TY  - JOUR
AU  - Savić, Jelena
AU  - Dilber, Sanda
AU  - Crevar-Sakač, Milkica
AU  - Vladimirov, Sote
AU  - Brborić, Jasmina
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3096
AB  - Lipophilicity parameters (logP) were determined for thirteen synthesized β-hydroxy-β-arilalkanoic acids using reversed phase high performance liquid chromatography. Anti-inflammatory activity and potential selectivity towards cyclooxygenase-2 inhibition of synthetized compounds was assessed. Stationary phase was octadecyl modified (C-18) silicagel, and four used mobile phases contained different amount of methanol. Both synthetized and standard compounds with known logP values (aspirin, ibuprofen, ketoprofen, naproxen and phenanthrene) were tested in a chromatographic system. Using retention times for each standard and synthesized compound logk values (logarithm of capacity factor) were calculated. Intercept on a graph showing dependency of logk from methanol amount in the mobile phase for each compound represents logKw(capacity factor when organic solvent amount is zero). Graph showing linear dependency of logP of standard compounds from experimentally obtained logKw values was plotted. LogP values for synthetized compounds were obtained by interpolation from the plotted graph. Obtained values are in a range from 2.901 to 3.847. The best correlation between experimentally obtained and predicted logP values was using KOWWIN software (R2=0.8864), which makes this software appropriate for predicting logP values of this type of compounds.
AB  - Parametri lipofilnosti (logP) su određeni za trinaest sintetisanih β-hidroksi-β-arilalkanskih kiselina primenom reverzno fazne tečne hromatografije. Ispitivanje je urađeno na derivatima kojima je tokom prethodnih istraživanja okarakterisana antiinflamatorna aktivnost i pretpostavljena je potencijalna selektivnost prema inhibiciji ciklooksigenaze-2. Oktadecil-modifikovani (C-18) silikagel je predstavljao stacionarnu fazu, a korišćene su četiri mobilne faze u kojima je variran udeo metanola. Hromatografski su testirana jedinjenja sa poznatim logP vrednostima (aspirin, ibuprofen, ketoprofen, naproksen i fenantren) i sintetisana jedinjenja. Na osnovu retencionog vremena za svako standardno i sintetisano jedinjenje izračunate su vrednosti logk (logaritam faktora kapaciteta). Odsečak na y osi grafika zavisnosti logk od udela metanola u mobilnoj fazi za svako jedinjenje predstavlja vrednost logKw (vrednost retencionog faktora za hromatografski sistem u kome je sadržaj organske komponente nula) za dato jedinjenje. Konstruisan je grafik zavisnosti logP za standardna jedinjenja od njihovih eksperimentalno dobijenih logKw vrednosti i uspostavljena je linearna zavisnost. Interpolacijom logKw sa grafika su očitane vrednosti logP za sintetisana jedinjenja. Dobijene vrednosti su u opsegu od 2,901 do 3,847. Za predviđanje logP vrednosti korišćeni su računarski programi: AlogPS, Molinspiration, MarvinSketch i KOWWIN. Najbolja korelacija između eksperimentalno određenih i predviđenih rezultata je u programu KOWWIN (R2=0,8864), što čini ovaj program pogodnim za predviđanje logP vrednosti ovog tipa jedinjenja.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Lipophilicity determination of β-hydroxy-β-arilalkanoic acids by reversed phase liquid chromatography under high pressure
T1  - Određivanje lipofilnosti β-hidroksi-β-arilalkanskih kiselina primenom reverzno-fazne tečne hromatografije pod visokim pritiskom
VL  - 68
IS  - 1
SP  - 34
EP  - 45
DO  - 10.5937/arhFarm1801034S
ER  - 

@article{
author = "Savić, Jelena and Dilber, Sanda and Crevar-Sakač, Milkica and Vladimirov, Sote and Brborić, Jasmina",
year = "2018",
abstract = "Lipophilicity parameters (logP) were determined for thirteen synthesized β-hydroxy-β-arilalkanoic acids using reversed phase high performance liquid chromatography. Anti-inflammatory activity and potential selectivity towards cyclooxygenase-2 inhibition of synthetized compounds was assessed. Stationary phase was octadecyl modified (C-18) silicagel, and four used mobile phases contained different amount of methanol. Both synthetized and standard compounds with known logP values (aspirin, ibuprofen, ketoprofen, naproxen and phenanthrene) were tested in a chromatographic system. Using retention times for each standard and synthesized compound logk values (logarithm of capacity factor) were calculated. Intercept on a graph showing dependency of logk from methanol amount in the mobile phase for each compound represents logKw(capacity factor when organic solvent amount is zero). Graph showing linear dependency of logP of standard compounds from experimentally obtained logKw values was plotted. LogP values for synthetized compounds were obtained by interpolation from the plotted graph. Obtained values are in a range from 2.901 to 3.847. The best correlation between experimentally obtained and predicted logP values was using KOWWIN software (R2=0.8864), which makes this software appropriate for predicting logP values of this type of compounds., Parametri lipofilnosti (logP) su određeni za trinaest sintetisanih β-hidroksi-β-arilalkanskih kiselina primenom reverzno fazne tečne hromatografije. Ispitivanje je urađeno na derivatima kojima je tokom prethodnih istraživanja okarakterisana antiinflamatorna aktivnost i pretpostavljena je potencijalna selektivnost prema inhibiciji ciklooksigenaze-2. Oktadecil-modifikovani (C-18) silikagel je predstavljao stacionarnu fazu, a korišćene su četiri mobilne faze u kojima je variran udeo metanola. Hromatografski su testirana jedinjenja sa poznatim logP vrednostima (aspirin, ibuprofen, ketoprofen, naproksen i fenantren) i sintetisana jedinjenja. Na osnovu retencionog vremena za svako standardno i sintetisano jedinjenje izračunate su vrednosti logk (logaritam faktora kapaciteta). Odsečak na y osi grafika zavisnosti logk od udela metanola u mobilnoj fazi za svako jedinjenje predstavlja vrednost logKw (vrednost retencionog faktora za hromatografski sistem u kome je sadržaj organske komponente nula) za dato jedinjenje. Konstruisan je grafik zavisnosti logP za standardna jedinjenja od njihovih eksperimentalno dobijenih logKw vrednosti i uspostavljena je linearna zavisnost. Interpolacijom logKw sa grafika su očitane vrednosti logP za sintetisana jedinjenja. Dobijene vrednosti su u opsegu od 2,901 do 3,847. Za predviđanje logP vrednosti korišćeni su računarski programi: AlogPS, Molinspiration, MarvinSketch i KOWWIN. Najbolja korelacija između eksperimentalno određenih i predviđenih rezultata je u programu KOWWIN (R2=0,8864), što čini ovaj program pogodnim za predviđanje logP vrednosti ovog tipa jedinjenja.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Lipophilicity determination of β-hydroxy-β-arilalkanoic acids by reversed phase liquid chromatography under high pressure, Određivanje lipofilnosti β-hidroksi-β-arilalkanskih kiselina primenom reverzno-fazne tečne hromatografije pod visokim pritiskom",
volume = "68",
number = "1",
pages = "34-45",
doi = "10.5937/arhFarm1801034S"
}

Savić, J., Dilber, S., Crevar-Sakač, M., Vladimirov, S.,& Brborić, J.. (2018). Lipophilicity determination of β-hydroxy-β-arilalkanoic acids by reversed phase liquid chromatography under high pressure. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(1), 34-45.
https://doi.org/10.5937/arhFarm1801034S

Savić J, Dilber S, Crevar-Sakač M, Vladimirov S, Brborić J. Lipophilicity determination of β-hydroxy-β-arilalkanoic acids by reversed phase liquid chromatography under high pressure. in Arhiv za farmaciju. 2018;68(1):34-45.
doi:10.5937/arhFarm1801034S .

Savić, Jelena, Dilber, Sanda, Crevar-Sakač, Milkica, Vladimirov, Sote, Brborić, Jasmina, "Lipophilicity determination of β-hydroxy-β-arilalkanoic acids by reversed phase liquid chromatography under high pressure" in Arhiv za farmaciju, 68, no. 1 (2018):34-45,
https://doi.org/10.5937/arhFarm1801034S . .

