TY  - JOUR
AU  - Radovanović, J
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Petrović, M
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/185
AB  - The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.
PB  - Medecine Et Hygiene, Geneva 4
T2  - European Journal of Drug Metabolism and Pharmacokinetics
T1  - An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets
VL  - 23
IS  - 1
SP  - 33
EP  - 40
DO  - 10.1007/BF03189824
ER  - 

@article{
author = "Radovanović, J and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Petrović, M",
year = "1998",
abstract = "The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.",
publisher = "Medecine Et Hygiene, Geneva 4",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets",
volume = "23",
number = "1",
pages = "33-40",
doi = "10.1007/BF03189824"
}

Radovanović, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Petrović, M.. (1998). An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets. in European Journal of Drug Metabolism and Pharmacokinetics
Medecine Et Hygiene, Geneva 4., 23(1), 33-40.
https://doi.org/10.1007/BF03189824

Radovanović J, Đurić Z, Jovanović M, Ibrić S, Petrović M. An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets. in European Journal of Drug Metabolism and Pharmacokinetics. 1998;23(1):33-40.
doi:10.1007/BF03189824 .

Radovanović, J, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Petrović, M, "An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets" in European Journal of Drug Metabolism and Pharmacokinetics, 23, no. 1 (1998):33-40,
https://doi.org/10.1007/BF03189824 . .

TY  - JOUR
AU  - Jovanović, M
AU  - Jovicić, G
AU  - Đurić, Zorica
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Radovanović, J
AU  - Nikolić, L
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/161
AB  - The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation.
PB  - Marcel Dekker Inc, New York
T2  - Drug Development and Industrial Pharmacy
T1  - Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets
VL  - 23
IS  - 6
SP  - 595
EP  - 602
DO  - 10.3109/03639049709149825
ER  - 

@article{
author = "Jovanović, M and Jovicić, G and Đurić, Zorica and Agbaba, Danica and Karljiković-Rajić, Katarina and Radovanović, J and Nikolić, L",
year = "1997",
abstract = "The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation.",
publisher = "Marcel Dekker Inc, New York",
journal = "Drug Development and Industrial Pharmacy",
title = "Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets",
volume = "23",
number = "6",
pages = "595-602",
doi = "10.3109/03639049709149825"
}

Jovanović, M., Jovicić, G., Đurić, Z., Agbaba, D., Karljiković-Rajić, K., Radovanović, J.,& Nikolić, L.. (1997). Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets. in Drug Development and Industrial Pharmacy
Marcel Dekker Inc, New York., 23(6), 595-602.
https://doi.org/10.3109/03639049709149825

Jovanović M, Jovicić G, Đurić Z, Agbaba D, Karljiković-Rajić K, Radovanović J, Nikolić L. Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets. in Drug Development and Industrial Pharmacy. 1997;23(6):595-602.
doi:10.3109/03639049709149825 .

Jovanović, M, Jovicić, G, Đurić, Zorica, Agbaba, Danica, Karljiković-Rajić, Katarina, Radovanović, J, Nikolić, L, "Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets" in Drug Development and Industrial Pharmacy, 23, no. 6 (1997):595-602,
https://doi.org/10.3109/03639049709149825 . .

TY  - JOUR
AU  - Jovanović, M
AU  - Jovičić, G
AU  - Đurić, Zorica
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Nikolić, L
AU  - Radovanović, J
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/168
AB  - The effect of four Eudragits used as matrix substances on the physical characteristics of tablets and on the dissolution rate of acetylsalicylic acid has been investigated. The concentration of matrix substance necessary for achieving the appropriate effect of sustained release of acetylsalicylic acid (ASA) depends on the type of Eudragit used. For tablets prepared using Eudragit RS-100, Eudragit L-100-55 and Eudragit S-100, the acceptable dissolution rate of ASA was obtained with only 3% of polymer. In the case of Eudragit RL-100, to obtain the same effect, 10% of polymer was required. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. The following mathematical models were employed: zero order equation, first order kinetics, Hixon-Crowell's cube root kinetics and diffusion model. The results indicated that the fitness of the kinetic model was dependent on the type of Eudragit used.
PB  - Magyar Gyogyszereszeti Tarsasag
T2  - Acta Pharmaceutica Hungarica
T1  - The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets
VL  - 67
IS  - 6
SP  - 229
EP  - 234
UR  - https://hdl.handle.net/21.15107/rcub_farfar_168
ER  - 

@article{
author = "Jovanović, M and Jovičić, G and Đurić, Zorica and Agbaba, Danica and Karljiković-Rajić, Katarina and Nikolić, L and Radovanović, J",
year = "1997",
abstract = "The effect of four Eudragits used as matrix substances on the physical characteristics of tablets and on the dissolution rate of acetylsalicylic acid has been investigated. The concentration of matrix substance necessary for achieving the appropriate effect of sustained release of acetylsalicylic acid (ASA) depends on the type of Eudragit used. For tablets prepared using Eudragit RS-100, Eudragit L-100-55 and Eudragit S-100, the acceptable dissolution rate of ASA was obtained with only 3% of polymer. In the case of Eudragit RL-100, to obtain the same effect, 10% of polymer was required. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. The following mathematical models were employed: zero order equation, first order kinetics, Hixon-Crowell's cube root kinetics and diffusion model. The results indicated that the fitness of the kinetic model was dependent on the type of Eudragit used.",
publisher = "Magyar Gyogyszereszeti Tarsasag",
journal = "Acta Pharmaceutica Hungarica",
title = "The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets",
volume = "67",
number = "6",
pages = "229-234",
url = "https://hdl.handle.net/21.15107/rcub_farfar_168"
}

Jovanović, M., Jovičić, G., Đurić, Z., Agbaba, D., Karljiković-Rajić, K., Nikolić, L.,& Radovanović, J.. (1997). The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets. in Acta Pharmaceutica Hungarica
Magyar Gyogyszereszeti Tarsasag., 67(6), 229-234.
https://hdl.handle.net/21.15107/rcub_farfar_168

Jovanović M, Jovičić G, Đurić Z, Agbaba D, Karljiković-Rajić K, Nikolić L, Radovanović J. The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets. in Acta Pharmaceutica Hungarica. 1997;67(6):229-234.
https://hdl.handle.net/21.15107/rcub_farfar_168 .

Jovanović, M, Jovičić, G, Đurić, Zorica, Agbaba, Danica, Karljiković-Rajić, Katarina, Nikolić, L, Radovanović, J, "The influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets" in Acta Pharmaceutica Hungarica, 67, no. 6 (1997):229-234,
https://hdl.handle.net/21.15107/rcub_farfar_168 .