TY  - JOUR
AU  - Ravnikar, Matjaž
AU  - Štrukelj, Borut
AU  - Otašević, Biljana
AU  - Sirše, Mateja
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5641
AB  - The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.
PB  - MDPI
T2  - Nutraceuticals
T1  - Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis
VL  - 4
IS  - 2
SP  - 273
EP  - 282
DO  - 10.3390/nutraceuticals4020017
ER  - 

@article{
author = "Ravnikar, Matjaž and Štrukelj, Borut and Otašević, Biljana and Sirše, Mateja",
year = "2024",
abstract = "The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.",
publisher = "MDPI",
journal = "Nutraceuticals",
title = "Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis",
volume = "4",
number = "2",
pages = "273-282",
doi = "10.3390/nutraceuticals4020017"
}

Ravnikar, M., Štrukelj, B., Otašević, B.,& Sirše, M.. (2024). Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis. in Nutraceuticals
MDPI., 4(2), 273-282.
https://doi.org/10.3390/nutraceuticals4020017

Ravnikar M, Štrukelj B, Otašević B, Sirše M. Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis. in Nutraceuticals. 2024;4(2):273-282.
doi:10.3390/nutraceuticals4020017 .

Ravnikar, Matjaž, Štrukelj, Borut, Otašević, Biljana, Sirše, Mateja, "Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis" in Nutraceuticals, 4, no. 2 (2024):273-282,
https://doi.org/10.3390/nutraceuticals4020017 . .