TY  - JOUR
AU  - Savić, Jelena
AU  - Dilber, Sanda
AU  - Vujić, Zorica
AU  - Vladimirov, Sote
AU  - Brborić, Jasmina
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3069
AB  - The pK(a) values of twelve beta-hydroxy-beta-arylalkanoic acids and ibuprofen were determined using a modified RP-HPLC method. The stationary phase was octadecyl modified (C-18) silica gel, and the mobile phases were mixtures of methanol and one of ten different buffers (60: 40 volume ratio). The mean retention time of each compound was plotted against the pH of each of the ten used mobile phases. The inflection point of the obtained sigmoidal curve represents the (s)(w)pK(a) of a compound. Using (s)(w)pKa in previously established equations for the specific methanol/buffer mixture, the (w)(w)pK(a) values (in pure water) were calculated. The obtained wwpKa values for the synthesized compounds were in a range from 3.40 to 3.74, and the (w)(w)pK(a) for ibuprofen was 4.27. The Predicted pK(a) values for this type of compounds in the MarvinSketch 5.11.5. Program were in poor correlation with the experimental results, while in ACD//I-Labs pK(a) values were calculated as a wide range.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - A modified RP-HPLC method for the determination of the pK(a) values of synthesized beta-hydroxy-beta-arylalkanoic acids
VL  - 83
IS  - 7-8
SP  - 875
EP  - 883
DO  - 10.2298/JSC170804045S
ER  - 

@article{
author = "Savić, Jelena and Dilber, Sanda and Vujić, Zorica and Vladimirov, Sote and Brborić, Jasmina",
year = "2018",
abstract = "The pK(a) values of twelve beta-hydroxy-beta-arylalkanoic acids and ibuprofen were determined using a modified RP-HPLC method. The stationary phase was octadecyl modified (C-18) silica gel, and the mobile phases were mixtures of methanol and one of ten different buffers (60: 40 volume ratio). The mean retention time of each compound was plotted against the pH of each of the ten used mobile phases. The inflection point of the obtained sigmoidal curve represents the (s)(w)pK(a) of a compound. Using (s)(w)pKa in previously established equations for the specific methanol/buffer mixture, the (w)(w)pK(a) values (in pure water) were calculated. The obtained wwpKa values for the synthesized compounds were in a range from 3.40 to 3.74, and the (w)(w)pK(a) for ibuprofen was 4.27. The Predicted pK(a) values for this type of compounds in the MarvinSketch 5.11.5. Program were in poor correlation with the experimental results, while in ACD//I-Labs pK(a) values were calculated as a wide range.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "A modified RP-HPLC method for the determination of the pK(a) values of synthesized beta-hydroxy-beta-arylalkanoic acids",
volume = "83",
number = "7-8",
pages = "875-883",
doi = "10.2298/JSC170804045S"
}

Savić, J., Dilber, S., Vujić, Z., Vladimirov, S.,& Brborić, J.. (2018). A modified RP-HPLC method for the determination of the pK(a) values of synthesized beta-hydroxy-beta-arylalkanoic acids. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 83(7-8), 875-883.
https://doi.org/10.2298/JSC170804045S

Savić J, Dilber S, Vujić Z, Vladimirov S, Brborić J. A modified RP-HPLC method for the determination of the pK(a) values of synthesized beta-hydroxy-beta-arylalkanoic acids. in Journal of the Serbian Chemical Society. 2018;83(7-8):875-883.
doi:10.2298/JSC170804045S .

Savić, Jelena, Dilber, Sanda, Vujić, Zorica, Vladimirov, Sote, Brborić, Jasmina, "A modified RP-HPLC method for the determination of the pK(a) values of synthesized beta-hydroxy-beta-arylalkanoic acids" in Journal of the Serbian Chemical Society, 83, no. 7-8 (2018):875-883,
https://doi.org/10.2298/JSC170804045S . .

TY  - JOUR
AU  - Savić, Jelena
AU  - Marković, Bojan
AU  - Vitnik, Vesna
AU  - Dilber, Sanda
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3032
AB  - pKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, and mobile phase was a mixture of methanol and one of nine different buffers (60:40, v/v). wspH values were measured after mixing methanol with an appropriate buffer. The mean retention time of each compound was plotted against wspH of each mobile phase. The inflection point of each sigmoidal curve represented wspK a of the compound. Using wspK a in already known equations for the specific methanol/buffer mixture, wwpK a values were calculated. Obtained pKa values for synthesized compounds were in a narrow range from 3.34-3.81 and pKa for ibuprofen was 4.45. Predicted pKa values for these compounds in SPARC software showed good correlation with experimental pKa values (R2=0.8048).
PB  - Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
T2  - Kragujevac Journal of Science
T1  - Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography
IS  - 40
SP  - 103
EP  - 111
DO  - 10.5937/KgJSci1840103S
ER  - 

@article{
author = "Savić, Jelena and Marković, Bojan and Vitnik, Vesna and Dilber, Sanda",
year = "2018",
abstract = "pKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, and mobile phase was a mixture of methanol and one of nine different buffers (60:40, v/v). wspH values were measured after mixing methanol with an appropriate buffer. The mean retention time of each compound was plotted against wspH of each mobile phase. The inflection point of each sigmoidal curve represented wspK a of the compound. Using wspK a in already known equations for the specific methanol/buffer mixture, wwpK a values were calculated. Obtained pKa values for synthesized compounds were in a narrow range from 3.34-3.81 and pKa for ibuprofen was 4.45. Predicted pKa values for these compounds in SPARC software showed good correlation with experimental pKa values (R2=0.8048).",
publisher = "Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac",
journal = "Kragujevac Journal of Science",
title = "Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography",
number = "40",
pages = "103-111",
doi = "10.5937/KgJSci1840103S"
}

Savić, J., Marković, B., Vitnik, V.,& Dilber, S.. (2018). Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography. in Kragujevac Journal of Science
Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac.(40), 103-111.
https://doi.org/10.5937/KgJSci1840103S

Savić J, Marković B, Vitnik V, Dilber S. Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography. in Kragujevac Journal of Science. 2018;(40):103-111.
doi:10.5937/KgJSci1840103S .

Savić, Jelena, Marković, Bojan, Vitnik, Vesna, Dilber, Sanda, "Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography" in Kragujevac Journal of Science, no. 40 (2018):103-111,
https://doi.org/10.5937/KgJSci1840103S . .

TY  - JOUR
AU  - Savić, Jelena
AU  - Dobričić, Vladimir
AU  - Nikolić, Katarina
AU  - Vladimirov, Sote
AU  - Dilber, Sanda
AU  - Brborić, Jasmina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2923
AB  - Prediction of gastrointestinal absorption of thirteen newly synthesized beta-hydroxy-beta-arylalkanoic acids (HAA) and ibuprofen was performed using PAMPA test The highest values of PAMPA parameters (%Tand P-app) were calculated for 1C, 1B and 2C and these parameters were significantly lower in comparison to ibuprofen. QSPR analysis was performed in order to identify molecular descriptors with the highest influence on %Tand-logP(app) and to create models which could be used for the design of novel HAA with improved gastrointestinal absorption. Obtained results indicate that introduction of branched side chain, as well as introduction of substituents on one phenyl ring (which disturb symmetry of the molecule) could have positive impact on gastrointestinal absorption. On the basis of these results, six novel HAA were designed and PAMPA parameters %Tand-logP(app) were predicted by use of selected QSPR models. Designed derivatives should have better gastrointestinal absorption than HAA tested in this study.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - In vitro prediction of gastrointestinal absorption of novel beta-hydroxy-beta-arylalkanoic acids using PAMPA technique
VL  - 100
SP  - 36
EP  - 41
DO  - 10.1016/j.ejps.2017.01.005
ER  - 

@article{
author = "Savić, Jelena and Dobričić, Vladimir and Nikolić, Katarina and Vladimirov, Sote and Dilber, Sanda and Brborić, Jasmina",
year = "2017",
abstract = "Prediction of gastrointestinal absorption of thirteen newly synthesized beta-hydroxy-beta-arylalkanoic acids (HAA) and ibuprofen was performed using PAMPA test The highest values of PAMPA parameters (%Tand P-app) were calculated for 1C, 1B and 2C and these parameters were significantly lower in comparison to ibuprofen. QSPR analysis was performed in order to identify molecular descriptors with the highest influence on %Tand-logP(app) and to create models which could be used for the design of novel HAA with improved gastrointestinal absorption. Obtained results indicate that introduction of branched side chain, as well as introduction of substituents on one phenyl ring (which disturb symmetry of the molecule) could have positive impact on gastrointestinal absorption. On the basis of these results, six novel HAA were designed and PAMPA parameters %Tand-logP(app) were predicted by use of selected QSPR models. Designed derivatives should have better gastrointestinal absorption than HAA tested in this study.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "In vitro prediction of gastrointestinal absorption of novel beta-hydroxy-beta-arylalkanoic acids using PAMPA technique",
volume = "100",
pages = "36-41",
doi = "10.1016/j.ejps.2017.01.005"
}

Savić, J., Dobričić, V., Nikolić, K., Vladimirov, S., Dilber, S.,& Brborić, J.. (2017). In vitro prediction of gastrointestinal absorption of novel beta-hydroxy-beta-arylalkanoic acids using PAMPA technique. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 100, 36-41.
https://doi.org/10.1016/j.ejps.2017.01.005

Savić J, Dobričić V, Nikolić K, Vladimirov S, Dilber S, Brborić J. In vitro prediction of gastrointestinal absorption of novel beta-hydroxy-beta-arylalkanoic acids using PAMPA technique. in European Journal of Pharmaceutical Sciences. 2017;100:36-41.
doi:10.1016/j.ejps.2017.01.005 .

Savić, Jelena, Dobričić, Vladimir, Nikolić, Katarina, Vladimirov, Sote, Dilber, Sanda, Brborić, Jasmina, "In vitro prediction of gastrointestinal absorption of novel beta-hydroxy-beta-arylalkanoic acids using PAMPA technique" in European Journal of Pharmaceutical Sciences, 100 (2017):36-41,
https://doi.org/10.1016/j.ejps.2017.01.005 . .

