić, Jelena, Vuković, Rade, Zeljković, Aleksandra, Janać, Jelena, Ivanišević, Jasmina, Todorović, Slađana, Mazibrada, Ilijana, Spasojević-Kalimanovska, Vesna, "Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus" in Clinical Biochemistry, 54 (2018):11-17,
https://doi.org/10.1016/j.clinbiochem.2018.01.026 . .