TY  - JOUR
AU  - Savić, Jelena
AU  - Dilber, Sanda
AU  - Milenković, Marina
AU  - Kotur-Stevuljević, Jelena
AU  - Marković, Bojan
AU  - Vladimirov, Sote
AU  - Brborić, Jasmina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2891
AB  - Background: Nonsteriodal anti-inflammatory drugs (NSAIDs) are numerous and widely used for more than 60 years, but there is still a strong need for developing novel selective NSAIDs. The need is justified by the fact that nonselective NSAIDs can produce serious gastric side effects and that some of the selective NSAID are withdrawn due to their cardiotoxic side effects. Methods: Eight beta-hydroxy-beta-arylpropanoic acids, which belong to the arylpropanoic acid class of compounds, structurally similar to some nonsteroidal anti-inflammatory drugs (NSAIDs), were docked into 3D catalytic site of both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Seven out of those eight acids were synthesized using already published modification of Reformatsky reaction additionally optimized by increasing temperature. Synthesized compounds were tested in vivo in order to elucidate anti-inflammatory activity, gastric tolerability and impact on liver function of rats. Results: Results of docking studies have indicated that all compounds have potential to selectively inhibit COX-2 isoform, but that the compounds containing polar substituents on phenyl ring are better inhibitors. Results of carrageenan-induced rat paw oedema test have shown that all compounds exhibit dose dependence and good gastric tolerability and none of the tested compounds have shown negative effect on liver function compared to ibuprofen. Conclusion: The compound containing polar nitro group in para position has shown the best docking results, anti-inflammatory activity, low hepatotoxicity and good gastric tolerability.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Medicinal Chemistry
T1  - Docking Studies, Synthesis and Biological Evaluation of beta-aryl-beta-hydroxy Propanoic Acids for Anti-inflammatory Activity
VL  - 13
IS  - 2
SP  - 186
EP  - 195
DO  - 10.2174/1573406412666160907150247
ER  - 

@article{
author = "Savić, Jelena and Dilber, Sanda and Milenković, Marina and Kotur-Stevuljević, Jelena and Marković, Bojan and Vladimirov, Sote and Brborić, Jasmina",
year = "2017",
abstract = "Background: Nonsteriodal anti-inflammatory drugs (NSAIDs) are numerous and widely used for more than 60 years, but there is still a strong need for developing novel selective NSAIDs. The need is justified by the fact that nonselective NSAIDs can produce serious gastric side effects and that some of the selective NSAID are withdrawn due to their cardiotoxic side effects. Methods: Eight beta-hydroxy-beta-arylpropanoic acids, which belong to the arylpropanoic acid class of compounds, structurally similar to some nonsteroidal anti-inflammatory drugs (NSAIDs), were docked into 3D catalytic site of both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Seven out of those eight acids were synthesized using already published modification of Reformatsky reaction additionally optimized by increasing temperature. Synthesized compounds were tested in vivo in order to elucidate anti-inflammatory activity, gastric tolerability and impact on liver function of rats. Results: Results of docking studies have indicated that all compounds have potential to selectively inhibit COX-2 isoform, but that the compounds containing polar substituents on phenyl ring are better inhibitors. Results of carrageenan-induced rat paw oedema test have shown that all compounds exhibit dose dependence and good gastric tolerability and none of the tested compounds have shown negative effect on liver function compared to ibuprofen. Conclusion: The compound containing polar nitro group in para position has shown the best docking results, anti-inflammatory activity, low hepatotoxicity and good gastric tolerability.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Medicinal Chemistry",
title = "Docking Studies, Synthesis and Biological Evaluation of beta-aryl-beta-hydroxy Propanoic Acids for Anti-inflammatory Activity",
volume = "13",
number = "2",
pages = "186-195",
doi = "10.2174/1573406412666160907150247"
}

Savić, J., Dilber, S., Milenković, M., Kotur-Stevuljević, J., Marković, B., Vladimirov, S.,& Brborić, J.. (2017). Docking Studies, Synthesis and Biological Evaluation of beta-aryl-beta-hydroxy Propanoic Acids for Anti-inflammatory Activity. in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 13(2), 186-195.
https://doi.org/10.2174/1573406412666160907150247

Savić J, Dilber S, Milenković M, Kotur-Stevuljević J, Marković B, Vladimirov S, Brborić J. Docking Studies, Synthesis and Biological Evaluation of beta-aryl-beta-hydroxy Propanoic Acids for Anti-inflammatory Activity. in Medicinal Chemistry. 2017;13(2):186-195.
doi:10.2174/1573406412666160907150247 .

Savić, Jelena, Dilber, Sanda, Milenković, Marina, Kotur-Stevuljević, Jelena, Marković, Bojan, Vladimirov, Sote, Brborić, Jasmina, "Docking Studies, Synthesis and Biological Evaluation of beta-aryl-beta-hydroxy Propanoic Acids for Anti-inflammatory Activity" in Medicinal Chemistry, 13, no. 2 (2017):186-195,
https://doi.org/10.2174/1573406412666160907150247 . .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Vićentijević, Nina
AU  - Malešević, Vladimir
AU  - Ćurčić, Marijana
AU  - Dilber, Sanda
AU  - Antonijević, Biljana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2780
AB  - Although fluoride doesn't have essential function in human growth and development, it is important to be taken in optimal amounts for caries preventive effects. Estimation of fluoride intake is especially important in preschool children when it comes to massive growth and development of the teeth in order to achieve caries protection and to avoid side effects if taken in excessive amounts (dental and skeletal fluorosis). The aim of this study was to determine the validity of a questionnaire created for assessment of fluoride intake through drinking water, toothpaste and fluoride supplements among preschool children. The first morning urine samples were collected from children aged 3 to 7 years (n=16). Fluoride concentrations in these samples were determined by fluoride ion-specific electrode. The questionnaires for parents were used to obtain data about the type of water and toothpaste, frequency of tooth brushing and fluoride supplements that children have used. Fluoride intake was estimated using a mathematical model given by the US Agency for Environ - mental Protection. Fluoride concentrations in urine were within 0.16-0.68 mg F-/L, while estimated daily intake levels of fluorides were within 0.0125-0.033 mg F-/kg/day. Using correlation analysis positive correlation between daily intake of fluorides, calculated on the basis of questionnaire data, and determined fluoride concentrations in urine was shown (r=0.59, p lt 0.05). However, the obtained results show that estimated daily fluoride intakes through drinking water and toothpaste, even including fluoride supplements (Fluorogal®, NaF, tablets 0.25 mg) were lower than adequate intake (0.05 mg F-/kg/day, EFSA ). Created questionnaire could provide adequate assessment of fluoride intake in preschool children. Calculated daily intakes of fluorides through drinking water, toothpaste and fluoride supplements for children aged 3 to 7 years were lower than optimal intakes for caries prevention effect.
AB  - Iako fluoridi nemaju esencijalnu ulogu u ljudskom rastu i razvoju, neophodno je da se unose u organizam u optimalnim količinama zbog povoljnih efekata na prevenciju karijesa. Procena njihovog unosa je posebno značajna kod dece predškolskog uzrasta kada dolazi do intenzivnog rasta i razvoja zuba kako bi se postigli preventivni efekti i izbegle posledice prekomernog unosa u vidu dentalne i skeletne fluoroze. Cilj ovog rada je bio da se utvrdi validnost anketnog upitnika kreiranog za procenu unosa fluorida putem vode za piće, paste za zube i suplemenata kod dece predškolskog uzrasta. Sakupljeni su prvi jutarnji uzorci urina dece uzrasta 3-7 godina (n=16) i u njima određen sadržaj fluorida pomoću fluoridne jon-selektivne elektrode. Upitnicima za roditelje dobijeni su podaci o vrsti vode koju deca piju, pasti za zube koju koriste, učestalosti pranja zuba i suplementima koje deca koriste. Unos fluorida je procenjen korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Koncentracije fluorida u urinu su se kretale u opsegu od 0,16 do 0,68 mg F-/L dok su procenjeni nivoi dnevnog unosa fluorida iznosili od 0,0125 do 0,033 mg F-/kg/dan. Primenom korelacione analize je pokazana pozitivna korelacija između dnevnih unosa fluorida izračunatih na osnovu podataka dobijenih anketnim upitnikom i određenih koncentracija fluorida u urinu (r=0,59, p lt 0,05). Osim toga, dobijeni rezultati pokazuju da je dnevni unos fluorida putem vode za piće i paste za zube, čak i uz primenu suplemenata fluorida (Fluorigal®, NaF, tablete 0,25 mg) niži od optimalnog (0,05 mg F-/kg/dan, EFSA). Kreirani anketni upitnik može da obezbedi adekvatnu procenu unosa fluorida kod dece predškolskog uzrasta. Izračunati dnevni unosi fluorida putem vode za piće, paste za zube i suplemenata fluorida kod dece uzrasta 3-7 godina su manji od optimalnih vrednosti za prevenciju karijesa.
PB  - Most Art doo, Beograd
T2  - MD - Medical data
T1  - Fluoride, urine, children, intake estimation, questionnaire validation
T1  - Validacija upitnika za procenu unosa fluorida kod dece predškolskog uzrasta
VL  - 9
IS  - 2
SP  - 95
EP  - 100
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2780
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Antonijević, Evica and Vićentijević, Nina and Malešević, Vladimir and Ćurčić, Marijana and Dilber, Sanda and Antonijević, Biljana",
year = "2017",
abstract = "Although fluoride doesn't have essential function in human growth and development, it is important to be taken in optimal amounts for caries preventive effects. Estimation of fluoride intake is especially important in preschool children when it comes to massive growth and development of the teeth in order to achieve caries protection and to avoid side effects if taken in excessive amounts (dental and skeletal fluorosis). The aim of this study was to determine the validity of a questionnaire created for assessment of fluoride intake through drinking water, toothpaste and fluoride supplements among preschool children. The first morning urine samples were collected from children aged 3 to 7 years (n=16). Fluoride concentrations in these samples were determined by fluoride ion-specific electrode. The questionnaires for parents were used to obtain data about the type of water and toothpaste, frequency of tooth brushing and fluoride supplements that children have used. Fluoride intake was estimated using a mathematical model given by the US Agency for Environ - mental Protection. Fluoride concentrations in urine were within 0.16-0.68 mg F-/L, while estimated daily intake levels of fluorides were within 0.0125-0.033 mg F-/kg/day. Using correlation analysis positive correlation between daily intake of fluorides, calculated on the basis of questionnaire data, and determined fluoride concentrations in urine was shown (r=0.59, p lt 0.05). However, the obtained results show that estimated daily fluoride intakes through drinking water and toothpaste, even including fluoride supplements (Fluorogal®, NaF, tablets 0.25 mg) were lower than adequate intake (0.05 mg F-/kg/day, EFSA ). Created questionnaire could provide adequate assessment of fluoride intake in preschool children. Calculated daily intakes of fluorides through drinking water, toothpaste and fluoride supplements for children aged 3 to 7 years were lower than optimal intakes for caries prevention effect., Iako fluoridi nemaju esencijalnu ulogu u ljudskom rastu i razvoju, neophodno je da se unose u organizam u optimalnim količinama zbog povoljnih efekata na prevenciju karijesa. Procena njihovog unosa je posebno značajna kod dece predškolskog uzrasta kada dolazi do intenzivnog rasta i razvoja zuba kako bi se postigli preventivni efekti i izbegle posledice prekomernog unosa u vidu dentalne i skeletne fluoroze. Cilj ovog rada je bio da se utvrdi validnost anketnog upitnika kreiranog za procenu unosa fluorida putem vode za piće, paste za zube i suplemenata kod dece predškolskog uzrasta. Sakupljeni su prvi jutarnji uzorci urina dece uzrasta 3-7 godina (n=16) i u njima određen sadržaj fluorida pomoću fluoridne jon-selektivne elektrode. Upitnicima za roditelje dobijeni su podaci o vrsti vode koju deca piju, pasti za zube koju koriste, učestalosti pranja zuba i suplementima koje deca koriste. Unos fluorida je procenjen korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Koncentracije fluorida u urinu su se kretale u opsegu od 0,16 do 0,68 mg F-/L dok su procenjeni nivoi dnevnog unosa fluorida iznosili od 0,0125 do 0,033 mg F-/kg/dan. Primenom korelacione analize je pokazana pozitivna korelacija između dnevnih unosa fluorida izračunatih na osnovu podataka dobijenih anketnim upitnikom i određenih koncentracija fluorida u urinu (r=0,59, p lt 0,05). Osim toga, dobijeni rezultati pokazuju da je dnevni unos fluorida putem vode za piće i paste za zube, čak i uz primenu suplemenata fluorida (Fluorigal®, NaF, tablete 0,25 mg) niži od optimalnog (0,05 mg F-/kg/dan, EFSA). Kreirani anketni upitnik može da obezbedi adekvatnu procenu unosa fluorida kod dece predškolskog uzrasta. Izračunati dnevni unosi fluorida putem vode za piće, paste za zube i suplemenata fluorida kod dece uzrasta 3-7 godina su manji od optimalnih vrednosti za prevenciju karijesa.",
publisher = "Most Art doo, Beograd",
journal = "MD - Medical data",
title = "Fluoride, urine, children, intake estimation, questionnaire validation, Validacija upitnika za procenu unosa fluorida kod dece predškolskog uzrasta",
volume = "9",
number = "2",
pages = "95-100",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2780"
}

Đukić-Ćosić, D., Antonijević, E., Vićentijević, N., Malešević, V., Ćurčić, M., Dilber, S.,& Antonijević, B.. (2017). Fluoride, urine, children, intake estimation, questionnaire validation. in MD - Medical data
Most Art doo, Beograd., 9(2), 95-100.
https://hdl.handle.net/21.15107/rcub_farfar_2780

Đukić-Ćosić D, Antonijević E, Vićentijević N, Malešević V, Ćurčić M, Dilber S, Antonijević B. Fluoride, urine, children, intake estimation, questionnaire validation. in MD - Medical data. 2017;9(2):95-100.
https://hdl.handle.net/21.15107/rcub_farfar_2780 .

Đukić-Ćosić, Danijela, Antonijević, Evica, Vićentijević, Nina, Malešević, Vladimir, Ćurčić, Marijana, Dilber, Sanda, Antonijević, Biljana, "Fluoride, urine, children, intake estimation, questionnaire validation" in MD - Medical data, 9, no. 2 (2017):95-100,
https://hdl.handle.net/21.15107/rcub_farfar_2780 .

TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Stanojković, Tatjana
AU  - Srdić-Rajić, Tatjana
AU  - Dilber, Sanda
AU  - Đorđević, Brižita
AU  - Stanković, Ivan
AU  - Juranić, Zorica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2671
AB  - Background/Aim. Numerous epidemiological studies have shown beneficial effects of cruciferous vegetables consumption in cancer chemoprevention. Biologically active compounds of different Brassicaceae species with antitumor potential are isothiocyanates, present in the form of their precursors - glucosinolates. The aim of this study was to determine the selectivity of antiproliferative action of dietary isothiocyanates for malignant versus normal cells. Methods. Antiproliferative activity of three isothiocyanates abundant in human diet: sulforaphane, benzyl isothiocyanate (BITC) and phenylethyl isothiocyanate, on human cervix carcinoma cell line - HeLa, melanoma cell line - Fem-x, and colon cancer cell line - LS 174, and on peripheral blood mononuclear cells (PBMC), with or without mitogen, were determined by MTT colorimetric assay 72 h after their continuous action. Results. All investigated isothiocyanates inhibited the proliferation of HeLa, Fem-x and LS 174 cells. On all cell lines treated, BITC was the most potent inhibitor of cell proliferation with half-maximum inhibitory concentration (IC50) values of 5.04 mmoL m-3 on HeLa cells, 2.76 mmol m-3 on Fem-x, and 14.30 mmol m-3 on LS 174 cells. Antiproliferative effects on human PBMC were with higher IC50 than on malignant cells. Indexes of selectivity, calculated as a ratio between IC50 values obtained on PBMC and malignant cells, were between 1.12 and 16.57, with the highest values obtained for the action of BITC on melanoma Fem-x cells. Conclusion. Based on its antiproliferative effects on malignant cells, as well as the selectivity of the action to malignant vs normal cells, benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention. In general, the safety of investigated compounds, in addition to their antitumor potential, should be considered as an important criterion in cancer chemoprevention. Screening of selectivity is a plausible approach to the evaluation of safety of both natural isothiocyanates and synthesised analogues of these bioactive compounds.
AB  - Uvod/Cilj. Brojne epidemiološke studije pokazale su povoljne efekte konzumiranja povrća iz familije kupusnjača (Brassicaceae) u hemioprevenciji karcinoma. Osnovni biološki aktivni sastojci ovog povrća su izotiocijanati, prisutni u obliku prekursora - glukozinolata. Cilj ovog rada bio je određivanje selektivnosti antiproliferativnog delovanja dijetetskih izotiocijanata na maligne ćelije u odnosu na normalne ćelije. Metode. Antiproliferativna aktivnost tri izotiocijanata zastupljena u ljudskoj ishrani: sulforafana (SFN), benzil-izotiocijanata (BITC) i feniletil-izotiocijanata (FEITC) na humane maligne ćelijske linije, HeLa, ćelijsku liniju karcinoma grlića materice, Fem-x, ćelijsku liniju melanoma, i LS 174, ćelijsku liniju karcinoma kolona, kao i na mononuklearne ćelije periferne krvi (MNĆPK), sa ili bez delovanja mitogena, određivana je MTT kalorimetrijskim testom, 72 h nakon kontinuiranog delovanja agenasa. Rezultati. Svi ispitivani izotiocijanati inhibirali su proliferaciju HeLa, Fem-x i LS 174 ćelija. Na svim ćelijskim linijama BITC je pokazao najizraženije delovanje sa vrednostima polumaksimalne inhibitorne koncentracije (IC50) od 5.04 mmol m-3 na HeLa ćelijama, 2,76 mmoL m-3 na Fem-x i 14,30 mmol m-3 na LS 174 ćelijama. Svi ispitivani izotiocijanati pokazali su citotoksično delovanje na MNĆPK, ali sa višim IC50 vrednostima u odnosu na maligne ćelije. Indeksi selektivnosti antitumorkog delovanja, izraženi kao odnos IC50 vrednosti dobijenih na MNĆPK i malignim ćelijama, bili su između 1,12 i 16,57, sa najvišom vrednosti pri delovanju BITC na Fem-x ćelije. Zaključak. Na osnovu antiproliferativne aktivnosti na maligne ćelije i selektivnosti antiproliferativnog delovanja na maligne u odnosu na normalne ćelije, benzil izotiocijanat se ističe kao perspektivni agens u hemioprevenciji karcinoma. Generalno, pored antitumorskog delovanja, bezbednost primene ovih jedinjenja treba da predstavlja važan kriterijum u izboru odgovarajućih izotiocijanata za primenu u primarnoj, sekundarnoj i tercijarnoj hemioprevenciji kancera. Ispitivanje selektivnosti predstavlja pogodan pristup oceni bezbednosti i prirodnih izotiocijanata i sintetskih analoga.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells
T1  - In vitro ispitivanje selektivnosti antiproliferativnog dejstva dijetetskih izotiocijanata na tumorske u odnosu na normalne humane ćelije
VL  - 73
IS  - 7
SP  - 636
EP  - 642
DO  - 10.2298/VSP141103066K
ER  - 

@article{
author = "Konić-Ristić, Aleksandra and Stanojković, Tatjana and Srdić-Rajić, Tatjana and Dilber, Sanda and Đorđević, Brižita and Stanković, Ivan and Juranić, Zorica",
year = "2016",
abstract = "Background/Aim. Numerous epidemiological studies have shown beneficial effects of cruciferous vegetables consumption in cancer chemoprevention. Biologically active compounds of different Brassicaceae species with antitumor potential are isothiocyanates, present in the form of their precursors - glucosinolates. The aim of this study was to determine the selectivity of antiproliferative action of dietary isothiocyanates for malignant versus normal cells. Methods. Antiproliferative activity of three isothiocyanates abundant in human diet: sulforaphane, benzyl isothiocyanate (BITC) and phenylethyl isothiocyanate, on human cervix carcinoma cell line - HeLa, melanoma cell line - Fem-x, and colon cancer cell line - LS 174, and on peripheral blood mononuclear cells (PBMC), with or without mitogen, were determined by MTT colorimetric assay 72 h after their continuous action. Results. All investigated isothiocyanates inhibited the proliferation of HeLa, Fem-x and LS 174 cells. On all cell lines treated, BITC was the most potent inhibitor of cell proliferation with half-maximum inhibitory concentration (IC50) values of 5.04 mmoL m-3 on HeLa cells, 2.76 mmol m-3 on Fem-x, and 14.30 mmol m-3 on LS 174 cells. Antiproliferative effects on human PBMC were with higher IC50 than on malignant cells. Indexes of selectivity, calculated as a ratio between IC50 values obtained on PBMC and malignant cells, were between 1.12 and 16.57, with the highest values obtained for the action of BITC on melanoma Fem-x cells. Conclusion. Based on its antiproliferative effects on malignant cells, as well as the selectivity of the action to malignant vs normal cells, benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention. In general, the safety of investigated compounds, in addition to their antitumor potential, should be considered as an important criterion in cancer chemoprevention. Screening of selectivity is a plausible approach to the evaluation of safety of both natural isothiocyanates and synthesised analogues of these bioactive compounds., Uvod/Cilj. Brojne epidemiološke studije pokazale su povoljne efekte konzumiranja povrća iz familije kupusnjača (Brassicaceae) u hemioprevenciji karcinoma. Osnovni biološki aktivni sastojci ovog povrća su izotiocijanati, prisutni u obliku prekursora - glukozinolata. Cilj ovog rada bio je određivanje selektivnosti antiproliferativnog delovanja dijetetskih izotiocijanata na maligne ćelije u odnosu na normalne ćelije. Metode. Antiproliferativna aktivnost tri izotiocijanata zastupljena u ljudskoj ishrani: sulforafana (SFN), benzil-izotiocijanata (BITC) i feniletil-izotiocijanata (FEITC) na humane maligne ćelijske linije, HeLa, ćelijsku liniju karcinoma grlića materice, Fem-x, ćelijsku liniju melanoma, i LS 174, ćelijsku liniju karcinoma kolona, kao i na mononuklearne ćelije periferne krvi (MNĆPK), sa ili bez delovanja mitogena, određivana je MTT kalorimetrijskim testom, 72 h nakon kontinuiranog delovanja agenasa. Rezultati. Svi ispitivani izotiocijanati inhibirali su proliferaciju HeLa, Fem-x i LS 174 ćelija. Na svim ćelijskim linijama BITC je pokazao najizraženije delovanje sa vrednostima polumaksimalne inhibitorne koncentracije (IC50) od 5.04 mmol m-3 na HeLa ćelijama, 2,76 mmoL m-3 na Fem-x i 14,30 mmol m-3 na LS 174 ćelijama. Svi ispitivani izotiocijanati pokazali su citotoksično delovanje na MNĆPK, ali sa višim IC50 vrednostima u odnosu na maligne ćelije. Indeksi selektivnosti antitumorkog delovanja, izraženi kao odnos IC50 vrednosti dobijenih na MNĆPK i malignim ćelijama, bili su između 1,12 i 16,57, sa najvišom vrednosti pri delovanju BITC na Fem-x ćelije. Zaključak. Na osnovu antiproliferativne aktivnosti na maligne ćelije i selektivnosti antiproliferativnog delovanja na maligne u odnosu na normalne ćelije, benzil izotiocijanat se ističe kao perspektivni agens u hemioprevenciji karcinoma. Generalno, pored antitumorskog delovanja, bezbednost primene ovih jedinjenja treba da predstavlja važan kriterijum u izboru odgovarajućih izotiocijanata za primenu u primarnoj, sekundarnoj i tercijarnoj hemioprevenciji kancera. Ispitivanje selektivnosti predstavlja pogodan pristup oceni bezbednosti i prirodnih izotiocijanata i sintetskih analoga.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells, In vitro ispitivanje selektivnosti antiproliferativnog dejstva dijetetskih izotiocijanata na tumorske u odnosu na normalne humane ćelije",
volume = "73",
number = "7",
pages = "636-642",
doi = "10.2298/VSP141103066K"
}

Konić-Ristić, A., Stanojković, T., Srdić-Rajić, T., Dilber, S., Đorđević, B., Stanković, I.,& Juranić, Z.. (2016). In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(7), 636-642.
https://doi.org/10.2298/VSP141103066K

Konić-Ristić A, Stanojković T, Srdić-Rajić T, Dilber S, Đorđević B, Stanković I, Juranić Z. In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells. in Vojnosanitetski pregled. 2016;73(7):636-642.
doi:10.2298/VSP141103066K .

Konić-Ristić, Aleksandra, Stanojković, Tatjana, Srdić-Rajić, Tatjana, Dilber, Sanda, Đorđević, Brižita, Stanković, Ivan, Juranić, Zorica, "In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells" in Vojnosanitetski pregled, 73, no. 7 (2016):636-642,
https://doi.org/10.2298/VSP141103066K . .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Milašinović, Nikola
AU  - Kotur-Stevuljević, Jelena
AU  - Dilber, Sanda
AU  - Kalagasidis-Krusić, Melina T.
AU  - Đorđević, Brižita
AU  - Knežević-Jugović, Zorica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2605
AB  - Alpha-lipoic acid is an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of alpha-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, alpha-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of alpha-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of alpha-lipoic acid obtained in this study was up to 53.9%. The structural interaction of alpha-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of alpha-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released alpha-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of alpha-lipoic acid.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity
VL  - 70
IS  - 1
SP  - 49
EP  - 58
DO  - 10.2298/HEMIND141119010V
ER  - 

@article{
author = "Vidović, Bojana and Milašinović, Nikola and Kotur-Stevuljević, Jelena and Dilber, Sanda and Kalagasidis-Krusić, Melina T. and Đorđević, Brižita and Knežević-Jugović, Zorica",
year = "2016",
abstract = "Alpha-lipoic acid is an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of alpha-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, alpha-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of alpha-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of alpha-lipoic acid obtained in this study was up to 53.9%. The structural interaction of alpha-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of alpha-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released alpha-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of alpha-lipoic acid.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity",
volume = "70",
number = "1",
pages = "49-58",
doi = "10.2298/HEMIND141119010V"
}

Vidović, B., Milašinović, N., Kotur-Stevuljević, J., Dilber, S., Kalagasidis-Krusić, M. T., Đorđević, B.,& Knežević-Jugović, Z.. (2016). Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 70(1), 49-58.
https://doi.org/10.2298/HEMIND141119010V

Vidović B, Milašinović N, Kotur-Stevuljević J, Dilber S, Kalagasidis-Krusić MT, Đorđević B, Knežević-Jugović Z. Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity. in Hemijska industrija. 2016;70(1):49-58.
doi:10.2298/HEMIND141119010V .

Vidović, Bojana, Milašinović, Nikola, Kotur-Stevuljević, Jelena, Dilber, Sanda, Kalagasidis-Krusić, Melina T., Đorđević, Brižita, Knežević-Jugović, Zorica, "Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity" in Hemijska industrija, 70, no. 1 (2016):49-58,
https://doi.org/10.2298/HEMIND141119010V . .

TY  - CONF
AU  - Dzigurski, Anka
AU  - Vidović, Bojana
AU  - Dilber, Sanda
AU  - Mihajlov, Tijana
AU  - Aracki-Jović, Milanka
AU  - Đorđević, Brižita
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2343
AB  - Introduction: Weight loss with preferential effect on the body fat,
especially visceral fat, could have important clinical benefits.
Objectives: The objective of this study was to evaluate the effect of
8-week personalized Chrono Nutrition weight management program
on body weight and body composition in obese women.
Method / Design: 157 obese women (aged 44,1 ± 12,7 years,
BMI= 35,5 ± 5,3 kg/m2, % body fat= 43,4 ± 4,9 %) participated in the
investigation. Participants were advised to have meals that contained
on certain well tolerated foods at a proper day time. Anthropometric
measurements and body composition by using a bioimpedance
analyzer Inbody 720 were assessed at the baseline, and after 4 and 8
weeks. Friedman test was used to compare anthropometric measurements during follow up, and post hoc comparisons with a Wilcoxon
signed-rank test was conducted with the applied Bonferroni correction method.
Results: Participants lost significant weight during the intervention (-5.1 kg at week 4 (p<0.001) and -3.5 kg at week 8 (p<0.001)). The
mean visceral fat area, mean total fat mass, and mean percent body
fat showed a trend of reduction during the whole period of the study
and the difference between each measurement remained statistically
significant (p<0,001). The mean skeletal muscle mass was reduced by
around 0,7 kg at the 4 weeks of program; the difference was statistically significant (p <0,001). Afterwards, towards week 8 of the program,
the mean value of the skeletal muscle mass showed no trend of further
reduction.
Conclusions: Chrono nutrition could be an effective and appropriate weight management program.
PB  - Karger, Basel
C3  - Annals of Nutrition and Metabolism
T1  - Changes of body composition during weight reduction program in obese women
VL  - 67
IS  - Supplement 1
SP  - 455
EP  - 455
DO  - 10.1159/000440895
ER  - 

@conference{
author = "Dzigurski, Anka and Vidović, Bojana and Dilber, Sanda and Mihajlov, Tijana and Aracki-Jović, Milanka and Đorđević, Brižita",
year = "2015",
abstract = "Introduction: Weight loss with preferential effect on the body fat,
especially visceral fat, could have important clinical benefits.
Objectives: The objective of this study was to evaluate the effect of
8-week personalized Chrono Nutrition weight management program
on body weight and body composition in obese women.
Method / Design: 157 obese women (aged 44,1 ± 12,7 years,
BMI= 35,5 ± 5,3 kg/m2, % body fat= 43,4 ± 4,9 %) participated in the
investigation. Participants were advised to have meals that contained
on certain well tolerated foods at a proper day time. Anthropometric
measurements and body composition by using a bioimpedance
analyzer Inbody 720 were assessed at the baseline, and after 4 and 8
weeks. Friedman test was used to compare anthropometric measurements during follow up, and post hoc comparisons with a Wilcoxon
signed-rank test was conducted with the applied Bonferroni correction method.
Results: Participants lost significant weight during the intervention (-5.1 kg at week 4 (p<0.001) and -3.5 kg at week 8 (p<0.001)). The
mean visceral fat area, mean total fat mass, and mean percent body
fat showed a trend of reduction during the whole period of the study
and the difference between each measurement remained statistically
significant (p<0,001). The mean skeletal muscle mass was reduced by
around 0,7 kg at the 4 weeks of program; the difference was statistically significant (p <0,001). Afterwards, towards week 8 of the program,
the mean value of the skeletal muscle mass showed no trend of further
reduction.
Conclusions: Chrono nutrition could be an effective and appropriate weight management program.",
publisher = "Karger, Basel",
journal = "Annals of Nutrition and Metabolism",
title = "Changes of body composition during weight reduction program in obese women",
volume = "67",
number = "Supplement 1",
pages = "455-455",
doi = "10.1159/000440895"
}

Dzigurski, A., Vidović, B., Dilber, S., Mihajlov, T., Aracki-Jović, M.,& Đorđević, B.. (2015). Changes of body composition during weight reduction program in obese women. in Annals of Nutrition and Metabolism
Karger, Basel., 67(Supplement 1), 455-455.
https://doi.org/10.1159/000440895

Dzigurski A, Vidović B, Dilber S, Mihajlov T, Aracki-Jović M, Đorđević B. Changes of body composition during weight reduction program in obese women. in Annals of Nutrition and Metabolism. 2015;67(Supplement 1):455-455.
doi:10.1159/000440895 .

Dzigurski, Anka, Vidović, Bojana, Dilber, Sanda, Mihajlov, Tijana, Aracki-Jović, Milanka, Đorđević, Brižita, "Changes of body composition during weight reduction program in obese women" in Annals of Nutrition and Metabolism, 67, no. Supplement 1 (2015):455-455,
https://doi.org/10.1159/000440895 . .

TY  - CONF
AU  - Dzigurski, Anka
AU  - Vidović, Bojana
AU  - Dilber, Sanda
AU  - Đorđević, Brižita
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2353
AB  - Introduction: Overweight and obesity are a well-known public
health problem associated with chronical diseases such as heart disease, stroke and type 2 diabetes. Body composition and nutritional status monitoring are very important for planning preventive measures
towards health promotion.
Objectives: The aim of this study was to evaluate nutritional status and body composition among a sample of adults in Vojvodina, a
northern region in Serbia.
Method / Design: 287 female and 105 male adults, aged between
18 to 65 years participated in the study. Nutritional status was defined
using body mass index (BMI), according to World Health Organization (WHO) criteria. Body composition was measured by InBody 720
body analyzer device, using the bioelectrical impedance method.
Results: A prevalence of overweight of 31,6% and of obesity by
58,6% were found. Additionally, 16,9% of subjects met criteria for class
2 obesity and 9,4% met criteria for extreme obesity. Women showed
higher percentage of overweight (33,4%) than men (26,7%) but levels
of obesity were higher in men (69,5%) than in women (54,7%). Mean
of % body fat within BMI groups: in normal BMI (22,57%), overweight
(32,74%) and obese (43,86%). The average values of the fitness score
and % skeletal muscle mass decrease with increasing age.
Conclusions: High prevalence of overweight and obesity requires
public health action. Healthy lifestyle, balanced diet with low caloric
intake and increased physical activity must be promoted within prevention strategy and control of obesity in adults in northern Serbia.
PB  - Karger, Basel
C3  - Annals of Nutrition and Metabolism
T1  - Body composition and nutritional status among adults in northern Serbia
VL  - 67
IS  - suppl 1
SP  - 452
EP  - 452
DO  - 10.1159/000440895
ER  - 

@conference{
author = "Dzigurski, Anka and Vidović, Bojana and Dilber, Sanda and Đorđević, Brižita",
year = "2015",
abstract = "Introduction: Overweight and obesity are a well-known public
health problem associated with chronical diseases such as heart disease, stroke and type 2 diabetes. Body composition and nutritional status monitoring are very important for planning preventive measures
towards health promotion.
Objectives: The aim of this study was to evaluate nutritional status and body composition among a sample of adults in Vojvodina, a
northern region in Serbia.
Method / Design: 287 female and 105 male adults, aged between
18 to 65 years participated in the study. Nutritional status was defined
using body mass index (BMI), according to World Health Organization (WHO) criteria. Body composition was measured by InBody 720
body analyzer device, using the bioelectrical impedance method.
Results: A prevalence of overweight of 31,6% and of obesity by
58,6% were found. Additionally, 16,9% of subjects met criteria for class
2 obesity and 9,4% met criteria for extreme obesity. Women showed
higher percentage of overweight (33,4%) than men (26,7%) but levels
of obesity were higher in men (69,5%) than in women (54,7%). Mean
of % body fat within BMI groups: in normal BMI (22,57%), overweight
(32,74%) and obese (43,86%). The average values of the fitness score
and % skeletal muscle mass decrease with increasing age.
Conclusions: High prevalence of overweight and obesity requires
public health action. Healthy lifestyle, balanced diet with low caloric
intake and increased physical activity must be promoted within prevention strategy and control of obesity in adults in northern Serbia.",
publisher = "Karger, Basel",
journal = "Annals of Nutrition and Metabolism",
title = "Body composition and nutritional status among adults in northern Serbia",
volume = "67",
number = "suppl 1",
pages = "452-452",
doi = "10.1159/000440895"
}

Dzigurski, A., Vidović, B., Dilber, S.,& Đorđević, B.. (2015). Body composition and nutritional status among adults in northern Serbia. in Annals of Nutrition and Metabolism
Karger, Basel., 67(suppl 1), 452-452.
https://doi.org/10.1159/000440895

Dzigurski A, Vidović B, Dilber S, Đorđević B. Body composition and nutritional status among adults in northern Serbia. in Annals of Nutrition and Metabolism. 2015;67(suppl 1):452-452.
doi:10.1159/000440895 .

Dzigurski, Anka, Vidović, Bojana, Dilber, Sanda, Đorđević, Brižita, "Body composition and nutritional status among adults in northern Serbia" in Annals of Nutrition and Metabolism, 67, no. suppl 1 (2015):452-452,
https://doi.org/10.1159/000440895 . .

TY  - CONF
AU  - Savić, Jelena
AU  - Brborić, Jasmina
AU  - Dilber, Sanda
AU  - Vladimirov, Sote
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5362
AB  - Although non-steroidal anti-inflammatory agents (NSAID) are numerous, broad used and can be procured as OTC drugs, search for new non-steroidal NSAID is continuing. Main motive is to find compound which selectively inhibits inducible form of enzyme cyclooxygenase (COX-2), but would have at least 10 times less effect on constitutive form (COX-1). If this selectivity concept is achieved, adverse effect on gastric mucosa would be avoided [1]. According to current docking studies, a compound is considered selective if it can maintain interactions in hydrophilic side pocket, so called P3 region in the active site of COX-2 [2]. The aim of this study was to determine the impact of substitution of one or both phenyl rings in 3-hydroxy-3,3-diphenylpropanoic acid with some simple substituents on selectivity towards COX-2 inhibition. Molecular docking calculations were performed using Autodock v4.0.1 into the 3D structure of the catalytic site of COX-2 enzyme (pdb code: 1cx2). Structure of each compound was generated using the ChemOffice v7.0 Ultra software package and have been MM2 optimized. Each docking experiment consisted of 100 docking runs with 150 individuals and 500,000 energy evaluations. The structures were incorporated into 40x40x40 grid points receptor pocket, which was centered to the position of ibuprofen in crystallographic structure of the complex. Ibuprofen was used as a reference compound because of its structure similarity to tested compounds. All of the compounds have lower binding energies than ibuprofen (Fig. 1) and all of these compounds have the right structure which enables penetration into P3 region in the COX-2. Compound containing dimethylamino group penetrates deepest into this region indicating the best selectivity ratio of all tested compounds.
PB  - Serbian Chemical Society
C3  - ICOSECS 8, 8th International Conference of the Chemical Societies of the South-East European Countries, BOOK OF ABSTRACTS, Belgrade, Serbia, June 27-29
T1  - Docking studies of 3-hydroxy-3-arylpropionic acids as potentially selective COX-2 inhibitors
SP  - 101
EP  - 101
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5362
ER  - 

@conference{
author = "Savić, Jelena and Brborić, Jasmina and Dilber, Sanda and Vladimirov, Sote",
year = "2013",
abstract = "Although non-steroidal anti-inflammatory agents (NSAID) are numerous, broad used and can be procured as OTC drugs, search for new non-steroidal NSAID is continuing. Main motive is to find compound which selectively inhibits inducible form of enzyme cyclooxygenase (COX-2), but would have at least 10 times less effect on constitutive form (COX-1). If this selectivity concept is achieved, adverse effect on gastric mucosa would be avoided [1]. According to current docking studies, a compound is considered selective if it can maintain interactions in hydrophilic side pocket, so called P3 region in the active site of COX-2 [2]. The aim of this study was to determine the impact of substitution of one or both phenyl rings in 3-hydroxy-3,3-diphenylpropanoic acid with some simple substituents on selectivity towards COX-2 inhibition. Molecular docking calculations were performed using Autodock v4.0.1 into the 3D structure of the catalytic site of COX-2 enzyme (pdb code: 1cx2). Structure of each compound was generated using the ChemOffice v7.0 Ultra software package and have been MM2 optimized. Each docking experiment consisted of 100 docking runs with 150 individuals and 500,000 energy evaluations. The structures were incorporated into 40x40x40 grid points receptor pocket, which was centered to the position of ibuprofen in crystallographic structure of the complex. Ibuprofen was used as a reference compound because of its structure similarity to tested compounds. All of the compounds have lower binding energies than ibuprofen (Fig. 1) and all of these compounds have the right structure which enables penetration into P3 region in the COX-2. Compound containing dimethylamino group penetrates deepest into this region indicating the best selectivity ratio of all tested compounds.",
publisher = "Serbian Chemical Society",
journal = "ICOSECS 8, 8th International Conference of the Chemical Societies of the South-East European Countries, BOOK OF ABSTRACTS, Belgrade, Serbia, June 27-29",
title = "Docking studies of 3-hydroxy-3-arylpropionic acids as potentially selective COX-2 inhibitors",
pages = "101-101",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5362"
}

Savić, J., Brborić, J., Dilber, S.,& Vladimirov, S.. (2013). Docking studies of 3-hydroxy-3-arylpropionic acids as potentially selective COX-2 inhibitors. in ICOSECS 8, 8th International Conference of the Chemical Societies of the South-East European Countries, BOOK OF ABSTRACTS, Belgrade, Serbia, June 27-29
Serbian Chemical Society., 101-101.
https://hdl.handle.net/21.15107/rcub_farfar_5362

Savić J, Brborić J, Dilber S, Vladimirov S. Docking studies of 3-hydroxy-3-arylpropionic acids as potentially selective COX-2 inhibitors. in ICOSECS 8, 8th International Conference of the Chemical Societies of the South-East European Countries, BOOK OF ABSTRACTS, Belgrade, Serbia, June 27-29. 2013;:101-101.
https://hdl.handle.net/21.15107/rcub_farfar_5362 .

Savić, Jelena, Brborić, Jasmina, Dilber, Sanda, Vladimirov, Sote, "Docking studies of 3-hydroxy-3-arylpropionic acids as potentially selective COX-2 inhibitors" in ICOSECS 8, 8th International Conference of the Chemical Societies of the South-East European Countries, BOOK OF ABSTRACTS, Belgrade, Serbia, June 27-29 (2013):101-101,
https://hdl.handle.net/21.15107/rcub_farfar_5362 .

TY  - JOUR
AU  - Vitnik, Vesna
AU  - Milenković, Marina
AU  - Dilber, Sanda
AU  - Vitnik, Željko J.
AU  - Juranić, Ivan O.
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1832
AB  - A series of α,β-unsaturated and α-bromo carboxylic acids were identified as potent antimicrobial agents. The antimicrobial activity was evaluated using the broth microdilution method. All acids 1-12 exhibited a significant activity against nine laboratory control strains of bacteria and two strains of yeast Candida albicans. The tested acids were efficiently prepared by optimized phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent with triethylbenzyl ammonium chloride (TEBA) as catalyst.
AB  - U ovom radu je prikazano in vitro ispitivanje antimikrobnog dejstva serije α,β-nezasićenih i α-bromkarboksilnih kiselina i pokazano je da su one potencijalno dobri antimikrobni agensi. Sve kiseline 1-12 pokazale su značajnu aktivnost prema devet sojeva bakterija i dva soja gljivica Candida albicans. Ispitivane kiseline sintetisane su u optimizovanoj reakciji ketona sa bromoformom i litijum-hidroksidom u smesi rastvarača (terc-butanol/voda). Kao katalizator za prenos između faza upotrebljen je trietilbenzilamonijum-hlorid (TEBA).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids
T1  - Optimizacija sinteze i in vitro proučavanje antimikrobnog dejstva α,β-nezasićenih i α-bromkarboksilnih kiselina
VL  - 77
IS  - 6
SP  - 741
EP  - 750
DO  - 10.2298/JSC111104016V
ER  - 

@article{
author = "Vitnik, Vesna and Milenković, Marina and Dilber, Sanda and Vitnik, Željko J. and Juranić, Ivan O.",
year = "2012",
abstract = "A series of α,β-unsaturated and α-bromo carboxylic acids were identified as potent antimicrobial agents. The antimicrobial activity was evaluated using the broth microdilution method. All acids 1-12 exhibited a significant activity against nine laboratory control strains of bacteria and two strains of yeast Candida albicans. The tested acids were efficiently prepared by optimized phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent with triethylbenzyl ammonium chloride (TEBA) as catalyst., U ovom radu je prikazano in vitro ispitivanje antimikrobnog dejstva serije α,β-nezasićenih i α-bromkarboksilnih kiselina i pokazano je da su one potencijalno dobri antimikrobni agensi. Sve kiseline 1-12 pokazale su značajnu aktivnost prema devet sojeva bakterija i dva soja gljivica Candida albicans. Ispitivane kiseline sintetisane su u optimizovanoj reakciji ketona sa bromoformom i litijum-hidroksidom u smesi rastvarača (terc-butanol/voda). Kao katalizator za prenos između faza upotrebljen je trietilbenzilamonijum-hlorid (TEBA).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids, Optimizacija sinteze i in vitro proučavanje antimikrobnog dejstva α,β-nezasićenih i α-bromkarboksilnih kiselina",
volume = "77",
number = "6",
pages = "741-750",
doi = "10.2298/JSC111104016V"
}

Vitnik, V., Milenković, M., Dilber, S., Vitnik, Ž. J.,& Juranić, I. O.. (2012). Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 77(6), 741-750.
https://doi.org/10.2298/JSC111104016V

Vitnik V, Milenković M, Dilber S, Vitnik ŽJ, Juranić IO. Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids. in Journal of the Serbian Chemical Society. 2012;77(6):741-750.
doi:10.2298/JSC111104016V .

Vitnik, Vesna, Milenković, Marina, Dilber, Sanda, Vitnik, Željko J., Juranić, Ivan O., "Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids" in Journal of the Serbian Chemical Society, 77, no. 6 (2012):741-750,
https://doi.org/10.2298/JSC111104016V . .

TY  - JOUR
AU  - Savić, Jelena
AU  - Dilber, Sanda
AU  - Marković, Bojan
AU  - Milenković, Marina
AU  - Vladimirov, Sote
AU  - Juranić, Ivan O.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1483
AB  - Six beta-hydroxy-beta-aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These acids belong to the aryl propanoic acid class of compounds, structurally similar to the NSAIDs, such as ibuprofen, and an anti-inflammatory activity is thus expected. The aim of this work was to determine anti-inflammatory activity, examine gastric tolerability, and to carry out molecular docking experiments to identify potential COX-2 inhibitors among the beta-hydroxy-beta-aryl propanoic acids, and to elucidate the effect a-methyl substitution on the anti-inflammatory activity. Anti-inflammatory activity and gastric tolerability were determined on rats using carragenan induced paw oedema method, and docking studies were carried out using Autodock v4.0.1. The range of ED(50) values is between 127 mu mol/kg and 15 mu mol/kg, while the result for ibuprofen is 51.7 mu mol/kg. Only slight hyperaemia or few petechiae were spotted on rat's stomach. The results indicate that all compounds possess significant anti-inflammatory activity after oral administration, and that 2-methyl-3-hydroxy-3,3-diphenylpropanoic acid has greatest activity, surpassing that of ibuprofen, a standard NSAID. Another compound, 3-hydroxy-3,3-diphenylpropanoic acid, shows activity matching that of ibuprofen, and is non-chiral and is proven to be non-toxic. The most of investigated compounds have interactions with P3 anchor site like COX-2 selective inhibitors. No tested substances or ibuprofen produced any significant gastric lesions.
PB  - MDPI, Basel
T2  - Molecules
T1  - Docking Studies and alpha-Substitution Effects on the Anti-Inflammatory Activity of beta-Hydroxy-beta-arylpropanoic Acids
VL  - 16
IS  - 8
SP  - 6645
EP  - 6655
DO  - 10.3390/molecules16086645
ER  - 

@article{
author = "Savić, Jelena and Dilber, Sanda and Marković, Bojan and Milenković, Marina and Vladimirov, Sote and Juranić, Ivan O.",
year = "2011",
abstract = "Six beta-hydroxy-beta-aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These acids belong to the aryl propanoic acid class of compounds, structurally similar to the NSAIDs, such as ibuprofen, and an anti-inflammatory activity is thus expected. The aim of this work was to determine anti-inflammatory activity, examine gastric tolerability, and to carry out molecular docking experiments to identify potential COX-2 inhibitors among the beta-hydroxy-beta-aryl propanoic acids, and to elucidate the effect a-methyl substitution on the anti-inflammatory activity. Anti-inflammatory activity and gastric tolerability were determined on rats using carragenan induced paw oedema method, and docking studies were carried out using Autodock v4.0.1. The range of ED(50) values is between 127 mu mol/kg and 15 mu mol/kg, while the result for ibuprofen is 51.7 mu mol/kg. Only slight hyperaemia or few petechiae were spotted on rat's stomach. The results indicate that all compounds possess significant anti-inflammatory activity after oral administration, and that 2-methyl-3-hydroxy-3,3-diphenylpropanoic acid has greatest activity, surpassing that of ibuprofen, a standard NSAID. Another compound, 3-hydroxy-3,3-diphenylpropanoic acid, shows activity matching that of ibuprofen, and is non-chiral and is proven to be non-toxic. The most of investigated compounds have interactions with P3 anchor site like COX-2 selective inhibitors. No tested substances or ibuprofen produced any significant gastric lesions.",
publisher = "MDPI, Basel",
journal = "Molecules",
title = "Docking Studies and alpha-Substitution Effects on the Anti-Inflammatory Activity of beta-Hydroxy-beta-arylpropanoic Acids",
volume = "16",
number = "8",
pages = "6645-6655",
doi = "10.3390/molecules16086645"
}

Savić, J., Dilber, S., Marković, B., Milenković, M., Vladimirov, S.,& Juranić, I. O.. (2011). Docking Studies and alpha-Substitution Effects on the Anti-Inflammatory Activity of beta-Hydroxy-beta-arylpropanoic Acids. in Molecules
MDPI, Basel., 16(8), 6645-6655.
https://doi.org/10.3390/molecules16086645

Savić J, Dilber S, Marković B, Milenković M, Vladimirov S, Juranić IO. Docking Studies and alpha-Substitution Effects on the Anti-Inflammatory Activity of beta-Hydroxy-beta-arylpropanoic Acids. in Molecules. 2011;16(8):6645-6655.
doi:10.3390/molecules16086645 .

Savić, Jelena, Dilber, Sanda, Marković, Bojan, Milenković, Marina, Vladimirov, Sote, Juranić, Ivan O., "Docking Studies and alpha-Substitution Effects on the Anti-Inflammatory Activity of beta-Hydroxy-beta-arylpropanoic Acids" in Molecules, 16, no. 8 (2011):6645-6655,
https://doi.org/10.3390/molecules16086645 . .

TY  - JOUR
AU  - Dilber, Sanda
AU  - Dobrić, Silva
AU  - Juranić, Zorica
AU  - Marković, Bojan
AU  - Vladimirov, Sote
AU  - Juranić, Ivan O.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1101
AB  - The article describes a two-step synthesis of diastereomeric 3-hydroxy-2methyl-3-( 4-biphenylyl) butanoic acids. In the first step an intermediate alpha-bromo propanoic acid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatsky reaction in presence of Zn in tetrahydrofuran (THF) at -5 to 10 C between the previously synthesized intermediate and 4-acetylbiphenyl. Synthesis of the other studied beta-hydroxy- beta-arylpropanoic acids has already been reported. These beta-hydroxy-beta-arylpropanoic acids belong to the arylpropanoic acid class of compounds, structurally similar to the NSAIDs such as ibuprofen. The anti-inflammatory activity and gastric tolerability of the synthesized compounds were evaluated. Molecular docking experiments were carried out to identify potential COX-2 inhibitors among the beta-hydroxy- beta-aryl-alkanoic acids class. The results indicate that all compounds possess significant anti-inflammatory activity after oral administration and that the compounds 2-(9-( 9-hydroxy-fluorenyl))-2-methylpropanoic acid ( 5) and 3-hydroxy-3,3-diphenyl- propanoic acid (3) possess the strongest anti-inflammatory activity, comparable to that of ibuprofen, a standard NSAID, and that none of tested substances or ibuprofen produced any significant gastric lesions.
PB  - Molecular Diversity Preservation Int, Basel
T2  - Molecules
T1  - Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids
VL  - 13
IS  - 3
SP  - 603
EP  - 615
DO  - 10.3390/molecules13030603
ER  - 

@article{
author = "Dilber, Sanda and Dobrić, Silva and Juranić, Zorica and Marković, Bojan and Vladimirov, Sote and Juranić, Ivan O.",
year = "2008",
abstract = "The article describes a two-step synthesis of diastereomeric 3-hydroxy-2methyl-3-( 4-biphenylyl) butanoic acids. In the first step an intermediate alpha-bromo propanoic acid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatsky reaction in presence of Zn in tetrahydrofuran (THF) at -5 to 10 C between the previously synthesized intermediate and 4-acetylbiphenyl. Synthesis of the other studied beta-hydroxy- beta-arylpropanoic acids has already been reported. These beta-hydroxy-beta-arylpropanoic acids belong to the arylpropanoic acid class of compounds, structurally similar to the NSAIDs such as ibuprofen. The anti-inflammatory activity and gastric tolerability of the synthesized compounds were evaluated. Molecular docking experiments were carried out to identify potential COX-2 inhibitors among the beta-hydroxy- beta-aryl-alkanoic acids class. The results indicate that all compounds possess significant anti-inflammatory activity after oral administration and that the compounds 2-(9-( 9-hydroxy-fluorenyl))-2-methylpropanoic acid ( 5) and 3-hydroxy-3,3-diphenyl- propanoic acid (3) possess the strongest anti-inflammatory activity, comparable to that of ibuprofen, a standard NSAID, and that none of tested substances or ibuprofen produced any significant gastric lesions.",
publisher = "Molecular Diversity Preservation Int, Basel",
journal = "Molecules",
title = "Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids",
volume = "13",
number = "3",
pages = "603-615",
doi = "10.3390/molecules13030603"
}

Dilber, S., Dobrić, S., Juranić, Z., Marković, B., Vladimirov, S.,& Juranić, I. O.. (2008). Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids. in Molecules
Molecular Diversity Preservation Int, Basel., 13(3), 603-615.
https://doi.org/10.3390/molecules13030603

Dilber S, Dobrić S, Juranić Z, Marković B, Vladimirov S, Juranić IO. Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids. in Molecules. 2008;13(3):603-615.
doi:10.3390/molecules13030603 .

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